Science 5 June 1992: Vol. 256. no. 5062, pp. 1452 - 1456 DOI: 10.1126/science.1604322

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Articles

Specification of DNA Binding Activity of NF-{kappa}B Proteins.

F. Wan and M. J. Lenardo (2009)
Cold Spring Harb Perspect Biol 1, a000067
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New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting.

A. D. Wells (2009)
J. Immunol. 182, 7331-7341
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Response to the Letter by Frantz and Bauersachs.

L. Timmers and D. P.V. de Kleijn (2009)
Circ. Res. 104, e61
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Targeted Deletion of Nuclear Factor {kappa}B p50 Enhances Cardiac Remodeling and Dysfunction Following Myocardial Infarction.

L. Timmers, J. K. van Keulen, I. E. Hoefer, M. F.L. Meijs, B. van Middelaar, K. den Ouden, C. J.A. van Echteld, G. Pasterkamp, and D. P.V. de Kleijn (2009)
Circ. Res. 104, 699-706
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Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.

S. Baenziger, M. Heikenwalder, P. Johansen, E. Schlaepfer, U. Hofer, R. C. Miller, S. Diemand, K. Honda, T. M. Kundig, A. Aguzzi, et al. (2009)
Blood 113, 377-388
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Oxidative, multistep activation of the noncanonical NF-{kappa}B pathway via disulfide Bcl-3/p50 complex.

S. Cristofanon, F. Morceau, A. I. Scovassi, M. Dicato, L. Ghibelli, and M. Diederich (2009)
FASEB J 23, 45-57
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Elevating Calcium in Th2 Cells Activates Multiple Pathways to Induce IL-4 Transcription and mRNA Stabilization.

L. Guo, J. F. Urban, J. Zhu, and W. E. Paul (2008)
J. Immunol. 181, 3984-3993
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Inhibition of Nuclear Factor-{kappa}B in T Cells Suppresses Lung Fibrosis.

H. Fujimoto, C. N. D'Alessandro-Gabazza, M. S. S. Palanki, P. E. Erdman, T. Takagi, E. C. Gabazza, N. E. Bruno, Y. Yano, T. Hayashi, S. Tamaki, et al. (2007)
Am. J. Respir. Crit. Care Med. 176, 1251-1260
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RelB, a New Partner of Aryl Hydrocarbon Receptor-Mediated Transcription.

C. F. A. Vogel, E. Sciullo, W. Li, P. Wong, G. Lazennec, and F. Matsumura (2007)
Mol. Endocrinol. 21, 2941-2955
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Ikaros Enforces the Costimulatory Requirement for IL2 Gene Expression and Is Required for Anergy Induction in CD4+ T Lymphocytes.

R. M. Thomas, N. Chunder, C. Chen, S. E. Umetsu, S. Winandy, and A. D. Wells (2007)
J. Immunol. 179, 7305-7315
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Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.

A. V. Villarino, C. M. Tato, J. S. Stumhofer, Z. Yao, Y. K. Cui, L. Hennighausen, J. J. O'Shea, and C. A. Hunter (2007)
J. Exp. Med. 204, 65-71
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Spontaneous, homeostatic, and inflammation-induced sleep in NF-{kappa}B p50 knockout mice.

K. A. Jhaveri, V. Ramkumar, R. A. Trammell, and L. A. Toth (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R1516-R1526
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Coordinated binding of NF-{kappa}B family members in the response of human cells to lipopolysaccharide.

J. Schreiber, R. G. Jenner, H. L. Murray, G. K. Gerber, D. K. Gifford, and R. A. Young (2006)
PNAS 103, 5899-5904
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Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome.

S. Ye (2006)
Cardiovasc Res 69, 636-645
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Defective Activation of ERK in Macrophages Lacking the p50/p105 Subunit of NF-{kappa}B Is Responsible for Elevated Expression of IL-12 p40 Observed after Challenge with Helicobacter hepaticus.

