Science 15 May 1992: Vol. 256. no. 5059, pp. 1021 - 1025 DOI: 10.1126/science.1589771

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Articles

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.

O.-H. Shin, J. Xu, J. Rizo, and T. C. Sudhof (2009)
PNAS 106, 16469-16474
 |  Abstract »  |  Full Text »  |  PDF »

The Ca2+ Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate.

A. Radhakrishnan, A. Stein, R. Jahn, and D. Fasshauer (2009)
J. Biol. Chem. 284, 25749-25760
 |  Abstract »  |  Full Text »  |  PDF »

A Pollen Protein, NaPCCP, That Binds Pistil Arabinogalactan Proteins Also Binds Phosphatidylinositol 3-Phosphate and Associates with the Pollen Tube Endomembrane System.

C. B. Lee, S. Kim, and B. McClure (2009)
Plant Physiology 149, 791-802
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Membrane Fusion: Grappling with SNARE and SM Proteins.

T. C. Sudhof and J. E. Rothman (2009)
Science 323, 474-477
 |  Abstract »  |  Full Text »  |  PDF »

Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events.

X. Xia, V. Lessmann, and T. F. J. Martin (2009)
J. Cell Sci. 122, 75-82
 |  Abstract »  |  Full Text »  |  PDF »

Arabidopsis Synaptotagmin 1 Is Required for the Maintenance of Plasma Membrane Integrity and Cell Viability.

A. L. Schapire, B. Voigt, J. Jasik, A. Rosado, R. Lopez-Cobollo, D. Menzel, J. Salinas, S. Mancuso, V. Valpuesta, F. Baluska, et al. (2008)
PLANT CELL 20, 3374-3388
 |  Abstract »  |  Full Text »  |  PDF »

Differential dependence of phasic transmitter release on synaptotagmin 1 at GABAergic and glutamatergic hippocampal synapses.

A. M. Kerr, E. Reisinger, and P. Jonas (2008)
PNAS 105, 15581-15586
 |  Abstract »  |  Full Text »  |  PDF »

Pollen Proteins Bind to the C-terminal Domain of Nicotiana alata Pistil Arabinogalactan Proteins.

C. B. Lee, K. N. Swatek, and B. McClure (2008)
J. Biol. Chem. 283, 26965-26973
 |  Abstract »  |  Full Text »  |  PDF »

Dynamics of Intracellular Oxygen in PC12 Cells upon Stimulation of Neurotransmission.

A. V. Zhdanov, M. W. Ward, J. H. M. Prehn, and D. B. Papkovsky (2008)
J. Biol. Chem. 283, 5650-5661
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons.

M. Dong, W. H. Tepp, H. Liu, E. A. Johnson, and E. R. Chapman (2007)
J. Cell Biol. 179, 1511-1522
 |  Abstract »  |  Full Text »  |  PDF »

Synaptotagmin C2A Loop 2 Mediates Ca2+-dependent SNARE Interactions Essential for Ca2+-triggered Vesicle Exocytosis.

K. L. Lynch, R.R.L. Gerona, E. C. Larsen, R. F. Marcia, J. C. Mitchell, and T.F.J. Martin (2007)
Mol. Biol. Cell 18, 4957-4968
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release.

S. Saraswati, B. Adolfsen, and J. T. Littleton (2007)
PNAS 104, 14122-14127
 |  Abstract »  |  Full Text »  |  PDF »

Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells.

K. L. Lynch and T. F. J. Martin (2007)
J. Cell Sci. 120, 617-627
 |  Abstract »  |  Full Text »  |  PDF »

C2B Polylysine Motif of Synaptotagmin Facilitates a Ca2+-independent Stage of Synaptic Vesicle Priming In Vivo.

C. A. Loewen, S.-M. Lee, Y.-K. Shin, and N. E. Reist (2006)
Mol. Biol. Cell 17, 5211-5226
 |  Abstract »  |  Full Text »  |  PDF »

Calcium signaling and exocytosis in adrenal chromaffin cells..

