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Science 28 August 1992:
Vol. 257. no. 5074, pp. 1276 - 1279
DOI: 10.1126/science.1381521
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Articles

Science, Vol 257, Issue 5074, 1276-1279
Copyright © 1992 by American Association for the Advancement of Science

articles

Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition

AB Malmberg and TL Yaksh

Department of Anesthesiology, University of California-San Diego, La Jolla 92093-0818.

Inhibition of cyclooxygenase by nonsteroidal anti-inflammatory drugs (NSAIDs) in the periphery is commonly accepted as the primary mechanism by which these agents produce a selective attenuation of pain (analgesia). NSAIDs are now shown to exert a direct spinal action by blocking the excessive sensitivity to pain (hyperalgesia) induced by the activation of spinal glutamate and substance P receptors. These findings demonstrate that the analgesic effects of NSAIDs can be dissociated from their anti-inflammatory actions. Spinal prostanoids are thus critical for the augmented processing of pain information at the spinal level.


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