M. F. Tomczak, M. Gadjeva, Y. Y. Wang, K. Brown, I. Maroulakou, P. N. Tsichlis, S. E. Erdman, J. G. Fox, and B. H. Horwitz (2006)
J. Immunol. 176, 1244-1251
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Resolution of Inflammation: Prostaglandin E2 Dissociates Nuclear Trafficking of Individual NF-{kappa}B Subunits (p65, p50) in Stimulated Rheumatoid Synovial Fibroblasts.

P. F. Gomez, M. H. Pillinger, M. Attur, N. Marjanovic, M. Dave, J. Park, C. O. Bingham III, H. Al-Mussawir, and S. B. Abramson (2005)
J. Immunol. 175, 6924-6930
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A Soluble Factor Secreted by an HIV-1-Resistant Cell Line Blocks Transcription through Inactivating the DNA-Binding Capacity of the NF-{kappa}B p65/p50 Dimer.

A. Lesner, Y. Li, J. Nitkiewicz, G. Li, A. Kartvelishvili, M. Kartvelishvili, and M. Simm (2005)
J. Immunol. 175, 2548-2554
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DNA Binding of Repressor Nuclear Factor-{kappa}B p50/p50 Depends on Phosphorylation of Ser337 by the Protein Kinase A Catalytic Subunit.

H. Guan, S. Hou, and R. P. Ricciardi (2005)
J. Biol. Chem. 280, 9957-9962
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Selective Blockade of NF-{kappa}B Activity in Airway Immune Cells Inhibits the Effector Phase of Experimental Asthma.

C. Desmet, P. Gosset, B. Pajak, D. Cataldo, M. Bentires-Alj, P. Lekeux, and F. Bureau (2004)
J. Immunol. 173, 5766-5775
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A Role for NF-{kappa}B Subunits p50 and p65 in the Inhibition of Lipopolysaccharide-Induced Shock.

M. Gadjeva, M. F. Tomczak, M. Zhang, Y. Y. Wang, K. Dull, A. B. Rogers, S. E. Erdman, J. G. Fox, M. Carroll, and B. H. Horwitz (2004)
J. Immunol. 173, 5786-5793
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Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-{kappa}B.

H. Harant and I. J. D. Lindley (2004)
Nucleic Acids Res. 32, 5280-5290
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Bcl-3 and NF{kappa}B p50-p50 Homodimers Act as Transcriptional Repressors in Tolerant CD4+ T Cells.

S. Grundstrom, P. Anderson, P. Scheipers, and A. Sundstedt (2004)
J. Biol. Chem. 279, 8460-8468
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NF-{kappa}B Is Required Within the Innate Immune System to Inhibit Microflora-Induced Colitis and Expression of IL-12 p40.

M. F. Tomczak, S. E. Erdman, T. Poutahidis, A. B. Rogers, H. Holcombe, B. Plank, J. G. Fox, and B. H. Horwitz (2003)
J. Immunol. 171, 1484-1492
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The Interferon-inducible p202a Protein Modulates NF-{kappa}B Activity by Inhibiting the Binding to DNA of p50/p65 Heterodimers and p65 Homodimers While Enhancing the Binding of p50 Homodimers.

X.-Y. Ma, H. Wang, B. Ding, H. Zhong, S. Ghosh, and P. Lengyel (2003)
J. Biol. Chem. 278, 23008-23019
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NF-{kappa}B1 Is Required for Optimal CD4+ Th1 Cell Development and Resistance to Leishmania major.

D. Artis, K. Speirs, K. Joyce, M. Goldschmidt, J. Caamano, C. A. Hunter, and P. Scott (2003)
J. Immunol. 170, 1995-2003
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IKKalpha , IKKbeta , and NEMO/IKKgamma Are Each Required for the NF-kappa B-mediated Inflammatory Response Program.

X. Li, P. E. Massa, A. Hanidu, G. W. Peet, P. Aro, A. Savitt, S. Mische, J. Li, and K. B. Marcu (2002)
J. Biol. Chem. 277, 45129-45140
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Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation.

