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Science 7 August 1992:
Vol. 257. no. 5071, pp. 806 - 809
DOI: 10.1126/science.1323145
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Articles

Science, Vol 257, Issue 5071, 806-809
Copyright © 1992 by American Association for the Advancement of Science

articles

Selective role of N-type calcium channels in neuronal migration

H Komuro and P Rakic

Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.

Analysis of neuronal migration in mouse cerebellar slice preparations by a laser scanning confocal microscope revealed that postmitotic granule cells initiate their migration only after the expression of N-type calcium channels on their plasmalemmal surface. Furthermore, selective blockade of these channels by addition of omega-conotoxin to the incubation medium curtailed cell movement. In contrast, inhibitors of L- and T-type calcium channels, as well as those of sodium and potassium channels, had no effect on the rate of granule cell migration. These results suggest that N-type calcium channels, which have been predominantly associated with neurotransmitter release in adult brain, also play a transient but specific developmental role in directed migration of immature neurons before the establishment of their synaptic circuits.


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