Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 September 1992:
Vol. 257. no. 5075, pp. 1398 - 1400
DOI: 10.1126/science.1529340
Prev | Table of Contents | Next

Articles

Science, Vol 257, Issue 5075, 1398-1400
Copyright © 1992 by American Association for the Advancement of Science

articles

MacroH2A, a core histone containing a large nonhistone region

Pehrson JR and VA Fried

Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111.

A histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes. Its N-terminal third is 64 percent identical to a full-length mouse H2A. However, it also contains a large nonhistone region. This region has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors. Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The single-macro domain protein LRP16 is an essential cofactor of androgen receptor.
J Yang, Y-L Zhao, Z-Q Wu, Y-L Si, Y-G Meng, X-B Fu, Y-M Mu, and W-D Han (2009)
Endocr. Relat. Cancer 16, 139-153
   Abstract »    Full Text »    PDF »
Crystal Structures of Two Coronavirus ADP-Ribose-1''-Monophosphatases and Their Complexes with ADP-Ribose: a Systematic Structural Analysis of the Viral ADRP Domain.
Y. Xu, L. Cong, C. Chen, L. Wei, Q. Zhao, X. Xu, Y. Ma, M. Bartlam, and Z. Rao (2009)
J. Virol. 83, 1083-1092
   Abstract »    Full Text »    PDF »
Weak but Uniform Enrichment of the Histone Variant macroH2A1 along the Inactive X Chromosome.
F. Mietton, A. K. Sengupta, A. Molla, G. Picchi, S. Barral, L. Heliot, T. Grange, A. Wutz, and S. Dimitrov (2009)
Mol. Cell. Biol. 29, 150-156
   Abstract »    Full Text »    PDF »
macroH2A1-Dependent Silencing of Endogenous Murine Leukemia Viruses.
L. N. Changolkar, G. Singh, and J. R. Pehrson (2008)
Mol. Cell. Biol. 28, 2059-2065
   Abstract »    Full Text »    PDF »
A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis.
E. Bernstein, T. L. Muratore-Schroeder, R. L. Diaz, J. C. Chow, L. N. Changolkar, J. Shabanowitz, E. Heard, J. R. Pehrson, D. F. Hunt, and C. D. Allis (2008)
PNAS 105, 1533-1538
   Abstract »    Full Text »    PDF »
H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way.
J. M. Eirin-Lopez, T. Ishibashi, and J. Ausio (2008)
FASEB J 22, 316-326
   Abstract »    Full Text »    PDF »
Collaborator of Stat6 (CoaSt6)-associated Poly(ADP-ribose) Polymerase Activity Modulates Stat6-dependent Gene Transcription.
S. Goenka, S. H. Cho, and M. Boothby (2007)
J. Biol. Chem. 282, 18732-18739
   Abstract »    Full Text »    PDF »
Biological Functions of DNA Methyltransferase 1 Require Its Methyltransferase Activity.
M. Damelin and T. H. Bestor (2007)
Mol. Cell. Biol. 27, 3891-3899
   Abstract »    Full Text »    PDF »
Poly(ADP-ribose) Polymerase 1 Is Inhibited by a Histone H2A Variant, MacroH2A, and Contributes to Silencing of the Inactive X Chromosome.
D. A. Nusinow, I. Hernandez-Munoz, T. G. Fazzio, G. M. Shah, W. L. Kraus, and B. Panning (2007)
J. Biol. Chem. 282, 12851-12859
   Abstract »    Full Text »    PDF »
Developmental Changes in Histone macroH2A1-Mediated Gene Regulation.
L. N. Changolkar, C. Costanzi, N. A. Leu, D. Chen, K. J. McLaughlin, and J. R. Pehrson (2007)
Mol. Cell. Biol. 27, 2758-2764
   Abstract »    Full Text »    PDF »
The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.
K. Ouararhni, R. Hadj-Slimane, S. Ait-Si-Ali, P. Robin, F. Mietton, A. Harel-Bellan, S. Dimitrov, and A. Hamiche (2006)