X.-Y. Zhou, Y. Yashiro-Ohtani, M. Nakahira, W. R. Park, R. Abe, T. Hamaoka, M. Naramura, H. Gu, and H. Fujiwara (2002)
J. Immunol. 168, 3847-3854
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A T Cell-specific Enhancer of the Human CD40 Ligand Gene.

L. A. Schubert, R. Q. Cron, A. M. Cleary, M. Brunner, A. Song, L.-S. Lu, P. Jullien, A. M. Krensky, and D. B. Lewis (2002)
J. Biol. Chem. 277, 7386-7395
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An I{kappa}B{alpha} Inhibitor Causes Leukemia Cell Death through a p38 MAP Kinase-dependent, NF-{kappa}B-independent Mechanism.

X. Hu, W. E. Janssen, L. C. Moscinski, M. Bryington, A. Dangsupa, N. Rezai-Zadeh, B. A. Babbin, and K. S. Zuckerman (2001)
Cancer Res. 61, 6290-6296
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Roles of Ets proteins, NF-{{kappa}}B and nocodazole in regulating induction of transcription of mouse germline Ig {{alpha}} RNA by transforming growth factor-{beta}1.

M.-J. Shi, S.-R. Park, P.-H. Kim, and J. Stavnezer (2001)
Int. Immunol. 13, 733-746
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Selective inhibition of interleukin-4 gene expression in human T cells by aspirin.

A. Cianferoni, J. T. Schroeder, J. Kim, J. W. Schmidt, L. M. Lichtenstein, S. N. Georas, and V. Casolaro (2001)
Blood 97, 1742-1749
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The Sympathetic Nerve---An Integrative Interface between Two Supersystems: The Brain and the Immune System.

I. J. Elenkov, R. L. Wilder, G. P. Chrousos, and E. S. Vizi (2000)
Pharmacol. Rev. 52, 595-638
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Lipopolysaccharide-triggered desensitization of TNF-{alpha} mRNA expression involves lack of phosphorylation of I{kappa}B{alpha} in a murine macrophage-like cell line, P388D1.

M. Fujihara, S. Wakamoto, T. Ito, M. Muroi, T. Suzuki, H. Ikeda, and K. Ikebuchi (2000)
J. Leukoc. Biol. 68, 267-276
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Inhibition of lipopolysaccharide-mediated NF{kappa}B activation by ethanol in human monocytes.

P. Mandrekar, D. Catalano, and G. Szabo (1999)
Int. Immunol. 11, 1781-1790
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Protein Kinase C and Calcineurin Synergize to Activate Ikappa B Kinase and NF-kappa B in T Lymphocytes.

S. A. Trushin, K. N. Pennington, A. Algeciras-Schimnich, and C. V. Paya (1999)
J. Biol. Chem. 274, 22923-22931
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Interleukin-9 Regulates NF-kappa B Activity Through BCL3 Gene Induction.

M. Richard, J. Louahed, J.-B. Demoulin, and J.-C. Renauld (1999)
Blood 93, 4318-4327
 |  Abstract »  |  Full Text »  |  PDF »

Sequences between the Enhancer and Promoter in the Long Terminal Repeat Affect Murine Leukemia Virus Pathogenicity and Replication in the Thymus.

F. K. Yoshimura, T. Wang, and M. Cankovic (1999)
J. Virol. 73, 4890-4898
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NF-kappa B1 (p50) Is Upregulated in Lipopolysaccharide Tolerance and Can Block Tumor Necrosis Factor Gene Expression.

S. Kastenbauer and H. W. L. Ziegler-Heitbrock (1999)
Infect. Immun. 67, 1553-1559
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An Essential Role for Nuclear Factor {kappa}B in Promoting Double Positive Thymocyte Apoptosis.

T. Hettmann, J. DiDonato, M. Karin, and J. M. Leiden (1999)
J. Exp. Med. 189, 145-158
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Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: A preliminary report.

E. Collantes, M V. Blázquez, V. Mazorra, A. Macho, E. Aranda, and E. Muñoz (1998)
Ann Rheum Dis 57, 738-741
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Tumor Necrosis Factor Alpha Transcription in Macrophages Is Attenuated by an Autocrine Factor That Preferentially Induces NF-kappa B p50.

