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Science 5 June 1992:
Vol. 256. no. 5062, pp. 1443 - 1445
DOI: 10.1126/science.1604319
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Articles

Science, Vol 256, Issue 5062, 1443-1445
Copyright © 1992 by American Association for the Advancement of Science

articles

Exhaustive matching of the entire protein sequence database

GH Gonnet, MA Cohen, and SA Benner

Institute for Scientific Computation, Swiss Federal Institute of Technology, Zurich, Switzerland.

The entire protein sequence database has been exhaustively matched. Definitive mutation matrices and models for scoring gaps were obtained from the matching and used to organize the sequence database as sets of evolutionarily connected components. The methods developed are general and can be used to manage sequence data generated by major genome sequencing projects. The alignments made possible by the exhaustive matching are the starting point for successful de novo prediction of the folded structures of proteins, for reconstructing sequences of ancient proteins and metabolisms in ancient organisms, and for obtaining new perspectives in structural biochemistry.


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