Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 August 1992:
Vol. 257. no. 5073, pp. 1089 - 1095
DOI: 10.1126/science.257.5073.1089
Prev | Table of Contents | Next

Articles

Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

Dorre A. Grueneberg 1, Sridaran Natesan 1, Cyrille Alexandre 1, and Michael Z. Gilman 1

1 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA resides within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of the specificity of action of homeodomain proteins in development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1.
C. W. Liew, K. D. Rand, R. J. Y. Simpson, W. W. Yung, R. E. Mansfield, M. Crossley, M. Proetorius-Ibba, C. Nerlov, F. M. Poulsen, and J. P. Mackay (2006)
J. Biol. Chem. 281, 28296-28306
   Abstract »    Full Text »    PDF »
Trans-Repressive Effect of NUP98-PMX1 on PMX1-Regulated c-FOS Gene through Recruitment of Histone Deacetylase 1 by FG Repeats..
X.-T. Bai, B.-W. Gu, T. Yin, C. Niu, X.-D. Xi, J. Zhang, Z. Chen, and S.-J. Chen (2006)
Cancer Res. 66, 4584-4590
   Abstract »    Full Text »    PDF »
Zinc Finger Proteins Act as Transcriptional Repressors of Alkaloid Biosynthesis Genes in Catharanthus roseus.
B. Pauw, F. A. O. Hilliou, V. S. Martin, G. Chatel, C. J. F. de Wolf, A. Champion, M. Pre, B. van Duijn, J. W. Kijne, L. van der Fits, et al. (2004)
J. Biol. Chem. 279, 52940-52948
   Abstract »    Full Text »    PDF »
Target Gene-Specific Modulation of Myocardin Activity by GATA Transcription Factors.
J. Oh, Z. Wang, D.-Z. Wang, C.-L. Lien, W. Xing, and E. N. Olson (2004)
Mol. Cell. Biol. 24, 8519-8528
   Abstract »    Full Text »    PDF »
Homeobox Protein Hex Facilitates Serum Responsive Factor-Mediated Activation of the SM22{alpha} Gene Transcription in Embryonic Fibroblasts.
Y. Oyama, K. Kawai-Kowase, K. Sekiguchi, M. Sato, H. Sato, M. Yamazaki, Y. Ohyama, Y. Aihara, T. Iso, E. Okamaoto, et al. (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 1602-1607
   Abstract »    Full Text »    PDF »
Myocardin and Prx1 Contribute to Angiotensin II-Induced Expression of Smooth Muscle {alpha}-Actin.
T. Yoshida, M. H. Hoofnagle, and G. K. Owens (2004)
Circ. Res. 94, 1075-1082
   Abstract »    Full Text »    PDF »
Combinatorial Control of Smooth Muscle-Specific Gene Expression.
M. S. Kumar and G. K. Owens (2003)
Arterioscler. Thromb. Vasc. Biol. 23, 737-747
   Abstract »    Full Text »    PDF »
Myocardin Is a Critical Serum Response Factor Cofactor in the Transcriptional Program Regulating Smooth Muscle Cell Differentiation.
K. L. Du, H. S. Ip, J. Li, M. Chen, F. Dandre, W. Yu, M. M. Lu, G. K. Owens, and M. S. Parmacek (2003)
Mol. Cell. Biol. 23, 2425-2437
   Abstract »    Full Text »    PDF »
Transcriptional activation by AP-2{alpha} is modulated by the oncogene DEK.
M. Campillos, M. A. Garcia, F. Valdivieso, and J. Vazquez (2003)
Nucleic Acids Res. 31, 1571-1575
   Abstract »    Full Text »    PDF »
Conserved homeodomain proteins interact with MADS box protein Mcm1 to restrict ECB-dependent transcription to the M/G1 phase of the cell cycle.
T. Pramila, S. Miles, D. GuhaThakurta, D. Jemiolo, and L. L. Breeden (2002)
Genes & Dev. 16, 3034-3045
   Abstract »    Full Text »    PDF »
A Triad of Serum Response Factor and the GATA and NK Families Governs the Transcription of Smooth and Cardiac Muscle Genes.
W. Nishida, M. Nakamura, S. Mori, M. Takahashi, Y. Ohkawa, S. Tadokoro, K. Yoshida, K. Hiwada, K.'i. Hayashi, and K. Sobue (2002)
J. Biol. Chem. 277, 7308-7317
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-beta Induction of Smooth Muscle Cell Phenotpye Requires Transcriptional and Post-transcriptional Control of Serum Response Factor.