M. Baer, A. Dillner, R. C. Schwartz, C. Sedon, S. Nedospasov, and P. F. Johnson (1998)
Mol. Cell. Biol. 18, 5678-5689
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Cyclosporin A-Resistant Transactivation of the IL-2 Promoter Requires Activity of Okadaic Acid-Sensitive Serine/Threonine Phosphatases.

G. Nebl, S. C. Meuer, and Y. Samstag (1998)
J. Immunol. 161, 1803-1810
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Impaired Activation of NFkappa B in T Cells From a Subset of Renal Cell Carcinoma Patients Is Mediated by Inhibition of Phosphorylation and Degradation of the Inhibitor, Ikappa Balpha.

W. Ling, P. Rayman, R. Uzzo, P. Clark, H. J. Kim, R. Tubbs, A. Novick, R. Bukowski, T. Hamilton, and J. Finke (1998)
Blood 92, 1334-1341
 |  Abstract »  |  Full Text »  |  PDF »

The Transcription Factor NF-kappa B/p50 Interacts with the blk Gene during B Cell Activation.

P. Zwollo, S. Rao, J. J. Wallin, E. R. Gackstetter, and M. E. Koshland (1998)
J. Biol. Chem. 273, 18647-18655
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V7 (CD101) Ligation Inhibits TCR/CD3-Induced IL-2 Production by Blocking Ca2+ Flux and Nuclear Factor of Activated T Cell Nuclear Translocation.

L. R. B. Soares, L. Tsavaler, A. Rivas, and E. G. Engleman (1998)
J. Immunol. 161, 209-217
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Ceramide Activates NFkappa B by Inducing the Processing of p105.

M. P. Boland and L. A. J. O'Neill (1998)
J. Biol. Chem. 273, 15494-15500
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Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells. DEPENDENCE ON THE c-Jun N-TERMINAL KINASE ACTIVATION PATHWAY.

D. Hata, J. Kitaura, S. E. Hartman, Y. Kawakami, T. Yokota, and T. Kawakami (1998)
J. Biol. Chem. 273, 10979-10987
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Activation of Transcriptionally Active Nuclear Factor-{kappa}B by Tumor Necrosis Factor-{alpha} and Its Inhibition by Antioxidants in Rat Thyroid FRTL-5 Cells.

T. Kikumori, F. Kambe, T. Nagaya, T. Imai, H. Funahashi, and H. Seo (1998)
Endocrinology 139, 1715-1722
 |  Abstract »  |  Full Text »  |  PDF »

Functional Consequences of Costimulation by ICAM-1 on IL-2 Gene Expression and T Cell Activation.

L. A. Zuckerman, L. Pullen, and J. Miller (1998)
J. Immunol. 160, 3259-3268
 |  Abstract »  |  Full Text »  |  PDF »

Discrimination between RelA and RelB Transcriptional Regulation by a Dominant Negative Mutant of Ikappa Balpha.

V. Ferreira, N. Tarantino, and M. Korner (1998)
J. Biol. Chem. 273, 592-599
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular ATP Activates Transcription Factor NF-{kappa}B through the P2Z Purinoreceptor by Selectively Targeting NF-{kappa}B p65 (RelA).

D. Ferrari, S. Wesselborg, M. K.A. Bauer, and K. Schulze-Osthoff (1997)
J. Cell Biol. 139, 1635-1643
 |  Abstract »  |  Full Text »  |  PDF »

Temporal and Subunit-specific Modulations of the Rel/NF-kappa B Transcription Factors Through CD28 Costimulation.

B. Kahn-Perles, C. Lipcey, P. Lecine, D. Olive, and J. Imbert (1997)
J. Biol. Chem. 272, 21774-21783
 |  Abstract »  |  Full Text »  |  PDF »

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-{kappa}B.

