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Science 22 May 1992:
Vol. 256. no. 5060, pp. 1217 - 1221
DOI: 10.1126/science.256.5060.1217
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Articles

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

Hannah Monyer 1, Rolf Sprengel 1, Ralf Schoepfer 1, Anne Herb 1, Miyoko Higuchi 1, Hilda Lomeli 1, Nail Burnashev 2, Bert Sakmann 2, and Peter H. Seeburg 1

1 Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, Heidelberg, Germany
2 Max-Planck-Institut fudigrr Medizinische Forschung, Jahnstrasse 29, 6900 Heidelberg delberg, Germany

The N-methyl d-aspartate (NMDA) receptor subtype of glutamate-gated ion channels possesses high calcium permeability and unique voltage-dependent sensitivity to magnesium and is modulated by glycine. Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% ientical in sequence. These are structurally related, with less than 20% sequence identity, to other excitatory amino acid receptor subunits, including the NMDA receptor subunit NMDAR1 (NR1). Upon expression in cultured cells, the new subunits yielded prominent, typical glutamate-and NMDA-activated currents only when they were in heteromeric configurations with NR1. NR1-NR2A and NR1-NR2C channels differed in gating behavior and magnesium sensitivity. Such heteromeric NMDA receptor subtypes may exist in neurons, since NR1 messenger RNA is synthesized throughout the mature rat brain, while NR2 messenger RNA show a differential distribution.


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T. A. Simeone, R. M. Sanchez, and J. M. Rho (2004)
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J Neurophysiol 90, 786-797
   Abstract »    Full Text »    PDF »
Decline of the Critical Period of Visual Plasticity Is Concurrent with the Reduction of NR2B Subunit of the Synaptic NMDA Receptor in Layer 4.
A. Erisir and J. L. Harris (2003)
J. Neurosci. 23, 5208-5218
   Abstract »    Full Text »    PDF »
Ochratoxin a reduces NMDA receptor subunits 2A and 2B concentrations in rat hippocampus: partial protective effect of melatonin.
N. Delibas, I. Altuntas, Z. Yonden, and N. Ozcelik (2003)
Human and Experimental Toxicology 22, 335-339
   Abstract »    PDF »
Asymmetrical Allocation of NMDA Receptor {epsilon}2 Subunits in Hippocampal Circuitry.
R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, and I. Ito (2003)
Science 300, 990-994
   Abstract »    Full Text »    PDF »
Pharmacology of delta 2 Glutamate Receptors: Effects of Pentamidine and Protons.
K. Williams, M. Dattilo, T. N. Sabado, K. Kashiwagi, and K. Igarashi. (2003)
J. Pharmacol. Exp. Ther. 305, 740-748
   Abstract »    Full Text »    PDF »
D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons.
M. Martina, N. V Krasteniakov, and R. Bergeron (2003)
J. Physiol. 548, 411-423
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Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice.
M. Fukaya, A. Kato, C. Lovett, S. Tonegawa, and M. Watanabe (2003)
PNAS 100, 4855-4860
   Abstract »    Full Text »    PDF »
RICS, a Novel GTPase-activating Protein for Cdc42 and Rac1, Is Involved in the beta -Catenin-N-cadherin and N-Methyl-D-aspartate Receptor Signaling.
T. Okabe, T. Nakamura, Y. N. Nishimura, K. Kohu, S. Ohwada, Y. Morishita, and T. Akiyama (2003)
J. Biol. Chem. 278, 9920-9927
   Abstract »    Full Text »    PDF »
Excitatory Amino Acid Receptors of the Electrosensory System: The NR1/NR2B N-Methyl-D-Aspartate Receptor.
E. Harvey-Girard and R. J. Dunn (2003)
J Neurophysiol 89, 822-832
   Abstract »    Full Text »    PDF »
Glycine Tranporter-1 Blockade Potentiates NMDA-Mediated Responses in Rat Prefrontal Cortical Neurons In Vitro and In Vivo.
L. Chen, M. Muhlhauser, and C. R. Yang (2003)
J Neurophysiol 89, 691-703
   Abstract »    Full Text »    PDF »
Chronic NMDA Receptor Blockade From Birth Delays the Maturation of NMDA Currents, but Does Not Affect AMPA/Kainate Currents.
M. T. Colonnese, J. Shi, and M. Constantine-Paton (2003)
J Neurophysiol 89, 57-68
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Colocalization and Hormone Regulation of Estrogen Receptor {alpha} and N-Methyl-D-Aspartate Receptor in the Hypothalamus of Female Rats.
T. R. Chakraborty, L. Ng, and A. C. Gore (2003)
Endocrinology 144, 299-305
   Abstract »    Full Text »    PDF »
KIF17 Dynamics and Regulation of NR2B Trafficking in Hippocampal Neurons.
L. Guillaud, M. Setou, and N. Hirokawa (2003)
J. Neurosci. 23, 131-140
   Abstract »    Full Text »    PDF »
Analysis of Transcriptional Regulatory Sequences of the N-Methyl-D-aspartate Receptor 2A Subunit Gene in Cultured Cortical Neurons and Transgenic Mice.
A. Desai, D. Turetsky, K. Vasudevan, and A. Buonanno (2002)
J. Biol. Chem. 277, 46374-46384
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Association of NR3A with the N-Methyl-D-aspartate Receptor NR1 and NR2 Subunits.
R. A. Al-Hallaq, B. R. Jarabek, Z. Fu, S. Vicini, B. B. Wolfe, and R. P. Yasuda (2002)
Mol. Pharmacol. 62, 1119-1127
   Abstract »    Full Text »    PDF »


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