K. K. Hirschi, L. Lai, N. S. Belaguli, D. A. Dean, R. J. Schwartz, and W. E. Zimmer (2002)
J. Biol. Chem. 277, 6287-6295
   Abstract »    Full Text »    PDF »
Functional Interaction of Jun and Homeodomain Proteins.
L. K. Schaefer, S. Wang, and T. S. Schaefer (2001)
J. Biol. Chem. 276, 43074-43082
   Abstract »    Full Text »    PDF »
The Role of Homeobox Genes in Vascular Remodeling and Angiogenesis.
D. H. Gorski and K. Walsh (2000)
Circ. Res. 87, 865-872
   Abstract »    Full Text »    PDF »
Cardiac Tissue Enriched Factors Serum Response Factor and GATA-4 Are Mutual Coregulators.
N. S. Belaguli, J. L. Sepulveda, V. Nigam, F. Charron, M. Nemer, and R. J. Schwartz (2000)
Mol. Cell. Biol. 20, 7550-7558
   Abstract »    Full Text »
Physical and Functional Interaction between the Y-Box Binding Protein YB-1 and Human Polyomavirus JC Virus Large T Antigen.
M. Safak, G. L. Gallia, S. A. Ansari, and K. Khalili (1999)
J. Virol. 73, 10146-10157
   Abstract »    Full Text »
Site-specific Heterodimerization by Paired Class Homeodomain Proteins Mediates Selective Transcriptional Responses.
S. C. Tucker and R. Wisdom (1999)
J. Biol. Chem. 274, 32325-32332
   Abstract »    Full Text »    PDF »
NUP98 Is Fused to PMX1 Homeobox Gene in Human Acute Myelogenous Leukemia With Chromosome Translocation t(1;11)(q23;p15).
T. Nakamura, Y. Yamazaki, Y. Hatano, and I. Miura (1999)
Blood 94, 741-747
   Abstract »    Full Text »    PDF »
Basic Fibroblast Growth Factor Activates Serum Response Factor Gene Expression by Multiple Distinct Signaling Mechanisms.
J. A. Spencer, M. L. Major, and R. P. Misra (1999)
Mol. Cell. Biol. 19, 3977-3988
   Abstract »    Full Text »    PDF »
Cooperative Transcriptional Activation by Serum Response Factor and the High Mobility Group Protein SSRP1.
J. A. Spencer, M. H. Baron, and E. N. Olson (1999)
J. Biol. Chem. 274, 15686-15693
   Abstract »    Full Text »    PDF »
The Tissue-Specific Transcription Factor Pit-1/GHF-1 Binds to the c-fos Serum Response Element and Activates c-fos Transcription.
C. Gaiddon, M. de Tapia, and J.-P. Loeffler (1999)
Mol. Endocrinol. 13, 742-751
   Abstract »    Full Text »
Context-dependent Transcriptional Cooperation Mediated by Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4.
I. Shiojima, I. Komuro, T. Oka, Y. Hiroi, T. Mizuno, E. Takimoto, K. Monzen, R. Aikawa, H. Akazawa, T. Yamazaki, et al. (1999)
J. Biol. Chem. 274, 8231-8239
   Abstract »    Full Text »    PDF »
Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene.
F. Naya, C Wu, J. Richardson, P Overbeek, and E. Olson (1999)
Development 126, 2045-2052
   Abstract »    PDF »
A role for serum response factor in coronary smooth muscle differentiation from proepicardial cells.
T. Landerholm, X. Dong, J Lu, N. Belaguli, R. Schwartz, and M. Majesky (1999)
Development 126, 2053-2062
   Abstract »    PDF »
Transcriptional Regulation of Smooth Muscle Contractile Apparatus Expression.
J. SOLWAY, S. M. FORSYTHE, A. J. HALAYKO, J. E. VIEIRA, M. B. HERSHENSON, and B. CAMORETTI-MERCADO (1998)
Am. J. Respir. Crit. Care Med. 158, S100-S108
   Abstract »    Full Text »    PDF »
Eucalypt MADS-Box Genes Expressed in Developing Flowers.
S. G. Southerton, H. Marshall, A. Mouradov, and R. D. Teasdale (1998)
Plant Physiology 118, 365-372
   Abstract »    Full Text »
Association of the TLX-2 Homeodomain and 14-3-3eta Signaling Proteins.
S. J. Tang, T.-C. Suen, R. R. McInnes, and M. Buchwald (1998)
J. Biol. Chem. 273, 25356-25363
   Abstract »    Full Text »    PDF »
The Molecular Basis of Rieger Syndrome. ANALYSIS OF PITX2 HOMEODOMAIN PROTEIN ACTIVITIES.
