Science 7 August 1992: Vol. 257. no. 5071, pp. 803 - 806 DOI: 10.1126/science.1379745

Prev | Table of Contents | Next

Articles

The 3BP2 Adapter Protein Is Required for Optimal B-Cell Activation and Thymus-Independent Type 2 Humoral Response.

G. Chen, I. D. Dimitriou, J. La Rose, S. Ilangumaran, W.-C. Yeh, G. Doody, M. Turner, J. Gommerman, and R. Rottapel (2007)
Mol. Cell. Biol. 27, 3109-3122
 |  Abstract »  |  Full Text »  |  PDF »

The Ccr4-Not Complex Independently Controls both Msn2-Dependent Transcriptional Activation--via a Newly Identified Glc7/Bud14 Type I Protein Phosphatase Module--and TFIID Promoter Distribution.

E. Lenssen, N. James, I. Pedruzzi, F. Dubouloz, E. Cameroni, R. Bisig, L. Maillet, M. Werner, J. Roosen, K. Petrovic, et al. (2005)
Mol. Cell. Biol. 25, 488-498
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Emerging European-Like Porcine Reproductive and Respiratory Syndrome Virus Isolates in the United States.

S. L. Ropp, C. E. M. Wees, Y. Fang, E. A. Nelson, K. D. Rossow, M. Bien, B. Arndt, S. Preszler, P. Steen, J. Christopher-Hennings, et al. (2004)
J. Virol. 78, 3684-3703
 |  Abstract »  |  Full Text »  |  PDF »

GC-GAP, a Rho Family GTPase-activating Protein That Interacts with Signaling Adapters Gab1 and Gab2.

C. Zhao, H. Ma, E. Bossy-Wetzel, S. A. Lipton, Z. Zhang, and G.-S. Feng (2003)
J. Biol. Chem. 278, 34641-34653
 |  Abstract »  |  Full Text »  |  PDF »

Dok-R Binds c-Abl and Regulates Abl Kinase Activity and Mediates Cytoskeletal Reorganization.

Z. Master, J. Tran, A. Bishnoi, S. H. Chen, J. M. L. Ebos, P. Van Slyke, R. S. Kerbel, and D. J. Dumont (2003)
J. Biol. Chem. 278, 30170-30179
 |  Abstract »  |  Full Text »  |  PDF »

Determinants of the Src Homology Domain 3-Like Fold.

J. A. D'Aquino and D. Ringe (2003)
J. Bacteriol. 185, 4081-4086
 |  Abstract »  |  Full Text »  |  PDF »

Intersectin 1L Guanine Nucleotide Exchange Activity Is Regulated by Adjacent src Homology 3 Domains That Are Also Involved in Endocytosis.

J. L. Zamanian and R. B. Kelly (2003)
Mol. Biol. Cell 14, 1624-1637
 |  Abstract »  |  Full Text »  |  PDF »

Ahi-1, a Novel Gene Encoding a Modular Protein with WD40-Repeat and SH3 Domains, Is Targeted by the Ahi-1 and Mis-2 Provirus Integrations.

X. Jiang, Z. Hanna, M. Kaouass, L. Girard, and P. Jolicoeur (2002)
J. Virol. 76, 9046-9059
 |  Abstract »  |  Full Text »  |  PDF »

The BCR Gene and Philadelphia Chromosome-positive Leukemogenesis.

E. Laurent, M. Talpaz, H. Kantarjian, and R. Kurzrock (2001)
Cancer Res. 61, 2343-2355
 |  Full Text »

SH3 domains: complexity in moderation.

B. Mayer (2001)
J. Cell Sci. 114, 1253-1263
 |  Abstract »  |  PDF »

Small GTP-Binding Proteins.

Y. Takai, T. Sasaki, and T. Matozaki (2001)
Physiol Rev 81, 153-208
 |  Abstract »  |  Full Text »  |  PDF »

The molecular biology of chronic myeloid leukemia.

M. W. N. Deininger, J. M. Goldman, and J. V. Melo (2000)
Blood 96, 3343-3356
 |  Full Text »  |  PDF »

Interaction between PAK and Nck: a Template for Nck Targets and Role of PAK Autophosphorylation.

