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Science 31 July 1992:
Vol. 257. no. 5070, pp. 669 - 671
DOI: 10.1126/science.1379742
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Articles

Science, Vol 257, Issue 5070, 669-671
Copyright © 1992 by American Association for the Advancement of Science

articles

Chloride-dependent cation conductance activated during cellular shrinkage

HC Chan and DJ Nelson

Department of Medicine, University of Chicago, IL 60637.

A chloride (Cl-)-dependent, nonselective cation conductance was activated during cellular shrinkage and inhibited during cellular swelling or by extracellular gadolinium. The shrinking-induced, nonselective cation conductance and the swelling-induced anion conductance appear to function in the regulation of cell volume in airway epithelia. The shrinking-induced cation conductance had an unusual dependence on Cl-: partial replacement of extracellular Cl- with aspartate reduced the magnitude of the shrinking-enhanced current without accompanying changes in the reversal potential. The Cl- dependence of the nonselective cation conductance could provide a mechanism that tightly regulates Cl- secretion and sodium reabsorption in cells under osmotic stress.


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