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Science 26 June 1992:
Vol. 256. no. 5065, pp. 1812 - 1815
DOI: 10.1126/science.1615326
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Articles

Science, Vol 256, Issue 5065, 1812-1815
Copyright © 1992 by American Association for the Advancement of Science

articles

Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut

PF Pimenta, SJ Turco, MJ McConville, PG Lawyer, PV Perkins, and DL Sacks

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Although leishmaniasis is transmitted to humans almost exclusively by the bite of infected phlebotomine sandflies, little is known about the molecules controlling the survival and development of Leishmania parasites in their insect vectors. Adhesion of Leishmania promastigotes to the midgut epithelial cells of the sandfly was found to be an inherent property of noninfective-stage promastigotes, which was lost during their transformation to metacyclic forms, thus permitting the selective release of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release was found to be controlled by specific developmental modifications in terminally exposed saccharides on lipophosphoglycan, the major surface molecule on Leishmania promastigotes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparisons of Mutants Lacking the Golgi UDP-Galactose or GDP-Mannose Transporters Establish that Phosphoglycans Are Important for Promastigote but Not Amastigote Virulence in Leishmania major.
A. A. Capul, S. Hickerson, T. Barron, S. J. Turco, and S. M. Beverley (2007)
Infect. Immun. 75, 4629-4637
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Sugar Nucleotide Pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.
D. C. Turnock and M. A. J. Ferguson (2007)
Eukaryot. Cell 6, 1450-1463
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Insight into a Conserved Lifestyle: Protein-Carbohydrate Adhesion Strategies of Vector-Borne Pathogens.
R. R. Dinglasan and M. Jacobs-Lorena (2005)
Infect. Immun. 73, 7797-7807
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Identification of Genes Encoding Arabinosyltransferases (SCA) Mediating Developmental Modifications of Lipophosphoglycan Required for Sand Fly Transmission of Leishmania major.
D. E. Dobson, B. J. Mengeling, S. Cilmi, S. Hickerson, S. J. Turco, and S. M. Beverley (2003)
J. Biol. Chem. 278, 28840-28848
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Specific Recognition of Leishmania major Poly-{beta}-galactosyl Epitopes by Galectin-9: POSSIBLE IMPLICATION OF GALECTIN-9 IN INTERACTION BETWEEN L. MAJOR AND HOST CELLS.
I. Pelletier, T. Hashidate, T. Urashima, N. Nishi, T. Nakamura, M. Futai, Y. Arata, K.-i. Kasai, M. Hirashima, J. Hirabayashi, et al. (2003)
J. Biol. Chem. 278, 22223-22230
   Abstract »    Full Text »    PDF »
Functional Identification of Galactosyltransferases (SCGs) Required for Species-specific Modifications of the Lipophosphoglycan Adhesin Controlling Leishmania major-Sand Fly Interactions.
D. E. Dobson, L. D. Scholtes, K. E. Valdez, D. R. Sullivan, B. J. Mengeling, S. Cilmi, S. J. Turco, and S. M. Beverley (2003)
J. Biol. Chem. 278, 15523-15531
   Abstract »    Full Text »    PDF »
Specific Recognition and Cleavage of Galectin-3 by Leishmania major through Species-specific Polygalactose Epitope.
I. Pelletier and S. Sato (2002)
J. Biol. Chem. 277, 17663-17670
   Abstract »    Full Text »    PDF »
The role of phosphoglycans in Leishmania-sand fly interactions.
D. L. Sacks, G. Modi, E. Rowton, G. Spath, L. Epstein, S. J. Turco, and S. M. Beverley (2000)
PNAS 97, 406-411
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The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.
M. Ferguson (1999)
J. Cell Sci. 112, 2799-2809
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Stage-specific Proteophosphoglycan from Leishmania mexicana Amastigotes. STRUCTURAL CHARACTERIZATION OF NOVEL MONO-, DI-, AND TRIPHOSPHORYLATED PHOSPHODIESTER-LINKED OLIGOSACCHARIDES.
T. Ilg, D. Craik, G. Currie, G. Multhaup, and A. Bacic (1998)
J. Biol. Chem. 273, 13509-13523
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Glycoprotein 46 mRNA Abundance Is Post-transcriptionally Regulated during Development of Leishmania chagasi Promastigotes to an Infectious Form.
J. K. Beetham, K. S. Myung, J. J. McCoy, M. E. Wilson, and J. E. Donelson (1997)
J. Biol. Chem. 272, 17360-17366
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Inhibition of Phagolysosomal Biogenesis by the Leishmania Lipophosphoglycan.
M. Desjardins and A. Descoteaux (1997)
J. Exp. Med. 185, 2061-2068
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Deficiency in beta 1,3-Galactosyltransferase of a Leishmania major Lipophosphoglycan Mutant Adversely Influences the Leishmania-Sand Fly Interaction.
B. A. Butcher, S. J. Turco, B. A. Hilty, P. F. Pimenta, M. Panunzio, and D. L. Sacks (1996)
J. Biol. Chem. 271, 20573-20579
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Surface antigens of Leishmania mexicana amastigotes: characterization of glycoinositol phospholipids and a macrophage-derived glycosphingolipid.
G Winter, M Fuchs, M. McConville, Y. Stierhof, and P Overath (1994)
J. Cell Sci. 107, 2471-2482
   Abstract »    PDF »
Gene deletion suggests a role for Trypanosoma cruzi surface glycoprotein GP72 in the insect and mammalian stages of the life cycle.
A. de Jesus, R Cooper, M Espinosa, J. Gomes, E. Garcia, S Paul, and G. Cross (1993)
J. Cell Sci. 106, 1023-1033
   Abstract »    PDF »
Phosphoglycan Repeat-deficient Leishmania mexicana Parasites Remain Infectious to Macrophages and Mice.
T. Ilg, M. Demar, and D. Harbecke (2001)
J. Biol. Chem. 276, 4988-4997
   Abstract »    Full Text »    PDF »


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