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Science 3 July 1992:
Vol. 257. no. 5066, pp. 103 - 106
DOI: 10.1126/science.1621083
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Articles

Science, Vol 257, Issue 5066, 103-106
Copyright © 1992 by American Association for the Advancement of Science

articles

Infection of Macaca nemestrina by human immunodeficiency virus type-1

MB Agy, LR Frumkin, L Corey, RW Coombs, SM Wolinsky, J Koehler, WR Morton, and MG Katze

Regional Primate Research Center, University of Washington, Seattle, WA 98195.

After observations that Macaca nemestrina were exceptionally susceptible to simian immunodeficiency virus and human immunodeficiency virus type-2 (HIV-2), studies of HIV-1 replication were initiated. Several strains of HIV-1, including a recent patient isolate, replicated in vitro in peripheral blood mononuclear cells (PBMCs) and in CD4-positive M. nemestrina lymphocytes in a CD4-dependent fashion. Eight animals were subsequently inoculated with either cell-associated or cell-free suspensions of HIV-1. All animals had HIV-1 isolated by cocultivation, had HIV-1 DNA in their PBMCs as shown by polymerase chain reaction, and experienced sustained seroconversion to a broad spectrum of HIV-1 proteins. Macaca nemestrina is an animal model of HIV-1 infections that provides opportunities for evaluating the pathogenesis of acute HIV-1 replication and candidate vaccines and therapies.


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