A. G. Garcia, A. M. Garcia-De-Diego, L. Gandia, R. Borges, and J. Garcia-Sancho (2006)
Physiol Rev 86, 1093-1131
 |  Abstract »  |  Full Text »  |  PDF »

FER-1 regulates Ca2+-mediated membrane fusion during C. elegans spermatogenesis.

N. L. Washington and S. Ward (2006)
J. Cell Sci. 119, 2552-2562
 |  Abstract »  |  Full Text »  |  PDF »

Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation.

C.-T. Wang, J. Bai, P. Y. Chang, E. R. Chapman, and M. B. Jackson (2006)
J. Physiol. 570, 295-307
 |  Abstract »  |  Full Text »  |  PDF »

Normal myoblast fusion requires myoferlin.

K. R. Doherty, A. Cave, D. B. Davis, A. J. Delmonte, A. Posey, J. U. Earley, M. Hadhazy, and E. M. McNally (2005)
Development 132, 5565-5575
 |  Abstract »  |  Full Text »  |  PDF »

Synaptic Pathology, Altered Gene Expression, and Degeneration in Photoreceptors Impacted by Drusen.

P. T. Johnson, M. N. Brown, B. C. Pulliam, D. H. Anderson, and L. V. Johnson (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4788-4795
 |  Abstract »  |  Full Text »  |  PDF »

Synaptotagmin Isoforms Couple Distinct Ranges of Ca2+, Ba2+, and Sr2+ Concentration to SNARE-mediated Membrane Fusion.

A. Bhalla, W. C. Tucker, and E. R. Chapman (2005)
Mol. Biol. Cell 16, 4755-4764
 |  Abstract »  |  Full Text »  |  PDF »

Three distinct kinetic groupings of the synaptotagmin family: Candidate sensors for rapid and delayed exocytosis.

E. Hui, J. Bai, P. Wang, M. Sugimori, R. R. Llinas, and E. R. Chapman (2005)
PNAS 102, 5210-5214
 |  Abstract »  |  Full Text »  |  PDF »

O-glycosylation is essential for intracellular targeting of synaptotagmins I and II in non-neuronal specialized secretory cells.

Y. Atiya-Nasagi, H. Cohen, O. Medalia, M. Fukudan, and R. Sagi-Eisenberg (2005)
J. Cell Sci. 118, 1363-1372
 |  Abstract »  |  Full Text »  |  PDF »

EBAG9 Adds a New Layer of Control on Large Dense-Core Vesicle Exocytosis via Interaction with Snapin.

C. Ruder, T. Reimer, I. Delgado-Martinez, R. Hermosilla, A. Engelsberg, R. Nehring, B. Dorken, and A. Rehm (2005)
Mol. Biol. Cell 16, 1245-1257
 |  Abstract »  |  Full Text »  |  PDF »

Recognition of a Basic AP-2 Binding Motif within the C2B Domain of Synaptotagmin Is Dependent on Multimerization.

I. Grass, S. Thiel, S. Honing, and V. Haucke (2004)
J. Biol. Chem. 279, 54872-54880
 |  Abstract »  |  Full Text »  |  PDF »

The Synaptotagmins: Calcium Sensors for Vesicular Trafficking.

M. Yoshihara and E. S. Montana (2004)
Neuroscientist 10, 566-574
 |  Abstract »  |  PDF »

Synaptotagmin I Synchronizes Transmitter Release in Mouse Hippocampal Neurons.

T.-i. Nishiki and G. J. Augustine (2004)
J. Neurosci. 24, 6127-6132
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of Ca2+-Regulated Membrane Fusion by Synaptotagmin and SNAREs.

W. C. Tucker, T. Weber, and E. R. Chapman (2004)
Science 304, 435-438
 |  Abstract »  |  Full Text »  |  PDF »

SNAP-23 Functions in Docking/Fusion of Granules at Low Ca2+.

E. Chieregatti, M. C. Chicka, E. R. Chapman, and G. Baldini (2004)
Mol. Biol. Cell 15, 1918-1930
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in the Effector Binding Loops in the C2A and C2B Domains of Synaptotagmin I Disrupt Exocytosis in a Nonadditive Manner.

