Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 8 May 1992:
Vol. 256. no. 5058, pp. 839 - 842
DOI: 10.1126/science.256.5058.839
Prev | Table of Contents | Next

Articles

Science, Vol 256, Issue 5058, 839-842
Copyright © 1992 by American Association for the Advancement of Science

articles

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

LL Isom, KS De Jongh, DE Patton, BF Reber, J Offord, H Charbonneau, K Walsh, AL Goldin, and WA Catterall

Department of Pharmacology, University of Washington, Seattle 98195.

Voltage-sensitive sodium channels are responsible for the initiation and propagation of the action potential and therefore are important for neuronal excitability. Complementary DNA clones encoding the beta 1 subunit of the rat brain sodium channel were isolated by a combination of polymerase chain reaction and library screening techniques. The deduced primary structure indicates that the beta 1 subunit is a 22,851-dalton protein that contains a single putative transmembrane domain and four potential extracellular N-linked glycosylation sites, consistent with biochemical data. Northern blot analysis reveals a 1,400-nucleotide messenger RNA in rat brain, heart, skeletal muscle, and spinal cord. Coexpression of beta 1 subunits with alpha subunits increases the size of the peak sodium current, accelerates its inactivation, and shifts the voltage dependence of inactivation to more negative membrane potentials. These results indicate that the beta 1 subunit is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the rat brain sodium channel.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding.
T. Yamagishi, W. Xiong, A. Kondratiev, P. Velez, A. Mendez-Fitzwilliam, J. R. Balser, E. Marban, and G. F. Tomaselli (2009)
Mol. Pharmacol. 76, 861-871
   Abstract »    Full Text »    PDF »
A Functional Null Mutation of SCN1B in a Patient with Dravet Syndrome.
G. A. Patino, L. R. F. Claes, L. F. Lopez-Santiago, E. A. Slat, R. S. R. Dondeti, C. Chen, H. A. O'Malley, C. B. B. Gray, H. Miyazaki, N. Nukina, et al. (2009)
J. Neurosci. 29, 10764-10778
   Abstract »    Full Text »    PDF »
Genetic Modulation of Impaired Cardiac Conduction: Sodium Channel {beta}4 Subunit Missing in Action.
A. L. George Jr (2009)
Circ. Res. 104, 1238-1239
   Full Text »    PDF »
A Mutation in the {beta}3 Subunit of the Cardiac Sodium Channel Associated With Brugada ECG Phenotype.
D. Hu, H. Barajas-Martinez, E. Burashnikov, M. Springer, Y. Wu, A. Varro, R. Pfeiffer, T. T. Koopmann, J. M. Cordeiro, A. Guerchicoff, et al. (2009)
Circ Cardiovasc Genet 2, 270-278
   Abstract »    Full Text »    PDF »
Sodium Channel {beta}1 Regulatory Subunit Deficiency Reduces Pancreatic Islet Glucose-Stimulated Insulin and Glucagon Secretion.
S. J. Ernst, L. Aguilar-Bryan, and J. L. Noebels (2009)
Endocrinology 150, 1132-1139
   Abstract »    Full Text »    PDF »
Regulation of Persistent Na Current by Interactions between {beta} Subunits of Voltage-Gated Na Channels.
T. K. Aman, T. M. Grieco-Calub, C. Chen, R. Rusconi, E. A. Slat, L. L. Isom, and I. M. Raman (2009)
J. Neurosci. 29, 2027-2042
   Abstract »    Full Text »    PDF »
Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis.
S. Sokolov, T. Scheuer, and W. A. Catterall (2008)
PNAS 105, 19980-19985
   Abstract »    Full Text »    PDF »
An Emerging Role for Voltage-Gated Na+ Channels in Cellular Migration: Regulation of Central Nervous System Development and Potentiation of Invasive Cancers.
W. J. Brackenbury, M. B.A. Djamgoz, and L. L. Isom (2008)
Neuroscientist 14, 571-583
   Abstract »    PDF »
scn1bb, a Zebrafish Ortholog of SCN1B Expressed in Excitable and Nonexcitable Cells, Affects Motor Neuron Axon Morphology and Touch Sensitivity.