Z.-s. Zhao, E. Manser, and L. Lim (2000)
Mol. Cell. Biol. 20, 3906-3917
 |  Abstract »  |  Full Text »

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase.

S. Wahl, H. Barth, T. Ciossek, K. Aktories, and B. K. Mueller (2000)
J. Cell Biol. 149, 263-270
 |  Abstract »  |  Full Text »  |  PDF »

R-Ras Contains a Proline-rich Site That Binds to SH3 Domains and Is Required for Integrin Activation by R-Ras.

B. Wang, J. X. Zou, B. Ek-Rylander, and E. Ruoslahti (2000)
J. Biol. Chem. 275, 5222-5227
 |  Abstract »  |  Full Text »  |  PDF »

The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains.

B. K. KAY, M. P. WILLIAMSON, and M. SUDOL (2000)
FASEB J 14, 231-241
 |  Abstract »  |  Full Text »

A Novel PF/PN Motif Inhibits Nuclear Localization and DNA Binding Activity of the ESX1 Homeoprotein.

Y.-T. Yan, S. M. Stein, J. Ding, M. M. Shen, and C. Abate-Shen (2000)
Mol. Cell. Biol. 20, 661-671
 |  Abstract »  |  Full Text »

Dissociation of patching by latent membrane protein-1 of Epstein-Barr virus from its stimulation of NF-{kappa}B activity.

T. Bloss, A. Kaykas, and B. Sugden (1999)
J. Gen. Virol. 80, 3227-3232
 |  Abstract »  |  Full Text »

Proline-rich Motifs of the Na+/H+ Exchanger 2 Isoform. BINDING OF Src HOMOLOGY DOMAIN 3 AND ROLE IN APICAL TARGETING IN EPITHELIA.

C.-W. Chow, M. Woodside, N. Demaurex, F. H. Yu, P. Plant, D. Rotin, S. Grinstein, and J. Orlowski (1999)
J. Biol. Chem. 274, 10481-10488
 |  Abstract »  |  Full Text »  |  PDF »

Sla1p Is a Functionally Modular Component of the Yeast Cortical Actin Cytoskeleton Required for Correct Localization of Both Rho1p-GTPase and Sla2p, a Protein with Talin Homology.

K. R. Ayscough, J. J. Eby, T. Lila, H. Dewar, K. G. Kozminski, and D. G. Drubin (1999)
Mol. Biol. Cell 10, 1061-1075
 |  Abstract »  |  Full Text »

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity.

D. I. Johnson (1999)
Microbiol. Mol. Biol. Rev. 63, 54-105
 |  Abstract »  |  Full Text »  |  PDF »

PrKX Is a Novel Catalytic Subunit of the cAMP-dependent Protein Kinase Regulated by the Regulatory Subunit Type I.

B. Zimmermann, J. A. Chiorini, Y. Ma, R. M. Kotin, and F. W. Herberg (1999)
J. Biol. Chem. 274, 5370-5378
 |  Abstract »  |  Full Text »  |  PDF »

ASAP1, a Phospholipid-Dependent Arf GTPase-Activating Protein That Associates with and Is Phosphorylated by Src.

M. T. Brown, J. Andrade, H. Radhakrishna, J. G. Donaldson, J. A. Cooper, and P. A. Randazzo (1998)
Mol. Cell. Biol. 18, 7038-7051
 |  Abstract »  |  Full Text »

Activation of Extracellular Signal-regulated Kinase 2 by a Novel Abl-binding Protein, ST5.

M. Majidi, A. E. Hubbs, and J. H. Lichy (1998)
J. Biol. Chem. 273, 16608-16614
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Candidate Human Spectrin Src Homology 3 Domain-binding Protein Suggests a General Mechanism of Association of Tyrosine Kinases with the Spectrin-based Membrane Skeleton.

D. Ziemnicka-Kotula, J. Xu, H. Gu, A. Potempska, K. S. Kim, E. C. Jenkins, E. Trenkner, and L. Kotula (1998)
J. Biol. Chem. 273, 13681-13692
 |  Abstract »  |  Full Text »  |  PDF »

Sequence Requirements for Association of Protein-tyrosine Phosphatase PEP with the Src Homology 3 Domain of Inhibitory Tyrosine Protein Kinase p50csk.

