Science 7 August 1992: Vol. 257. no. 5071, pp. 789 - 792 DOI: 10.1126/science.1323143

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Articles

Surface CD152 (CTLA-4) Expression and Signaling Dictates Longevity of CD28null T Cells.

H. Hoff, K. Knieke, Z. Cabail, H. Hirseland, G. Vratsanos, G.-R. Burmester, G. Jorch, S. G. Nadler, B. Broker, K. Hebel, et al. (2009)
J. Immunol. 182, 5342-5351
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Linking of CD80 on CD4+ T Cells Activates a Calcium-Dependent Signaling Pathway.

J. R. Podojil and S. D. Miller (2009)
J. Immunol. 182, 766-773
 |  Abstract »  |  Full Text »  |  PDF »

Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody.

N. Beyersdorf, X. Ding, G. Blank, K. M. Dennehy, T. Kerkau, and T. Hunig (2008)
Blood 112, 4328-4336
 |  Abstract »  |  Full Text »  |  PDF »

PD-1-Dependent Mechanisms Maintain Peripheral Tolerance of Donor-Reactive CD8+ T Cells to Transplanted Tissue.

B. H. Koehn, M. L. Ford, I. R. Ferrer, K. Borom, S. Gangappa, A. D. Kirk, and C. P. Larsen (2008)
J. Immunol. 181, 5313-5322
 |  Abstract »  |  Full Text »  |  PDF »

CTLA4Ig treatment in patients with multiple sclerosis: An open-label, phase 1 clinical trial.

V. Viglietta, K. Bourcier, G. J. Buckle, B. Healy, H. L. Weiner, D. A. Hafler, S. Egorova, C.R.G. Guttmann, J. R. Rusche, and S. J. Khoury (2008)
Neurology 71, 917-924
 |  Abstract »  |  Full Text »  |  PDF »

Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.

R.-J. Swijnenburg, S. Schrepfer, J. A. Govaert, F. Cao, K. Ransohoff, A. Y. Sheikh, M. Haddad, A. J. Connolly, M. M. Davis, R. C. Robbins, et al. (2008)
PNAS 105, 12991-12996
 |  Abstract »  |  Full Text »  |  PDF »

A Critical Precursor Frequency of Donor-Reactive CD4+ T Cell Help Is Required for CD8+ T Cell-Mediated CD28/CD154-Independent Rejection.

M. L. Ford, M. E. Wagener, S. S. Hanna, T. C. Pearson, A. D. Kirk, and C. P. Larsen (2008)
J. Immunol. 180, 7203-7211
 |  Abstract »  |  Full Text »  |  PDF »

Signaling through Fc{gamma}RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation.

H. S. Bandukwala, B. S. Clay, J. Tong, P. D. Mody, J. L. Cannon, R. A. Shilling, J. S. Verbeek, J. V. Weinstock, J. Solway, and A. I. Sperling (2007)
J. Exp. Med. 204, 1875-1889
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation blockade--what will the future bring?.

F. Vincenti (2007)
Nephrol. Dial. Transplant. 22, 1293-1296
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Pivotal Advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection.

H.-P. Raue and M. K. Slifka (2007)
J. Leukoc. Biol. 81, 1165-1175
 |  Abstract »  |  Full Text »  |  PDF »

Recovery of Islet {beta}-Cell Function in Streptozotocin- Induced Diabetic Mice: An Indirect Role for the Spleen.

D. Yin, J. Tao, D. D. Lee, J. Shen, M. Hara, J. Lopez, A. Kuznetsov, L. H. Philipson, and A. S. Chong (2006)
Diabetes 55, 3256-3263
 |  Abstract »  |  Full Text »  |  PDF »

Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.

C. H. Miao, P. Ye, A. R. Thompson, D. J. Rawlings, and H. D. Ochs (2006)
Blood 108, 19-27
 |  Abstract »  |  Full Text »  |  PDF »

Biological and biomaterial approaches for improved islet transplantation..