B. A. Amendt, L. B. Sutherland, E. V. Semina, and A. F. Russo (1998)
J. Biol. Chem. 273, 20066-20072
   Abstract »    Full Text »    PDF »
Transcription Factor Pip Can Enhance DNA Binding by E47, Leading to Transcriptional Synergy Involving Multiple Protein Domains.
S. Nagulapalli and M. L. Atchison (1998)
Mol. Cell. Biol. 18, 4639-4650
   Abstract »    Full Text »
TFII-I Enhances Activation of the c-fos Promoter through Interactions with Upstream Elements.
D.-W. Kim, V. Cheriyath, A. L. Roy, and B. H. Cochran (1998)
Mol. Cell. Biol. 18, 3310-3320
   Abstract »    Full Text »
Substitution of the Degenerate Smooth Muscle (SM) alpha -Actin CC(A/T-rich)6GG Elements with c-fos Serum Response Elements Results in Increased Basal Expression but Relaxed SM Cell Specificity and Reduced Angiotensin II Inducibility.
M. B. Hautmann, C. S. Madsen, C. P. Mack, and G. K. Owens (1998)
J. Biol. Chem. 273, 8398-8406
   Abstract »    Full Text »    PDF »
Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators.
C Mailhos, S Andre, B Mollereau, A Goriely, A Hemmati-Brivanlou, and C Desplan (1998)
Development 125, 937-947
   Abstract »    PDF »
Regulation of SRF Activity by Rho Family GTPases.
R. TREISMAN, A.S. ALBERTS, and E. SAHAI (1998)
Cold Spring Harb Symp Quant Biol 63, 643-652
   Abstract »    PDF »
The Homeodomain Protein Arix Interacts Synergistically with Cyclic AMP to Regulate Expression of Neurotransmitter Biosynthetic Genes.
D. J. Swanson, E. Zellmer, and E. J. Lewis (1997)
J. Biol. Chem. 272, 27382-27392
   Abstract »    Full Text »    PDF »
Angiotensin II–Induced Stimulation of Smooth Muscle {alpha}-Actin Expression by Serum Response Factor and the Homeodomain Transcription Factor MHox.
M. B. Hautmann, M. M. Thompson, E. A. Swartz, E. N. Olson, and G. K. Owens (1997)
Circ. Res. 81, 600-610
   Abstract »    Full Text »
Smooth Muscle Cell Phenotype-dependent Transcriptional Regulation of the alpha 1 Integrin Gene.
H. Obata, K.'i. Hayashi, W. Nishida, T. Momiyama, A. Uchida, T. Ochi, and K. Sobue (1997)
J. Biol. Chem. 272, 26643-26651
   Abstract »    Full Text »    PDF »
A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I.
D. A. Grueneberg, R. W. Henry, A. Brauer, C. D. Novina, V. Cheriyath, A. L. Roy, and M. Gilman (1997)
Genes & Dev. 11, 2482-2493
   Abstract »    Full Text »    PDF »
Prospero is a panneural transcription factor that modulates homeodomain protein activity.
B. Hassan, L. Li, K. A. Bremer, W. Chang, J. Pinsonneault, and H. Vaessin (1997)
PNAS 94, 10991-10996
   Abstract »    Full Text »    PDF »
Organization and Myogenic Restricted Expression of the Murine Serum Response Factor Gene. A ROLE FOR AUTOREGULATION.
N. S. Belaguli, L. A. Schildmeyer, and R. J. Schwartz (1997)
J. Biol. Chem. 272, 18222-18231
   Abstract »    Full Text »    PDF »
Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity.
H. Le, R. L. Tanguay, M. L. Balasta, C.-C. Wei, K. S. Browning, A. M. Metz, D. J. Goss, and D. R. Gallie (1997)
J. Biol. Chem. 272, 16247-16255
   Abstract »    Full Text »    PDF »
The Paired-domain Regulates DNA Binding by the Homeodomain within the Intact Pax-3 Protein.
D. A. Underhill and P. Gros (1997)
J. Biol. Chem. 272, 14175-14182
   Abstract »    Full Text »    PDF »
A Transforming Growth Factor beta (TGFbeta ) Control Element Drives TGFbeta -induced Stimulation of Smooth Muscle alpha -Actin Gene Expression in Concert with Two CArG Elements.
M. B. Hautmann, C. S. Madsen, and G. K. Owens (1997)
J. Biol. Chem. 272, 10948-10956
   Abstract »    Full Text »    PDF »
Sequences Outside the Homeodomain of Bicoid Are Required for Protein-Protein Interaction.