P. Wang, C.-T. Wang, J. Bai, M. B. Jackson, and E. R. Chapman (2003)
J. Biol. Chem. 278, 47030-47037
 |  Abstract »  |  Full Text »  |  PDF »

Controversies in synaptic vesicle exocytosis.

R. M. Weimer and E. M. Jorgensen (2003)
J. Cell Sci. 116, 3661-3666
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Examining Synaptotagmin 1 Function in Dense Core Vesicle Exocytosis under Direct Control of Ca2+.

J. B. Sorensen, R. Fernandez-Chacon, T. C. Sudhof, and E. Neher (2003)
J. Gen. Physiol. 122, 265-276
 |  Abstract »  |  Full Text »  |  PDF »

Presynaptic Capacitance Measurements and Ca2+ Uncaging Reveal Submillisecond Exocytosis Kinetics and Characterize the Ca2+ Sensitivity of Vesicle Pool Depletion at a Fast CNS Synapse.

M. Wolfel and R. Schneggenburger (2003)
J. Neurosci. 23, 7059-7068
 |  Abstract »  |  Full Text »  |  PDF »

Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells.

W. C. Tucker, J. M. Edwardson, J. Bai, H.-J. Kim, T. F.J. Martin, and E. R. Chapman (2003)
J. Cell Biol. 162, 199-209
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Modulation of GABAergic Transmission by Muscarinic Receptors in a Mouse Transgenic Model of Alzheimer's Disease.

P. Zhong, Z. Gu, X. Wang, H. Jiang, J. Feng, and Z. Yan (2003)
J. Biol. Chem. 278, 26888-26896
 |  Abstract »  |  Full Text »  |  PDF »

Secretory Granule Exocytosis.

R. D. Burgoyne and A. Morgan (2003)
Physiol Rev 83, 581-632
 |  Abstract »  |  Full Text »  |  PDF »

The C2A Domain of Synaptotagmin Alters the Kinetics of Voltage-gated Ca2+ Channels Cav1.2 (Lc-type) and Cav2.3 (R-type).

R. Cohen, L. A. Elferink, and D. Atlas (2003)
J. Biol. Chem. 278, 9258-9266
 |  Abstract »  |  Full Text »  |  PDF »

Visualization of synaptotagmin I oligomers assembled onto lipid monolayers.

Y. Wu, Y. He, J. Bai, S.-R. Ji, W. C. Tucker, E. R. Chapman, and S.-F. Sui (2003)
PNAS 100, 2082-2087
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Calcium-independent Synaptotagmin Binding to Target SNAREs.

C. Rickman and B. Davletov (2003)
J. Biol. Chem. 278, 5501-5504
 |  Abstract »  |  Full Text »  |  PDF »

Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells.

M. Kreft, V. Kuster, S. Grilc, M. Rupnik, I. Milisav, and R. Zorec (2003)
Am J Physiol Cell Physiol 284, C547-C554
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms Underlying the Neuronal Calcium Sensor-1-evoked Enhancement of Exocytosis in PC12 Cells.

S. Koizumi, P. Rosa, G. B. Willars, R. A. J. Challiss, E. Taverna, M. Francolini, M. D. Bootman, P. Lipp, K. Inoue, J. Roder, et al. (2002)
J. Biol. Chem. 277, 30315-30324
 |  Abstract »  |  Full Text »  |  PDF »

Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I.

L. K. Mahal, S. M. Sequeira, J. M. Gureasko, and T. H. Sollner (2002)
J. Cell Biol. 158, 273-282
 |  Abstract »  |  Full Text »  |  PDF »

X-ray Structure of a Neuronal Complexin-SNARE Complex from Squid.

A. Bracher, J. Kadlec, H. Betz, and W. Weissenhorn (2002)
J. Biol. Chem. 277, 26517-26523
 |  Abstract »  |  Full Text »  |  PDF »

Ca2+-regulated, neurosecretory granule channel involved in release from neurohypophysial terminals.

Y. Yin, G. Dayanithi, and J. R Lemos (2002)
J. Physiol. 539, 409-418
 |  Abstract »  |  Full Text »  |  PDF »

The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis.

