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Science 10 July 1992:
Vol. 257. no. 5067, pp. 251 - 255
DOI: 10.1126/science.1321497
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Articles

Science, Vol 257, Issue 5067, 251-255
Copyright © 1992 by American Association for the Advancement of Science

articles

Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs

S Miyazaki, M Yuzaki, K Nakada, H Shirakawa, S Nakanishi, S Nakade, and K Mikoshiba

Department of Physiology, Tokyo Women's Medical College, Japan.

The concentration of cytoplasmic free calcium (Ca2+) increases in various stimulated cells in a wave (Ca2+ wave) and in periodic transients (Ca2+ oscillations). These phenomena are explained by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release (CICR) from separate intracellular stores, but decisive evidence is lacking. A monoclonal antibody to the IP3 receptor inhibited both IICR and CICR upon injection of IP3 and Ca2+ into hamster eggs, respectively. The antibody completely blocked sperm-induced Ca2+ waves and Ca2+ oscillations. The results indicate that Ca2+ release in fertilized hamster eggs is mediated solely by the IP3 receptor, and Ca(2+)-sensitized IICR, but not CICR, generates Ca2+ waves and Ca2+ oscillations.


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Region-specific Activity of the Plasma Membrane Ca[IMAGE]Pump and Delayed Activation of Ca[IMAGE]Entry Characterize the Polarized, Agonist-evoked Ca[IMAGE]Signals in Exocrine Cells.
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The Effect of Mersalyl on Inositol Trisphosphate Receptor Binding and Ion Channel Function.
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Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.
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Development 121, 2233-2244
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Spatiotemporal dynamics of intracellular [Ca2+]i oscillations during the growth and meiotic maturation of mouse oocytes.
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Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs.
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Involvement of inositol 1,4,5-trisphosphate-mediated Ca2+ release in early and late events of mouse egg activation.
Z Xu, G. Kopf, and R. Schultz (1994)
Development 120, 1851-1859
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The Relationship Between Oxytocin, Phosphoinositide-Specific Phospholipase C, and Phasic Myometrial Contractions.
M. Phillippe (1994)
Reproductive Sciences 1, 49-54
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Calcium mobilization by dual receptors during fertilization of sea urchin eggs.
H. Lee, R Aarhus, and T. Walseth (1993)
Science 261, 352-355
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Fertilisation and thimerosal stimulate similar calcium spiking patterns in mouse oocytes but by separate mechanisms.
T. Cheek, O. McGuinness, C Vincent, R. Moreton, M. Berridge, and M. Johnson (1993)
Development 119, 179-189
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Evidence That Fertilization Activates Starfish Eggs by Sequential Activation of a Src-like Kinase and Phospholipase Cgamma.
A. F. Giusti, W. Xu, B. Hinkle, M. Terasaki, and L. A. Jaffe (2000)
J. Biol. Chem. 275, 16788-16794
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Molecular Characterization of the Starfish Inositol 1,4,5-Trisphosphate Receptor and Its Role during Oocyte Maturation and Fertilization.
H. Iwasaki, K. Chiba, T. Uchiyama, F. Yoshikawa, F. Suzuki, M. Ikeda, T. Furuichi, and K. Mikoshiba (2002)
J. Biol. Chem. 277, 2763-2772
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