Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 June 1992:
Vol. 256. no. 5065, pp. 1823 - 1825
DOI: 10.1126/science.1352066
Prev | Table of Contents | Next

Articles

Science, Vol 256, Issue 5065, 1823-1825
Copyright © 1992 by American Association for the Advancement of Science

articles

Involvement of the N-methyl D-aspartate (NMDA) receptor in synapse elimination during cerebellar development

S Rabacchi, Y Bailly, N Delhaye-Bouchaud, and J Mariani

Universite Pierre and Marie Curie, Institut des Neurosciences, Paris, France.

In many instances, the establishment of highly specific neuronal connections during development results from the rearrangement of axonal projections through the trimming of exuberant collaterals or the elimination of functional synapses or both. Although the involvement of the N-methyl D-aspartate (NMDA) subtype of the glutamate receptor has been demonstrated in the shaping of axonal arbors, its participation in the process of selective stabilization of synapses remains an open issue. In this study, the effects of chronic in vivo application of D,L-2-amino-5-phosphonovaleric acid (D,L-APV), a selective antagonist of the NMDA receptor, on the synapse elimination process that takes place in the developing cerebellum of the rat have been analyzed. D,L-APV treatment prevented the regression of supernumerary climbing fiber synapses in 49 percent of the recorded Purkinje cells, while the inactive isomer L-APV was ineffective. Thus, activation of the NMDA receptor is a critical step in the regression of functional synapses during development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum.
E. Lorenzetto, L. Caselli, G. Feng, W. Yuan, J. M. Nerbonne, J. R. Sanes, and M. Buffelli (2009)
PNAS 106, 16475-16480
   Abstract »    Full Text »    PDF »
Synapse elimination in olivo-cerebellar explants occurs during a critical period and leaves an indelible trace in Purkinje cells.
M. Letellier, R. Wehrle, J. Mariani, and A. M. Lohof (2009)
PNAS 106, 14102-14107
   Abstract »    Full Text »    PDF »
Homosynaptic Long-Term Synaptic Potentiation of the "Winner" Climbing Fiber Synapse in Developing Purkinje Cells.
L. W. J. Bosman, H. Takechi, J. Hartmann, J. Eilers, and A. Konnerth (2008)
J. Neurosci. 28, 798-807
   Abstract »    Full Text »    PDF »
Distinct Structural and Ionotropic Roles of NMDA Receptors in Controlling Spine and Synapse Stability.
V. A. Alvarez, D. A. Ridenour, and B. L. Sabatini (2007)
J. Neurosci. 27, 7365-7376
   Abstract »    Full Text »    PDF »
Reinnervation of Late Postnatal Purkinje Cells by Climbing Fibers: Neosynaptogenesis without Transient Multi-Innervation.
M. Letellier, Y. Bailly, V. Demais, R. M. Sherrard, J. Mariani, and A. M. Lohof (2007)
J. Neurosci. 27, 5373-5383
   Abstract »    Full Text »    PDF »
Development and Elimination of Endbulb Synapses in the Chick Cochlear Nucleus.
T. Lu and L. O. Trussell (2007)
J. Neurosci. 27, 808-817
   Abstract »    Full Text »    PDF »
The Cationic Amino Acid Transporters CAT1 and CAT3 Mediate NMDA Receptor Activation-Dependent Changes in Elaboration of Neuronal Processes via the Mammalian Target of Rapamycin mTOR Pathway.
Y. Huang, B. N. Kang, J. Tian, Y. Liu, H. R. Luo, L. Hester, and S. H. Snyder (2007)
J. Neurosci. 27, 449-458
   Abstract »    Full Text »    PDF »
Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse.
D. Arsenault and Z.-w. Zhang (2006)
J. Physiol. 573, 121-132
   Abstract »    Full Text »    PDF »
Differential dependence of axo-dendritic and axo-somatic GABAergic synapses on GABAA receptors containing the alpha1 subunit in Purkinje cells..
J.-M. Fritschy, P. Panzanelli, J. E. Kralic, K. E. Vogt, and M. Sassoe-Pognetto (2006)
J. Neurosci. 26, 3245-3255
   Abstract »    Full Text »    PDF »
Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain.
