Science 28 August 1992: Vol. 257. no. 5074, pp. 1220 - 1224 DOI: 10.1126/science.1355616

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Articles

Assessment of the Antioxidant and Reactive Oxygen Species Scavenging Activity of Methanolic Extract of Caesalpinia crista Leaf.

S. Mandal, B. Hazra, R. Sarkar, S. Biswas, and N. Mandal (2009)
Evid. Based Complement. Altern. Med.
 |  Abstract »  |  Full Text »  |  PDF »

Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine.

L. Klipcan, N. Moor, N. Kessler, and M. G. Safro (2009)
PNAS 106, 11045-11048
 |  Abstract »  |  Full Text »  |  PDF »

Impact of Lifelong Sedentary Behavior on Mitochondrial Function of Mice Skeletal Muscle.

P. A. Figueiredo, S. K. Powers, R. M. Ferreira, F. Amado, H. J. Appell, and J. A. Duarte (2009)
J Gerontol A Biol Sci Med Sci
 |  Abstract »  |  Full Text »  |  PDF »

Protein Oxidation During Long Storage: Identification of the Oxidation Sites in Dihydrofolate Reductase from Escherichia coli through LC-MS and Fragment Studies.

T. Takenawa, A. Yokota, M. Oda, H. Takahashi, and M. Iwakura (2009)
J. Biochem. 145, 517-523
 |  Abstract »  |  Full Text »  |  PDF »

Protein-Repairing Methionine Sulfoxide Reductases in Photosynthetic Organisms: Gene Organization, Reduction Mechanisms, and Physiological Roles.

L. Tarrago, E. Laugier, and P. Rey (2009)
Mol Plant 2, 202-217
 |  Abstract »  |  Full Text »  |  PDF »

MsrB1 (Methionine-R-sulfoxide Reductase 1) Knock-out Mice: ROLES OF MsrB1 IN REDOX REGULATION AND IDENTIFICATION OF A NOVEL SELENOPROTEIN FORM.

D. E. Fomenko, S. V. Novoselov, S. K. Natarajan, B. C. Lee, A. Koc, B. A. Carlson, T.-H. Lee, H.-Y. Kim, D. L. Hatfield, and V. N. Gladyshev (2009)
J. Biol. Chem. 284, 5986-5993
 |  Abstract »  |  Full Text »  |  PDF »

Aging Impairs Skeletal Muscle Mitochondrial Bioenergetic Function.

P. A. Figueiredo, S. K. Powers, R. M. Ferreira, H. J. Appell, and J. A. Duarte (2009)
J Gerontol A Biol Sci Med Sci
 |  Abstract »  |  Full Text »  |  PDF »

Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain.

Z. Lappalainen, J. Lappalainen, N. K. J. Oksala, D. E. Laaksonen, S. Khanna, C. K. Sen, and M. Atalay (2009)
J Appl Physiol 106, 461-467
 |  Abstract »  |  Full Text »  |  PDF »

Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin.

G. J. Fisher, T. Quan, T. Purohit, Y. Shao, M. K. Cho, T. He, J. Varani, S. Kang, and J. J. Voorhees (2009)
Am. J. Pathol. 174, 101-114
 |  Abstract »  |  Full Text »  |  PDF »

Selective benefits of damage partitioning in unicellular systems and its effects on aging.

N. Erjavec, M. Cvijovic, E. Klipp, and T. Nystrom (2008)
PNAS 105, 18764-18769
 |  Abstract »  |  Full Text »  |  PDF »

Age-Related Markers Assayed at Different Developmental Stages of the Annual Fish Nothobranchius rachovii.

C.-Y. Hsu, Y.-C. Chiu, W.-L. Hsu, and Y.-P. Chan (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 1267-1276
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span of Drosophila melanogaster.

S. K. Legan, I. Rebrin, R. J. Mockett, S. N. Radyuk, V. I. Klichko, R. S. Sohal, and W. C. Orr (2008)
J. Biol. Chem. 283, 32492-32499
 |  Abstract »  |  Full Text »  |  PDF »

Relationship between dialysate oxidized protein and peritoneal membrane transport properties in patients on peritoneal dialysis.

