Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Applied Biosystems Megaplex

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 July 1992:
Vol. 257. no. 5068, pp. 383 - 387
DOI: 10.1126/science.1352913
Prev | Table of Contents | Next

Articles

Science, Vol 257, Issue 5068, 383-387
Copyright © 1992 by American Association for the Advancement of Science

articles

Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells

PU Cameron, PS Freudenthal, JM Barker, S Gezelter, K Inaba, and RM Steinman

Laboratory for Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021.

The paucity of virus-laden CD4+ cells in individuals infected with human immunodeficiency virus type-1 (HIV-1) contrasts with the greatly reduced numbers and function of these lymphocytes. A pathway is described whereby dendritic cells carry HIV-1 to uninfected T cells, amplifying the cytopathic effects of small amounts of virus. After exposure to HIV-1, dendritic cells continue to present superantigens and antigens, forming clusters with T cells that are driven to replicate. Infection of the dendritic cells cannot be detected, but the clustered T cells form syncytia, release virions, and die. Carriage of HIV-1 by dendritic cells may facilitate the lysis and loss of antigen specific CD4+ T cells in acquired immunodeficiency syndrome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Virological Consequences of Early Events following Cell-Cell Contact between Human Immunodeficiency Virus Type 1-Infected and Uninfected CD4+ Cells.
E. Ruggiero, R. Bona, C. Muratori, and M. Federico (2008)
J. Virol. 82, 7773-7789
   Abstract »    Full Text »    PDF »
The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways.
A. A. Lambert, C. Gilbert, M. Richard, A. D. Beaulieu, and M. J. Tremblay (2008)
Blood 112, 1299-1307
   Abstract »    Full Text »    PDF »
Feline immunodeficiency virus dendritic cell infection and transfer.
W. S. Sprague, M. Robbiani, P. R. Avery, K. P. O'Halloran, and E. A. Hoover (2008)
J. Gen. Virol. 89, 709-715
   Abstract »    Full Text »    PDF »
Dendritic Cells Are Less Susceptible to Human Immunodeficiency Virus Type 2 (HIV-2) Infection than to HIV-1 Infection.
M. G. Duvall, K. Lore, H. Blaak, D. A. Ambrozak, W. C. Adams, K. Santos, C. Geldmacher, J. R. Mascola, A. J. McMichael, A. Jaye, et al. (2007)
J. Virol. 81, 13486-13498
   Abstract »    Full Text »    PDF »
Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.
L. de Witte, M. Bobardt, U. Chatterji, G. Degeest, G. David, T. B. H. Geijtenbeek, and P. Gallay (2007)
PNAS 104, 19464-19469
   Abstract »    Full Text »    PDF »
Fc{gamma}RIIa Genotype Predicts Progression of HIV Infection.
D. N. Forthal, G. Landucci, J. Bream, L. P. Jacobson, T. B. Phan, and B. Montoya (2007)
J. Immunol. 179, 7916-7923
   Abstract »    Full Text »    PDF »
Predominant Mode of Human Immunodeficiency Virus Transfer between T Cells Is Mediated by Sustained Env-Dependent Neutralization-Resistant Virological Synapses.
P. Chen, W. Hubner, M. A. Spinelli, and B. K. Chen (2007)
J. Virol. 81, 12582-12595
   Abstract »    Full Text »    PDF »
Survival of Chlamydia muridarum within Dendritic Cells.
J. Rey-Ladino, X. Jiang, B. R. Gabel, C. Shen, and R. C. Brunham (2007)
Infect. Immun. 75, 3707-3714
   Abstract »    Full Text »    PDF »
Maturation of Blood-Derived Dendritic Cells Enhances Human Immunodeficiency Virus Type 1 Capture and Transmission.
