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Science 28 August 1992:
Vol. 257. no. 5074, pp. 1255 - 1258
DOI: 10.1126/science.1519062
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Articles

Science, Vol 257, Issue 5074, 1255-1258
Copyright © 1992 by American Association for the Advancement of Science

articles

Deactivation of visual transduction without guanosine triphosphate hydrolysis by G protein

MA Erickson, P Robinson, and J Lisman

Department of Biochemistry, Brandeis University, Waltham, MA 02254.

G proteins couple receptors to their target enzymes in many signal transduction cascades. It has generally been thought that deactivation of such cascades cannot occur without the hydrolysis of guanosine triphosphate (GTP) by G protein. This requirement has now been reexamined in both vertebrate and invertebrate phototransduction. Results indicate that GTP hydrolysis is not required for deactivation. Evidence is presented for an alternative model in which the target enzyme is deactivated by an inhibitory factor that is available even when GTP hydrolysis is blocked.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase..
S. H. Tsang, M. L. Woodruff, C.-K. Chen, C. Y. Yamashita, M. C. Cilluffo, A. L. Rao, D. B. Farber, and G. L. Fain (2006)
J. Neurosci. 26, 4472-4480
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The Glutamic Acid-rich Protein-2 (GARP2) Is a High Affinity Rod Photoreceptor Phosphodiesterase (PDE6)-binding Protein That Modulates Its Catalytic Properties.
D. C. Pentia, S. Hosier, and R. H. Cote (2006)
J. Biol. Chem. 281, 5500-5505
   Abstract »    Full Text »    PDF »
Acceleration of Key Reactions as a Strategy to Elucidate the Rate-Limiting Chemistry Underlying Phototransduction Inactivation.
M. J. Kennedy, M. E. Sowa, T. G. Wensel, and J. B. Hurley (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1016-1022
   Abstract »    Full Text »    PDF »
Adaptation in Vertebrate Photoreceptors.
G. L. Fain, H. R. Matthews, M. C. Cornwall, and Y. Koutalos (2001)
Physiol Rev 81, 117-151
   Abstract »    Full Text »    PDF »
A Possible Role of RGS9 in Phototransduction. A BRIDGE BETWEEN THE cGMP-PHOSPHODIESTERASE SYSTEM AND THE GUANYLYL CYCLASE SYSTEM.
K. Seno, A. Kishigami, S. Ihara, T. Maeda, V. A. Bondarenko, Y. Nishizawa, J. Usukura, A. Yamazaki, and F. Hayashi (1998)
J. Biol. Chem. 273, 22169-22172
   Abstract »    Full Text »    PDF »
Ca2+/calmodulin-binding peptides block phototransduction in Limulus ventral photoreceptors: Evidence for direct inhibition of phospholipase C.
E. A. Richard, S. Ghosh, J. M. Lowenstein, and J. E. Lisman (1997)
PNAS 94, 14095-14099
   Abstract »    Full Text »    PDF »
Regulation of Transducin GTPase Activity by Human Retinal RGS.
M. Natochin, A. E. Granovsky, and N. O. Artemyev (1997)
J. Biol. Chem. 272, 17444-17449
   Abstract »    Full Text »    PDF »
The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro.
E. Faurobert and J. B. Hurley (1997)
PNAS 94, 2945-2950
   Abstract »    Full Text »    PDF »
Phosphorylation by Cyclin-dependent Protein Kinase 5 of the Regulatory Subunit of Retinal cGMP Phosphodiesterase. II. ITS ROLE IN THE TURNOFF OF PHOSPHODIESTERASE IN VIVO.
F. Hayashi, I. Matsuura, S. Kachi, T. Maeda, M. Yamamoto, Y. Fujii, H. Liu, M. Yamazaki, J. Usukura, and A. Yamazaki (2000)
J. Biol. Chem. 275, 32958-32965
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)