S. Latcha, S. Hong, N. Gibbons, N. Kohn, and J. Mattana (2008)
Nephrol. Dial. Transplant. 23, 3295-3301
 |  Abstract »  |  Full Text »  |  PDF »

The Campylobacter jejuni Thiol Peroxidases Tpx and Bcp Both Contribute to Aerotolerance and Peroxide-Mediated Stress Resistance but Have Distinct Substrate Specificities.

J. M. Atack, P. Harvey, M. A. Jones, and D. J. Kelly (2008)
J. Bacteriol. 190, 5279-5290
 |  Abstract »  |  Full Text »  |  PDF »

Oral Glycotoxins Determine the Effects of Calorie Restriction on Oxidant Stress, Age-Related Diseases, and Lifespan.

W. Cai, J. C. He, L. Zhu, X. Chen, F. Zheng, G. E. Striker, and H. Vlassara (2008)
Am. J. Pathol. 173, 327-336
 |  Abstract »  |  Full Text »  |  PDF »

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.

R. I. Morimoto (2008)
Genes & Dev. 22, 1427-1438
 |  Abstract »  |  Full Text »  |  PDF »

Gene polymorphisms of oxidative stress enzymes: prediction of elderly renutrition.

E. E Fabre, A. Raynaud-Simon, J.-L. Golmard, M. Hebert, X. Dulcire, M. Succari, J. Myara, D. Durand, and V. Nivet-Antoine (2008)
Am. J. Clinical Nutrition 87, 1504-1512
 |  Abstract »  |  Full Text »  |  PDF »

Age-Related Correlation Between Antioxidant Enzymes and DNA Damage With Smoking and Body Mass Index.

P. K. Reddy Thavanati, K. R. Kanala, A. E. de Dios, and J. M. Cantu Garza (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 360-364
 |  Abstract »  |  Full Text »  |  PDF »

Deterioration of western redcedar (Thuja plicata Donn ex D. Don) seeds: protein oxidation and in vivo NMR monitoring of storage oils.

V. V. Terskikh, Y. Zeng, J. A. Feurtado, M. Giblin, S. R. Abrams, and A. R. Kermode (2008)
J. Exp. Bot. 59, 765-777
 |  Abstract »  |  Full Text »  |  PDF »

Plasma Biomarkers of Oxidative Stress: Relationship to Lung Disease and Inhaled Nitric Oxide Therapy in Premature Infants.

P. L. Ballard, W. E. Truog, J. D. Merrill, A. Gow, M. Posencheg, S. G. Golombek, L. A. Parton, X. Luan, A. Cnaan, and R. A. Ballard (2008)
Pediatrics 121, 555-561
 |  Abstract »  |  Full Text »  |  PDF »

TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity.

E. Kubo, N. Fatma, Y. Akagi, D. R. Beier, S. P. Singh, and D. P. Singh (2008)
Am J Physiol Cell Physiol 294, C842-C855
 |  Abstract »  |  Full Text »  |  PDF »

Myosin Transducer Mutations Differentially Affect Motor Function, Myofibril Structure, and the Performance of Skeletal and Cardiac Muscles.

A. Cammarato, C. M. Dambacher, A. F. Knowles, W. A. Kronert, R. Bodmer, K. Ocorr, and S. I. Bernstein (2008)
Mol. Biol. Cell 19, 553-562
 |  Abstract »  |  Full Text »  |  PDF »

Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1.

G. Reverter-Branchat, E. Cabiscol, J. Tamarit, M. A. Sorolla, M. Angeles de la Torre, and J. Ros (2007)
Microbiology 153, 3667-3676
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p.

N. Erjavec, L. Larsson, J. Grantham, and T. Nystrom (2007)
Genes & Dev. 21, 2410-2421
 |  Abstract »  |  Full Text »  |  PDF »

Protein-bound 4-Hydroxy-2-nonenal: AN ENDOGENOUS TRIGGERING ANTIGEN OF ANTI-DNA RESPONSE.

K. Toyoda, R. Nagae, M. Akagawa, K. Ishino, T. Shibata, S. Ito, N. Shibata, T. Yamamoto, M. Kobayashi, Y. Takasaki, et al. (2007)
J. Biol. Chem. 282, 25769-25778
 |  Abstract »  |  Full Text »  |  PDF »

Aging, Resting Metabolic Rate, and Oxidative Damage: Results From the Louisiana Healthy Aging Study.

