Science 17 July 1992: Vol. 257. no. 5068, pp. 379 - 382 DOI: 10.1126/science.1631559

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Articles

Interleukin-17 and Type 17 Helper T Cells.

P. Miossec, T. Korn, and V. K. Kuchroo (2009)
N. Engl. J. Med. 361, 888-898
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Soluble interleukin-2 receptor retains prognostic value in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP (RCHOP) therapy.

D. Ennishi, M. Yokoyama, Y. Terui, H. Asai, S. Sakajiri, Y. Mishima, S. Takahashi, H. Komatsu, K. Ikeda, K. Takeuchi, et al. (2009)
Ann. Onc. 20, 526-533
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Ligand-independent Homomeric and Heteromeric Complexes between Interleukin-2 or -9 Receptor Subunits and the {gamma} Chain.

Y. Malka, T. Hornakova, Y. Royer, L. Knoops, J.-C. Renauld, S. N. Constantinescu, and Y. I. Henis (2008)
J. Biol. Chem. 283, 33569-33577
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Bloodlines of haematopoietic stem cell research in Japan.

H. Ema and H. Nakauchi (2008)
Phil Trans R Soc B 363, 2089-2097
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Late Expression of Granulysin by Microbicidal CD4+ T Cells Requires PI3K- and STAT5-Dependent Expression of IL-2R{beta} That Is Defective in HIV-Infected Patients.

C. F. Zheng, G. J. Jones, M. Shi, J. C. D. Wiseman, K. J. Marr, B. M. Berenger, S. M. Huston, M. J. Gill, A. M. Krensky, P. Kubes, et al. (2008)
J. Immunol. 180, 7221-7229
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Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor {beta}-chain.

Y. Yamashita, K. Kojima, T. Tsukahara, H. Agawa, K. Yamada, Y. Amano, N. Kurotori, N. Tanaka, K. Sugamura, and T. Takeshita (2008)
J. Cell Sci. 121, 1727-1738
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Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes.

O. Boyman, M. Kovar, M. P. Rubinstein, C. D. Surh, and J. Sprent (2006)
Science 311, 1924-1927
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Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor.

D. J. Stauber, E. W. Debler, P. A. Horton, K. A. Smith, and I. A. Wilson (2006)
PNAS 103, 2788-2793
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Structure of the Quaternary Complex of Interleukin-2 with Its {alpha}, {beta}, and {gamma}c Receptors.

X. Wang, M. Rickert, and K. C. Garcia (2005)
Science 310, 1159-1163
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Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chainnull mice.

F. Ishikawa, M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, T. Watanabe, K. Akashi, L. D. Shultz, and M. Harada (2005)
Blood 106, 1565-1573
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IL-2 Responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2R{beta} transgenic mice.

F. Gesbert, J.-L. Moreau, and J. Theze (2005)
Int. Immunol. 17, 1093-1102
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Transcriptional Regulation of the Mouse IL-7 Receptor {alpha} Promoter by Glucocorticoid Receptor.

H.-C. Lee, H. Shibata, S. Ogawa, K. Maki, and K. Ikuta (2005)
J. Immunol. 174, 7800-7806
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Enhanced Expression of Interleukin-18 and its Receptor in Idiopathic Pulmonary Fibrosis.

Y. Kitasato, T. Hoshino, M. Okamoto, S. Kato, Y. Koda, N. Nagata, M. Kinoshita, H. Koga, D.-Y. Yoon, H. Asao, et al. (2004)
Am. J. Respir. Cell Mol. Biol. 31, 619-625
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Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.

J. L. Roberts, A. Lengi, S. M. Brown, M. Chen, Y.-J. Zhou, J. J. O'Shea, and R. H. Buckley (2004)
Blood 103, 2009-2018
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Impaired TCR-Mediated Induction of Ki67 by Naive CD4+ T Cells Is Only Occasionally Corrected by Exogenous IL-2 in HIV-1 Infection.

S. F. Sieg, D. A. Bazdar, and M. M. Lederman (2003)
J. Immunol. 171, 5208-5214
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Expression of IL-2 receptor {beta} and {gamma} chains by human gingival fibroblasts and up-regulation of adhesion to neutrophils in response to IL-2.