A. J. Fein, M. A. Wright, E. A. Slat, A. B. Ribera, and L. L. Isom (2008)
J. Neurosci. 28, 12510-12522
   Abstract »    Full Text »    PDF »
The voltage-gated Na+ channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the {beta}3 subunit.
Z.-N. Zhang, Q. Li, C. Liu, H.-B. Wang, Q. Wang, and L. Bao (2008)
J. Cell Sci. 121, 3243-3252
   Abstract »    Full Text »    PDF »
Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation.
B. W. Jarecki, P. L. Sheets, J. O. Jackson II, and T. R. Cummins (2008)
J. Physiol. 586, 4137-4153
   Abstract »    Full Text »    PDF »
Role of the amino and carboxy termini in isoform-specific sodium channel variation.
A. Lee and A. L. Goldin (2008)
J. Physiol. 586, 3917-3926
   Abstract »    Full Text »    PDF »
Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells.
S. H. Yoshimura, S. Iwasaka, W. Schwarz, and K. Takeyasu (2008)
J. Cell Sci. 121, 2159-2168
   Abstract »    Full Text »    PDF »
Postnatal Changes in the Inactivation Properties of Voltage-Gated Sodium Channels Contribute to the Mature Firing Pattern of Spinal Motoneurons.
K. P. Carlin, J. Liu, and L. M. Jordan (2008)
J Neurophysiol 99, 2864-2876
   Abstract »    Full Text »    PDF »
Properties of Wild-Type and Fluorescent Protein-Tagged Mouse Tetrodotoxin-Resistant Sodium Channel (NaV1.8) Heterologously Expressed in Rat Sympathetic Neurons.
G. G. Schofield, H. L. Puhl 3rd, and S. R. Ikeda (2008)
J Neurophysiol 99, 1917-1927
   Abstract »    Full Text »    PDF »
Voltage-Gated Na+ Channel {beta}1 Subunit-Mediated Neurite Outgrowth Requires Fyn Kinase and Contributes to Postnatal CNS Development In Vivo.
W. J. Brackenbury, T. H. Davis, C. Chen, E. A. Slat, M. J. Detrow, T. L. Dickendesher, B. Ranscht, and L. L. Isom (2008)
J. Neurosci. 28, 3246-3256
   Abstract »    Full Text »    PDF »
Sites and Molecular Mechanisms of Modulation of NaV1.2 Channels by Fyn Tyrosine Kinase.
D. Beacham, M. Ahn, W. A. Catterall, and T. Scheuer (2007)
J. Neurosci. 27, 11543-11551
   Abstract »    Full Text »    PDF »
Modulatory Proteins Can Rescue a Trafficking Defective Epileptogenic Nav1.1 Na+ Channel Mutant.
R. Rusconi, P. Scalmani, R. R. Cassulini, G. Giunti, A. Gambardella, S. Franceschetti, G. Annesi, E. Wanke, and M. Mantegazza (2007)
J. Neurosci. 27, 11037-11046
   Abstract »    Full Text »    PDF »
SCN4B-Encoded Sodium Channel 4 Subunit in Congenital Long-QT Syndrome.
A. Medeiros-Domingo, T. Kaku, D. J. Tester, P. Iturralde-Torres, A. Itty, B. Ye, C. Valdivia, K. Ueda, S. Canizales-Quinteros, M. T. Tusie-Luna, et al. (2007)
Circulation 116, 134-142
   Abstract »    Full Text »    PDF »
Developmental Changes in Two Voltage-Dependent Sodium Currents in Utricular Hair Cells.
J. R. A. Wooltorton, S. Gaboyard, K. M. Hurley, S. D. Price, J. L. Garcia, M. Zhong, A. Lysakowski, and R. A. Eatock (2007)
J Neurophysiol 97, 1684-1704
   Abstract »    Full Text »    PDF »
A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation.
W. Xiong, Y. Z. Farukhi, Y. Tian, D. DiSilvestre, R. A. Li, and G. F. Tomaselli (2006)
J. Physiol. 576, 739-754
   Abstract »    Full Text »    PDF »
Isoform-specific Effects of the beta2 Subunit on Voltage-gated Sodium Channel Gating.
D. Johnson and E. S. Bennett (2006)
J. Biol. Chem. 281, 25875-25881
   Abstract »    Full Text »    PDF »
Overview of Molecular Relationships in the Voltage-Gated Ion Channel Superfamily.