M. I. Frisard, A. Broussard, S. S. Davies, L. J. Roberts II, J. Rood, L. d. Jonge, X. Fang, S. M. Jazwinski, W. A. Deutsch, E. Ravussin, et al. (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 752-759
 |  Abstract »  |  Full Text »  |  PDF »

Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae.

N. Erjavec and T. Nystrom (2007)
PNAS 104, 10877-10881
 |  Abstract »  |  Full Text »  |  PDF »

Manganese Inhalation by Rhesus Monkeys is Associated with Brain Regional Changes in Biomarkers of Neurotoxicity.

K. M. Erikson, D. C. Dorman, L. H. Lash, and M. Aschner (2007)
Toxicol. Sci. 97, 459-466
 |  Abstract »  |  Full Text »  |  PDF »

The Response of Carbon Metabolism and Antioxidant Defenses of Alfalfa Nodules to Drought Stress and to the Subsequent Recovery of Plants.

L. Naya, R. Ladrera, J. Ramos, E. M. Gonzalez, C. Arrese-Igor, F. R. Minchin, and M. Becana (2007)
Plant Physiology 144, 1104-1114
 |  Abstract »  |  Full Text »  |  PDF »

Age-Associated Decrease in Proteasome Content and Activities in Human Dermal Fibroblasts: Restoration of Normal Level of Proteasome Subunits Reduces Aging Markers in Fibroblasts From Elderly Persons.

J. S. Hwang, J. S. Hwang, I. Chang, and S. Kim (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 490-499
 |  Abstract »  |  Full Text »  |  PDF »

Circulating Glycotoxins and Dietary Advanced Glycation Endproducts: Two Links to Inflammatory Response, Oxidative Stress, and Aging.

J. Uribarri, W. Cai, M. Peppa, S. Goodman, L. Ferrucci, G. Striker, and H. Vlassara (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 427-433
 |  Abstract »  |  Full Text »  |  PDF »

Carbonylation of Adipose Proteins in Obesity and Insulin Resistance: Identification of Adipocyte Fatty Acid-binding Protein as a Cellular Target of 4-Hydroxynonenal.

P. A. Grimsrud, M. J. Picklo Sr., T. J. Griffin, and D. A. Bernlohr (2007)
Mol. Cell. Proteomics 6, 624-637
 |  Abstract »  |  Full Text »  |  PDF »

An Insight into the Mechanism of Human Cysteine Dioxygenase: KEY ROLES OF THE THIOETHER-BONDED TYROSINE-CYSTEINE COFACTOR.

S. Ye, X. Wu, L. Wei, D. Tang, P. Sun, M. Bartlam, and Z. Rao (2007)
J. Biol. Chem. 282, 3391-3402
 |  Abstract »  |  Full Text »  |  PDF »

Age-Associated Decline in Effective Immune Synapse Formation of CD4+ T Cells Is Reversed by Vitamin E Supplementation.

M. G. Marko, T. Ahmed, S. C. Bunnell, D. Wu, H. Chung, B. T. Huber, and S. N. Meydani (2007)
J. Immunol. 178, 1443-1449
 |  Abstract »  |  Full Text »  |  PDF »

Nutrition, physical activity, and cardiovascular disease: An update.

L. J. Ignarro, M. L. Balestrieri, and C. Napoli (2007)
Cardiovasc Res 73, 326-340
 |  Abstract »  |  Full Text »  |  PDF »

Extent of Modifications in Human Proteome Samples and Their Effect on Dynamic Range of Analysis in Shotgun Proteomics.

M. L. Nielsen, M. M. Savitski, and R. A. Zubarev (2006)
Mol. Cell. Proteomics 5, 2384-2391
 |  Abstract »  |  Full Text »  |  PDF »

Formation of N{epsilon}-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification.

Y. Kawai, H. Fujii, M. Okada, Y. Tsuchie, K. Uchida, and T. Osawa (2006)
J. Lipid Res. 47, 1386-1398
 |  Abstract »  |  Full Text »  |  PDF »

Elimination of damaged proteins during differentiation of embryonic stem cells.

M. Hernebring, G. Brolen, H. Aguilaniu, H. Semb, and T. Nystrom (2006)
PNAS 103, 7700-7705
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Memory and Hematopoietic Stem Cell Aging.

L. M. Kamminga and G. de Haan (2006)
Stem Cells 24, 1143-1149
 |  Abstract »  |  Full Text »  |  PDF »

Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis.

