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Science 22 May 1992:
Vol. 256. no. 5060, pp. 1193 - 1195
DOI: 10.1126/science.256.5060.1193
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Articles

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

Herminio Reyes 1, Suzanne Reisz-Porszasz 2, and Oliver Hankinson 1

1 Department of Pathology, Laboratory Medicine, and Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024
2 Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024

The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects. The ligand-bound receptor activates Cyp1a1 gene transcription through interaction with specific DNA sequences, termed xenobiotic responsive elements (XREs). The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function. Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor. Furthermore, Arnt and the ligand-binding subunit of the receptor were extracted as a complex from the nuclei of cells treated with ligand. Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit.


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   Abstract »    Full Text »    PDF »
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Evidence That the Co-chaperone p23 Regulates Ligand Responsiveness of the Dioxin (Aryl Hydrocarbon) Receptor.
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M. E Andersen and R. B Conolly (1998)
Human and Experimental Toxicology 17, 683-690
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The Involvement of Aryl Hydrocarbon Receptor in the Activation of Transforming Growth Factor-beta and Apoptosis.
H. Zaher, P. M. Fernandez-Salguero, J. Letterio, M. S. Sheikh, A. J. Fornace Jr., A. B. Roberts, and F. J. Gonzalez (1998)
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Macrophage Activation by Polycyclic Aromatic Hydrocarbons: Evidence for the Involvement of Stress-Activated Protein Kinases, Activator Protein-1, and Antioxidant Response Elements.
D. Ng, N. Kokot, T. Hiura, M. Faris, A. Saxon, and A. Nel (1998)
J. Immunol. 161, 942-951
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Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim.
T. K. Darlington, K. Wager-Smith, M. F. Ceriani, D. Staknis, N. Gekakis, T. D. Steeves, C. J. Weitz, J. S. Takahashi, and S. A. Kay (1998)
Science 280, 1599-1603
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Interference between Progesterone and Dioxin Signal Transduction Pathways. DIFFERENT MECHANISMS ARE INVOLVED IN REPRESSION BY THE PROGESTERONE RECEPTOR A AND B ISOFORMS.
C. W. Kuil, A. Brouwer, P. T. van der Saag, and B. van der Burg (1998)
J. Biol. Chem. 273, 8829-8834
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Aryl Hydrocarbon Receptor-Dependent Suppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of IgM Secretion in Activated B Cells.
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Constitutive Activation of the Aromatic Hydrocarbon Receptor.
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J. Biol. Chem. 272, 21221-21226
   Abstract »    Full Text »    PDF »
Determination of Aryl Hydrocarbon Receptor Nuclear Translocator Protein Concentration and Subcellular Localization in Hepatic and Nonhepatic Cell Culture Lines: Development of Quantitative Western Blotting Protocols for Calculation of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Nuclear Translocator Protein in Total Cell Lysates.
J. L. Holmes and R. S. Pollenz (1997)
Mol. Pharmacol. 52, 202-211
   Abstract »    Full Text »
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.