F. H. Yu, V. Yarov-Yarovoy, G. A. Gutman, and W. A. Catterall (2005)
Pharmacol. Rev. 57, 387-395
   Full Text »    PDF »
Upregulation of the Voltage-Gated Sodium Channel {beta}2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons.
M. Pertin, R.-R. Ji, T. Berta, A. J. Powell, L. Karchewski, S. N. Tate, L. L. Isom, C. J. Woolf, N. Gilliard, D. R. Spahn, et al. (2005)
J. Neurosci. 25, 10970-10980
   Abstract »    Full Text »    PDF »
Molecular Physiology of Cardiac Repolarization.
J. M. Nerbonne and R. S. Kass (2005)
Physiol Rev 85, 1205-1253
   Abstract »    Full Text »    PDF »
Sodium Channel Inactivation: Molecular Determinants and Modulation.
W. Ulbricht (2005)
Physiol Rev 85, 1271-1301
   Abstract »    Full Text »    PDF »
Functional genomics of cardiac ion channel genes.
S. Demolombe, C. Marionneau, S. Le Bouter, F. Charpentier, and D. Escande (2005)
Cardiovasc Res 67, 438-447
   Abstract »    Full Text »    PDF »
Sodium channels as macromolecular complexes: Implications for inherited arrhythmia syndromes.
L.S. Meadows and L.L. Isom (2005)
Cardiovasc Res 67, 448-458
   Abstract »    Full Text »    PDF »
Temporal and spatial expression pattern of {beta}1 sodium channel subunit during heart development.
J. N. Dominguez, F. Navarro, D. Franco, R. P. Thompson, and A. E. Aranega (2005)
Cardiovasc Res 65, 842-850
   Abstract »    Full Text »    PDF »
Specific Modulation of Na+ Channels in Hippocampal Neurons by Protein Kinase C{epsilon}.
Y. Chen, A. R. Cantrell, R. O. Messing, T. Scheuer, and W. A. Catterall (2005)
J. Neurosci. 25, 507-513
   Abstract »    Full Text »    PDF »
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart.
C. Marionneau, B. Couette, J. Liu, H. Li, M. E. Mangoni, J. Nargeot, M. Lei, D. Escande, and S. Demolombe (2005)
J. Physiol. 562, 223-234
   Abstract »    Full Text »    PDF »
Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles.
V. Haufe, J.M. Cordeiro, T. Zimmer, Y.S. Wu, S. Schiccitano, K. Benndorf, and R. Dumaine (2005)
Cardiovasc Res 65, 117-127
   Abstract »    Full Text »    PDF »
Heterophilic Interactions of Sodium Channel {beta}1 Subunits with Axonal and Glial Cell Adhesion Molecules.
D. P. McEwen and L. L. Isom (2004)
J. Biol. Chem. 279, 52744-52752
   Abstract »    Full Text »    PDF »
D2 Dopamine Receptor-Mediated Modulation of Voltage-Dependent Na+ Channels Reduces Autonomous Activity in Striatal Cholinergic Interneurons.
N. Maurice, J. Mercer, C. S. Chan, S. Hernandez-Lopez, J. Held, T. Tkatch, and D. J. Surmeier (2004)
J. Neurosci. 24, 10289-10301
   Abstract »    Full Text »    PDF »
The Sialic Acid Component of the {beta}1 Subunit Modulates Voltage-gated Sodium Channel Function.
D. Johnson, M. L. Montpetit, P. J. Stocker, and E. S. Bennett (2004)
J. Biol. Chem. 279, 44303-44310
   Abstract »    Full Text »    PDF »
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis.
F. H. Yu and W. A. Catterall (2004)
Sci. STKE 2004, re15
   Abstract »    Full Text »    PDF »
Contactin Associates with Sodium Channel Nav1.3 in Native Tissues and Increases Channel Density at the Cell Surface.
B. S. Shah, A. M. Rush, S. Liu, L. Tyrrell, J. A. Black, S. D. Dib-Hajj, and S. G. Waxman (2004)
J. Neurosci. 24, 7387-7399
   Abstract »    Full Text »    PDF »
Mice Lacking Sodium Channel {beta}1 Subunits Display Defects in Neuronal Excitability, Sodium Channel Expression, and Nodal Architecture.