A. S. Narang and R. I. Mahato (2006)
Pharmacol. Rev. 58, 194-243
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAPK plays a role in IL-4 synthesis in jacalin plus CD28-stimulated CD4+ T cells--II.

S. M. L. Tamma, K. W. Chung, T. Patel, S. P. Balan, and S. Pahwa (2006)
J. Leukoc. Biol. 79, 1339-1347
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated Memory Cell Homeostasis during T Cell Depletion and Approaches to Overcome It..

D. C. Neujahr, C. Chen, X. Huang, J. F. Markmann, S. Cobbold, H. Waldmann, M. H. Sayegh, W. W. Hancock, and L. A. Turka (2006)
J. Immunol. 176, 4632-4639
 |  Abstract »  |  Full Text »  |  PDF »

The lectin jacalin plus costimulation with anti-CD28 antibody induces phosphorylation of p38 MAPK and IL-4 synthesis-I.

S. M. L. Tamma, S. P. Balan, K. W. Chung, and S. Pahwa (2006)
J. Leukoc. Biol. 79, 876-880
 |  Abstract »  |  Full Text »  |  PDF »

Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance.

W Chalermskulrat, K P McKinnon, W J Brickey, I P Neuringer, R C Park, D G Sterka, B R Long, P McNeillie, R J Noelle, J P Ting, et al. (2006)
Thorax 61, 61-67
 |  Abstract »  |  Full Text »  |  PDF »

CD80/CD86 Costimulation Regulates Acute Vascular Rejection.

K. A. Hosiawa, H. Wang, M. E. DeVries, B. Garcia, W. Liu, D. Zhou, A. Akram, J. Jiang, H. Sun, M. J. Cameron, et al. (2005)
J. Immunol. 175, 6197-6204
 |  Abstract »  |  Full Text »  |  PDF »

Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.

P. H. Tan, J. B. Yates, S.-A. Xue, C. Chan, W. J. Jordan, J. E. Harper, M. P. Watson, R. Dong, M. A. Ritter, R. I. Lechler, et al. (2005)
Blood 106, 2936-2943
 |  Abstract »  |  Full Text »  |  PDF »

Induction of transplantation tolerance in non-human primate preclinical models.

D. A Hale, K. Dhanireddy, D. Bruno, and A. D Kirk (2005)
Phil Trans R Soc B 360, 1723-1737
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the Underlying Cellular Mechanisms of Anti-CD154-Induced Graft Tolerance: The Interplay of Clonal Anergy and Immune Regulation.

S. A. Quezada, K. Bennett, B. R. Blazar, A. Y. Rudensky, S. Sakaguchi, and R. J. Noelle (2005)
J. Immunol. 175, 771-779
 |  Abstract »  |  Full Text »  |  PDF »

Achieving Permanent Survival of Islet Xenografts by Independent Manipulation of Direct and Indirect T-Cell Responses.

V. Mirenda, D. Golshayan, J. Read, I. Berton, A. N. Warrens, A. Dorling, and R. I. Lechler (2005)
Diabetes 54, 1048-1055
 |  Abstract »  |  Full Text »  |  PDF »

Immune regulatory activity of CD34+ progenitor cells: evidence for a deletion-based mechanism mediated by TNF-{alpha}.

H. Gur, R. Krauthgamer, E. Bachar-Lustig, H. Katchman, R. Arbel-Goren, A. Berrebi, T. Klein, A. Nagler, A. Tabilio, M. F. Martelli, et al. (2005)
Blood 105, 2585-2593
 |  Abstract »  |  Full Text »  |  PDF »

Block and tackle: CTLA4Ig takes on lupus.

A Davidson, B Diamond, D Wofsy, and D Daikh (2005)
Lupus 14, 197-203
 |  Abstract »  |  PDF »

Indefinite Survival of Neonatal Porcine Islet Xenografts by Simultaneous Targeting of LFA-1 and CD154 or CD45RB.