J. B. Sorensen, U. Matti, S.-H. Wei, R. B. Nehring, T. Voets, U. Ashery, T. Binz, E. Neher, and J. Rettig (2002)
PNAS 99, 1627-1632
 |  Abstract »  |  Full Text »  |  PDF »

Role of Electrostatic and Hydrophobic Interactions in Ca2+-Dependent Phospholipid Binding by the C2A-Domain From Synaptotagmin I.

S. H. Gerber, J. Rizo, and T. C. Sudhof (2002)
Diabetes 51, S12-18
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Synaptotagmin II restrains phorbolester-induced downregulation of protein kinase C{alpha} by diverting the kinase from a degradative pathway to the recycling endocytic compartment.

Z. Peng, E. Grimberg, and R. Sagi-Eisenberg (2002)
J. Cell Sci. 115, 3083-3092
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of a Mutant Exhibiting Conditional Sorting to Dense Core Secretory Granules in Tetrahymena thermophila.

G. R. Bowman and A. P. Turkewitz (2001)
Genetics 159, 1605-1616
 |  Abstract »  |  Full Text »  |  PDF »

Ion selectivities of the Ca2+ sensors for exocytosis in rat phaeochromocytoma cells.

T. Kishimoto, T.-T. Liu, Y. Ninomiya, H. Takagi, T. Yoshioka, G. C R Ellis-Davies, Y. Miyashita, and H. Kasai (2001)
J. Physiol. 533, 627-637
 |  Abstract »  |  Full Text »  |  PDF »

Synaptotagmin I Expression in Mast Cells of Normal Human Tissues, Systemic Mast Cell Disease, and a Human Mast Cell Leukemia Cell Line.

N. Kimura, S.-i. Shiraishi, K. Mizunashi, H. Ohtsu, and I. Kimura (2001)
J. Histochem. Cytochem. 49, 341-346
 |  Abstract »  |  Full Text »

synaptotagmin Mutants Reveal Essential Functions for the C2B Domain in Ca2+-Triggered Fusion and Recycling of Synaptic Vesicles In Vivo.

J. T. Littleton, J. Bai, B. Vyas, R. Desai, A. E. Baltus, M. B. Garment, S. D. Carlson, B. Ganetzky, and E. R. Chapman (2001)
J. Neurosci. 21, 1421-1433
 |  Abstract »  |  Full Text »  |  PDF »

The C2b Domain of Synaptotagmin Is a Ca2+-Sensing Module Essential for Exocytosis.

R. C. Desai, B. Vyas, C. A. Earles, J. T. Littleton, J. A. Kowalchyck, T. F.J. Martin, and E.R. Chapman (2000)
J. Cell Biol. 150, 1125-1136
 |  Abstract »  |  Full Text »  |  PDF »

Accumulation of Synaptosomal-Associated Protein of 25 kDa (SNAP-25) and Other Proteins Associated with the Secretory Pathway in GH4C1 Cells Upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor.

M. S. Lee, Y. L. Zhu, Z. Sun, H. Rhee, A. Jeromin, J. Roder, and P. S. Dannies (2000)
Endocrinology 141, 3485-3492
 |  Abstract »  |  Full Text »  |  PDF »

Immunoisolation of GABA-Specific Synaptic Vesicles Defines a Functionally Distinct Subset of Synaptic Vesicles.

S. Takamori, D. Riedel, and R. Jahn (2000)
J. Neurosci. 20, 4904-4911
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric green fluorescent protein-aequorin as bioluminescent Ca2+ reporters at the single-cell level.

V. Baubet, H. Le Mouellic, A. K. Campbell, E. Lucas-Meunier, P. Fossier, and P. Brulet (2000)
PNAS 97, 7260-7265
 |  Abstract »  |  Full Text »  |  PDF »

The C Terminus of SNAP25 Is Essential for Ca2+-dependent Binding of Synaptotagmin to SNARE Complexes.

R. R. L. Gerona, E. C. Larsen, J. A. Kowalchyk, and T. F. J. Martin (2000)
J. Biol. Chem. 275, 6328-6336
 |  Abstract »  |  Full Text »  |  PDF »

Ca2+ Influx Inhibits Dynamin and Arrests Synaptic Vesicle Endocytosis at the Active Zone.

