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Science 28 August 1992: Vol. 257. no. 5074, pp. 1248 - 1251 DOI: 10.1126/science.1325670
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Articles
Science, Vol 257, Issue 5074, 1248-1251
Copyright © 1992 by American Association for the Advancement of Science
The cloning of a family of genes that encode the melanocortin receptors
KG Mountjoy,
LS Robbins,
MT Mortrud,
and
RD Cone
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201.
Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.
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- Overexpression of Glutathione-S-Transferase A1 in Benign Adrenocortical Adenomas from Patients with Cushing's Syndrome.
- D. Sarkar, T. Imai, F. Kambe, A. Shibata, S. Ohmori, S. Hayasaka, H. Funahashi, and H. Seo (2001)
J. Clin. Endocrinol. Metab.
86, 1653-1659
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- Selective Enhancement of L-Type Calcium Currents by Corticotropin in Acutely Isolated Rat Amygdala Neurons.
- C. Young, Y.-C. Huang, C.-H. Lin, Y.-Z. Shen, and P.-W. Gean (2001)
Mol. Pharmacol.
59, 604-611
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- Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome.
- A. Lacroix, N. N'Diaye, J. Tremblay, and P. Hamet (2001)
Endocr. Rev.
22, 75-110
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- The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes.
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J. Cell Sci.
114, 1019-1024
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- Stimulation of Intracellular Free Calcium in GH3 Cells by {{gamma}}3-Melanocyte-Stimulating Hormone. Involvement of a Novel Melanocortin Receptor?.
- L. Langouche, M. Roudbaraki, K. Pals, and C. Denef (2001)
Endocrinology
142, 257-266
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- Chronic Blockade of the Melanocortin 4 Receptor Subtype Leads to Obesity Independently of Neuropeptide Y Action, with No Adverse Effects on the Gonadotropic and Somatotropic Axes.
- P. D. Raposinho, E. Castillo, V. D'alleves, P. Broqua, F. P. Pralong, and M. L. Aubert (2000)
Endocrinology
141, 4419-4427
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- Functional Adrenocorticotropic Hormone Receptor in Cultured Human Vascular Endothelial Cells : Possible Role in Control of Blood Pressure.
- H. Hatakeyama, S. Inaba, N. Taniguchi, and I. Miyamori (2000)
Hypertension
36, 862-865
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- Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation.
- N. Flanagan, E. Healy, A. Ray, S. Philips, C. Todd, I. J. Jackson, M. A. Birch-Machin, and J. L. Rees (2000)
Hum. Mol. Genet.
9, 2531-2537
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- Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.
- C. R. Goding (2000)
Genes & Dev.
14, 1712-1728
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- Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress.
- A. Slominski, J. Wortsman, T. Luger, R. Paus, and S. Solomon (2000)
Physiol Rev
80, 979-1020
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- Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.
- P. C. White and P. W. Speiser (2000)
Endocr. Rev.
21, 245-291
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- alpha -Melanocyte-stimulating Hormone Reduces Impact of Proinflammatory Cytokine and Peroxide-generated Oxidative Stress on Keratinocyte and Melanoma Cell Lines.
- J. W. Haycock, S. J. Rowe, S. Cartledge, A. Wyatt, G. Ghanem, R. Morandini, I. G. Rennie, and S. MacNeil (2000)
J. Biol. Chem.
275, 15629-15636
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- Regulation by Adrenocorticotropin (ACTH), Angiotensin II, Transforming Growth Factor-{beta}, and Insulin-Like Growth Factor I of Bovine Adrenal Cell Steroidogenic Capacity and Expression of ACTH Receptor, Steroidogenic Acute Regulatory Protein, Cytochrome P450c17, and 3{beta}-Hydroxysteroid Dehydrogenase.
- C. Le Roy, J. Y. Li, D. M. Stocco, D. Langlois, and J. M. Saez (2000)
Endocrinology
141, 1599-1607
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- Agouti and Agouti-related Protein: Analogies and Contrasts.
- D. M. Dinulescu and R. D. Cone (2000)
J. Biol. Chem.
275, 6695-6698
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- Functional Characterization of Mutations in Melanocortin-4 Receptor Associated with Human Obesity.
- G. Ho and R. G. MacKenzie (1999)
J. Biol. Chem.
274, 35816-35822
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- Evidence That Melanocortin 4 Receptor Mediates Hemorrhagic Shock Reversal Caused by Melanocortin Peptides.
- S. Guarini, C. Bazzani, M. M. Cainazzo, C. Mioni, G. Ferrazza, A. V. Vergoni, H. B. Schiöth, J. E. S. Wikberg, and A. Bertolini (1999)
J. Pharmacol. Exp. Ther.
291, 1023-1027
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- Physiological Regulation of G Protein-Linked Signaling.
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Physiol Rev
79, 1373-1430
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- Receptor-Mediated Modulation of Murine Mast Cell Function by {alpha}-Melanocyte Stimulating Hormone.
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J. Immunol.
163, 3363-3368
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- Functional Characterization of Naturally Occurring Mutations of the Human Adrenocorticotropin Receptor: Poor Correlation of Phenotype and Genotype.
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J. Clin. Endocrinol. Metab.
84, 2766-2770
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- Conformation of the Core Sequence in Melanocortin Peptides Directs Selectivity for the Melanocortin MC3 and MC4 Receptors.
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274, 16853-16860
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- Bovine Thrombospondin-2: Complete Complementary Deoxyribonucleic Acid Sequence and Immunolocalization in the External Zones of the Adrenal Cortex.
- M. Danik, A. M. Chinn, B. Lafeuillade, M. Keramidas, S. Aguesse-Germon, A. Penhoat, H. Chen, D. F. Mosher, E. M. Chambaz, and J.-J. Feige (1999)
Endocrinology
140, 2771-2780
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- Contribution of Melanocortin Receptor Exoloops to Agouti-related Protein Binding.
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