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Science 24 July 1992: Vol. 257. no. 5069, pp. 545 - 548 DOI: 10.1126/science.1636092
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Articles
Science, Vol 257, Issue 5069, 545-548
Copyright © 1992 by American Association for the Advancement of Science
Transforming growth factor-beta in leishmanial infection: a parasite escape mechanism
M Barral-Netto,
A Barral,
CE Brownell,
YA Skeiky,
LR Ellingsworth,
DR Twardzik,
and
SG Reed
Federal University of Bahia School of Medicine, Brazil.
The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infection. Transforming growth factor-beta (TGF-beta) is a multipotential cytokine with diverse effects on cells of the immune system, including down-regulation of certain macrophage functions. Leishmanial infection induced the production of active TGF-beta, both in vitro and in vivo. TGF-beta was important for determining in vivo susceptibility to experimental leishmanial infection.
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