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Science 28 August 1992:
Vol. 257. no. 5074, pp. 1248 - 1251
DOI: 10.1126/science.1325670

Articles

Science, Vol 257, Issue 5074, 1248-1251
Copyright © 1992 by American Association for the Advancement of Science


articles

The cloning of a family of genes that encode the melanocortin receptors

KG Mountjoy, LS Robbins, MT Mortrud, and RD Cone

Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201.

Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.


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Chronic Blockade of the Melanocortin 4 Receptor Subtype Leads to Obesity Independently of Neuropeptide Y Action, with No Adverse Effects on the Gonadotropic and Somatotropic Axes.
P. D. Raposinho, E. Castillo, V. D'alleves, P. Broqua, F. P. Pralong, and M. L. Aubert (2000)
Endocrinology 141, 4419-4427
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Functional Adrenocorticotropic Hormone Receptor in Cultured Human Vascular Endothelial Cells : Possible Role in Control of Blood Pressure.
H. Hatakeyama, S. Inaba, N. Taniguchi, and I. Miyamori (2000)
Hypertension 36, 862-865
   Abstract »    Full Text »    PDF »
Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation.
N. Flanagan, E. Healy, A. Ray, S. Philips, C. Todd, I. J. Jackson, M. A. Birch-Machin, and J. L. Rees (2000)
Hum. Mol. Genet. 9, 2531-2537
   Abstract »    Full Text »    PDF »
Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.
C. R. Goding (2000)
Genes & Dev. 14, 1712-1728
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Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress.
A. Slominski, J. Wortsman, T. Luger, R. Paus, and S. Solomon (2000)
Physiol Rev 80, 979-1020
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Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.
P. C. White and P. W. Speiser (2000)
Endocr. Rev. 21, 245-291
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alpha -Melanocyte-stimulating Hormone Reduces Impact of Proinflammatory Cytokine and Peroxide-generated Oxidative Stress on Keratinocyte and Melanoma Cell Lines.
J. W. Haycock, S. J. Rowe, S. Cartledge, A. Wyatt, G. Ghanem, R. Morandini, I. G. Rennie, and S. MacNeil (2000)
J. Biol. Chem. 275, 15629-15636
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Regulation by Adrenocorticotropin (ACTH), Angiotensin II, Transforming Growth Factor-{beta}, and Insulin-Like Growth Factor I of Bovine Adrenal Cell Steroidogenic Capacity and Expression of ACTH Receptor, Steroidogenic Acute Regulatory Protein, Cytochrome P450c17, and 3{beta}-Hydroxysteroid Dehydrogenase.
C. Le Roy, J. Y. Li, D. M. Stocco, D. Langlois, and J. M. Saez (2000)
Endocrinology 141, 1599-1607
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Agouti and Agouti-related Protein: Analogies and Contrasts.
D. M. Dinulescu and R. D. Cone (2000)
J. Biol. Chem. 275, 6695-6698
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Functional Characterization of Mutations in Melanocortin-4 Receptor Associated with Human Obesity.
G. Ho and R. G. MacKenzie (1999)
J. Biol. Chem. 274, 35816-35822
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Evidence That Melanocortin 4 Receptor Mediates Hemorrhagic Shock Reversal Caused by Melanocortin Peptides.
S. Guarini, C. Bazzani, M. M. Cainazzo, C. Mioni, G. Ferrazza, A. V. Vergoni, H. B. Schiöth, J. E. S. Wikberg, and A. Bertolini (1999)
J. Pharmacol. Exp. Ther. 291, 1023-1027
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Physiological Regulation of G Protein-Linked Signaling.
A. J. Morris and C. C. Malbon (1999)
Physiol Rev 79, 1373-1430
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Receptor-Mediated Modulation of Murine Mast Cell Function by {alpha}-Melanocyte Stimulating Hormone.
S. Adachi, T. Nakano, H. Vliagoftis, and D. D. Metcalfe (1999)
J. Immunol. 163, 3363-3368
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Functional Characterization of Naturally Occurring Mutations of the Human Adrenocorticotropin Receptor: Poor Correlation of Phenotype and Genotype.
L. L. K. Elias, A. Huebner, G. D. Pullinger, A. Mirtella, and A. J. L. Clark (1999)
J. Clin. Endocrinol. Metab. 84, 2766-2770
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Conformation of the Core Sequence in Melanocortin Peptides Directs Selectivity for the Melanocortin MC3 and MC4 Receptors.
J. Oosterom, W. A. J. Nijenhuis, W. M. M. Schaaper, J. Slootstra, R. H. Meloen, W. H. H. Gispen, J. P. H. Burbach, and R. A. H. Adan (1999)
J. Biol. Chem. 274, 16853-16860
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Bovine Thrombospondin-2: Complete Complementary Deoxyribonucleic Acid Sequence and Immunolocalization in the External Zones of the Adrenal Cortex.
M. Danik, A. M. Chinn, B. Lafeuillade, M. Keramidas, S. Aguesse-Germon, A. Penhoat, H. Chen, D. F. Mosher, E. M. Chambaz, and J.-J. Feige (1999)
Endocrinology 140, 2771-2780
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Contribution of Melanocortin Receptor Exoloops to Agouti-related Protein Binding.
Y.-k. Yang, C. J. Dickinson, Q. Zeng, J.-Y. Li, D. A. Thompson, and I. Gantz (1999)
J. Biol. Chem. 274, 14100-14106
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