S. Kakizawa, T. Miyazaki, D. Yanagihara, M. Iino, M. Watanabe, and M. Kano (2005)
PNAS 102, 19180-19185
   Abstract »    Full Text »    PDF »
How do developing synapses acquire AMPA receptors?.
B. A. Clark (2005)
J. Physiol. 564, 669
   Full Text »    PDF »
Regionally Specific Distribution of Corticospinal Synapses Because of Activity-Dependent Synapse Elimination In Vitro.
T. Ohno, H. Maeda, and M. Sakurai (2004)
J. Neurosci. 24, 1377-1384
   Abstract »    Full Text »    PDF »
Glial Glutamate Transporters and Maturation of the Mouse Somatosensory Cortex.
B. Voutsinos-Porche, G. Knott, K. Tanaka, C. Quairiaux, E. Welker, and G. Bonvento (2003)
Cereb Cortex 13, 1110-1121
   Abstract »    Full Text »    PDF »
NMDA Receptor Blockade in the Superior Colliculus Increases Receptive Field Size Without Altering Velocity and Size Tuning.
K. A. Razak, L. Huang, and S. L. Pallas (2003)
J Neurophysiol 90, 110-119
   Abstract »    Full Text »    PDF »
NMDA Receptors in Cortical Development are Essential for the Generation of Coordinated Increases in [Ca2+]i in 'Neuronal Domains'.
H. Okada, N. Miyakawa, H. Mori, M. Mishina, Y. Miyamoto, and T. Hisatsune (2003)
Cereb Cortex 13, 749-757
   Abstract »    Full Text »    PDF »
Sodium Imaging of Climbing Fiber Innervation Fields in Developing Mouse Purkinje Cells.
B. Scelfo, P. Strata, and T. Knopfel (2003)
J Neurophysiol 89, 2555-2563
   Abstract »    Full Text »    PDF »
Silent Synapses in Developing Cerebellar Granule Neurons.
G. Losi, K. Prybylowski, Z. Fu, J. H. Luo, and S. Vicini (2002)
J Neurophysiol 87, 1263-1270
   Abstract »    Full Text »    PDF »
Endogenous Activation of Group-I Metabotropic Glutamate Receptors Is Required for Differentiation and Survival of Cerebellar Purkinje Cells.
M. V. Catania, M. Bellomo, V. Di Giorgi-Gerevini, G. Seminara, R. Giuffrida, R. Romeo, A. De Blasi, and F. Nicoletti (2001)
J. Neurosci. 21, 7664-7673
   Abstract »    Full Text »    PDF »
Developmental Depression of Glutamate Neurotransmission by Chronic Low-Level Activation of NMDA Receptors.
J. Shi, S. M. Aamodt, M. Townsend, and M. Constantine-Paton (2001)
J. Neurosci. 21, 6233-6244
   Abstract »    Full Text »    PDF »
Developmental Regulation and Specific Brain Distribution of Phosphorabphilin.
D. L. Foletti and R. H. Scheller (2001)
J. Neurosci. 21, 5461-5472
   Abstract »    Full Text »    PDF »
Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles.
M. Ito (2001)
Physiol Rev 81, 1143-1195
   Abstract »    Full Text »    PDF »
Neuregulins and the Shaping of Synapses.
M. Ozaki (2001)
Neuroscientist 7, 146-154
   Abstract »    PDF »
Critical Period for Activity-Dependent Synapse Elimination in Developing Cerebellum.
S. Kakizawa, M. Yamasaki, M. Watanabe, and M. Kano (2000)
J. Neurosci. 20, 4954-4961
   Abstract »    Full Text »    PDF »
Olivocerebellar Climbing Fibers in the Granuloprival Cerebellum: Morphological Study of Individual Axonal Projections in the X-Irradiated Rat.
I. Sugihara, Y. Bailly, and J. Mariani (2000)
J. Neurosci. 20, 3745-3760
   Abstract »    Full Text »    PDF »
Chronic NMDA Exposure Accelerates Development of GABAergic Inhibition in the Superior Colliculus.
S. M. Aamodt, J. Shi, M. T. Colonnese, W. Veras, and M. Constantine-Paton (2000)
J Neurophysiol 83, 1580-1591
   Abstract »    Full Text »    PDF »
Cerebellar Granule Cell-Specific and Inducible Expression of Cre Recombinase in the Mouse.
M. Tsujita, H. Mori, M. Watanabe, M. Suzuki, J.-i. Miyazaki, and M. Mishina (1999)
J. Neurosci. 19, 10318-10323
   Abstract »    Full Text »    PDF »
Distinct kainate receptor phenotypes in immature and mature mouse cerebellar granule cells.
T C. Smith, L.-Y. Wang, and J. R Howe (1999)
J. Physiol. 517, 51-58
   Abstract »    Full Text »    PDF »