G. R. Rayat and R. G. Gill (2005)
Diabetes 54, 443-451
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin.

M. H. Albert, X.-Z. Yu, P. J. Martin, and C. Anasetti (2005)
Blood 105, 1355-1361
 |  Abstract »  |  Full Text »  |  PDF »

Recent Advances in the Treatment of Graft-Versus-Host Disease.

T. Iwasaki (2004)
Clin. Med. Res. 2, 243-252
 |  Abstract »  |  Full Text »  |  PDF »

Role of B7 in T Cell Tolerance.

J. Lohr, B. Knoechel, E. C. Kahn, and A. K. Abbas (2004)
J. Immunol. 173, 5028-5035
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Oligonucleotides Down-Regulating Costimulation Confer Diabetes-Preventive Properties to Nonobese Diabetic Mouse Dendritic Cells.

J. Machen, J. Harnaha, R. Lakomy, A. Styche, M. Trucco, and N. Giannoukakis (2004)
J. Immunol. 173, 4331-4341
 |  Abstract »  |  Full Text »  |  PDF »

Melanoma cells transfected to express CD83 induce antitumor immunity that can be increased by also engaging CD137.

S. Yang, Y. Yang, J. Raycraft, H. Zhang, S. Kanan, Y. Guo, Z. Ronai, I. Hellstrom, and K. E. Hellstrom (2004)
PNAS 101, 4990-4995
 |  Abstract »  |  Full Text »  |  PDF »

CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells.

Y. Zheng, C. N. Manzotti, M. Liu, F. Burke, K. I. Mead, and D. M. Sansom (2004)
J. Immunol. 172, 2778-2784
 |  Abstract »  |  Full Text »  |  PDF »

Long-Term Survival of Xenografted Neonatal Cardiomyocytes by Adenovirus-Mediated CTLA4-Ig Expression and CD40 Blockade.

T.-S. Li, H. Ito, K. Kajiwara, and K. Hamano (2003)
Circulation 108, 1760-1765
 |  Abstract »  |  Full Text »  |  PDF »

Differential Localization and Function of ADP-Ribosylation Factor-6 in Anergic Human T Cells: A Potential Marker for Their Identification.

D. Tzachanis, L. J. Appleman, A. A. F. L. van Puijenbroek, A. Berezovskaya, L. M. Nadler, and V. A. Boussiotis (2003)
J. Immunol. 171, 1691-1696
 |  Abstract »  |  Full Text »  |  PDF »

BCL6 Controls the Expression of the B7-1/CD80 Costimulatory Receptor in Germinal Center B Cells.

H. Niu, G. Cattoretti, and R. Dalla-Favera (2003)
J. Exp. Med. 198, 211-221
 |  Abstract »  |  Full Text »  |  PDF »

CTLA4Ig-gene transfection inhibits obliterative airway disease in rats.

Y. Kita, K. Suzuki, H. Nogimura, T. Takahashi, and T. Kazui (2003)
Ann. Thorac. Surg. 75, 1123-1127
 |  Abstract »  |  Full Text »  |  PDF »

CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties.

C. Vasu, A. Wang, S. R. Gorla, S. Kaithamana, B. S. Prabhakar, and M. J. Holterman (2003)
Int. Immunol. 15, 167-175
 |  Abstract »  |  Full Text »  |  PDF »

IFN-{gamma} Production Is Specifically Regulated by IL-10 in Mice Made Tolerant with Anti-CD40 Ligand Antibody and Intact Active Bone.

D. Yin, N. Dujovny, L. Ma, A. Varghese, J. Shen, D. K. Bishop, and A. S. Chong (2003)
J. Immunol. 170, 853-860
 |  Abstract »  |  Full Text »  |  PDF »

Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing.

R. M. Sutherland, B. S. McKenzie, Y. Zhan, A. J. Corbett, A. Fox-Marsh, H. M. Georgiou, L. C. Harrison, and A. M. Lew (2002)
Int. Immunol. 14, 953-962
 |  Abstract »  |  Full Text »  |  PDF »

Intact Active Bone Transplantation Synergizes with Anti-CD40 Ligand Therapy to Induce B Cell Tolerance.

