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Science 29 May 1992:
Vol. 256. no. 5061, pp. 1321 - 1324
DOI: 10.1126/science.1598576
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Articles

Science, Vol 256, Issue 5061, 1321-1324
Copyright © 1992 by American Association for the Advancement of Science

articles

Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth

AM Posselt, CF Barker, AL Friedman, and A Naji

Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.

Spontaneous diabetes in the BioBreeding (BB) rat, like human type I diabetes, results from the destruction of pancreatic islets by autoreactive T lymphocytes recognizing beta cell-specific antigens. T cell tolerance is in part mediated by interactions of maturing thymocytes with antigens expressed in the thymic microenvironment; islets were therefore implanted into the thymus of neonatal diabetes-prone BB rats to determine whether exposure of T cell precursors to beta cell antigens could influence the development of diabetes. This treatment completely prevented diabetes and insulitis in the native pancreas. The effect may be the result of specific modulation of diabetogenic T cells maturing in an islet-bearing thymus.


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