Blockade of N-methyl-D-aspartate receptor activation suppresses learning-induced synaptic elimination.
J. Bock and K. Braun (1999)
PNAS 96, 2485-2490
   Abstract »    Full Text »    PDF »
Phospholipase Cbeta 4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum.
M. Kano, K. Hashimoto, M. Watanabe, H. Kurihara, S. Offermanns, H. Jiang, Y. Wu, K. Jun, H.-S. Shin, Y. Inoue, et al. (1998)
PNAS 95, 15724-15729
   Abstract »    Full Text »    PDF »
Functional Change of NMDA Receptors Related to Enhancement of Susceptibility to Neurotoxicity in the Developing Pontine Nucleus.
A. Mitani, M. Watanabe, and K. Kataoka (1998)
J. Neurosci. 18, 7941-7952
   Abstract »    Full Text »    PDF »
Glutamate Receptor Targeting to Synaptic Populations on Purkinje Cells Is Developmentally Regulated.
H.-M. Zhao, R. J. Wenthold, and R. S. Petralia (1998)
J. Neurosci. 18, 5517-5528
   Abstract »    Full Text »    PDF »
AMPA and NMDA Receptors Expressed by Differentiating Xenopus Spinal Neurons.
E. L. Gleason and N. C. Spitzer (1998)
J Neurophysiol 79, 2986-2998
   Abstract »    Full Text »    PDF »
Topical Review: Glutamate in Neurologic Diseases.
P. Bittigau and C. Ikonomidou (1997)
J Child Neurol 12, 471-485
   Abstract »    PDF »
Functional Respiratory Rhythm Generating Networks in Neonatal Mice Lacking NMDAR1 Gene.
G. D. Funk, S. M. Johnson, J. C. Smith, X.-W. Dong, J. Lai, and J. L. Feldman (1997)
J Neurophysiol 78, 1414-1420
   Abstract »    Full Text »    PDF »
Glutamate-Dependent Activation of NF-kappa B During Mouse Cerebellum Development.
L. Guerrini, A. Molteni, T. Wirth, B. Kistler, and F. Blasi (1997)
J. Neurosci. 17, 6057-6063
   Abstract »    Full Text »    PDF »
Temporal Correlations between Functional and Molecular Changes in NMDA Receptors and GABA Neurotransmission in the Superior Colliculus.
J. Shi, S. M. Aamodt, and M. Constantine-Paton (1997)
J. Neurosci. 17, 6264-6276
   Abstract »    Full Text »    PDF »
Experimental Down-Regulation of the NMDA Channel Associated With Synapse Pruning.
P. W. Hickmott and M. Constantine-Paton (1997)
J Neurophysiol 78, 1096-1107
   Abstract »    Full Text »    PDF »
Transient Synaptic Potentiation in the Visual Cortex. II. Developmental Regulation.
K. Harsanyi and M. J. Friedlander (1997)
J Neurophysiol 77, 1284-1293
   Abstract »    Full Text »    PDF »
D-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors.
M. J. Schell, R. O. Brady Jr., M. E. Molliver, and S. H. Snyder (1997)
J. Neurosci. 17, 1604-1615
   Abstract »    Full Text »    PDF »
Motor Discoordination Results from Combined Gene Disruption of the NMDA Receptor NR2A and NR2C Subunits, But Not from Single Disruption of the NR2A or NR2C Subunit.
H. Kadotani, T. Hirano, M. Masugi, K. Nakamura, K. Nakao, M. Katsuki, and S. Nakanishi (1996)
J. Neurosci. 16, 7859-7867
   Abstract »    Full Text »    PDF »
Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism.
Z. Xia, H. Dudek, C. K. Miranti, and M. E. Greenberg (1996)
J. Neurosci. 16, 5425-5436
   Abstract »    Full Text »    PDF »
Functional NMDA Receptors Are Transiently Active and Support the Survival of Purkinje Cells in Culture.
M. Yuzaki, D. Forrest, L. M. Verselis, S. C. Sun, T. Curran, and J. A. Connor (1996)
J. Neurosci. 16, 4651-4661
   Abstract »    Full Text »    PDF »
Functional Correlation of NMDA Receptor epsilon  Subunits Expression with the Properties of Single-Channel and Synaptic Currents in the Developing Cerebellum.
T. Takahashi, D. Feldmeyer, N. Suzuki, K. Onodera, S. G. Cull-Candy, K. Sakimura, and M. Mishina (1996)
J. Neurosci. 16, 4376-4382
   Abstract »    Full Text »    PDF »
The 5`-Untranslated Region of the N-Methyl-D-aspartate Receptor NR2A Subunit Controls Efficiency of Translation.
M. W. Wood, H. M. A. VanDongen, and A. M. J. VanDongen (1996)
J. Biol. Chem. 271, 8115-8120
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)