D. Yin, L. Ma, A. Varghese, J. Shen, and A. S.-F. Chong (2002)
J. Immunol. 168, 5352-5358
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo CD86 Blockade Inhibits CD4+ T Cell Activation, Whereas CD80 Blockade Potentiates CD8+ T Cell Activation and CTL Effector Function.

T. J. Lang, P. Nguyen, R. Peach, W. C. Gause, and C. S. Via (2002)
J. Immunol. 168, 3786-3792
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Administration of CTLA4-Ig as Protein or cDNA on Corneal Allograft Survival.

R. M. Comer, W. J. King, N. Ardjomand, S. Theoharis, A. J. T. George, and D. F. P. Larkin (2002)
Invest. Ophthalmol. Vis. Sci. 43, 1095-1103
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: CD83 Regulates the Development of Cellular Immunity.

N. Scholler, M. Hayden-Ledbetter, A. Dahlin, I. Hellstrom, K. E. Hellstrom, and J. A. Ledbetter (2002)
J. Immunol. 168, 2599-2602
 |  Abstract »  |  Full Text »  |  PDF »

Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.

F. Haspot, F. Villemain, G. Laflamme, F. Coulon, D. Olive, J. Tiollier, J.-P. Soulillou, and B. Vanhove (2002)
Blood 99, 2228-2234
 |  Abstract »  |  Full Text »  |  PDF »

Calcineurin Inhibitor-Free CD28 Blockade-Based Protocol Protects Allogeneic Islets in Nonhuman Primates.

A. B. Adams, N. Shirasugi, M. M. Durham, E. Strobert, D. Anderson, P. Rees, S. Cowan, H. Xu, Y. Blinder, M. Cheung, et al. (2002)
Diabetes 51, 265-270
 |  Abstract »  |  Full Text »  |  PDF »

Without CD4 Help, CD8 Rejection of Pig Xenografts Requires CD28 Costimulation But Not Perforin Killing.

Y. Zhan, J. L. Brady, R. M. Sutherland, and A. M. Lew (2001)
J. Immunol. 167, 6279-6285
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD28 for the Generation and Expansion of Antigen-Specific CD8+ T Lymphocytes During Infection with Listeria monocytogenes.

H.-W. Mittrucker, M. Kursar, A. Kohler, R. Hurwitz, and S. H. E. Kaufmann (2001)
J. Immunol. 167, 5620-5627
 |  Abstract »  |  Full Text »  |  PDF »

Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State.

A. Bar-Or, E. M. L Oliveira, D. E. Anderson, J. I. Krieger, M. Duddy, K. C. O'Connor, and D. A. Hafler (2001)
J. Immunol. 167, 5669-5677
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Membrane Lymphotoxin Regulates CD8+ T Cell-Mediated Intestinal Allograft Rejection.

Z. Guo, J. Wang, L. Meng, Q. Wu, O. Kim, J. Hart, G. He, P. Zhou, J. R. Thistlethwaite Jr., M.-L. Alegre, et al. (2001)
J. Immunol. 167, 4796-4800
 |  Abstract »  |  Full Text »  |  PDF »

Immunotoxins Containing Recombinant Anti-CTLA-4 Single-Chain Fragment Variable Antibodies and Saporin: In Vitro Results and In Vivo Effects in an Acute Rejection Model.

P.-L. Tazzari, L. Polito, A. Bolognesi, M.-P. Pistillo, P. Capanni, G. L. Palmisano, R. M. Lemoli, A. Curti, L. Biancone, G. Camussi, et al. (2001)
J. Immunol. 167, 4222-4229
 |  Abstract »  |  Full Text »  |  PDF »

An Antagonist IL-15/Fc Protein Prevents Costimulation Blockade-Resistant Rejection.

