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Science 5 June 1992:
Vol. 256. no. 5062, pp. 1436 - 1439
DOI: 10.1126/science.1604317
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Articles

Science, Vol 256, Issue 5062, 1436-1439
Copyright © 1992 by American Association for the Advancement of Science

articles

Sexually antagonistic genes: experimental evidence

WR Rice

Biology Board of Studies, University of California, Santa Cruz 95064.

When selection differs between the sexes, a mutation beneficial to one sex may be harmful to the other (sexually antagonistic). Because the sexes share a common gene pool, selection in one sex can interfere with the other's adaptive evolution. Theory predicts that sexually antagonistic mutations should accumulate in tight linkage with a new sex-determining gene, even when the harm to benefit ratio is high. Genetic markers and artificial selection were used to make a pair of autosomal genes segregate like a new pair of sex-determining genes in a Drosophila melanogaster model system. A 29-generation study provides experimental evidence that sexually antagonistic genes may be common in nature and will accumulate in response to a new sex-determining gene.


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