N. Izquierdo-Useros, J. Blanco, I. Erkizia, M. T. Fernandez-Figueras, F. E. Borras, M. Naranjo-Gomez, M. Bofill, L. Ruiz, B. Clotet, and J. Martinez-Picado (2007)
J. Virol. 81, 7559-7570
   Abstract »    Full Text »    PDF »
IgG Opsonization of HIV Impedes Provirus Formation in and Infection of Dendritic Cells and Subsequent Long-Term Transfer to T Cells.
D. Wilflingseder, Z. Banki, E. Garcia, M. Pruenster, G. Pfister, B. Muellauer, D. S. Nikolic, C. Gassner, C. G. Ammann, M. P. Dierich, et al. (2007)
J. Immunol. 178, 7840-7848
   Abstract »    Full Text »    PDF »
CD4 Coexpression Regulates DC-SIGN-Mediated Transmission of Human Immunodeficiency Virus Type 1.
J.-H. Wang, A. M. Janas, W. J. Olson, V. N. KewalRamani, and L. Wu (2007)
J. Virol. 81, 2497-2507
   Abstract »    Full Text »    PDF »
Preferential Infection of Dendritic Cells during Human Immunodeficiency Virus Type 1 Infection of Blood Leukocytes.
P. U. Cameron, A. J. Handley, D. C. Baylis, A. E. Solomon, N. Bernard, D. F. J. Purcell, and S. R. Lewin (2007)
J. Virol. 81, 2297-2306
   Abstract »    Full Text »    PDF »
Dendritic Cell-Mediated trans-Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Independent of DC-SIGN.
C. Boggiano, N. Manel, and D. R. Littman (2007)
J. Virol. 81, 2519-2523
   Abstract »    Full Text »    PDF »
DEC-205-Mediated Internalization of HIV-1 Results in the Establishment of Silent Infection in Renal Tubular Cells.
I. Hatsukari, P. Singh, N. Hitosugi, D. Messmer, E. Valderrama, S. Teichberg, W. Chaung, E. Gross, H. Schmidtmayerova, and P. C. Singhal (2007)
J. Am. Soc. Nephrol. 18, 780-787
   Abstract »    Full Text »    PDF »
Feline immunodeficiency virus infection is enhanced by feline bone marrow-derived dendritic cells.
F. J. U. M. van der Meer, N. M. P. Schuurman, and H. F. Egberink (2007)
J. Gen. Virol. 88, 251-258
   Abstract »    Full Text »    PDF »
Role of gp120 in dendritic cell dysfunction in HIV infection.
C. Chougnet and S. Gessani (2006)
J. Leukoc. Biol. 80, 994-1000
   Abstract »    Full Text »    PDF »
Slamming the door on unwanted guests: why preemptive strikes at the mucosa may be the best strategy against HIV.
S. Trapp, S. G. Turville, and M. Robbiani (2006)
J. Leukoc. Biol. 80, 1076-1083
   Full Text »    PDF »
HIV interactions with dendritic cells: has our focus been too narrow?.
H. Donaghy, J. Wilkinson, and A. L. Cunningham (2006)
J. Leukoc. Biol. 80, 1001-1012
   Abstract »    Full Text »    PDF »
Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition.
F. Groot, T. M. M. van Capel, M. L. Kapsenberg, B. Berkhout, and E. C. de Jong (2006)
Blood 108, 1957-1964
   Abstract »    Full Text »    PDF »
DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets..
C. Chaipan, E. J. Soilleux, P. Simpson, H. Hofmann, T. Gramberg, A. Marzi, M. Geier, E. A. Stewart, J. Eisemann, A. Steinkasserer, et al. (2006)
J. Virol. 80, 8951-8960
   Abstract »    Full Text »    PDF »
Innate and Adaptive Mucosal Immunity in Protection against HIV Infection.
L.A. Bergmeier and T. Lehner (2006)
Adv. Dent. Res. 19, 21-28
   Abstract »    Full Text »    PDF »
Dendritic Cells and HIV Infection: Activating Dendritic Cells to Boost Immunity.
N. Teleshova, J. Kenney, and M. Robbiani (2006)
Adv. Dent. Res. 19, 36-41
   Abstract »    Full Text »    PDF »
Measles Virus Targets DC-SIGN To Enhance Dendritic Cell Infection..
L. de Witte, M. Abt, S. Schneider-Schaulies, Y. van Kooyk, and T. B. H. Geijtenbeek (2006)
J. Virol. 80, 3477-3486