D. Yuan, X. Ma, and J. Ma (1996)
J. Biol. Chem. 271, 21660-21665
   Abstract »    Full Text »    PDF »
Expression of the Serum Response Factor Gene Is Regulated by Serum Response Factor Binding Sites.
J. A. Spencer and R. P. Misra (1996)
J. Biol. Chem. 271, 16535-16543
   Abstract »    Full Text »    PDF »
Multiple Enhancer Elements Mediate Induction of c-fos in Vascular Smooth Muscle Cells.
Y.-Q. Chen, D. M. Gilliam, B. Rydzewski, and A. J. Naftilan (1996)
Hypertension 27, 1224-1233
   Abstract »    Full Text »
The Interaction between Ku Antigen and REF1 Protein Mediates Negative Gene Regulation by Extracellular Calcium.
U.-i. Chung, T. Igarashi, T. Nishishita, H. Iwanari, A. Iwamatsu, A. Suwa, T. Mimori, K. Hata, S. Ebisu, E. Ogata, et al. (1996)
J. Biol. Chem. 271, 8593-8598
   Abstract »    Full Text »    PDF »
Activity of the Distal Positive Element of the Peripherin Gene Is Dependent on Proteins Binding to an Ets-like Recognition Site and a Novel Inverted Repeat Site.
L. Chang and M. A. Thompson (1996)
J. Biol. Chem. 271, 6467-6475
   Abstract »    Full Text »    PDF »
Both the paired domain and homeodomain are required for in vivo function of Drosophila Paired.
P Miskiewicz, D Morrissey, Y Lan, L Raj, S Kessler, M Fujioka, T Goto, and M Weir (1996)
Development 122, 2709-2718
   Abstract »    PDF »
The Drosophila morphogenetic protein Bicoid binds DNA cooperatively.
X Ma, D Yuan, K Diepold, T Scarborough, and J Ma (1996)
Development 122, 1195-1206
   Abstract »    PDF »
Determining the Requirements for Cooperative DNA Binding by Swi5p and Pho2p (Grf10p/Bas2p) at the HO Promoter.
R. M. Brazas, L. T. Bhoite, M. D. Murphy, Y. Yu, Y. Chen, D. W. Neklason, and D. J. Stillman (1995)
J. Biol. Chem. 270, 29151-29161
   Abstract »    Full Text »    PDF »
Interaction of Oct-1 with TFIIB.
H. Nakshatri, P. Nakshatri, and R. A. Currie (1995)
J. Biol. Chem. 270, 19613-19623
   Abstract »    Full Text »    PDF »
A cis-Acting Element in Rous Sarcoma Virus Long Terminal Repeat Required for Promoter Repression by HeLa Nuclear Protein p21.
C.-H. Yeh and A. J. Shatkin (1995)
J. Biol. Chem. 270, 15815-15820
   Abstract »    Full Text »    PDF »
The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages..
J F Martin, A Bradley, and E N Olson (1995)
Genes & Dev. 9, 1237-1249
   Abstract »    PDF »
A Retinoic Acid–Induced Clonal Cell Line Derived From Multipotential P19 Embryonal Carcinoma Cells Expresses Smooth Muscle Characteristics.
R. S. Blank, E. A. Swartz, M. M. Thompson, E. N. Olson, and G. K. Owens (1995)
Circ. Res. 76, 742-749
   Abstract »    Full Text »
Epidermal Growth Factor Stimulation of the Human Gastrin Promoter Requires Sp1.
J. L. Merchant, A. Shiotani, E. R. Mortensen, D. K. Shumaker, and D. R. Abraczinskas (1995)
J. Biol. Chem. 270, 6314-6319
   Abstract »    Full Text »    PDF »
Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins..
C P Chang, W F Shen, S Rozenfeld, H J Lawrence, C Largman, and M L Cleary (1995)
Genes & Dev. 9, 663-674
   Abstract »    PDF »
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus..
D D Spyropoulos and M R Capecchi (1994)
Genes & Dev. 8, 1949-1961
   Abstract »    PDF »
Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis.
D. Edmondson, G. Lyons, J. Martin, and E. Olson (1994)
Development 120, 1251-1263
   Abstract »    PDF »
DNA bending and orientation-dependent function of YY1 in the c-fos promoter..
S Natesan and M Z Gilman (1993)
Genes & Dev. 7, 2497-2509
   Abstract »    PDF »
Cooperative dimerization of paired class homeo domains on DNA..
D Wilson, G Sheng, T Lecuit, N Dostatni, and C Desplan (1993)
Genes & Dev. 7, 2120-2134
   Abstract »    PDF »
HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization.