M. A. Cousin and P. J. Robinson (2000)
J. Neurosci. 20, 949-957
 |  Abstract »  |  Full Text »  |  PDF »

Targeting of synaptotagmin to neurite terminals in neuronally differentiated PC12 cells.

P. Krasnov and G Enikolopov (2000)
J. Cell Sci. 113, 1389-1404
 |  Abstract »  |  PDF »

Crystal Structure of the Cytosolic C2a-C2b Domains of Synaptotagmin III: Implications for Ca+2-Independent Snare Complex Interaction.

R. B. Sutton, J. A. Ernst, and A. T. Brunger (1999)
J. Cell Biol. 147, 589-598
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Expression of Dynamin in the Chick Retinotectal System.

M. Bergmann, D. Grabs, and G. Rager (1999)
J. Histochem. Cytochem. 47, 1297-1306
 |  Abstract »  |  Full Text »

The Calcineurin-Dynamin 1 Complex as a Calcium Sensor for Synaptic Vesicle Endocytosis.

M. M. Lai, J. J. Hong, A. M. Ruggiero, P. E. Burnett, V. I. Slepnev, P. De Camilli, and S. H. Snyder (1999)
J. Biol. Chem. 274, 25963-25966
 |  Abstract »  |  Full Text »  |  PDF »

Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release.

A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff (1999)
Physiol Rev 79, 1019-1088
 |  Abstract »  |  Full Text »  |  PDF »

Functional and Biochemical Analysis of the C2 Domains of Synaptotagmin IV.

D. M. Thomas, G. D. Ferguson, H. R. Herschman, and L. A. Elferink (1999)
Mol. Biol. Cell 10, 2285-2295
 |  Abstract »  |  Full Text »

Synaptotagmin II Negatively Regulates Ca2+-triggered Exocytosis of Lysosomes in Mast Cells.

D. Baram, R. Adachi, O. Medalia, M. Tuvim, B. F. Dickey, Y. A. Mekori, and R. Sagi-Eisenberg (1999)
J. Exp. Med. 189, 1649-1658
 |  Abstract »  |  Full Text »  |  PDF »

The Synaptophysin-Synaptobrevin Complex: a Hallmark of Synaptic Vesicle Maturation.

A. Becher, A. Drenckhahn, I. Pahner, M. Margittai, R. Jahn, and G. Ahnert-Hilger (1999)
J. Neurosci. 19, 1922-1931
 |  Abstract »  |  Full Text »  |  PDF »

Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses.

L.-G. Wu, R. E. Westenbroek, J. G. G. Borst, W. A. Catterall, and B. Sakmann (1999)
J. Neurosci. 19, 726-736
 |  Abstract »  |  Full Text »  |  PDF »

Calcium-dependent Oligomerization of Synaptotagmins I and II. SYNAPTOTAGMINS I AND II ARE LOCALIZED ON THE SAME SYNAPTIC VESICLE AND HETERODIMERIZE IN THE PRESENCE OF CALCIUM.

S. L. Osborne, J. Herreros, P. I. H. Bastiaens, and G. Schiavo (1999)
J. Biol. Chem. 274, 59-66
 |  Abstract »  |  Full Text »  |  PDF »

Delineation of the Oligomerization, AP-2 Binding, and Synprint Binding Region of the C2B Domain of Synaptotagmin.

E. R. Chapman, R. C. Desai, A. F. Davis, and C. K. Tornehl (1998)
J. Biol. Chem. 273, 32966-32972
 |  Abstract »  |  Full Text »  |  PDF »

Human Phosphoinositide 3-Kinase C2beta , the Role of Calcium and the C2 Domain in Enzyme Activity.

A. Arcaro, S. Volinia, M. J. Zvelebil, R. Stein, S. J. Watton, M. J. Layton, I. Gout, K. Ahmadi, J. Downward, and M. D. Waterfield (1998)
J. Biol. Chem. 273, 33082-33090
 |  Abstract »  |  Full Text »  |  PDF »

The buffer barrier hypothesis, [Ca2+]i homogeneity, and sarcoplasmic reticulum function in swine carotid artery.