C. Chen, R. E. Westenbroek, X. Xu, C. A. Edwards, D. R. Sorenson, Y. Chen, D. P. McEwen, H. A. O'Malley, V. Bharucha, L. S. Meadows, et al. (2004)
J. Neurosci. 24, 4030-4042
   Abstract »    Full Text »    PDF »
Sodium Channel {beta}1 Subunit-mediated Modulation of Nav1.2 Currents and Cell Surface Density Is Dependent on Interactions with Contactin and Ankyrin.
D. P. McEwen, L. S. Meadows, C. Chen, V. Thyagarajan, and L. L. Isom (2004)
J. Biol. Chem. 279, 16044-16049
   Abstract »    Full Text »    PDF »
Distinct Subcellular Localization of Different Sodium Channel {alpha} and {beta} Subunits in Single Ventricular Myocytes From Mouse Heart.
S. K.G. Maier, R. E. Westenbroek, K. A. McCormick, R. Curtis, T. Scheuer, and W. A. Catterall (2004)
Circulation 109, 1421-1427
   Abstract »    Full Text »    PDF »
A Nonsense Mutation of the Sodium Channel Gene SCN2A in a Patient with Intractable Epilepsy and Mental Decline.
K. Kamiya, M. Kaneda, T. Sugawara, E. Mazaki, N. Okamura, M. Montal, N. Makita, M. Tanaka, K. Fukushima, T. Fujiwara, et al. (2004)
J. Neurosci. 24, 2690-2698
   Abstract »    Full Text »    PDF »
Production of Resurgent Current in NaV1.6-Null Purkinje Neurons by Slowing Sodium Channel Inactivation with {beta}-Pompilidotoxin.
T. M. Grieco and I. M. Raman (2004)
J. Neurosci. 24, 35-42
   Abstract »    Full Text »    PDF »
Altered Gating and Local Anesthetic Block Mediated by Residues in the I-S6 and II-S6 Transmembrane Segments of Voltage-Dependent Na+ Channels.
A. Kondratiev and G. F. Tomaselli (2003)
Mol. Pharmacol. 64, 741-752
   Abstract »    Full Text »    PDF »
Molecular Motions of the Outer Ring of Charge of the Sodium Channel: Do They Couple to Slow Inactivation?.
W. Xiong, R. A. Li, Y. Tian, and G. F. Tomaselli (2003)
J. Gen. Physiol. 122, 323-332
   Abstract »    Full Text »    PDF »
Sodium Channel {beta}4, a New Disulfide-Linked Auxiliary Subunit with Similarity to {beta}2.
F. H. Yu, R. E. Westenbroek, I. Silos-Santiago, K. A. McCormick, D. Lawson, P. Ge, H. Ferriera, J. Lilly, P. S. DiStefano, W. A. Catterall, et al. (2003)
J. Neurosci. 23, 7577-7585
   Abstract »    Full Text »    PDF »
Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel {alpha} Subunits.
G. Lemaillet, B. Walker, and S. Lambert (2003)
J. Biol. Chem. 278, 27333-27339
   Abstract »    Full Text »    PDF »
Mechanism linking NMDA receptor activation to modulation of voltage-gated sodium current in distal retina.
S. F. Davis and C. L. Linn (2003)
Am J Physiol Cell Physiol 284, C1193-C1204
   Abstract »    Full Text »    PDF »
A negatively charged residue in the outer mouth of rat sodium channel determines the gating kinetics of the channel.
Z. Zhang, Y. Xu, P. H. Dong, D. Sharma, and N. Chiamvimonvat (2003)
Am J Physiol Cell Physiol 284, C1247-C1254
   Abstract »    Full Text »    PDF »
Functional and Biochemical Analysis of a Sodium Channel beta 1 Subunit Mutation Responsible for Generalized Epilepsy with Febrile Seizures Plus Type 1.
L. S. Meadows, J. Malhotra, A. Loukas, V. Thyagarajan, K. A. Kazen-Gillespie, M. C. Koopman, S. Kriegler, L. L. Isom, and D. S. Ragsdale (2002)
J. Neurosci. 22, 10699-10709
   Abstract »    Full Text »    PDF »
The Human Heart and Rat Brain IIA Na+ Channels Interact with Different Molecular Regions of the {beta}1 Subunit.