A. Gregorieff, J.-F. Cloutier, and A. Veillette (1998)
J. Biol. Chem. 273, 13217-13222
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Heterologous Gene Expression by the Large Isoform of Hepatitis Delta Antigen.

Y. Wei and D. Ganem (1998)
J. Virol. 72, 2089-2096
 |  Abstract »  |  Full Text »  |  PDF »

A Role for CAP, a Novel, Multifunctional Src Homology 3 Domain-containing Protein in Formation of Actin Stress Fibers and Focal Adhesions.

V. Ribon, R. Herrera, B. K. Kay, and A. R. Saltiel (1998)
J. Biol. Chem. 273, 4073-4080
 |  Abstract »  |  Full Text »  |  PDF »

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity.

S.-T. Wen and R. A. Van Etten (1997)
Genes & Dev. 11, 2456-2467
 |  Abstract »  |  Full Text »  |  PDF »

Rho GTPases and signaling networks.

L. Van Aelst and C. D'Souza-Schorey (1997)
Genes & Dev. 11, 2295-2322
 |  Full Text »  |  PDF »

Efficient Assembly of Functional Cytochrome P450 2C2 Requires a Spacer Sequence between the N-terminal Signal Anchor and Catalytic Domains.

C.-D. Chen, B. Doray, and B. Kemper (1997)
J. Biol. Chem. 272, 22891-22897
 |  Abstract »  |  Full Text »  |  PDF »

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.

A. E. Salcini, S. Confalonieri, M. Doria, E. Santolini, E. Tassi, O. Minenkova, G. Cesareni, P. G. Pelicci, and P. P. Di Fiore (1997)
Genes & Dev. 11, 2239-2249
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of B Cell Receptor and B Cell Receptor-Fcgamma RIIB1 Engagement on Docking of Csk to GTPase-activating Protein (GAP)-associated p62.

M. Vuica, S. Desiderio, and J. P. Schneck (1997)
J. Exp. Med. 186, 259-267
 |  Abstract »  |  Full Text »  |  PDF »

ArgBP2, a Multiple Src Homology 3 Domain-containing, Arg/Abl-interacting Protein, Is Phosphorylated in v-Abl-transformed Cells and Localized in Stress Fibers and Cardiocyte Z-disks.

B. Wang, E. A. Golemis, and G. D. Kruh (1997)
J. Biol. Chem. 272, 17542-17550
 |  Abstract »  |  Full Text »  |  PDF »

Protein binding and signaling properties of RIN1 suggest a unique effector function.

L. Han, D. Wong, A. Dhaka, D. Afar, M. White, W. Xie, H. Herschman, O. Witte, and J. Colicelli (1997)
PNAS 94, 4954-4959
 |  Abstract »  |  Full Text »  |  PDF »

Myosin I Overexpression Impairs Cell Migration.

K. D. Novak and M. A. Titus (1997)
J. Cell Biol. 136, 633-647
 |  Abstract »  |  Full Text »  |  PDF »

Different Structural Requirements at Specific Proline Residue Positions in the Conserved Proline-rich Region of Cytochrome P450 2C2.

C.-D. Chen and B. Kemper (1996)
J. Biol. Chem. 271, 28607-28611
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Evidence That Formins Function within the Nucleus.

D. C. Chan and P. Leder (1996)
J. Biol. Chem. 271, 23472-23477
 |  Abstract »  |  Full Text »  |  PDF »

A Potential SH3 Domain-binding Site in the Crk SH2 Domain.

M. Anafi, M. K. Rosen, G. D. Gish, L. E. Kay, and T. Pawson (1996)
J. Biol. Chem. 271, 21365-21374
 |  Abstract »  |  Full Text »  |  PDF »

An Activating Mutation in the ATP Binding Site of the ABL Kinase Domain.

P. B. Allen and L. M. Wiedemann (1996)
J. Biol. Chem. 271, 19585-19591
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin..

K Alexandropoulos and D Baltimore (1996)
Genes & Dev. 10, 1341-1355
 |  Abstract »  |  PDF »

Direct Binding of C-terminal Region of p130[IMAGE] to SH2 and SH3 Domains of Src Kinase.

T. Nakamoto, R. Sakai, K. Ozawa, Y. Yazaki, and H. Hirai (1996)
J. Biol. Chem. 271, 8959-8965
 |  Abstract »  |  Full Text »  |  PDF »

The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.