   Abstract »    Full Text »    PDF »
(C3) The Oral Epithelial Cell and First Encounters with HIV-1.
M.C. Herzberg, A. Weinberg, and S.M. Wahl (2006)
Adv. Dent. Res. 19, 158-166
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Fusion to Dendritic Cells Declines as Cells Mature.
M. Cavrois, J. Neidleman, J. F. Kreisberg, D. Fenard, C. Callebaut, and W. C. Greene (2006)
J. Virol. 80, 1992-1999
   Abstract »    Full Text »    PDF »
Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection.
R. D. Wiley and S. Gummuluru (2006)
PNAS 103, 738-743
   Abstract »    Full Text »    PDF »
Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells.
K. Lore, A. Smed-Sorensen, J. Vasudevan, J. R. Mascola, and R. A. Koup (2005)
J. Exp. Med. 201, 2023-2033
   Abstract »    Full Text »    PDF »
DC-SIGN-mediated Infectious Synapse Formation Enhances X4 HIV-1 Transmission from Dendritic Cells to T Cells.
J.-F. Arrighi, M. Pion, E. Garcia, J.-M. Escola, Y. van Kooyk, T. B. Geijtenbeek, and V. Piguet (2004)
J. Exp. Med. 200, 1279-1288
   Abstract »    Full Text »    PDF »
C-type Lectins L-SIGN and DC-SIGN Capture and Transmit Infectious Hepatitis C Virus Pseudotype Particles.
P.-Y. Lozach, A. Amara, B. Bartosch, J.-L. Virelizier, F. Arenzana-Seisdedos, F.-L. Cosset, and R. Altmeyer (2004)
J. Biol. Chem. 279, 32035-32045
   Abstract »    Full Text »    PDF »
HIV Transmission: Closing All the Doors.
C. W. Davis and R. W. Doms (2004)
J. Exp. Med. 199, 1037-1040
   Full Text »    PDF »
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.
S. G. Turville, J. J. Santos, I. Frank, P. U. Cameron, J. Wilkinson, M. Miranda-Saksena, J. Dable, H. Stossel, N. Romani, M. Piatak Jr, et al. (2004)
Blood 103, 2170-2179
   Abstract »    Full Text »    PDF »
Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus.
K. Tenner-Racz, C. S. Hennig, K. Uberla, H. Stoiber, R. Ignatius, J. Heeney, R. M. Steinman, and P. Racz (2004)
PNAS 101, 3017-3022
   Abstract »    Full Text »    PDF »
DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2.
P.-Y. Lozach, H. Lortat-Jacob, A. De Lacroix De Lavalette, I. Staropoli, S. Foung, A. Amara, C. Houles, F. Fieschi, O. Schwartz, J.-L. Virelizier, et al. (2003)
J. Biol. Chem. 278, 20358-20366
   Abstract »    Full Text »    PDF »
Decreased Stimulation of CD4+ T Cell Proliferation and IL-2 Production by Highly Enriched Populations of HIV-Infected Dendritic Cells.
T. Kawamura, H. Gatanaga, D. L. Borris, M. Connors, H. Mitsuya, and A. Blauvelt (2003)
J. Immunol. 170, 4260-4266
   Abstract »    Full Text »    PDF »
SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran.
Y.-S. Kang, S. Yamazaki, T. Iyoda, M. Pack, S. A. Bruening, J. Y. Kim, K. Takahara, K. Inaba, R. M. Steinman, and C. G. Park (2003)
Int. Immunol. 15, 177-186
   Abstract »    Full Text »    PDF »
Identification of Different Binding Sites in the Dendritic Cell-specific Receptor DC-SIGN for Intercellular Adhesion Molecule 3 and HIV-1.
T. B. H. Geijtenbeek, G. C. F. van Duijnhoven, S. J. van Vliet, E. Krieger, G. Vriend, C. G. Figdor, and Y. van Kooyk (2002)
J. Biol. Chem. 277, 11314-11320
   Abstract »    Full Text »    PDF »
Host Determinants in HIV Infection and Disease: Part 1: Cellular and Humoral Immune Responses.
C. M. Hogan and S. M. Hammer (2001)
Ann Intern Med 134, 761-776
   Abstract »    Full Text »    PDF »
How does HIV cause AIDS?.
R. Weiss (1993)
Science 260, 1273-1279
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)