A. Ozawa, H. Tada, R. Tamai, A. Uehara, K. Watanabe, T. Yamaguchi, H. Shimauchi, H. Takada, and S. Sugawara (2003)
J. Leukoc. Biol. 74, 352-359
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Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis.

S.-K. Lee, J. F. Kalinowski, S. L. Jastrzebski, L. Puddington, and J. A. Lorenzo (2003)
Endocrinology 144, 3524-3531
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Structural Analysis and Modeling of a Synthetic Interleukin-2 Mimetic and Its Interleukin-2R{beta}2 Receptor.

T. Rose, J.-L. Moreau, R. Eckenberg, and J. Theze (2003)
J. Biol. Chem. 278, 22868-22876
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Diaminobiotin and Desthiobiotin Have Biotin-Like Activities in Jurkat Cells.

R. Rodriguez-Melendez, B. Lewis, R. J. McMahon, and J. Zempleni (2003)
J. Nutr. 133, 1259-1264
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Anti-apoptotic Signaling by the Interleukin-2 Receptor Reveals a Function for Cytoplasmic Tyrosine Residues within the Common gamma (gamma c) Receptor Subunit.

M. J. Lindemann, M. Benczik, and S. L. Gaffen (2003)
J. Biol. Chem. 278, 10239-10249
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Oxidative Folding of Interleukin-2 Is Impaired in Flavin-Deficient Jurkat Cells, Causing Intracellular Accumulation of Interleukin-2 and Increased Expression of Stress Response Genes.

G. Camporeale and J. Zempleni (2003)
J. Nutr. 133, 668-672
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Clinical advances in therapies targeting the interleukin-2 receptor.

A.C. Church (2003)
QJM 96, 91-102
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Interleukin-2 receptor-gamma -dependent endocytosis depends on biotin in Jurkat cells.

R. Rodriguez-Melendez, G. Camporeale, J. B. Griffin, and J. Zempleni (2003)
Am J Physiol Cell Physiol 284, C415-C421
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Immunodeficiency Disorders.

M. D. Cooper, L. L. Lanier, M. E. Conley, and J. M. Puck (2003)
Hematology 2003, 314-330
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Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
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Cytokine and Cytokine Receptor Pleiotropy and Redundancy.

K. Ozaki and W. J. Leonard (2002)
J. Biol. Chem. 277, 29355-29358
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Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox.

G. Gorgun and F. Foss (2002)
Blood 100, 1399-1403
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Expression of the interleukin-2 receptor {alpha} (CD25) is selectively decreased on decidual CD4+ and CD8+ T lymphocytes in normal pregnancies.

K.-H. Chao, M.-Y. Wu, J.-H. Yang, S.-U. Chen, Y.-S. Yang, and H.-N. Ho (2002)
Mol. Hum. Reprod. 8, 667-673
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Biotin Supply Affects Expression of Biotin Transporters, Biotinylation of Carboxylases and Metabolism of Interleukin-2 in Jurkat Cells.

K. C. Manthey, J. B. Griffin, and J. Zempleni (2002)
J. Nutr. 132, 887-892
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Lineage infidelity in myeloid cells with TCR gene rearrangement: A latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling.

A. G. King, M. Kondo, D. C. Scherer, and I. L. Weissman (2002)
PNAS 99, 4508-4513
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Specificity of Interleukin-2 Receptor gamma Chain Superfamily Cytokines Is Mediated by Insulin Receptor Substrate-dependent Pathway.

H. Xiao, T. Yin, X.-Y. Wang, T. Uchida, J. Chung, M. F. White, and Y.-C. Yang (2002)
J. Biol. Chem. 277, 8091-8098
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Cutting Edge: The Common {{gamma}}-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex.

H. Asao, C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya, D. Foster, and K. Sugamura (2001)
J. Immunol. 167, 1-5
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Unstimulated Human CD4 Lymphocytes Express a Cytoplasmic Immature Form of the Common Cytokine Receptor {{gamma}}-Chain.

L. Bani, V. Pasquier, M. Kryworuchko, J. Salamero, and J. Theze (2001)
J. Immunol. 167, 344-349
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Lentivirus Vector-Mediated Hematopoietic Stem Cell Gene Transfer of Common Gamma-Chain Cytokine Receptor in Rhesus Macaques.