R Hoskins, A. Hajnal, S. Harp, and S. Kim (1996)
Development 122, 97-111
 |  Abstract »  |  PDF »

Enhanced Affinities and Specificities of Consolidated Ligands for the Src Homology (SH) 3 and SH2 Domains of Abelson Protein-tyrosine Kinase.

D. Cowburn, J. Zheng, Q. Xu, and G. Barany (1995)
J. Biol. Chem. 270, 26738-26741
 |  Abstract »  |  Full Text »  |  PDF »

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity..

Z Dai and A M Pendergast (1995)
Genes & Dev. 9, 2569-2582
 |  Abstract »  |  PDF »

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity..

Y Shi, K Alin, and S P Goff (1995)
Genes & Dev. 9, 2583-2597
 |  Abstract »  |  PDF »

Identification of a Mouse p21[IMAGE] Activated Kinase.

S. Bagrodia, S. J. Taylor, C. L. Creasy, J. Chernoff, and R. A. Cerione (1995)
J. Biol. Chem. 270, 22731-22737
 |  Abstract »  |  Full Text »  |  PDF »

An SH3-binding Site Conserved in Bruton's Tyrosine Kinase and Related Tyrosine Kinases Mediates Specific Protein Interactions in Vitro and in Vivo.

W. Yang, S. N. Malek, and S. Desiderio (1995)
J. Biol. Chem. 270, 20832-20840
 |  Abstract »  |  Full Text »  |  PDF »

The SH3 Domain of Crk Binds Specifically to a Conserved Proline-rich Motif in Eps15 and Eps15R.

C. Schumacher, B. S. Knudsen, T. Ohuchi, P. P. D. Fiore, R. H. Glassman, and H. Hanafusa (1995)
J. Biol. Chem. 270, 15341-15347
 |  Abstract »  |  Full Text »  |  PDF »

The Ras GTPase-activating Protein (GAP) Is an SH3 Domain-binding Protein and Substrate for the Src-related Tyrosine Kinase, Hck.

S. D. Briggs, S. S. Bryant, R. Jove, S. D. Sanderson, and T. E. Smithgall (1995)
J. Biol. Chem. 270, 14718-14724
 |  Abstract »  |  Full Text »  |  PDF »

Functional Interaction between c-Src and Its Mitotic Target, Sam 68.

S. J. Taylor, M. Anafi, T. Pawson, and D. Shalloway (1995)
J. Biol. Chem. 270, 10120-10124
 |  Abstract »  |  Full Text »  |  PDF »

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain..

C M Horvath, Z Wen, and J E Darnell (1995)
Genes & Dev. 9, 984-994
 |  Abstract »  |  PDF »

A Novel Ligand for SH3 Domains.

M. M. Chou and H. Hanafusa (1995)
J. Biol. Chem. 270, 7359-7364
 |  Abstract »  |  Full Text »  |  PDF »

An Actin Monomer Binding Activity Localizes to the Carboxyl-terminal Half of the Saccharomyces cerevisiae Cyclase-associated Protein.

N. L. Freeman, Z. Chen, J. Horenstein, A. Weber, and J. Field (1995)
J. Biol. Chem. 270, 5680-5685
 |  Abstract »  |  Full Text »  |  PDF »

AFAP-120.

D. C. Flynn, T. C. Koay, C. G. Humphries, and A. C. Guappone (1995)
J. Biol. Chem. 270, 3894-3899
 |  Abstract »  |  Full Text »  |  PDF »

Crk Interacts with Tyrosine-phosphorylated p116 upon T Cell Activation.

S. Sawasdikosol, K. S. Ravichandran, K. K. Lee, J.-H. Chang, and S. J. Burakoff (1995)
J. Biol. Chem. 270, 2893-2896
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of an Autoinhibitory Domain in Human Mitogen-activated Protein Kinase-activated Protein Kinase 2.

Y.-L. Zu, Y. Ai, and C.-K. Huang (1995)
J. Biol. Chem. 270, 202-206
 |  Abstract »  |  Full Text »  |  PDF »

SH3 Domains Specifically Regulate Kinase Activity of Expressed Src Family Proteins.

