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Science 31 July 1992:
Vol. 257. no. 5070, pp. 678 - 679
DOI: 10.1126/science.1496381
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Articles

Science, Vol 257, Issue 5070, 678-679
Copyright © 1992 by American Association for the Advancement of Science

articles

Specialized role for a murine class I-b MHC molecule in prokaryotic host defenses

RJ Kurlander, SM Shawar, ML Brown, and RR Rich

Department of Medicine, Duke Medical Center, Durham, NC 27710.

Although nonclassical (class I-b) gene products represent the majority of murine major histocompatibility complex (MHC) genes, the role of these relatively nonpolymorphic molecules remains uncertain. Recently, one such protein, H-2M3 (formerly designated Hmt), was shown to bind and specifically present N-formylated peptides to cytotoxic T lymphocytes. Because N-formylation is characteristic of prokaryotic proteins, this MHC molecule may be especially adapted for a role in the mammalian defense against bacterial attack. The current studies demonstrate that an MHC molecule, indistinguishable from H-2M3, presents antigens derived from the intracellular pathogen Listeria monocytogenes to Listeria-specific CD8+ cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Mitochondrial DNA segregation in hematopoietic lineages does not depend on MHC presentation of mitochondrially encoded peptides.
B. J. Battersby, M. E. Redpath, and E. A. Shoubridge (2005)
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The non-classical HLA class I molecule HFE does not influence the NK-like activity contained in fresh human PBMCs and does not interact with NK cells.
S. Pascolo, F. Ginhoux, N. Laham, S. Walter, O. Schoor, J. Probst, P. Rohrlich, F. Obermayr, P. Fisch, O. Danos, et al. (2005)
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Bacterial and Host Factors Involved in the Major Histocompatibility Complex Class Ib-Restricted Presentation of Salmonella Hsp 60: Novel Pathway.
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The Listeria monocytogenes lemA Gene Product Is Not Required for Intracellular Infection or To Activate fMIGWII-Specific T Cells.
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CD8 T Cell Detection of Bacterial Infection: Sniffing for Formyl Peptides Derived from Mycobacterium tuberculosis.
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Variable Immunodominance Hierarchies for H2-M3-Restricted N-Formyl Peptides Following Bacterial Infection.
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Partially TAP-Independent Protection Against Listeria monocytogenes by H2-M3-Restricted CD8+ T Cells.
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Host Immune Response to Intracellular Bacteria: A Role for MHC-Linked Class-Ib Antigen-Presenting Molecules.
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The Adjacent Flanking Region Plays a Critical Role in Facilitating the Presentation of the Listeria monocytogenes Product lemA to H2 M3wt-Restricted, Peptide-Specific Murine CD8 Cells.
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H2-M3–restricted T Cells in Bacterial Infection: Rapid Primary but Diminished Memory Responses.
K. M. Kerksiek, D. H. Busch, I. M. Pilip, S. E. Allen, and E. G. Pamer (1999)
J. Exp. Med. 190, 195-204
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Response to Listeria monocytogenes in Mice Lacking MHC Class Ia Molecules.
M. S. Seaman, B. Perarnau, K. F. Lindahl, F. A. Lemonnier, and J. Forman (1999)
J. Immunol. 162, 5429-5436
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The Alloreactive T Cell Response Against the Class Ib Molecule H2-M3 Is Specific for High Affinity Peptides.
V. M. Dabhi, R. Hovik, L. Van Kaer, and K. Fischer Lindahl (1998)
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Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells.
Y. Vugmeyster, R. Glas, B. Perarnau, F. A. Lemonnier, H. Eisen, and H. Ploegh (1998)
PNAS 95, 12492-12497
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Listeria monocytogenes-Infected Hepatocytes Are Targets of Major Histocompatibility Complex Class Ib-Restricted Antilisterial Cytotoxic T Lymphocytes.
H. G. A. Bouwer, A. Bai, J. Forman, S. H. Gregory, E. J. Wing, R. A. Barry, and D. J. Hinrichs (1998)
Infect. Immun. 66, 2814-2817
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H2-M3 Restricted Presentation of a Listeria-derived Leader Peptide.
M. F. Princiotta, L. L. Lenz, M. J. Bevan, and U. D. Staerz (1998)
J. Exp. Med. 187, 1711-1719
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Interaction of HLA-E with Peptides and the Peptide Transporter In Vitro: Implications for its Function in Antigen Presentation.
M. Ulbrecht, S. Modrow, R. Srivastava, P. A. Peterson, and E. H. Weiss (1998)
J. Immunol. 160, 4375-4385
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The Recognition of the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule, T10, by the gamma delta T Cell, G8.
M. P. Crowley, Z. Reich, N. Mavaddat, J. D. Altman, and Y.-h. Chien (1997)
J. Exp. Med. 185, 1223-1230
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