N. Miyoshi, H. Oubrahim, P. B. Chock, and E. R. Stadtman (2006)
PNAS 103, 1727-1731
 |  Abstract »  |  Full Text »  |  PDF »

Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.

C.-C. Hsieh and J. Papaconstantinou (2006)
FASEB J 20, 259-268
 |  Abstract »  |  Full Text »  |  PDF »

Flight activity, mortality rates, and lipoxidative damage in Drosophila..

T. Magwere, R. Pamplona, S. Miwa, P. Martinez-Diaz, M. Portero-Otin, M. D. Brand, and L. Partridge (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 136-145
 |  Abstract »  |  Full Text »  |  PDF »

Preferential degradation of oxidized proteins by the 20S proteasome may be inhibited in aging and in inflammatory neuromuscular diseases.

K. J.A. Davies and R. Shringarpure (2006)
Neurology 66, S93-S96
 |  Abstract »  |  Full Text »  |  PDF »

Normal brain ageing: models and mechanisms.

E. C Toescu (2005)
Phil Trans R Soc B 360, 2347-2354
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor-{alpha}-Induced Iron Sequestration and Oxidative Stress in Human Endothelial Cells.

M. Nanami, T. Ookawara, Y. Otaki, K. Ito, R. Moriguchi, K. Miyagawa, Y. Hasuike, M. Izumi, H. Eguchi, K. Suzuki, et al. (2005)
Arterioscler. Thromb. Vasc. Biol. 25, 2495-2501
 |  Abstract »  |  Full Text »  |  PDF »

Acrolein Impairs ATP Binding Cassette Transporter A1-dependent Cholesterol Export from Cells through Site-specific Modification of Apolipoprotein A-I.

B. Shao, X. Fu, T. O. McDonald, P. S. Green, K. Uchida, K. D. O'Brien, J. F. Oram, and J. W. Heinecke (2005)
J. Biol. Chem. 280, 36386-36396
 |  Abstract »  |  Full Text »  |  PDF »

Proteomic Identification of Oxidatively Modified Retinal Proteins in a Chronic Pressure-Induced Rat Model of Glaucoma.

G. Tezel, X. Yang, and J. Cai (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3177-3187
 |  Abstract »  |  Full Text »  |  PDF »

Differential Impact of Environmental Stresses on the Pea Mitochondrial Proteome.

N. L. Taylor, J. L. Heazlewood, D. A. Day, and A. H. Millar (2005)
Mol. Cell. Proteomics 4, 1122-1133
 |  Abstract »  |  Full Text »  |  PDF »

Hypoxia-reoxygenation induces premature senescence in FA bone marrow hematopoietic cells.

X. Zhang, J. Li, D. P. Sejas, and Q. Pang (2005)
Blood 106, 75-85
 |  Abstract »  |  Full Text »  |  PDF »

Curcumin and Turmeric Delay Streptozotocin-Induced Diabetic Cataract in Rats.

P. Suryanarayana, M. Saraswat, T. Mrudula, T. P. Krishna, K. Krishnaswamy, and G. B. Reddy (2005)
Invest. Ophthalmol. Vis. Sci. 46, 2092-2099
 |  Abstract »  |  Full Text »  |  PDF »

Patterns of Protein Oxidation in Arabidopsis Seeds and during Germination.

C. Job, L. Rajjou, Y. Lovigny, M. Belghazi, and D. Job (2005)
Plant Physiology 138, 790-802
 |  Abstract »  |  Full Text »  |  PDF »

The ATM/p53/p21 Pathway Influences Cell Fate Decision between Apoptosis and Senescence in Reoxygenated Hematopoietic Progenitor Cells.

X. Zhang, J. Li, D. P. Sejas, and Q. Pang (2005)
J. Biol. Chem. 280, 19635-19640
 |  Abstract »  |  Full Text »  |  PDF »

Human Ran Cysteine 112 Oxidation by Pervanadate Regulates Its Binding to Keratins.

G.-Z. Tao, Q. Zhou, P. Strnad, M. R. Salemi, Y. M. Lee, and M. B. Omary (2005)
J. Biol. Chem. 280, 12162-12167
 |  Abstract »  |  Full Text »  |  PDF »

Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors.