D. S. An, S. K. P. Kung, A. Bonifacino, R. P. Wersto, M. E. Metzger, B. A. Agricola, S. H. Mao, I. S. Y. Chen, and R. E. Donahue (2001)
J. Virol. 75, 3547-3555
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A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1{beta}2.

N. L. Monson, T. J. Fenske, S. Wei, A. J. Okragly, J. L.O. de Jong, M. Haak-Frendscho, J. O’Shea, J. Djeu, and P. M. Sondel (2001)
J. Leukoc. Biol. 69, 419-425
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Involvement of the Ubiquitin-Proteasome Pathway in the Degradation of Nontyrosine Kinase-Type Cytokine Receptors of IL-9, IL-2, and Erythropoietin.

C.-H. Yen, Y.-C. Yang, S. K. Ruscetti, R. A. Kirken, R. M. Dai, and C.-C. H. Li (2000)
J. Immunol. 165, 6372-6380
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Advances in interleukin 2 receptor targeted treatment.

J. C Morris and T. A Waldmann (2000)
Ann Rheum Dis 59, i109-114
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IL-2R{beta} Agonist P1-30 Acts in Synergy with IL-2, IL-4, IL-9, and IL-15: Biological and Molecular Effects.

R. Eckenberg, J.-L. Moreau, O. Melnyk, and J. Theze (2000)
J. Immunol. 165, 4312-4318
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Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor: Formation of a Functional Heteromeric Complex Requires Interleukin 7 Receptor.

L. S. Park, U. Martin, K. Garka, B. Gliniak, J. P. Di Santo, W. Muller, D. A. Largaespada, N. G. Copeland, N. A. Jenkins, A. G. Farr, et al. (2000)
J. Exp. Med. 192, 659-670
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Efficient Internalization of IL-2 Depends on the Distal Portion of the Cytoplasmic Tail of the IL-2R Common {gamma}-Chain and a Lymphoid Cell Environment.

A. Yu, F. Olosz, C. Y. Choi, and T. R. Malek (2000)
J. Immunol. 165, 2556-2562
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Stable and functional lymphoid reconstitution of common cytokine receptor gamma chain deficient mice by retroviral-mediated gene transfer.

C. Soudais, T. Shiho, L. I. Sharara, D. Guy-Grand, T. Taniguchi, A. Fischer, and J. P. Di Santo (2000)
Blood 95, 3071-3077
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IFN-{alpha}2b Reduces IL-2 Production and IL-2 Receptor Function in Primary CD4+ T Cells.

D. Zella, F. Romerio, S. Curreli, P. Secchiero, C. Cicala, D. Zagury, and R. C. Gallo (2000)
J. Immunol. 164, 2296-2302
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Inhibition of Interleukin 7 Receptor Signaling by Antigen Receptor Assembly.

F. M. Smart and A. R. Venkitaraman (2000)
J. Exp. Med. 191, 737-742
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The First {alpha} Helix of Interleukin (Il)-2 Folds as a Homotetramer, Acts as an Agonist of the IL-2 Receptor {beta} Chain, and Induces Lymphokine-Activated Killer Cells.

R. Eckenberg, T. Rose, J.-L. Moreau, R. Weil, F. Gesbert, S. Dubois, D. Tello, M. Bossus, H. Gras, A. Tartar, et al. (2000)
J. Exp. Med. 191, 529-540
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IL-2 Unresponsiveness in Anergic CD4+ T Cells Is Due to Defective Signaling Through the Common {gamma}-Chain of the IL-2 Receptor.

S. Grundstrom, M. Dohlsten, and A. Sundstedt (2000)
J. Immunol. 164, 1175-1184
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Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease.

D. Przepiorka, N. A. Kernan, C. Ippoliti, E. B. Papadopoulos, S. Giralt, I. Khouri, J.-G. Lu, J. Gajewski, A. Durett, K. Cleary, et al. (2000)
Blood 95, 83-89
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Possible Involvement of a Novel STAM-associated Molecule "AMSH" in Intracellular Signal Transduction Mediated by Cytokines.

