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Science 17 July 1992:
Vol. 257. no. 5068, pp. 377 - 379
DOI: 10.1126/science.1631558
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Articles
Science, Vol 257, Issue 5068, 377-379
Copyright © 1992 by American Association for the Advancement of Science
Recovery from hemophilia B Leyden: an androgen-responsive element in the factor IX promoter
M Crossley,
M Ludwig,
KM Stowell,
P De Vos,
K Olek,
and
GG Brownlee
Chemical Pathology Unit, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.
One form of the inherited, X-linked, bleeding disorder, hemophilia B, resolves after puberty. Mutations at -20 and -26 in the clotting factor IX promoter impair transcription by disrupting the binding site for the liver-enriched transcription factor LF-A1/HNF4. The -26 but not the -20 mutation also disrupts an androgen-responsive element, which overlaps the LF-A1/HNF4 site. This explains the improvement seen in patients with the -20 mutation and the failure of the -26 patient to recover.
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