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Science 4 September 1992:
Vol. 257. no. 5075, pp. 1401 - 1403
DOI: 10.1126/science.1382313

Articles

Science, Vol 257, Issue 5075, 1401-1403
Copyright © 1992 by American Association for the Advancement of Science


articles

Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor

A Yanagisawa-Miwa, Y Uchida, F Nakamura, T Tomaru, H Kido, T Kamijo, T Sugimoto, K Kaji, M Utsuyama, C Kurashima, and al. et

Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.

Coronary collateral vessels reduce damage to ischemic myocardium after coronary obstruction. Factors that stimulate collateral formation are expected to have ameliorating effects on myocardial infarction. In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reduced infarct size. Treatment with bFGF increased the number of arterioles and capillaries in the infarct. Thus, the angiogenic action of bFGF might lead to a reduction in infarct size. The application of bFGF might bring about a therapeutic modality for the salvage of infarcted myocardium.


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Molecular Mechanisms of Coronary Collateral Vessel Growth.
W. Schaper and W. D. Ito (1996)
Circ. Res. 79, 911-919
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Reduction in Myocardial Infarct Size by Basic Fibroblast Growth Factor After Temporary Coronary Occlusion in a Canine Model.
M. C.G. Horrigan, A. I. MacIsaac, F. A. Nicolini, D. G. Vince, P. Lee, S. G. Ellis, and E. J. Topol (1996)
Circulation 94, 1927-1933
   Abstract »    Full Text »
Functional Upregulation of the Vascular Endothelial Growth Factor Receptor KDR by Hypoxia.
J. Waltenberger, U. Mayr, S. Pentz, and V. Hombach (1996)
Circulation 94, 1647-1654
   Abstract »    Full Text »
Elevated Basic Fibroblast Growth Factor in Pericardial Fluid of Patients With Unstable Angina.
M. Fujita, M. Ikemoto, M. Kishishita, H. Otani, R. Nohara, T. Tanaka, S.-i. Tamaki, A. Yamazato, and S. Sasayama (1996)
Circulation 94, 610-613
   Abstract »    Full Text »
Direct In Vivo Gene Transfer to Canine Myocardium Using a Replication-Deficient Adenovirus Vector.
C. J. Magovern, C. A. Mack, J. Zhang, R. T. Hahn, W. Ko, O. W. Isom, R. G. Crystal, and T. K. Rosengart (1996)
Ann. Thorac. Surg. 62, 425-433
   Abstract »    Full Text »
THE USE OF BIOLOGIC GLUE FOR BETTER ADHESIONS BETWEEN THE SKELETAL MUSCLE FLAP AND THE MYOCARDIUM AND FOR INCREASING CAPILLARY INGROWTH.
V. Chekanov, V. Nikolaychik, and G. Tchekanov (1996)
J. Thorac. Cardiovasc. Surg. 111, 678-680
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THE EFFECT OF BASIC FIBROBLAST GROWTH FACTOR ON THE BLOOD FLOW AND MORPHOLOGIC FEATURES OF A LATISSIMUS DORSI CARDIOMYOPLASTY.
J. D. Mannion, V. Blood, W. Bailey, T. L. Bauer, M. G. Magno, F. DiMeo, A. Epple, and F. G. Spinale (1996)
J. Thorac. Cardiovasc. Surg. 111, 19-28
   Abstract »    Full Text »
Basic Fibroblast Growth Factor Increases Regional Cerebral Blood Flow and Reduces Infarct Size After Experimental Ischemia in a Rat Model.
R. Tanaka, Y. Miyasaka, K. Yada, T. Ohwada, and T. Kameya (1995)
Stroke 26, 2154-2159
   Abstract »    Full Text »
Synergistic Effect of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor on Angiogenesis In Vivo.
T. Asahara, C. Bauters, L. P. Zheng, S. Takeshita, S. Bunting, N. Ferrara, J. F. Symes, and J. M. Isner (1995)
Circulation 92, 365-371
   Abstract »    Full Text »
Potential Gene Therapy Strategies in the Treatment of Cardiovascular Disease.
R. T. Rowland, J. C. Cleveland Jr, X. Meng, A. H. Harken, and J. M. Brown (1995)
Ann. Thorac. Surg. 60, 721-728
   Abstract »    Full Text »
Arterial Gene Therapy for Therapeutic Angiogenesis in Patients With Peripheral Artery Disease.
J. M. Isner, K. Walsh, J. Symes, A. Pieczek, S. Takeshita, J. Lowry, S. Rossow, K. Rosenfield, L. Weir, E. Brogi, et al. (1995)
Circulation 91, 2687-2692
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Effects of a Single Administration of Fibroblast Growth Factor on Vascular Wall Reaction to Injury.
M. A. Parish, E. A. Grossi, F. G. Baumann, T. Asai, D. B. Rifkin, S. B. Colvin, and A. C. Galloway (1995)
Ann. Thorac. Surg. 59, 948-954
   Abstract »    Full Text »
Expression of Vascular Endothelial Growth Factor From a Defective Herpes Simplex Virus Type 1 Amplicon Vector Induces Angiogenesis in Mice.
E. A. Mesri, H. J. Federoff, and M. Brownlee (1995)
Circ. Res. 76, 161-167
   Abstract »    Full Text »
Effects of Chronic Systemic Administration of Basic Fibroblast Growth Factor on Collateral Development in the Canine Heart.
D. F. Lazarous, M. Scheinowitz, M. Shou, E. Hodge, M. A. S. Rajanayagam, S. Hunsberger, W. G. Robison Jr, J. A. Stiber, R. Correa, S. E. Epstein, et al. (1995)
Circulation 91, 145-153
   Abstract »    Full Text »



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