N. Tanaka, K. Kaneko, H. Asao, H. Kasai, Y. Endo, T. Fujita, T. Takeshita, and K. Sugamura (1999)
J. Biol. Chem. 274, 19129-19135
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Integrin-regulated Secretion of Interleukin 4: A Novel Pathway of Mechanotransduction in Human Articular Chondrocytes.

S.J. Millward-Sadler, M.O. Wright, H.-S. Lee, K. Nishida, H. Caldwell, G. Nuki, and D.M. Salter (1999)
J. Cell Biol. 145, 183-189
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Downregulation of JAK3 Protein Levels in T Lymphocytes by Prostaglandin E2 and Other Cyclic Adenosine Monophosphate-Elevating Agents: Impact on Interleukin-2 Receptor Signaling Pathway.

V. Kolenko, P. Rayman, B. Roy, M. K. Cathcart, J. O'Shea, R. Tubbs, L. Rybicki, R. Bukowski, and J. Finke (1999)
Blood 93, 2308-2318
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Human Peripheral Blood Mononuclear Cells Express Gonadotropin-Releasing Hormone (GnRH), GnRH Receptor, and Interleukin-2 Receptor {gamma}-Chain Messenger Ribonucleic Acids That Are Regulated by GnRH in Vitro.

H.-F. Chen, E.-B. Jeung, M. Stephenson, and P. C. K. Leung (1999)
J. Clin. Endocrinol. Metab. 84, 743-750
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Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency.

S. Kumaki, N. Ishii, M. Minegishi, S. Tsuchiya, D. Cosman, K. Sugamura, and T. Konno (1999)
Blood 93, 607-612
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Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus.

W.J. LEONARD, K. IMADA, H. NAKAJIMA, A. PUEL, E. SOLDAINI, and S. JOHN (1999)
Cold Spring Harb Symp Quant Biol 64, 417-424
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IL-2R{alpha} on One Cell Can Present IL-2 to IL-2R{beta}/{gamma}c on Another Cell to Augment IL-2 Signaling.

D. M. Eicher and T. A. Waldmann (1998)
J. Immunol. 161, 5430-5437
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Molecular Mapping with Functional Antibodies Localizes Critical Sites on the Human IL Receptor Common {gamma} ({gamma}c) Chain.

N. Raskin, A. Jakubowski, I. Sizing, D. L. Olson, S. L. Kalled, C. A. Hession, C. D. Benjamin, D. P. Baker, and L. C. Burkly (1998)
J. Immunol. 161, 3474-3483
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Endocytosis of the Common Cytokine Receptor gamma c Chain. IDENTIFICATION OF SEQUENCES INVOLVED IN INTERNALIZATION AND DEGRADATION.

E. Morelon and A. Dautry-Varsat (1998)
J. Biol. Chem. 273, 22044-22051
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A New Tyrosine-phosphorylated 97-kDa Adaptor Protein Mediates Interleukin-2-induced Association of SHP-2 with p85-Phosphatidylinositol 3-Kinase in Human T Lymphocytes.

F. Gesbert, C. Guenzi, and J. Bertoglio (1998)
J. Biol. Chem. 273, 18273-18281
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Differential Regulation of the Janus Kinase-STAT Pathway and Biologic Function of IL-13 in Primary Human NK and T Cells: A Comparative Study with IL-4.

C.-R. Yu, R. A. Kirken, M. G. Malabarba, H. A. Young, and J. R. Ortaldo (1998)
J. Immunol. 161, 218-227
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Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes.

H. Ogata, D. Ford, N. Kouttab, T. C. King, N. Vita, A. Minty, J. Stoeckler, D. Morgan, C. Girasole, J. W. Morgan, et al. (1998)
J. Biol. Chem. 273, 9864-9871
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Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression.

M. H. Kaplan, C. Daniel, U. Schindler, and M. J. Grusby (1998)
Mol. Cell. Biol. 18, 1996-2003
 |  Abstract »  |  Full Text »

Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression.

J. Zamorano, H. Y. Wang, R. Wang, Y. Shi, G. D. Longmore, and A. D. Keegan (1998)
J. Immunol. 160, 3502-3512
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Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production.