S. Ferrari-Lacraz, X. X. Zheng, Y. S. Kim, Y. Li, W. Maslinski, X. C. Li, and T. B. Strom (2001)
J. Immunol. 167, 3478-3485
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory T Cells Induced by 1{alpha},25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance.

S. Gregori, M. Casorati, S. Amuchastegui, S. Smiroldo, A. M. Davalli, and L. Adorini (2001)
J. Immunol. 167, 1945-1953
 |  Abstract »  |  Full Text »  |  PDF »

B7 Interactions with CD28 and CTLA-4 Control Tolerance or Induction of Mucosal Inflammation in Chronic Experimental Colitis.

Z. Liu, K. Geboes, P. Hellings, P. Maerten, H. Heremans, P. Vandenberghe, L. Boon, P. van Kooten, P. Rutgeerts, and J. L. Ceuppens (2001)
J. Immunol. 167, 1830-1838
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of CD28 Expression by CD28GR, a Novel Promoter Element Located in Exon 1 of the CD28 Gene.

C. J. Lin and R. C. Tam (2001)
J. Immunol. 166, 6134-6143
 |  Abstract »  |  Full Text »  |  PDF »

CD28 and CTLA4 Coordinately Regulate Airway Inflammatory Cell Recruitment and T-Helper Cell Differentiation after Inhaled Allergen.

J. S. Burr, S. L. Kimzey, D. R. Randolph, and J. M. Green (2001)
Am. J. Respir. Cell Mol. Biol. 24, 563-568
 |  Abstract »  |  Full Text »

Anergy Induction by Dimeric TCR Ligands.

H. Appel, N. P. Seth, L. Gauthier, and K. W. Wucherpfennig (2001)
J. Immunol. 166, 5279-5285
 |  Abstract »  |  Full Text »  |  PDF »

Is Islet Transplantation a Realistic Therapy for the Treatment of Type 1 Diabetes in the Near Future?.

R. B. Stevens, S. Matsumoto, and C. L. Marsh (2001)
Clin. Diabetes 19, 51-60
 |  Abstract »  |  Full Text »  |  PDF »

CD28-B7-Mediated T Cell Costimulation in Chronic Cardiac Allograft Rejection : Differential Role of B7-1 in Initiation versus Progression of Graft Arteriosclerosis.

K. S. Kim, M. D. Denton, A. Chandraker, A. Knoflach, R. Milord, A. M. Waaga, L. A. Turka, M. E. Russell, R. Peach, and M. H. Sayegh (2001)
Am. J. Pathol. 158, 977-986
 |  Abstract »  |  Full Text »  |  PDF »

Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation.

R. D. Molano, T. Berney, H. Li, P. Cattan, A. Pileggi, C. Vizzardelli, N. S. Kenyon, C. Ricordi, L. C. Burkly, and L. Inverardi (2001)
Diabetes 50, 270-276
 |  Abstract »  |  Full Text »

B7/CD28 Costimulation Is Critical in Susceptibility to Pseudomonas aeruginosa Corneal Infection: A Comparative Study Using Monoclonal Antibody Blockade and CD28-Deficient Mice.

L. D. Hazlett, S. McClellan, R. Barrett, and X. Rudner (2001)
J. Immunol. 166, 1292-1299
 |  Abstract »  |  Full Text »  |  PDF »

Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice.

P. J. Quesenberry, S. Zhong, H. Wang, and M. Stewart (2001)
Blood 97, 557-564
 |  Abstract »  |  Full Text »  |  PDF »

In Situ Expression of Soluble B7-1 in the Context of Oncolytic Herpes Simplex Virus Induces Potent Antitumor Immunity.

T. Todo, R. L. Martuza, M. J. Dallman, and S. D. Rabkin (2001)
Cancer Res. 61, 153-161
 |  Abstract »  |  Full Text »

CD4 Help-Independent Induction of Cytotoxic CD8 Cells to Allogeneic P815 Tumor Cells Is Absolutely Dependent on Costimulation.

Y. Zhan, A. J. Corbett, J. L. Brady, R. M. Sutherland, and A. M. Lew (2000)
J. Immunol. 165, 3612-3619
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation of T Cells.