C. S. Abrams and W. Zhao (1995)
J. Biol. Chem. 270, 333-339
 |  Abstract »  |  Full Text »  |  PDF »

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions.

S Feng, J. Chen, H Yu, J. Simon, and S. Schreiber (1994)
Science 266, 1241-1247
 |  Abstract »  |  PDF »

Cloning of a Grb2 isoform with apoptotic properties.

I Fath, F Schweighoffer, I Rey, M. Multon, J Boiziau, M Duchesne, and B Tocque (1994)
Science 264, 971-974
 |  Abstract »  |  PDF »

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites..

R Ren, Z S Ye, and D Baltimore (1994)
Genes & Dev. 8, 783-795
 |  Abstract »  |  PDF »

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.

C. Pleiman, W. Hertz, and J. Cambier (1994)
Science 263, 1609-1612
 |  Abstract »  |  PDF »

The Molecular Basis of Leukemia.

M. J. Cline (1994)
N. Engl. J. Med. 330, 328-336
 |  Full Text »

Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex.

B. Skalhegg, K Tasken, V Hansson, H. Huitfeldt, T Jahnsen, and T Lea (1994)
Science 263, 84-87
 |  Abstract »  |  PDF »

Aspects of growth factor signal transduction in the cell cytoplasm.

B. Panaretto (1994)
J. Cell Sci. 107, 747-752
 |  PDF »

Closing in on SH2 specificity.

R. Birge and H Hanafusa (1993)
Science 262, 1522-1524
 |  PDF »

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.

K. Ravichandran, K. Lee, Z Songyang, L. Cantley, P Burn, and S. Burakoff (1993)
Science 262, 902-905
 |  Abstract »  |  PDF »

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes.

K Baltensperger, L. Kozma, A. Cherniack, J. Klarlund, A Chawla, U Banerjee, and M. Czech (1993)
Science 260, 1950-1952
 |  Abstract »  |  PDF »

The function of GRB2 in linking the insulin receptor to Ras signaling pathways.

E. Skolnik, A Batzer, N Li, C. Lee, E Lowenstein, M Mohammadi, B Margolis, and J Schlessinger (1993)
Science 260, 1953-1955
 |  Abstract »  |  PDF »

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

P Chardin, J. Camonis, N. Gale, L van Aelst, J Schlessinger, M. Wigler, and D Bar-Sagi (1993)
Science 260, 1338-1343
 |  Abstract »  |  PDF »

Identification of a ten-amino acid proline-rich SH3 binding site.

R Ren, B. Mayer, P Cicchetti, and D Baltimore (1993)
Science 259, 1157-1161
 |  Abstract »  |  PDF »

Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling.

M Duchesne, F Schweighoffer, F Parker, F Clerc, Y Frobert, M. Thang, and B Tocque (1993)
Science 259, 525-528
 |  Abstract »  |  PDF »

Binding of the alpha-fodrin SH3 domain to the leading lamellae of locomoting chicken fibroblasts.

J Merilainen, R Palovuori, R Sormunen, V. Wasenius, and V. Lehto (1993)
J. Cell Sci. 105, 647-654
 |  Abstract »  |  PDF »

Solution structure of the SH3 domain of Src and identification of its ligand-binding site.

H Yu, M. Rosen, T. Shin, C Seidel-Dugan, J. Brugge, and S. Schreiber (1992)
Science 258, 1665-1668
 |  Abstract »  |  PDF »

Cytoskeleton--plasma membrane interactions.

E. Luna and A. Hitt (1992)
Science 258, 955-964
 |  Abstract »  |  PDF »

A Nuclear SH3 Domain-binding Protein That Colocalizes with mRNA Splicing Factors and Intermediate Filament-containing Perinuclear Networks.

G. Craggs, P. M. Finan, D. Lawson, J. Wingfield, T. Perera, S. Gadher, N. F. Totty, and S. Kellie (2001)
J. Biol. Chem. 276, 30552-30560
 |  Abstract »  |  Full Text »  |  PDF »

RICH, a Rho GTPase-activating Protein Domain-containing Protein Involved in Signaling by Cdc42 and Rac1.

N. Richnau and P. Aspenstrom (2001)
J. Biol. Chem. 276, 35060-35070
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products