M. R. Boothby, A. L. Mora, D. C. Scherer, J. A. Brockman, and D. W. Ballard (1997)
J. Exp. Med. 185, 1897-1907
 |  Abstract »  |  Full Text »  |  PDF »

Transcription Factor Activation during Signal-induced Apoptosis of Immature CD4+CD8+ Thymocytes. A PROTECTIVE ROLE OF c-Fos.

V. N. Ivanov and V. N. Ivanov (1997)
J. Biol. Chem. 272, 8558-8566
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Mouse Neuropeptide Y Y1 Receptor Gene Transcription: A Potential Role for Nuclear Factor-kappa B/Rel Proteins.

R. Musso, M. Grilli, A. Oberto, S. R. Gamalero, and C. Eva (1997)
Mol. Pharmacol. 51, 27-35
 |  Abstract »  |  Full Text »

Interleukin-1beta and Glutamate Activate the NF-kappa B/Rel Binding Site from the Regulatory Region of the Amyloid Precursor Protein Gene in Primary Neuronal Cultures.

M. Grilli, F. Goffi, M. Memo, and P. Spano (1996)
J. Biol. Chem. 271, 15002-15007
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells.

C. C. W. Hughes and J. S. Pober (1996)
J. Biol. Chem. 271, 5369-5377
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-1alpha Activates an NF-kappaB-like Factor in Osteoclast-like Cells.

E. Jimi, T. Ikebe, N. Takahashi, M. Hirata, T. Suda, and T. Koga (1996)
J. Biol. Chem. 271, 4605-4608
 |  Abstract »  |  Full Text »  |  PDF »

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation..

I M Verma, J K Stevenson, E M Schwarz, D Van Antwerp, and S Miyamoto (1995)
Genes & Dev. 9, 2723-2735
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Identification and Characterization of a kappaB/Rel Binding Site in the Regulatory Region of the Amyloid Precursor Protein Gene.

M. Grilli, M. Ribola, A. Alberici, A. Valerio, M. Memo, and P. Spano (1995)
J. Biol. Chem. 270, 26774-26777
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Activates Nuclear Factor kappaB in Mammalian Cells through a Raf-1-mediated Pathway.

F. Bertrand, C. Philippe, P. J. Antoine, L. Baud, A. Groyer, J. Capeau, and G.èl. Cherqui (1995)
J. Biol. Chem. 270, 24435-24441
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Human P-selectin Promoter by Bcl-3 and Specific Homodimeric Members of the NF-kappaB/Rel Family.

J. Pan and R. P. McEver (1995)
J. Biol. Chem. 270, 23077-23083
 |  Abstract »  |  Full Text »  |  PDF »

Differential Transcriptional Activation in Vitro by NF-kappaB/Rel Proteins.

R. Lin, D. Gewert, and J. Hiscott (1995)
J. Biol. Chem. 270, 3123-3131
 |  Abstract »  |  Full Text »  |  PDF »

T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis.

J. Critchfield, M. Racke, J. Zuniga-Pflucker, B Cannella, C. Raine, J Goverman, and M. Lenardo (1994)
Science 263, 1139-1143
 |  Abstract »  |  PDF »

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors..

A A Beg and A S Baldwin (1993)
Genes & Dev. 7, 2064-2070
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Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy.

S.-M. Kang, B. Beverly, A.-C. Tran, K. Brorson, R. H. Schwartz, and M. J. Lenardot (1992)
Science 257, 1134-1138
 |  Abstract »  |  PDF »

Topoisomerase II Is Required for Mitoxantrone to Signal Nuclear Factor kappa B Activation in HL60 Cells.

M. P. Boland, K. A. Fitzgerald, and L. A. J. O'Neill (2000)
J. Biol. Chem. 275, 25231-25238
 |  Abstract »  |  Full Text »  |  PDF »

NF-kappa B1 (p50) Homodimers Contribute to Transcription of the bcl-2 Oncogene.

J. F. Kurland, R. Kodym, M. D. Story, K. B. Spurgers, T. J. McDonnell, and R. E. Meyn (2001)
J. Biol. Chem. 276, 45380-45386
 |  Abstract »  |  Full Text »  |  PDF »

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