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Science 5 June 1992:
Vol. 256. no. 5062, pp. 1448 - 1452
DOI: 10.1126/science.1604321
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Articles
Science, Vol 256, Issue 5062, 1448-1452
Copyright © 1992 by American Association for the Advancement of Science
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells
KL Philpott,
JL Viney,
G Kay,
S Rastan,
EM Gardiner,
S Chae,
AC Hayday,
and
MJ Owen
Imperial Cancer Research Fund, London, United Kingdom.
Vertebrate T cells express either an alpha beta or gamma delta T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. alpha beta + T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of alpha beta + T cells on B cell development is poorly understood. To investigate the developmental effects of alpha beta + T cells on B cells and gamma delta + T cells, mice homozygous for a disrupted TCR alpha gene were generated. The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells.
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