Genes & Dev. 20, 3324-3336
   Abstract »    Full Text »    PDF »
Structural and Functional Basis for ADP-Ribose and Poly(ADP-Ribose) Binding by Viral Macro Domains..
M.-P. Egloff, H. Malet, A. Putics, M. Heinonen, H. Dutartre, A. Frangeul, A. Gruez, V. Campanacci, C. Cambillau, J. Ziebuhr, et al. (2006)
J. Virol. 80, 8493-8502
   Abstract »    Full Text »    PDF »
Histone variants--the structure behind the function.
J. Ausio (2006)
Brief Funct Genomic Proteomic 5, 228-243
   Abstract »    Full Text »    PDF »
The Histone Variant Macro-H2A Preferentially Forms "Hybrid Nucleosomes".
S. Chakravarthy and K. Luger (2006)
J. Biol. Chem. 281, 25522-25531
   Abstract »    Full Text »    PDF »
Chromosome-wide, allele-specific analysis of the histone code on the human X chromosome.
C. M. Valley, L. M. Pertz, B. S. Balakumaran, and H. F. Willard (2006)
Hum. Mol. Genet. 15, 2335-2347
   Abstract »    Full Text »    PDF »
macroH2A1 Histone Variants Are Depleted on Active Genes but Concentrated on the Inactive X Chromosome.
L. N. Changolkar and J. R. Pehrson (2006)
Mol. Cell. Biol. 26, 4410-4420
   Abstract »    Full Text »    PDF »
Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast..
C. B. Millar, F. Xu, K. Zhang, and M. Grunstein (2006)
Genes & Dev. 20, 711-722
   Abstract »    Full Text »    PDF »
Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor..
S. Goenka and M. Boothby (2006)
PNAS 103, 4210-4215
   Abstract »    Full Text »    PDF »
Allele-specific deposition of macroH2A1 in imprinting control regions.
J. H. Choo, J. D. Kim, J. H. Chung, L. Stubbs, and J. Kim (2006)
Hum. Mol. Genet. 15, 717-724
   Abstract »    Full Text »    PDF »
Mechanism of Polymerase II Transcription Repression by the Histone Variant macroH2A.
C.-M. Doyen, W. An, D. Angelov, V. Bondarenko, F. Mietton, V. M. Studitsky, A. Hamiche, R. G. Roeder, P. Bouvet, and S. Dimitrov (2006)
Mol. Cell. Biol. 26, 1156-1164
   Abstract »    Full Text »    PDF »
Mapping Post-translational Modifications of the Histone Variant MacroH2A1 Using Tandem Mass Spectrometry.
F. Chu, D. A. Nusinow, R. J. Chalkley, K. Plath, B. Panning, and A. L. Burlingame (2006)
Mol. Cell. Proteomics 5, 194-203
   Abstract »    Full Text »    PDF »
Tandem chimerism as a means to increase protein complexity in the human genome.
G. Parra, A. Reymond, N. Dabbouseh, E. T. Dermitzakis, R. Castelo, T. M. Thomson, S. E. Antonarakis, and R. Guigo (2006)
Genome Res. 16, 37-44
   Abstract »    Full Text »    PDF »
B-aggressive Lymphoma Family Proteins Have Unique Domains That Modulate Transcription and Exhibit Poly(ADP-ribose) Polymerase Activity.
R. C. T. Aguiar, K. Takeyama, C. He, K. Kreinbrink, and M. A. Shipp (2005)
J. Biol. Chem. 280, 33756-33765
   Abstract »    Full Text »    PDF »
Structural Characterization of the Histone Variant macroH2A.
S. Chakravarthy, S. K. Y. Gundimella, C. Caron, P.-Y. Perche, J. R. Pehrson, S. Khochbin, and K. Luger (2005)
Mol. Cell. Biol. 25, 7616-7624
   Abstract »    Full Text »    PDF »
RNA meets chromatin.
E. Bernstein and C. D. Allis (2005)
Genes & Dev. 19, 1635-1655
   Abstract »    Full Text »    PDF »
Proteome Analysis of Human Metaphase Chromosomes.
S. Uchiyama, S. Kobayashi, H. Takata, T. Ishihara, N. Hori, T. Higashi, K. Hayashihara, T. Sone, D. Higo, T. Nirasawa, et al. (2005)
J. Biol. Chem. 280, 16994-17004
   Abstract »    Full Text »    PDF »
