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Science 24 July 1992:
Vol. 257. no. 5069, pp. 531 - 534
DOI: 10.1126/science.1386162
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Articles

Science, Vol 257, Issue 5069, 531-534
Copyright © 1992 by American Association for the Advancement of Science

articles

Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia

T Inaba, WM Roberts, LH Shapiro, KW Jolly, SC Raimondi, SD Smith, and AT Look

Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.

A t(17;19) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed in liver and kidney, but not in lymphoid cells, and was found to be closely related to the leucine zipper-containing transcription factors DBP (albumin D-box binding protein) and TEF (thyrotroph embryonic factor), which regulate developmental stage-specific gene expression.


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