L. BUGEON and M. J. DALLMAN (2000)
Am. J. Respir. Crit. Care Med. 162, S164-168
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulatory Blockade Exacerbates Disease Severity and Accelerates Epitope Spreading in a Virus-Induced Autoimmune Disease.

K. L. Neville, M. C. Dal Canto, J. A. Bluestone, and S. D. Miller (2000)
J. Virol. 74, 8349-8357
 |  Abstract »  |  Full Text »

Porcine CTLA4-Ig Lacks a MYPPPY Motif, Binds Inefficiently to Human B7 and Specifically Suppresses Human CD4+ T Cell Responses Costimulated by Pig But Not Human B7.

A. N. Vaughan, P. Malde, N. J. Rogers, I. M. Jackson, R. I. Lechler, and A. Dorling (2000)
J. Immunol. 165, 3175-3181
 |  Abstract »  |  Full Text »  |  PDF »

Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis.

K. Shimizu, U. Schonbeck, F. Mach, P. Libby, and R. N. Mitchell (2000)
J. Immunol. 165, 3506-3518
 |  Abstract »  |  Full Text »  |  PDF »

Autoantigen-Specific CD4+CD28low T Cell Subset Prevents Autoimmune Exocrinopathy in Murine Sjogren's Syndrome.

K. Saegusa, N. Ishimaru, K. Yanagi, N. Haneji, M. Nishino, M. Azuma, I. Saito, and Y. Hayashi (2000)
J. Immunol. 165, 2251-2257
 |  Abstract »  |  Full Text »  |  PDF »

Association of B7-1 Co-Stimulation with the Development of Graft Arterial Disease : Studies Using Mice Lacking B7-1, B7-2, or B7-1/B7-2.

Y. Furukawa, D. A. Mandelbrot, P. Libby, A. H. Sharpe, and R. N. Mitchell (2000)
Am. J. Pathol. 157, 473-484
 |  Abstract »  |  Full Text »  |  PDF »

CTLA-4 (CD152) Can Inhibit T Cell Activation by Two Different Mechanisms Depending on Its Level of Cell Surface Expression.

B. M. Carreno, F. Bennett, T. A. Chau, V. Ling, D. Luxenberg, J. Jussif, M. L. Baroja, and J. Madrenas (2000)
J. Immunol. 165, 1352-1356
 |  Abstract »  |  Full Text »  |  PDF »

Primary Structure and Functional Characterization of a Soluble, Alternatively Spliced Form of B7-1.

S. J. Faas, M. A. Giannoni, A. P. Mickle, C. L. Kiesecker, D. J. Reed, D. Wu, W. L. Fodor, J. P. Mueller, L. A. Matis, and R. P. Rother (2000)
J. Immunol. 164, 6340-6348
 |  Abstract »  |  Full Text »  |  PDF »

Tolerance to Cardiac Allografts Via Local and Systemic Mechanisms After Adenovirus-Mediated CTLA4Ig Expression.

C. Guillot, P. Mathieu, H. Coathalem, B. Le Mauff, M. G. Castro, L. Tesson, C. Usal, T. Laumonier, S. Brouard, J.-P. Soulillou, et al. (2000)
J. Immunol. 164, 5258-5268
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of CD86 and CD40 induces alloantigen-specific immunoregulatory T cells that remain anergic even after reversal of hyporesponsiveness.

H. J. P. M. Koenen and I. Joosten (2000)
Blood 95, 3153-3161
 |  Abstract »  |  Full Text »  |  PDF »

CTLA4Ig Gene Transfer Prolongs Survival and Induces Donor-Specific Tolerance in a Rat Renal Allograft.

S. TOMASONI, N. AZZOLLINI, F. CASIRAGHI, M. C. CAPOGROSSI, G. REMUZZI, and A. BENIGNI (2000)
J. Am. Soc. Nephrol. 11, 747-752
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate Regulation of T Cell Activation by CD2 and CD28.