Y. Zhao, H. Sun, J. Lu, X. Li, X. Chen, D. Tao, W. Huang, and B. Huang (2005)
J. Exp. Biol. 208, 697-705
 |  Abstract »  |  Full Text »  |  PDF »

Localization of Nitration and Chlorination Sites on Apolipoprotein A-I Catalyzed by Myeloperoxidase in Human Atheroma and Associated Oxidative Impairment in ABCA1-dependent Cholesterol Efflux from Macrophages.

L. Zheng, M. Settle, G. Brubaker, D. Schmitt, S. L. Hazen, J. D. Smith, and M. Kinter (2005)
J. Biol. Chem. 280, 38-47
 |  Abstract »  |  Full Text »  |  PDF »

Methionine Sulfoxide Reduction and Assimilation in Escherichia coli: New Role for the Biotin Sulfoxide Reductase BisC.

B. Ezraty, J. Bos, F. Barras, and L. Aussel (2005)
J. Bacteriol. 187, 231-237
 |  Abstract »  |  Full Text »  |  PDF »

Cytosolic Ascorbate Peroxidase 1 Is a Central Component of the Reactive Oxygen Gene Network of Arabidopsis.

S. Davletova, L. Rizhsky, H. Liang, Z. Shengqiang, D. J. Oliver, J. Coutu, V. Shulaev, K. Schlauch, and R. Mittler (2005)
PLANT CELL 17, 268-281
 |  Abstract »  |  Full Text »  |  PDF »

Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging.

J. Kanski, A. Behring, J. Pelling, and C. Schoneich (2005)
Am J Physiol Heart Circ Physiol 288, H371-H381
 |  Abstract »  |  Full Text »  |  PDF »

Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria.

T.-S. Chang, C.-S. Cho, S. Park, S. Yu, S. W. Kang, and S. G. Rhee (2004)
J. Biol. Chem. 279, 41975-41984
 |  Abstract »  |  Full Text »  |  PDF »

Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate.

H. Nakagawa, K. Hasumi, J.-T. Woo, K. Nagai, and M. Wachi (2004)
Carcinogenesis 25, 1567-1574
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative Damage to Specific Proteins in Replicative and Chronological-aged Saccharomyces cerevisiae: COMMON TARGETS AND PREVENTION BY CALORIE RESTRICTION.

G. Reverter-Branchat, E. Cabiscol, J. Tamarit, and J. Ros (2004)
J. Biol. Chem. 279, 31983-31989
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Mitochondrial "swirls" induced by oxygen stress and in the Drosophila mutant hyperswirl.

D. W. Walker and S. Benzer (2004)
PNAS 101, 10290-10295
 |  Abstract »  |  Full Text »  |  PDF »

Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging.

A. Koc, A. P. Gasch, J. C. Rutherford, H.-Y. Kim, and V. N. Gladyshev (2004)
PNAS 101, 7999-8004
 |  Abstract »  |  Full Text »  |  PDF »

Progression and Specificity of Protein Oxidation in the Life Cycle of Arabidopsis thaliana.

E. Johansson, O. Olsson, and T. Nystrom (2004)
J. Biol. Chem. 279, 22204-22208
 |  Abstract »  |  Full Text »  |  PDF »

Starvation response in mouse liver shows strong correlation with life-span-prolonging processes.

M. Bauer, A. C. Hamm, M. Bonaus, A. Jacob, J. Jaekel, H. Schorle, M. J. Pankratz, and J. D. Katzenberger (2004)
Physiol Genomics 17, 230-244
 |  Abstract »  |  Full Text »  |  PDF »

Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids.

S. Yamada, T. Funada, N. Shibata, M. Kobayashi, Y. Kawai, E. Tatsuda, A. Furuhata, and K. Uchida (2004)
J. Lipid Res. 45, 626-634
 |  Abstract »  |  Full Text »  |  PDF »

Exploiting Proteomics in the Discovery of Drugs That Target Mitochondrial Oxidative Damage.

B. W. Gibson (2004)
Sci. Aging Knowl. Environ. 2004, pe12
 |  Abstract »  |  Full Text »

Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.

A. Csiszar, Z. Ungvari, A. Koller, J. G. Edwards, and G. Kaley (2004)
Physiol Genomics 17, 21-30
 |  Abstract »  |  Full Text »  |  PDF »

Antioxidant Supplementation Normalizes Elevated Protein Kinase C Activity in the Proximal Tubules of Old Rats.