P. H. Maxwell, G. U. Dachs, J. M. Gleadle, L. G. Nicholls, A. L. Harris, I. J. Stratford, O. Hankinson, C. W. Pugh, and P. J. Ratcliffe (1997)
PNAS 94, 8104-8109
   Abstract »    Full Text »    PDF »
Cloning of Two Human Homologs of the Drosophila single-minded Gene SIM1 on Chromosome 6q and SIM2 on 21q Within the Down Syndrome Chromosomal Region.
R. Chrast, H. S. Scott, H. Chen, J. Kudoh, C. Rossier, S. Minoshima, Y. Wang, N. Shimizu, and S. E. Antonarakis (1997)
Genome Res. 7, 615-624
   Abstract »    Full Text »    PDF »
Regulation of Dioxin Receptor Function by Omeprazole.
N. Dzeletovic, J. McGuire, M. Daujat, J. Tholander, M. Ema, Y. Fujii-Kuriyama, J. Bergman, P. Maurel, and L. Poellinger (1997)
J. Biol. Chem. 272, 12705-12713
   Abstract »    Full Text »    PDF »
Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the alpha Subunit.
C. W. Pugh, J. F. O'Rourke, M. Nagao, J. M. Gleadle, and P. J. Ratcliffe (1997)
J. Biol. Chem. 272, 11205-11214
   Abstract »    Full Text »    PDF »
Mapping the Protein/DNA Contact Sites of the Ah Receptor and Ah Receptor Nuclear Translocator.
H. I. Swanson and J.-h. Yang (1996)
J. Biol. Chem. 271, 31657-31665
   Abstract »    Full Text »    PDF »
Isolation and Expression of cDNAs from Rainbow Trout (Oncorhynchus mykiss) That Encode Two Novel Basic Helix-Loop-Helix/PER-ARNT-SIM (bHLH/PAS) Proteins with Distinct Functions in the Presence of the Aryl Hydrocarbon Receptor. EVIDENCE FOR ALTERNATIVE mRNA SPLICING AND DOMINANT NEGATIVE ACTIVITY IN THE bHLH/PAS FAMILY.
R. S. Pollenz, H. R. Sullivan, J. Holmes, B. Necela, and R. E. Peterson (1996)
J. Biol. Chem. 271, 30886-30896
   Abstract »    Full Text »    PDF »
Isolation and Characterization of the Human Cytochrome P450 CYP1B1 Gene.
Y. M. Tang, Y.-Y. P. Wo, J. Stewart, A. L. Hawkins, C. A. Griffin, T. R. Sutter, and W. F. Greenlee (1996)
J. Biol. Chem. 271, 28324-28330
   Abstract »    Full Text »    PDF »
Expression of the Aryl Hydrocarbon Receptor Is Regulated by Serum and Mitogenic Growth Factors in Murine 3T3 Fibroblasts.
C. Vaziri, A. Schneider, D. H. Sherr, and D. V. Faller (1996)
J. Biol. Chem. 271, 25921-25927
   Abstract »    Full Text »    PDF »
Induction of Phosphoglycerate Kinase 1Gene Expression by Hypoxia. ROLES OF ARNT AND HIF1alpha.
H. Li, H. P. Ko, and J. P. Whitlock Jr. (1996)
J. Biol. Chem. 271, 21262-21267
   Abstract »    Full Text »    PDF »
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1.
B.-H. Jiang, E. Rue, G. L. Wang, R. Roe, and G. L. Semenza (1996)
J. Biol. Chem. 271, 17771-17778
   Abstract »    Full Text »    PDF »
Cooperative Interaction between AhRbulletArnt and Sp1 for the Drug-inducible Expression of CYP1A1 Gene.
A. Kobayashi, K. Sogawa, and Y. Fujii-Kuriyama (1996)
J. Biol. Chem. 271, 12310-12316
   Abstract »    Full Text »    PDF »
Antiestrogenic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Are Mediated by Direct Transcriptional Interference with the Liganded Estrogen Receptor.
I. Kharat and F. Saatcioglu (1996)
J. Biol. Chem. 271, 10533-10537
   Abstract »    Full Text »    PDF »
Functional Characterization of DNA-binding Domains of the Subunits of the Heterodimeric Aryl Hydrocarbon Receptor Complex Imputing Novel and Canonical Basic Helix-Loop-Helix Protein-DNA Interactions.
S. G. Bacsi and O. Hankinson (1996)
J. Biol. Chem. 271, 8843-8850
   Abstract »    Full Text »    PDF »
Xenobiotic Responsive Element-mediated Transcriptional Activation in the UDP-glucuronosyltransferase Family 1 Gene Complex.
Y. Emi, S.-i. Ikushiro, and T. Iyanagi (1996)
J. Biol. Chem. 271, 3952-3958
   Abstract »    Full Text »    PDF »


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