K. Siemasko, A. S-F. Chong, H.-M. Jack, H. Gong, J. W. Williams, and A. Finnegan (1998)
J. Immunol. 160, 1581-1588
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Interleukin-2 Stimulation Induces Tyrosine Phosphorylation of p120-Cbl and CrkL and Formation of Multimolecular Signaling Complexes in T Lymphocytes and Natural Killer Cells.

F. Gesbert, C. Garbay, and J. Bertoglio (1998)
J. Biol. Chem. 273, 3986-3993
 |  Abstract »  |  Full Text »  |  PDF »

Opposite CD4/CD8 Lineage Decisions of CD4+8+ Mouse and Rat Thymocytes to Equivalent Triggering Signals: Correlation with Thymic Expression of a Truncated CD8{alpha} Chain in Mice But Not Rats.

R. Mitnacht, A. Bischof, N. Torres-Nagel, and T. Hunig (1998)
J. Immunol. 160, 700-707
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of Antibody-Dependent Cellular Cytotoxicity of Neonatal Cells by Interleukin-2 (IL-2) and IL-12.

Q. H. Nguyen, R. L. Roberts, B. J. Ank, S.-J. Lin, C. K. Lau, and E. R. Stiehm (1998)
Clin. Vaccine Immunol. 5, 98-104
 |  Abstract »  |  Full Text »

c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3'-Kinase Pathway.

H. Ueno, K. Sasaki, H. Honda, T. Nakamoto, T. Yamagata, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai (1998)
Blood 91, 46-53
 |  Abstract »  |  Full Text »  |  PDF »

Further Analysis of Interleukin-2 Receptor Subunit Expression on the Different Human Peripheral Blood Mononuclear Cell Subsets.

D. David, L. Bani, J.-L. Moreau, C. Demaison, K. Sun, O. Salvucci, T. Nakarai, M. de Montalembert, S. Chouaib, M. Joussemet, et al. (1998)
Blood 91, 165-172
 |  Abstract »  |  Full Text »  |  PDF »

Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule. ITS SUPPRESSIVE EFFECT ON CYTOKINE-INDUCED CELL GROWTH.

H. Asao, Y. Sasaki, T. Arita, N. Tanaka, K. Endo, H. Kasai, T. Takeshita, Y. Endo, T. Fujita, and K. Sugamura (1997)
J. Biol. Chem. 272, 32785-32791
 |  Abstract »  |  Full Text »  |  PDF »

Full Immunologic Reconstitution Following Nonconditioned Bone Marrow Transplantation for Canine X-Linked Severe Combined Immunodeficiency.

P. J. Felsburg, R. L. Somberg, B. J. Hartnett, S. F. Suter, P. S. Henthorn, P. F. Moore, K. I. Weinberg, and H. D. Ochs (1997)
Blood 90, 3214-3221
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Functional cleavage of the common cytokine receptor gamma  chain (gamma c) by calpain.

M. Noguchi, A. Sarin, M. J. Aman, H. Nakajima, E. W. Shores, P. A. Henkart, and W. J. Leonard (1997)
PNAS 94, 11534-11539
 |  Abstract »  |  Full Text »  |  PDF »

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

N. Noben-Trauth, L. D. Shultz, F. Brombacher, J. F. Urban Jr., H. Gu, and W. E. Paul (1997)
PNAS 94, 10838-10843
 |  Abstract »  |  Full Text »  |  PDF »

Critical Cytoplasmic Domains of Human Interleukin-9 Receptor alpha  Chain in Interleukin-9-mediated Cell Proliferation and Signal Transduction.

Y. X. Zhu, H. B. Sun, M. L.-S. Tsang, J. McMahel, S. Grigsby, T. Yin, and Y.-C. Yang (1997)
J. Biol. Chem. 272, 21334-21340
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Interleukin (IL)-13 Binding and Signaling by the gamma c Chain of the IL-2 Receptor.

N. I. Obiri, T. Murata, W. Debinski, and R. K. Puri (1997)
J. Biol. Chem. 272, 20251-20258
 |  Abstract »  |  Full Text »  |  PDF »

Clonal Proliferation and Cytokine Requirement of Murine Progenitors for Natural Killer Cells.

