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Science 8 May 1992:
Vol. 256. no. 5058, pp. 843 - 846
DOI: 10.1126/science.256.5058.843
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Articles

Science, Vol 256, Issue 5058, 843-846
Copyright © 1992 by American Association for the Advancement of Science

articles

Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment

JS Schneider, A Pope, K Simpson, J Taggart, MG Smith, and L DiStefano

Department of Neurology, Hahnemann University, School of Medicine, Philadelphia, PA 19102.

A parkinsonian syndrome can be produced in nonhuman primates by administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Parkinsonian-like symptoms induced acutely by MPTP were ameliorated after treatment with GM1 ganglioside, a substance shown to have neurotrophic effects on the damaged dopamine system in rodents. Treatment with GM1 ganglioside also increased striatal dopamine and metabolite levels and enhanced the dopaminergic innervation of the striatum as demonstrated by tyrosine hydroxylase immunohistochemistry. These results suggest that GM1 ganglioside may hold promise as a therapeutic agent for the treatment of Parkinson's disease.


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