Beyond the Xi: MacroH2A CHROMATIN DISTRIBUTION AND POST-TRANSLATIONAL MODIFICATION IN AN AVIAN SYSTEM.
D. W. Abbott, B. P. Chadwick, A. A. Thambirajah, and J. Ausio (2005)
J. Biol. Chem. 280, 16437-16445
   Abstract »    Full Text »    PDF »
DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A.
Y. Ma, S. B. Jacobs, L. Jackson-Grusby, M.-A. Mastrangelo, J. A. Torres-Betancourt, R. Jaenisch, and T. P. Rasmussen (2005)
J. Cell Sci. 118, 1607-1616
   Abstract »    Full Text »    PDF »
Localisation of histone macroH2A1.2 to the XY-body is not a response to the presence of asynapsed chromosome axes.
S. Hoyer-Fender, E. Czirr, R. Radde, J. M. A. Turner, S. K. Mahadevaiah, J. R. Pehrson, and P. S. Burgoyne (2004)
J. Cell Sci. 117, 189-198
   Abstract »    Full Text »    PDF »
Structural Characterization of Histone H2A Variants.
S. CHAKRAVARTHY, Y. BAO, V.A. ROBERTS, D. TREMETHICK, and K. LUGER (2004)
Cold Spring Harb Symp Quant Biol 69, 227-234
   Abstract »    PDF »
Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome.
B. P. Chadwick and H. F. Willard (2002)
J. Cell Biol. 157, 1113-1123
   Abstract »    Full Text »    PDF »
Characterization of the Stability and Folding of H2A.Z Chromatin Particles. IMPLICATIONS FOR TRANSCRIPTIONAL ACTIVATION.
D. W. Abbott, V. S. Ivanova, X. Wang, W. M. Bonner, and J. Ausio (2001)
J. Biol. Chem. 276, 41945-41949
   Abstract »    Full Text »    PDF »
Histone variant macroH2A contains two distinct macrochromatin domains capable of directing macroH2A to the inactive X chromosome.
B. P. Chadwick, C. M. Valley, and H. F. Willard (2001)
Nucleic Acids Res. 29, 2699-2705
   Abstract »    Full Text »    PDF »
Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant.
B. P. Chadwick and H. F. Willard (2001)
Hum. Mol. Genet. 10, 1101-1113
   Abstract »    Full Text »    PDF »
A Novel Chromatin Protein, Distantly Related to Histone H2A, Is Largely Excluded from the Inactive X Chromosome.
B. P. Chadwick and H. F. Willard (2001)
J. Cell Biol. 152, 375-384
   Abstract »    Full Text »    PDF »
BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration.
R. C. T. Aguiar, Y. Yakushijin, S. Kharbanda, R. Salgia, J. A. Fletcher, and M. A. Shipp (2000)
Blood 96, 4328-4334
   Abstract »    Full Text »    PDF »
Dynamic Relocalization of Histone MacroH2A1 from Centrosomes to Inactive X Chromosomes during X Inactivation.
T. P. Rasmussen, M.-A. Mastrangelo, A. Eden, J. R. Pehrson, and R. Jaenisch (2000)
J. Cell Biol. 150, 1189-1198
   Abstract »    Full Text »    PDF »
Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos.
C Costanzi, P Stein, D. Worrad, R. Schultz, and J. Pehrson (2000)
Development 127, 2283-2289
   Abstract »    PDF »
The Histone Database: a comprehensive WWW resource for histones and histone fold-containing proteins.
S. A. Sullivan, L. Aravind, I. Makalowska, A. D. Baxevanis, and D. Landsman (2000)
Nucleic Acids Res. 28, 320-322
   Abstract »    Full Text »    PDF »
Histone MacroH2A1.2 Relocates to the Inactive X Chromosome after Initiation and Propagation of X-Inactivation.
J. E. Mermoud, C. Costanzi, J. R. Pehrson, and N. Brockdorff (1999)
J. Cell Biol. 147, 1399-1408
   Abstract »    Full Text »    PDF »
MACROH2A2, a New Member of the MACROH2A Core Histone Family.
C. Costanzi and J. R. Pehrson (2001)
J. Biol. Chem. 276, 21776-21784
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)