Y. Aiba, F. Hirayama, and M. Ogawa (1997)
Blood 89, 4005-4012
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Pathways of Interleukin-5 Synthesis in Allergen-Specific Human T-Cell Clones Are Suppressed by Glucocorticoids.

A. Mori, O. Kaminuma, M. Suko, S. Inoue, T. Ohmura, A. Hoshino, Y. Asakura, K. Miyazawa, T. Yokota, Y. Okumura, et al. (1997)
Blood 89, 2891-2900
 |  Abstract »  |  Full Text »  |  PDF »

Identification, Purification, and Characterization of a Soluble Interleukin (IL)-13-binding Protein. EVIDENCE THAT IT IS DISTINCT FROM THE CLONED IL-13 RECEPTOR AND IL-4 RECEPTOR alpha -CHAINS.

J.-G. Zhang, D. J. Hilton, T. A. Willson, C. McFarlane, B. A. Roberts, R. L. Moritz, R. J. Simpson, W. S. Alexander, D. Metcalf, and N. A. Nicola (1997)
J. Biol. Chem. 272, 9474-9480
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2 (IL-2)-mediated Induction of the IL-2 Receptor alpha Chain Gene. CRITICAL ROLE OF TWO FUNCTIONALLY REDUNDANT TYROSINE RESIDUES IN THE IL-2 RECEPTOR beta CHAIN CYTOPLASMIC DOMAIN AND SUGGESTION THAT THESE RESIDUES MEDIATE MORE THAN STAT5 ACTIVATION.

D. P. Ascherman, T.-S. Migone, M. C. Friedmann, and W. J. Leonard (1997)
J. Biol. Chem. 272, 8704-8709
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma c chain for Janus kinase activation leading to T cell proliferation.

B. H. Nelson, B. C. McIntosh, L. L. Rosencrans, and P. D. Greenberg (1997)
PNAS 94, 1878-1883
 |  Abstract »  |  Full Text »  |  PDF »

Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells.

K. Saijo, S. Y. Park, Y. Ishida, H. Arase, and T. Saito (1997)
J. Exp. Med. 185, 351-356
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-15 Triggers the Proliferation and Cytotoxicity of Granular Lymphocytes in Patients With Lymphoproliferative Disease of Granular Lymphocytes.

R. Zambello, M. Facco, L. Trentin, R. Sancetta, C. Tassinari, A. Perin, A. Milani, G. Pizzolo, F. Rodeghiero, C. Agostini, et al. (1997)
Blood 89, 201-211
 |  Abstract »  |  Full Text »  |  PDF »

A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common beta -Chain Is Necessary and Sufficient for High Affinity Binding and Signaling by All Three Ligands.

J. M. Woodcock, C. J. Bagley, B. Zacharakis, and A. F. Lopez (1996)
J. Biol. Chem. 271, 25999-26006
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4-induced STAT6 Recognizes and Activates a Target Site in the Promoter of the Interleukin-4 Receptor Gene.

H. Kotanides and N. C. Reich (1996)
J. Biol. Chem. 271, 25555-25561
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of Two Alternative Splice Variants of Human Interleukin-2.

V. N. Tsytsikov, V. V. Yurovsky, S. P. Atamas, W. J. Alms, and B. White (1996)
J. Biol. Chem. 271, 23055-23060
 |  Abstract »  |  Full Text »  |  PDF »

Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-gamma.

S. V. Kotenko, L. S. Izotova, B. P. Pollack, G. Muthukumaran, K. Paukku, O. Silvennoinen, J. N. Ihle, and S. Pestka (1996)
J. Biol. Chem. 271, 17174-17182
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 Family of Cytokines Induced Activation of Different Functional Sites Expressed by gp130 Transducing Protein.

S. Chevalier, M. Fourcin, O. Robledo, J. Wijdenes, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 14764-14772
 |  Abstract »  |  Full Text »  |  PDF »

Tissue-specific Activity of the gamma c Chain Gene Promoter Depends upon an Ets Binding Site and Is Regulated by GA-binding Protein.