J. M. Green, V. Karpitskiy, S. L. Kimzey, and A. S. Shaw (2000)
J. Immunol. 164, 3591-3595
 |  Abstract »  |  Full Text »  |  PDF »

The B7/CD28/CTLA4 T-Cell Activation Pathway . Implications for Inflammatory Lung Disease.

J. M. Green (2000)
Am. J. Respir. Cell Mol. Biol. 22, 261-264
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B7-1 (CD80) and B7-2 (CD86) Have Complementary Roles in Mediating Allergic Pulmonary Inflammation and Airway Hyperresponsiveness.

D. A. Mark, C. E. Donovan, G. T. De Sanctis, H. Z. He, M. Cernadas, L. Kobzik, D. L. Perkins, A. Sharpe, and P. W. Finn (2000)
Am. J. Respir. Cell Mol. Biol. 22, 265-271
 |  Abstract »  |  Full Text »

Naive CD8+ T Cells Do Not Require Costimulation for Proliferation and Differentiation into Cytotoxic Effector Cells.

B. Wang, R. Maile, R. Greenwood, E. J. Collins, and J. A. Frelinger (2000)
J. Immunol. 164, 1216-1222
 |  Abstract »  |  Full Text »  |  PDF »

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis.

C. L. Vanderlugt, K. L. Neville, K. M. Nikcevich, T. N. Eagar, J. A. Bluestone, and S. D. Miller (2000)
J. Immunol. 164, 670-678
 |  Abstract »  |  Full Text »  |  PDF »

Development of Human T-Cell Leukemia Virus Type 1-Transformed Tumors in Rats following Suppression of T-Cell Immunity by CD80 and CD86 Blockade.

S. Hanabuchi, T. Ohashi, Y. Koya, H. Kato, F. Takemura, K. Hirokawa, T. Yoshiki, H. Yagita, K. Okumura, and M. Kannagi (2000)
J. Virol. 74, 428-435
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Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection.

J. M. Lumsden, J. M. Roberts, N. L. Harris, R. J. Peach, and F. Ronchese (2000)
J. Immunol. 164, 79-85
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A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade.

A. M. Girvin, M. C. Dal Canto, L. Rhee, B. Salomon, A. Sharpe, J. A. Bluestone, and S. D. Miller (2000)
J. Immunol. 164, 136-143
 |  Abstract »  |  Full Text »  |  PDF »

Reduced Ultraviolet-Induced Carcinogenesis in Mice with a Functional Disruption in B7-Mediated Costimulation.

S. Beissert, J. A. Bluestone, I. Mindt, M. Voskort, D. Metze, A. Mehling, T. A. Luger, T. Schwarz, and S. Grabbe (1999)
J. Immunol. 163, 6725-6731
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of T Cell Costimulation by CTLA4-Ig Inhibits Lung Inflammation in Murine Hypersensitivity Pneumonitis.

E. Israel-Assayag, M. Fournier, and Y. Cormier (1999)
J. Immunol. 163, 6794-6799
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of Antigen-Presenting Cell Functions After Administration of Mitogenic Anti-CD3 Monoclonal Antibodies in Mice.

E. Muraille, F. Andris, B. Pajak, K. M. Wissing, T. De Smedt, F. Desalle, M. Goldman, M.-L. Alegre, J. Urbain, M. Moser, et al. (1999)
Blood 94, 4347-4357
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Targeted toxins.

M W J d. Brok, G C de Gast, J H M Schellens, and J H Beijnen (1999)
Journal of Oncology Pharmacy Practice 5, 149-165
 |  Abstract »  |  PDF »

Effect of Anti-B7-1 and Anti-B7-2 mAb on Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease.

A. Inoue, C.-S. Koh, M. Yamazaki, and H. Yagita (1999)
J. Immunol. 163, 6180-6186
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A20 Inhibits Cytokine-Induced Apoptosis and Nuclear Factor {kappa}B-Dependent Gene Activation in Islets.

