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Science 7 August 1992:
Vol. 257. no. 5071, pp. 815 - 818
DOI: 10.1126/science.1323146
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Articles

Science, Vol 257, Issue 5071, 815-818
Copyright © 1992 by American Association for the Advancement of Science

articles

IP3 receptor: localization to plasma membrane of T cells and cocapping with the T cell receptor

AA Khan, JP Steiner, MG Klein, MF Schneider, and SH Snyder

Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205.

Immune responses in lymphocytes require cellular accumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca(2+)-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)