S. Markiewicz, R. Bosselut, F. L. Deist, J.-P. d. Villartay, C. Hivroz, J. Ghysdael, A. Fischer, and G. d. S. Basile (1996)
J. Biol. Chem. 271, 14849-14855
 |  Abstract »  |  Full Text »  |  PDF »

A Point Mutation in Interleukin-2 That Alters Ligand Internalization.

D. Z. Chang, Z. Wu, and T. L. Ciardelli (1996)
J. Biol. Chem. 271, 13349-13355
 |  Abstract »  |  Full Text »  |  PDF »

DAB[IMAGE] Interleukin-2 Receptor Binding Domain Mutations.

J. C. vanderSpek, J. A. Sutherland, M. Ratnarathorn, K. Howland, T. L. Ciardelli, and J. R. Murphy (1996)
J. Biol. Chem. 271, 12145-12149
 |  Abstract »  |  Full Text »  |  PDF »

Biophysical Characterization of a Recombinant Soluble Interleukin 2 Receptor (Tac).

R. P. Junghans, A. L. Stone, and M. S. Lewis (1996)
J. Biol. Chem. 271, 10453-10460
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of Human Stat5B.

J.-X. Lin, J. Mietz, W. S. Modi, S. John, and W. J. Leonard (1996)
J. Biol. Chem. 271, 10738-10744
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced alpha-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation.

I. Flores, T. Casaseca, C. Martinez-A, H. Kanoh, and I. Merida (1996)
J. Biol. Chem. 271, 10334-10340
 |  Abstract »  |  Full Text »  |  PDF »

Saturation Mutagenesis of the WSXWS Motif of the Erythropoietin Receptor.

D. J. Hilton, S. S. Watowich, L. Katz, and H. F. Lodish (1996)
J. Biol. Chem. 271, 4699-4708
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction Pathway of Interleukin-4 and Interleukin-13 in Human B Cells Derived from X-linked Severe Combined Immunodeficiency Patients.

K. Izuhara, T. Heike, T. Otsuka, K. Yamaoka, M. Mayumi, T. Imamura, Y. Niho, and N. Harada (1996)
J. Biol. Chem. 271, 619-622
 |  Abstract »  |  Full Text »  |  PDF »

Functional Characterization of the Human Interleukin-15 Receptor alpha Chain and Close Linkage of IL15RA and IL2RA Genes.

D. M. Anderson, S. Kumaki, M. Ahdieh, J. Bertles, M. Tometsko, A. Loomis, J. Giri, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, et al. (1995)
J. Biol. Chem. 270, 29862-29869
 |  Abstract »  |  Full Text »  |  PDF »

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development.

S. M. Russell, N. Tayebi, H. Nakajima, M. C. Riedy, J. L. Roberts, M. J. Aman, T.-S. Migone, M. Noguchi, M. L. Markert, R. H. Buckley, et al. (1995)
Science 270, 797-800
 |  Abstract »  |  PDF »

Growth Signal Transduction by the Human Interleukin-2 Receptor Requires Cytoplasmic Tyrosines of the beta Chain and Non-tyrosine Residues of the [IMAGE](c) Chain.

M. A. Goldsmith, S. Y. Lai, W. Xu, M. C. Amaral, E. S. Kuczek, L. J. Parent, G. B. Mills, K. L. Tarr, G. D. Longmore, and W. C. Greene (1995)
J. Biol. Chem. 270, 21729-21737
 |  Abstract »  |  Full Text »  |  PDF »

The Primary Immunodeficiencies.

F. S. Rosen, M. D. Cooper, and R. J.P. Wedgwood (1995)
N. Engl. J. Med. 333, 431-440
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Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

T. Migone, J. Lin, A Cereseto, J. Mulloy, J. O'Shea, G Franchini, and W. Leonard (1995)
Science 269, 79-81
 |  Abstract »  |  PDF »

Solution Assembly of a Soluble, Heteromeric, High Affinity Interleukin-2 Receptor Complex.

Z. Wu, K. W. Johnson, B. Goldstein, Y. Choi, S. F. Eaton, T. M. Laue, and T. L. Ciardelli (1995)
J. Biol. Chem. 270, 16039-16044
 |  Abstract »  |  Full Text »  |  PDF »

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