M. Asghar and M. F. Lokhandwala (2004)
Experimental Biology and Medicine 229, 270-275
 |  Abstract »  |  Full Text »  |  PDF »

Evidence of myofibrillar protein oxidation induced by postischemic reperfusion in isolated rat hearts.

M. Canton, I. Neverova, R. Menabo, J. Van Eyk, and F. Di Lisa (2004)
Am J Physiol Heart Circ Physiol 286, H870-H877
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional regulation of the Drosophila catalase gene by the DRE/DREF system.

S. Y. Park, Y.-S. Kim, D.-J. Yang, and M.-A. Yoo (2004)
Nucleic Acids Res. 32, 1318-1324
 |  Abstract »  |  Full Text »  |  PDF »

Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content.

S. Judge, A. Judge, T. Grune, and C. Leeuwenburgh (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R254-R259
 |  Abstract »  |  Full Text »  |  PDF »

N{epsilon}-(3-Methylpyridinium)lysine, a Major Antigenic Adduct Generated in Acrolein-modified Protein.

A. Furuhata, T. Ishii, S. Kumazawa, T. Yamada, T. Nakayama, and K. Uchida (2003)
J. Biol. Chem. 278, 48658-48665
 |  Abstract »  |  Full Text »  |  PDF »

Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage.

C. von Kobbe, J. A. Harrigan, A. May, P. L. Opresko, L. Dawut, W.-H. Cheng, and V. A. Bohr (2003)
Mol. Cell. Biol. 23, 8601-8613
 |  Abstract »  |  Full Text »  |  PDF »

Excitatory Amino Acids and Multiple Sclerosis: Evidence From Cerebrospinal Fluid.

P. Sarchielli, L. Greco, A. Floridi, A. Floridi, and V. Gallai (2003)
Arch Neurol 60, 1082-1088
 |  Abstract »  |  Full Text »  |  PDF »

Hypochlorous Acid Generated by Myeloperoxidase Modifies Adjacent Tryptophan and Glycine Residues in the Catalytic Domain of Matrix Metalloproteinase-7 (Matrilysin): AN OXIDATIVE MECHANISM FOR RESTRAINING PROTEOLYTIC ACTIVITY DURING INFLAMMATION.

X. Fu, S. Y. Kassim, W. C. Parks, and J. W. Heinecke (2003)
J. Biol. Chem. 278, 28403-28409
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Free Radical Scavenger, Edarabone, Protects Against Cisplatin-Induced Acute Renal Damage in Vitro and in Vivo.

M. Satoh, N. Kashihara, S. Fujimoto, H. Horike, T. Tokura, T. Namikoshi, T. Sasaki, and H. Makino (2003)
J. Pharmacol. Exp. Ther. 305, 1183-1190
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the Pro-apoptotic Gene gadd153/chop Is Elevated in Liver with Aging and Sensitizes Cells to Oxidant Injury.

S. Ikeyama, X.-T. Wang, J. Li, A. Podlutsky, J. L. Martindale, G. Kokkonen, R. van Huizen, M. Gorospe, and N. J. Holbrook (2003)
J. Biol. Chem. 278, 16726-16731
 |  Abstract »  |  Full Text »  |  PDF »

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation.

H. A. Woo, H. Z. Chae, S. C. Hwang, K.-S. Yang, S. W. Kang, K. Kim, and S. G. Rhee (2003)
Science 300, 653-656
 |  Abstract »  |  Full Text »  |  PDF »

Asymmetric Inheritance of Oxidatively Damaged Proteins During Cytokinesis.

H. Aguilaniu, L. Gustafsson, M. Rigoulet, and T. Nystrom (2003)
Science 299, 1751-1753
 |  Abstract »  |  Full Text »  |  PDF »

Age-related Base Excision Repair Activity in Mouse Brain and Liver Nuclear Extracts.

G. W. Intano, E. J. Cho, C. A. McMahan, and C. A. Walter (2003)
J. Gerontol. A Biol. Sci. Med. Sci. 58, B205-211
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Streptococcus agalactiae ClpP serine protease in heat-induced stress defence and growth arrest.

S. Nair, C. Poyart, J.-L. Beretti, H. Veiga-Fernandes, P. Berche, and P. Trieu-Cuot (2003)
Microbiology 149, 407-417
 |  Abstract »  |  Full Text »  |  PDF »

How does calorie restriction work?.

J. Koubova and L. Guarente (2003)
Genes & Dev. 17, 313-321
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Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants.

