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Science 31 July 1992:
Vol. 257. no. 5070, pp. 682 - 685
DOI: 10.1126/science.1496383
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Articles

Science, Vol 257, Issue 5070, 682-685
Copyright © 1992 by American Association for the Advancement of Science

articles

Participation in normal immune responses of a metastasis-inducing splice variant of CD44

R Arch, K Wirth, M Hofmann, H Ponta, S Matzku, P Herrlich, and M Zoller

Deutsches Krebsforschungszentrum Heidelberg, Institut fur Radiologie und Pathophysiologie, Heidelberg, Germany.

A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic spread of tumor cells can catalyze an essential step in the process of lymphocyte activation supports the idea that metastasizing tumor cells mimic lymphocyte behavior.


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A PCR-based method for the analysis of human CD44 splice products..
D H van Weering, P D Baas, and J L Bos (1993)
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N. Matter, M. Marx, S. Weg-Remers, H. Ponta, P. Herrlich, and H. Konig (2000)
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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway.
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