S. T. Grey, M. B. Arvelo, W. Hasenkamp, F. H. Bach, and C. Ferran (1999)
J. Exp. Med. 190, 1135-1146
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of CD28 Expression by Oligonucleotide Decoys to the Regulatory Element in Exon 1 of the CD28 Gene.

R. C. Tam, C. J. Lin, C. Lim, B. Pai, and V. Stoisavljevic (1999)
J. Immunol. 163, 4292-4299
 |  Abstract »  |  Full Text »  |  PDF »

The Future of Organ and Tissue Transplantation: Can T-Cell Costimulatory Pathway Modifiers Revolutionize the Prevention of Graft Rejection?.

D. M. Harlan and A. D. Kirk (1999)
JAMA 282, 1076-1082
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Costimulatory Molecule CD28 in the Development of Lupus in MRL/lpr Mice.

Y. Tada, K. Nagasawa, A. Ho, F. Morito, S. Koarada, O. Ushiyama, N. Suzuki, A. Ohta, and T. W. Mak (1999)
J. Immunol. 163, 3153-3159
 |  Abstract »  |  Full Text »  |  PDF »

CD4-Mediated Signals Induce T Cell Dysfunction In Vivo.

N. Chirmule, A. Avots, S. M. L. Tamma, S. Pahwa, and E. Serfling (1999)
J. Immunol. 163, 644-649
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Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens.

D. J. Morgan, H. T. C. Kreuwel, and L. A. Sherman (1999)
J. Immunol. 163, 723-727
 |  Abstract »  |  Full Text »  |  PDF »

Transplantation of Anergic Histoincompatible Bone Marrow Allografts.

E. C. Guinan, V. A. Boussiotis, D. Neuberg, L. L. Brennan, N. Hirano, L. M. Nadler, and J. G. Gribben (1999)
N. Engl. J. Med. 340, 1704-1714
 |  Abstract »  |  Full Text »  |  PDF »

CTLA4 Signals Are Required to Optimally Induce Allograft Tolerance with Combined Donor-Specific Transfusion and Anti-CD154 Monoclonal Antibody Treatment.

X. X. Zheng, T. G. Markees, W. W. Hancock, Y. Li, D. L. Greiner, X. C. Li, J. P. Mordes, M. H. Sayegh, A. A. Rossini, and T. B. Strom (1999)
J. Immunol. 162, 4983-4990
 |  Abstract »  |  Full Text »  |  PDF »

Tolerance to Antigen-Presenting Cell-Depleted Islet Allografts Is CD4 T Cell Dependent.

M. Coulombe, H. Yang, L. A. Wolf, and R. G. Gill (1999)
J. Immunol. 162, 2503-2510
 |  Abstract »  |  Full Text »  |  PDF »

The Role of CD80, CD86, and CTLA4 in Alloimmune Responses and the Induction of Long-Term Allograft Survival.

T. A. Judge, Z. Wu, X.-G. Zheng, A. H. Sharpe, M. H. Sayegh, and L. A. Turka (1999)
J. Immunol. 162, 1947-1951
 |  Abstract »  |  Full Text »  |  PDF »

TRFK-5 Reverses Established Airway Eosinophilia But Not Established Hyperresponsiveness in a Murine Model of Chronic Asthma.

M. MATHUR, K. HERRMANN, X. LI, Y. QIN, J. WEINSTOCK, D. ELLIOTT, J. MONAHAN, and P. PADRID (1999)
Am. J. Respir. Crit. Care Med. 159, 580-587
 |  Abstract »  |  Full Text »

Induction of Specific T Cell Tolerance by Fas Ligand- Expressing Antigen-Presenting Cells.

H.-g. Zhang, X. Su, D. Liu, W. Liu, P. Yang, Z. Wang, C. K. Edwards, H. Bluethmann, J. D. Mountz, and T. Zhou (1999)
J. Immunol. 162, 1423-1430
 |  Abstract »  |  Full Text »  |  PDF »

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