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Science 12 June 1992: Vol. 256. no. 5063, pp. 1555 - 1560 DOI: 10.1126/science.1350865
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Articles
Science, Vol 256, Issue 5063, 1555-1560
Copyright © 1992 by American Association for the Advancement of Science
Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1
J Ericson,
S Thor,
T Edlund,
TM Jessell,
and
T Yamada
Department of Microbiology, Umea University, Sweden.
Motor neurons in the embryonic chick spinal cord express a homeobox gene, Islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of Islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish Islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.
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- Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation.
- A. G. Estevez, N. Spear, S. M. Manuel, R. Radi, C. E. Henderson, L. Barbeito, and J. S. Beckman (1998)
J. Neurosci.
18, 923-931
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- Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development.
- J Adam, A Myat, I Le Roux, M Eddison, D Henrique, D Ish-Horowicz, and J Lewis (1998)
Development
125, 4645-4654
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- Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene.
- J. LeCouter, B Kablar, P. Whyte, C Ying, and M. Rudnicki (1998)
Development
125, 4669-4679
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- Function and specificity of LIM domains in Drosophila nervous system and wing development.
- D. O'Keefe, S Thor, and J. Thomas (1998)
Development
125, 3915-3923
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- The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.
- J. Incardona, W Gaffield, R. Kapur, and H Roelink (1998)
Development
125, 3553-3562
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- Neuronal differentiation of PC12 cells induced by engrailed homeodomain is DNA-binding specific and independent of MAP kinases.
- J. Cosgaya, A Aranda, J Cruces, and E Martin-Blanco (1998)
J. Cell Sci.
111, 2377-2384
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- Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.
- M. Matise, D. Epstein, H. Park, K. Platt, and A. Joyner (1998)
Development
125, 2759-2770
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- Progenitors of dorsal commissural interneurons are defined by MATH1 expression.
- A. Helms and J. Johnson (1998)
Development
125, 919-928
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- The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm.
- M Ensini, T. Tsuchida, H. Belting, and T. Jessell (1998)
Development
125, 969-982
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- Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary.
- J Ericson, S Norlin, T. Jessell, and T Edlund (1998)
Development
125, 1005-1015
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- Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice.
- L Tiret, H Le Mouellic, M Maury, and P Brulet (1998)
Development
125, 279-291
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- Mosaics of Islet-1-Expressing Amacrine Cells Assembled by Short-Range Cellular Interactions.
- L. Galli-Resta, G. Resta, S.-S. Tan, and B. E. Reese (1997)
J. Neurosci.
17, 7831-7838
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- Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic Insult In Vitro.
- N. Miao, M. Wang, J. A. Ott, J. S. D'Alessandro, T. M. Woolf, D. A. Bumcrot, N. K. Mahanthappa, and K. Pang (1997)
J. Neurosci.
17, 5891-5899
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- Notochord to endoderm signaling is required for pancreas development.
- S. Kim, M Hebrok, and D. Melton (1997)
Development
124, 4243-4252
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- PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development.
- J. Burrill, L Moran, M. Goulding, and H Saueressig (1997)
Development
124, 4493-4503
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- NeuroM, a neural helix-loop-helix transcription factor, defines a new transition stage in neurogenesis.
- T Roztocil, L Matter-Sadzinski, C Alliod, M Ballivet, and J. Matter (1997)
Development
124, 3263-3272
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