T. Zimmer and K. Benndorf (2002)
J. Gen. Physiol. 120, 887-895
   Abstract »    Full Text »    PDF »
Interaction between Fast and Ultra-slow Inactivation in the Voltage-gated Sodium Channel. DOES THE INACTIVATION GATE STABILIZE THE CHANNEL STRUCTURE?.
K. Hilber, W. Sandtner, O. Kudlacek, B. Schreiner, I. Glaaser, W. Schutz, H. A. Fozzard, S. C. Dudley, and H. Todt (2002)
J. Biol. Chem. 277, 37105-37115
   Abstract »    Full Text »    PDF »
Interaction of the Nav1.2a Subunit of the Voltage-dependent Sodium Channel with Nodal AnkyrinG. IN VITRO MAPPING OF THE INTERACTING DOMAINS AND ASSOCIATION IN SYNAPTOSOMES.
M. Bouzidi, N. Tricaud, P. Giraud, E. Kordeli, G. Caillol, C. Deleuze, F. Couraud, and G. Alcaraz (2002)
J. Biol. Chem. 277, 28996-29004
   Abstract »    Full Text »    PDF »
Structural Requirements for Interaction of Sodium Channel beta 1 Subunits with Ankyrin.
J. D. Malhotra, M. C. Koopmann, K. A. Kazen-Gillespie, N. Fettman, M. Hortsch, and L. L. Isom (2002)
J. Biol. Chem. 277, 26681-26688
   Abstract »    Full Text »    PDF »
Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels.
A. Scholz (2002)
Br. J. Anaesth. 89, 52-61
   Abstract »    Full Text »    PDF »
Genetics of Epilepsy.
L. J. Willmore and Y. Ueda (2002)
J Child Neurol 17, S18-S27
   Abstract »    PDF »
The sodium channel {beta}-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart.
A. I Fahmi, M. Patel, E. B Stevens, A. L Fowden, J. E. John III, K. Lee, R. Pinnock, K. Morgan, A. P Jackson, and J. I Vandenberg (2001)
J. Physiol. 537, 693-700
   Abstract »    Full Text »    PDF »
Direct Interaction with Contactin Targets Voltage-gated Sodium Channel Nav1.9/NaN to the Cell Membrane.
C.-j. Liu, S. D. Dib-Hajj, J. A. Black, J. Greenwood, Z. Lian, and S. G. Waxman (2001)
J. Biol. Chem. 276, 46553-46561
   Abstract »    Full Text »    PDF »
Gating Properties of Nav1.7 and Nav1.8 Peripheral Nerve Sodium Channels.
K. Vijayaragavan, M. E. O'Leary, and M. Chahine (2001)
J. Neurosci. 21, 7909-7918
   Abstract »    Full Text »    PDF »
Molecular Architecture of the Voltage-Dependent Na Channel: Functional Evidence for {alpha} Helices in the Pore.
T. Yamagishi, R. A. Li, K. Hsu, E. Marban, and G. F. Tomaselli (2001)
J. Gen. Physiol. 118, 171-182
   Abstract »    Full Text »    PDF »
Developmental expression of the novel voltage-gated sodium channel auxiliary subunit {beta}3, in rat CNS.
B S Shah, E B Stevens, R D Pinnock, A K Dixon, and K Lee (2001)
J. Physiol. 534, 763-776
   Abstract »    Full Text »    PDF »
Sodium channel {beta}1 and {beta}3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain.
C. F. Ratcliffe, R. E. Westenbroek, R. Curtis, and W. A. Catterall (2001)
J. Cell Biol. 154, 427-434
   Abstract »    Full Text »    PDF »
Skeletal muscle disuse induces fibre type-dependent enhancement of Na+ channel expression.
J.-F. Desaphy, S. Pierno, C. Leoty, A. L. George Jr, A. De Luca, and D. C. Camerino (2001)
Brain 124, 1100-1113
   Abstract »    Full Text »    PDF »
Characterization of Sodium Channel {{alpha}}- and {beta}-Subunits in Rat and Mouse Cardiac Myocytes.
J. D. Malhotra, C. Chen, I. Rivolta, H. Abriel, R. Malhotra, L. N. Mattei, F. C. Brosius, R. S. Kass, and L. L. Isom (2001)
Circulation 103, 1303-1310
   Abstract »    Full Text »    PDF »
Sodium Channel {beta} Subunits: Anything but Auxiliary.