C. M Rembold and X.-L. Chen (1998)
J. Physiol. 513, 477-492
 |  Abstract »  |  Full Text »  |  PDF »

Lipid Binding Ridge on Loops 2 and 3 of the C2A Domain of Synaptotagmin I as Revealed by NMR Spectroscopy.

Y. K. Chae, F. Abildgaard, E. R. Chapman, and J. L. Markley (1998)
J. Biol. Chem. 273, 25659-25663
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Clostridium botulinum Type B Neurotoxin Associated with Infant Botulism in Japan.

S. Kozaki, Y. Kamata, T.-i. Nishiki, H. Kakinuma, H. Maruyama, H. Takahashi, T. Karasawa, K. Yamakawa, and S. Nakamura (1998)
Infect. Immun. 66, 4811-4816
 |  Abstract »  |  Full Text »  |  PDF »

Morphologically Docked Synaptic Vesicles Are Reduced in synaptotagmin Mutants of Drosophila.

N. E. Reist, J. Buchanan, J. Li, A. DiAntonio, E. M. Buxton, and T. L. Schwarz (1998)
J. Neurosci. 18, 7662-7673
 |  Abstract »  |  Full Text »  |  PDF »

TrkB and TrkC Signaling Are Required for Maturation and Synaptogenesis of Hippocampal Connections.

A. Martinez, S. Alcantara, V. Borrell, J. A. Del Rio, J. Blasi, R. Otal, N. Campos, A. Boronat, M. Barbacid, I. Silos-Santiago, et al. (1998)
J. Neurosci. 18, 7336-7350
 |  Abstract »  |  Full Text »  |  PDF »

C2-domains, Structure and Function of a Universal Ca2+-binding Domain.

J. Rizo and T. C. Sudhof (1998)
J. Biol. Chem. 273, 15879-15882
 |  Full Text »  |  PDF »

Stabilization of the Receptor Protein Tyrosine Phosphatase-Like Protein ICA512 in GH4C1 Cells upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor.

M. S. Lee, R. Dirkx Jr., M. Solimena, and P. S. Dannies (1998)
Endocrinology 139, 2727-2733
 |  Abstract »  |  Full Text »  |  PDF »

Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers.

E. R. Chapman and A. F. Davis (1998)
J. Biol. Chem. 273, 13995-14001
 |  Abstract »  |  Full Text »  |  PDF »

Functional Analysis of the C2A Domain of Synaptotagmin 1: Implications for Calcium-Regulated Secretion.

D. M. Thomas and L. A. Elferink (1998)
J. Neurosci. 18, 3511-3520
 |  Abstract »  |  Full Text »  |  PDF »

The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization.

P. J. Plant, H. Yeger, O. Staub, P. Howard, and D. Rotin (1997)
J. Biol. Chem. 272, 32329-32336
 |  Abstract »  |  Full Text »  |  PDF »

Functional Importance of Synaptobrevin and SNAP-25 during Exocytosis of Histamine by Rat Gastric Enterochromaffin-Like Cells.

B. Hohne-Zell, A. Galler, W. Schepp, M. Gratzl, and C. Prinz (1997)
Endocrinology 138, 5518-5526
 |  Abstract »  |  Full Text »  |  PDF »

Ca2+/Calmodulin Causes Rab3A to Dissociate from Synaptic Membranes.

J. B. Park, C. C. Farnsworth, and J. A. Glomset (1997)
J. Biol. Chem. 272, 20857-20865
 |  Abstract »  |  Full Text »  |  PDF »

Regulated Secretion in Platelets: Identification of Elements of the Platelet Exocytosis Machinery.

P. P. Lemons, D. Chen, A. M. Bernstein, M. K. Bennett, and S.W. Whiteheart (1997)
Blood 90, 1490-1500
 |  Abstract »  |  Full Text »  |  PDF »

The Evolutionary Pressure to Inactivate. A SUBCLASS OF SYNAPTOTAGMINS WITH AN AMINO ACID SUBSTITUTION THAT ABOLISHES Ca2+ BINDING.

