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Science 21 August 1992:
Vol. 257. no. 5073, pp. 1128 - 1130
DOI: 10.1126/science.257.5073.1128
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Articles

Mutations in the Rod Domains of Keratins 1 and 10 in Epidermolytic Hyperkeratosis

J. A. Rothnagel 1, A. M. Dominey 1, L. D. Dempsey 1, M. A. Longley 1, D. A. Greenhalgh 1, T. A. Gagne 1, M. Huber 2, E. Frenk 2, D. Hohl 2, and D. R. Roop 1

1 Departments of Cell Biology and Dermatology, Baylor College of Medicine, Houston, TX 77030
2 Department of Dermatology, CHUV, Hopital Beaumont, Lausanne, Switzerland

Epidermolytic hyperkeratosis is a hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. In one family, affected individuals exhibited a mutation in the highly conserved carboxyl terminal of the rod domain of keratin 1. In two other families, affected individuals had mutations in the highly conserved amino terminal of the rod domain of keratin 10. Structural analysis of these mutations predicts that heterodimer formation would be unaffected, although filament assembly and elongation would be severely compromised. These data imply that an intact keratin intermediate filament network is required for the maintenance of both cellular and tissue integrity.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)