L. L. Isom (2001)
Neuroscientist 7, 42-54
   Abstract »    PDF »
Cardiac sodium channel and inherited arrhythmia syndromes.
C. R Bezzina, M. B Rook, and A. A.M Wilde (2001)
Cardiovasc Res 49, 257-271
   Full Text »    PDF »
Coexpression with beta 1-subunit modifies the kinetics and fatty acid block of hH1alpha Na+ channels.
Y.-F. Xiao, S. N. Wright, G. K. Wang, J. P. Morgan, and A. Leaf (2000)
Am J Physiol Heart Circ Physiol 279, H35-H46
   Abstract »    Full Text »    PDF »
Coregulation of Voltage-Dependent Kinetics of Na+ and K+ Currents in Electric Organ.
M. L. McAnelly and H. H. Zakon (2000)
J. Neurosci. 20, 3408-3414
   Abstract »    Full Text »    PDF »
Sodium Channel beta Subunits Mediate Homophilic Cell Adhesion and Recruit Ankyrin to Points of Cell-Cell Contact.
J. D. Malhotra, K. Kazen-Gillespie, M. Hortsch, and L. L. Isom (2000)
J. Biol. Chem. 275, 11383-11388
   Abstract »    Full Text »    PDF »
Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels.
B. Sampo, N. Tricaud, C. Leveque, M. Seagar, F. Couraud, and B. Dargent (2000)
PNAS 97, 3666-3671
   Abstract »    Full Text »    PDF »
Pathobiology of Visceral Pain: Molecular Mechanisms and Theraputic Implications. I. Cellular and molecular biology of sodium channel beta -subunits: therapeutic implications for pain?.
L. L. Isom (2000)
Am J Physiol Gastrointest Liver Physiol 278, G349-G353
   Abstract »    Full Text »    PDF »
Cloning, Localization, and Functional Expression of Sodium Channel beta 1A Subunits.
K. A. Kazen-Gillespie, D. S. Ragsdale, M. R. D'Andrea, L. N. Mattei, K. E. Rogers, and L. L. Isom (2000)
J. Biol. Chem. 275, 1079-1088
   Abstract »    Full Text »    PDF »
Cardiac Na+ Channel Dysfunction in Brugada Syndrome Is Aggravated by {beta}1-Subunit.
N. Makita, N. Shirai, D. W. Wang, K. Sasaki, A. L. George Jr, M. Kanno, and A. Kitabatake (2000)
Circulation 101, 54-60
   Abstract »    Full Text »    PDF »
The Extracellular Domain of the beta 1 Subunit Is Both Necessary and Sufficient for beta 1-like Modulation of Sodium Channel Gating.
K. A. McCormick, J. Srinivasan, K. White, T. Scheuer, and W. A. Catterall (1999)
J. Biol. Chem. 274, 32638-32646
   Abstract »    Full Text »    PDF »
Functional Roles of the Extracellular Segments of the Sodium Channel alpha Subunit in Voltage-dependent Gating and Modulation by beta 1 Subunits.
Y. Qu, J. C. Rogers, S.-F. Chen, K. A. McCormick, T. Scheuer, and W. A. Catterall (1999)
J. Biol. Chem. 274, 32647-32654
   Abstract »    Full Text »    PDF »
Voltage-Gated Ion Channels and Hereditary Disease.
F. Lehmann-Horn and K. Jurkat-Rott (1999)
Physiol Rev 79, 1317-1372
   Abstract »    Full Text »    PDF »
Tenascin-R Is a Functional Modulator of Sodium Channel beta Subunits.
Z.-C. Xiao, D. S. Ragsdale, J. D. Malhotra, L. N. Mattei, P. E. Braun, M. Schachner, and L. L. Isom (1999)
J. Biol. Chem. 274, 26511-26517
   Abstract »    Full Text »    PDF »
High Conductance Sustained Single-Channel Activity Responsible for the Low-Threshold Persistent Na+ Current in Entorhinal Cortex Neurons.
J. Magistretti, D. S. Ragsdale, and A. Alonso (1999)
J. Neurosci. 19, 7334-7341
   Abstract »    Full Text »    PDF »
Local Anesthetic Anchoring to Cardiac Sodium Channels : Implications Into Tissue-Selective Drug Targeting.