S Wagner and M. Green (1993)
Science 262, 395-399
   Abstract »    PDF »
Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3.
D Xue, Y Tu, and M Chalfie (1993)
Science 261, 1324-1328
   Abstract »    PDF »
Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins..
Y O Yuan, I L Stroke, and S Fields (1993)
Genes & Dev. 7, 1584-1597
   Abstract »    PDF »
The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences..
S K Chan and R S Mann (1993)
Genes & Dev. 7, 796-811
   Abstract »    PDF »
The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.
I Valarche, J. Tissier-Seta, M. Hirsch, S Martinez, C Goridis, and J. Brunet (1993)
Development 119, 881-896
   Abstract »    PDF »
A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.
R. Breitbart, C. Liang, L. Smoot, D. Laheru, V Mahdavi, and B Nadal-Ginard (1993)
Development 118, 1095-1106
   Abstract »    PDF »
Induction of Smooth Muscle alpha -Actin in Vascular Smooth Muscle Cells by Arginine Vasopressin Is Mediated by c-Jun Amino-terminal Kinases and p38 Mitogen-activated Protein Kinase.
C. Garat, V. Van Putten, Z. A. Refaat, C. Dessev, S.-Y. Han, and R. A. Nemenoff (2000)
J. Biol. Chem. 275, 22537-22543
   Abstract »    Full Text »    PDF »
The Smooth Muscle gamma -Actin Gene Promoter Is a Molecular Target for the Mouse bagpipe Homologue, mNkx3-1, and Serum Response Factor.
J. A. Carson, R. A. Fillmore, R. J. Schwartz, and W. E. Zimmer (2000)
J. Biol. Chem. 275, 39061-39072
   Abstract »    Full Text »    PDF »
A Set of Hox Proteins Interact with the Maf Oncoprotein to Inhibit Its DNA Binding, Transactivation, and Transforming Activities.
K. Kataoka, K. Yoshitomo-Nakagawa, S. Shioda, and M. Nishizawa (2001)
J. Biol. Chem. 276, 819-826
   Abstract »    Full Text »    PDF »
Superactivation of Pax6-mediated Transactivation from Paired Domain-binding Sites by DNA-independent Recruitment of Different Homeodomain Proteins.
I. Mikkola, J.-A. Bruun, T. Holm, and T. Johansen (2001)
J. Biol. Chem. 276, 4109-4118
   Abstract »    Full Text »    PDF »
Muscle Specificity Encoded by Specific Serum Response Factor-binding Sites.
P. S. Chang, L. Li, J. McAnally, and E. N. Olson (2001)
J. Biol. Chem. 276, 17206-17212
   Abstract »    Full Text »    PDF »
Identification of Barx2B, a Serum Response Factor-associated Homeodomain Protein.
B. P. Herring, A. M. Kriegel, and A. M. Hoggatt (2001)
J. Biol. Chem. 276, 14482-14489
   Abstract »    Full Text »    PDF »
The Identification of Prx1 Transcription Regulatory Domains Provides a Mechanism for Unequal Compensation by the Prx1 and Prx2 Loci.
R. A. Norris and M. J. Kern (2001)
J. Biol. Chem. 276, 26829-26837
   Abstract »    Full Text »    PDF »
Binding of Serum Response Factor to CArG Box Sequences Is Necessary but Not Sufficient to Restrict Gene Expression to Arterial Smooth Muscle Cells.
M. Strobeck, S. Kim, J. C. L. Zhang, C. Clendenin, K. L. Du, and M. S. Parmacek (2001)
J. Biol. Chem. 276, 16418-16424
   Abstract »    Full Text »    PDF »
Transcriptional Activation of beta -Tropomyosin Mediated by Serum Response Factor and a Novel Barx Homologue, Barx1b, in Smooth Muscle Cells.
M. Nakamura, W. Nishida, S. Mori, K. Hiwada, K.'i. Hayashi, and K. Sobue (2001)
J. Biol. Chem. 276, 18313-18320
   Abstract »    Full Text »    PDF »
Differential Binding of an SRF/NK-2/MEF2 Transcription Factor Complex in Normal Versus Neoplastic Smooth Muscle Tissues.
C. J. Phiel, V. Gabbeta, L. M. Parsons, D. Rothblat, R. P. Harvey, and K. M. McHugh (2001)
J. Biol. Chem. 276, 34637-34650
   Abstract »    Full Text »    PDF »
Alx4 Binding to LEF-1 Regulates N-CAM Promoter Activity.
K. Boras and P. A. Hamel (2002)
J. Biol. Chem. 277, 1120-1127
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)