C. von Poser, K. Ichtchenko, X. Shao, J. Rizo, and T. C. Sudhof (1997)
J. Biol. Chem. 272, 14314-14319
 |  Abstract »  |  Full Text »  |  PDF »

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses.

G. Schiavo, G. Stenbeck, J. E. Rothman, and T. H. Sollner (1997)
PNAS 94, 997-1001
 |  Abstract »  |  Full Text »  |  PDF »

Direct Interaction of the Rat unc-13 Homologue Munc13-1 with the N Terminus of Syntaxin.

A. Betz, M. Okamoto, F. Benseler, and N. Brose (1997)
J. Biol. Chem. 272, 2520-2526
 |  Abstract »  |  Full Text »  |  PDF »

Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions.

D. Singleton, T. Wu, and J. Castle (1997)
J. Cell Sci. 110, 2099-2107
 |  Abstract »  |  PDF »

Long Term Blockade of Serotonin Reuptake Affects Synaptotagmin Phosphorylation in the Hippocampus.

M. Popoli, A. Venegoni, C. Vocaturo, L. Buffa, J. Perez, E. Smeraldi, and G. Racagni (1997)
Mol. Pharmacol. 51, 19-26
 |  Abstract »  |  Full Text »

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin.

G. Schiavo, Q.-M. Gu, G. D. Prestwich, T. H. Sollner, and J. E. Rothman (1996)
PNAS 93, 13327-13332
 |  Abstract »  |  Full Text »  |  PDF »

Doc2 Enhances Ca[IMAGE]-dependent Exocytosis from PC12 Cells.

S. Orita, T. Sasaki, R. Komuro, G. Sakaguchi, M. Maeda, H. Igarashi, and Y. Takai (1996)
J. Biol. Chem. 271, 7257-7260
 |  Abstract »  |  Full Text »  |  PDF »

Clostridial Neurotoxins and Substrate Proteolysis in Intact Neurons.

L. C. Williamson, J. L. Halpern, C. Montecucco, J. E. Brown, and E. A. Neale (1996)
J. Biol. Chem. 271, 7694-7699
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Function for the Second C2 Domain of Synaptotagmin.

E. R. Chapman, S. An, J. M. Edwardson, and R. Jahn (1996)
J. Biol. Chem. 271, 5844-5849
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Ca[IMAGE]-dependent Properties of the First and Second C(2)-domains of Synaptotagmin I.

S. Sugita, Y. Hata, and T. C. Südhof (1996)
J. Biol. Chem. 271, 1262-1265
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Ca[IMAGE] and Sr[IMAGE] Binding Properties of Synaptotagmins.

C. Li, B. A. Davletov, and T. C. Südhof (1995)
J. Biol. Chem. 270, 24898-24902
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C(2)-domain Proteins.

N. Brose, K. Hofmann, Y. Hata, and T. C. Südhof (1995)
J. Biol. Chem. 270, 25273-25280
 |  Abstract »  |  Full Text »  |  PDF »

C2 Region-derived Peptides Inhibit Translocation and Function of beta Protein Kinase C in Vivo.

D. Ron, J. Luo, and D. Mochly-Rosen (1995)
J. Biol. Chem. 270, 24180-24187
 |  Abstract »  |  Full Text »  |  PDF »

Ca[IMAGE] Regulates the Interaction between Synaptotagmin and Syntaxin 1.

E. R. Chapman, P. I. Hanson, S. An, and R. Jahn (1995)
J. Biol. Chem. 270, 23667-23671
 |  Abstract »  |  Full Text »  |  PDF »

The Biochemistry of Neurotransmitter Secretion.

S. M. Bajjalieh and R. H. Scheller (1995)
J. Biol. Chem. 270, 1971-1974
 |  Full Text »  |  PDF »

Inhibition of regulated catecholamine secretion from PC12 cells by the Ca2+/calmodulin kinase II inhibitor KN-62.

E. Schweitzer, M. Sanderson, and C. Wasterlain (1995)
J. Cell Sci. 108, 2619-2628
 |  Abstract »  |  PDF »

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