J. Turchan, C.B. Pocernich, C. Gairola, A. Chauhan, G. Schifitto, D.A. Butterfield, S. Buch, O. Narayan, A. Sinai, J. Geiger, et al. (2003)
Neurology 60, 307-314
 |  Abstract »  |  Full Text »  |  PDF »

Global Role for ClpP-Containing Proteases in Stationary-Phase Adaptation of Escherichia coli.

D. Weichart, N. Querfurth, M. Dreger, and R. Hengge-Aronis (2003)
J. Bacteriol. 185, 115-125
 |  Abstract »  |  Full Text »  |  PDF »

Global Loss of Na,K-ATPase and Its Nitric Oxide-Mediated Regulation in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis.

D. Z. Ellis, J. Rabe, and K. J. Sweadner (2003)
J. Neurosci. 23, 43-51
 |  Abstract »  |  Full Text »  |  PDF »

Covalent Modification of Epithelial Fatty Acid-binding Protein by 4-Hydroxynonenal in Vitro and in Vivo. EVIDENCE FOR A ROLE IN ANTIOXIDANT BIOLOGY.

A. Bennaars-Eiden, L. Higgins, A. V. Hertzel, R. J. Kapphahn, D. A. Ferrington, and D. A. Bernlohr (2002)
J. Biol. Chem. 277, 50693-50702
 |  Abstract »  |  Full Text »  |  PDF »

Lipid Peroxidation and the Aging Process.

D. Pratic̣ (2002)
Sci. Aging Knowl. Environ. 2002, re5-5
 |  Abstract »  |  Full Text »  |  PDF »

Role of Reactive Oxygen Species in Cells Overexpressing Manganese Superoxide Dismutase: Mechanism for Induction of Radioresistance.

Y. Takada, M. Hachiya, S.-H. Park, Y. Osawa, T. Ozawa, and M. Akashi (2002)
Mol. Cancer Res. 1, 137-146
 |  Abstract »  |  Full Text »  |  PDF »

Lycopene, Tomatoes, and the Prevention of Coronary Heart Disease.

A. V. Rao (2002)
Experimental Biology and Medicine 227, 908-913
 |  Abstract »  |  Full Text »  |  PDF »

Setting a Trap for Aging-Related Genes in Drosophila.

J. Tower (2002)
Sci. Aging Knowl. Environ. 2002, pe15-15
 |  Abstract »  |  Full Text »

Oxidative Stress, Mitochondrial DNA Mutation, and Impairment of Antioxidant Enzymes in Aging.

Y.-H. Wei and H.-C. Lee (2002)
Experimental Biology and Medicine 227, 671-682
 |  Abstract »  |  Full Text »  |  PDF »

Ageing-associated aberration in meiosis of oocytes from senescence-accelerated mice.

L. Liu and D. L. Keefe (2002)
Hum. Reprod. 17, 2678-2685
 |  Abstract »  |  Full Text »  |  PDF »

Exposure of Yeast Cells to Anoxia Induces Transient Oxidative Stress. IMPLICATIONS FOR THE INDUCTION OF HYPOXIC GENES.

R. Dirmeier, K. M. O'Brien, M. Engle, A. Dodd, E. Spears, and R. O. Poyton (2002)
J. Biol. Chem. 277, 34773-34784
 |  Abstract »  |  Full Text »  |  PDF »

Thiolation of Protein-bound Carcinogenic Aldehyde. AN ELECTROPHILIC ACROLEIN-LYSINE ADDUCT THAT COVALENTLY BINDS TO THIOLS.

A. Furuhata, M. Nakamura, T. Osawa, and K. Uchida (2002)
J. Biol. Chem. 277, 27919-27926
 |  Abstract »  |  Full Text »  |  PDF »

The mitochondrial DNA polymerase as a target of oxidative damage.

M. A. Graziewicz, B. J. Day, and W. C. Copeland (2002)
Nucleic Acids Res. 30, 2817-2824
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative stress inactivates the human DNA mismatch repair system.

C. L. Chang, G. Marra, D. P. Chauhan, H. T. Ha, D. K. Chang, L. Ricciardiello, A. Randolph, J. M. Carethers, and C. R. Boland (2002)
Am J Physiol Cell Physiol 283, C148-C154
 |  Abstract »  |  Full Text »  |  PDF »

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