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Science 12 June 1992:
Vol. 256. no. 5063, pp. 1555 - 1560
DOI: 10.1126/science.1350865

Articles

Science, Vol 256, Issue 5063, 1555-1560
Copyright © 1992 by American Association for the Advancement of Science


articles

Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1

J Ericson, S Thor, T Edlund, TM Jessell, and T Yamada

Department of Microbiology, Umea University, Sweden.

Motor neurons in the embryonic chick spinal cord express a homeobox gene, Islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of Islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish Islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.


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Development 125, 3553-3562
   Abstract »    PDF »
Neuronal differentiation of PC12 cells induced by engrailed homeodomain is DNA-binding specific and independent of MAP kinases.
J. Cosgaya, A Aranda, J Cruces, and E Martin-Blanco (1998)
J. Cell Sci. 111, 2377-2384
   Abstract »    PDF »
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.
M. Matise, D. Epstein, H. Park, K. Platt, and A. Joyner (1998)
Development 125, 2759-2770
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Progenitors of dorsal commissural interneurons are defined by MATH1 expression.
A. Helms and J. Johnson (1998)
Development 125, 919-928
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The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm.
M Ensini, T. Tsuchida, H. Belting, and T. Jessell (1998)
Development 125, 969-982
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Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary.
J Ericson, S Norlin, T. Jessell, and T Edlund (1998)
Development 125, 1005-1015
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Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice.
L Tiret, H Le Mouellic, M Maury, and P Brulet (1998)
Development 125, 279-291
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Mosaics of Islet-1-Expressing Amacrine Cells Assembled by Short-Range Cellular Interactions.
L. Galli-Resta, G. Resta, S.-S. Tan, and B. E. Reese (1997)
J. Neurosci. 17, 7831-7838
   Abstract »    Full Text »    PDF »
Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic Insult In Vitro.
N. Miao, M. Wang, J. A. Ott, J. S. D'Alessandro, T. M. Woolf, D. A. Bumcrot, N. K. Mahanthappa, and K. Pang (1997)
J. Neurosci. 17, 5891-5899
   Abstract »    Full Text »    PDF »
Notochord to endoderm signaling is required for pancreas development.
S. Kim, M Hebrok, and D. Melton (1997)
Development 124, 4243-4252
   Abstract »    PDF »



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