R. A. Li, R. G. Tsushima, K. Himmeldirk, D. S. Dime, and P. H. Backx (1999)
Circ. Res. 85, 88-98
   Abstract »    Full Text »    PDF »
Structure and function of the cardiac sodium channels.
J. R. Balser (1999)
Cardiovasc Res 42, 327-328
   Abstract »    Full Text »    PDF »
{beta}-adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+: Na+ selectivity.
R. Chandra, V. S. Chauhan, C.F. Starmer, and A. O. Grant (1999)
Cardiovasc Res 42, 490-502
   Abstract »    Full Text »    PDF »
Whether "Slip-Mode Conductance" Occurs.
H. B. Nuss, E. Marbán;, C. W. Balke, L. Goldman, R. Aggarwal, S. R. Shorofsky;, J. dos Santos Cruz, L. F. Santana, C. A. Frederick, L. L. Isom, et al. (1999)
Science 284, 711a-711
   Full Text »
Ion channel genes and human neurological disease: Recent progress, prospects, and challenges.
E. C. Cooper and L. Y. Jan (1999)
PNAS 96, 4759-4766
   Abstract »    Full Text »    PDF »
cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS.
E M Fitzgerald, K Okuse, J N Wood, A C Dolphin, and S J Moss (1999)
J. Physiol. 516, 433-446
   Abstract »    Full Text »    PDF »
The {beta} Subunit Increases the Ca2+ Sensitivity of Large Conductance Ca2+-activated Potassium Channels by Retaining the Gating in the Bursting States.
C. M. Nimigean and K. L. Magleby (1999)
J. Gen. Physiol. 113, 425-440
   Abstract »    Full Text »    PDF »
Molecular and functional remodeling of electrogenic membrane of hypothalamic neurons in response to changes in their input.
M. Tanaka, T. R. Cummins, K. Ishikawa, J. A. Black, Y. Ibata, and S. G. Waxman (1999)
PNAS 96, 1088-1093
   Abstract »    Full Text »    PDF »
Hyperkalemic periodic paralysis M1592V mutation modifies activation in human skeletal muscle Na+ channel.
C. V. Rojas, A. Neely, G. Velasco-Loyden, V. Palma, and M. Kukuljan (1999)
Am J Physiol Cell Physiol 276, C259-C266
   Abstract »    Full Text »    PDF »
Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R.
J. Srinivasan, M. Schachner, and W. A. Catterall (1998)
PNAS 95, 15753-15757
   Abstract »    Full Text »    PDF »
Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat {micro}1 skeletal muscle sodium channel.
N. G Kambouris, L. A Hastings, S. Stepanovic, E. Marban, G. F Tomaselli, and J. R Balser (1998)
J. Physiol. 512, 693-705
   Abstract »    Full Text »    PDF »
Lidocaine Action on Na+ Currents in Ventricular Myocytes From the Epicardial Border Zone of the Infarcted Heart.
J. Pu, J. R. Balser, and P. A. Boyden (1998)
Circ. Res. 83, 431-440
   Abstract »    Full Text »    PDF »
Modulation of Cardiac Na+ Current Phenotype by ß1-Subunit Expression.
S. Kupershmidt, T. Yang, and D. M. Roden (1998)
Circ. Res. 83, 441-447
   Abstract »    Full Text »    PDF »
Functional Analysis of the Mouse Scn8a Sodium Channel.
M. R. Smith, R. D. Smith, N. W. Plummer, M. H. Meisler, and A. L. Goldin (1998)
J. Neurosci. 18, 6093-6102
   Abstract »    Full Text »    PDF »
Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation.
R. L. Sah, R. G. Tsushima, and P. H. Backx (1998)
Am J Physiol Cell Physiol 275, C389-C400
   Abstract »    Full Text »    PDF »
Novel LQT-3 Mutation Affects Na+ Channel Activity Through Interactions Between {alpha}- and ß1-Subunits.
R. H. An, X. L. Wang, B. Kerem, J. Benhorin, A. Medina, M. Goldmit, and R. S. Kass (1998)
Circ. Res. 83, 141-146
   Abstract »    Full Text »    PDF »
Structure and function of voltage-gated sodium channels.
E. Marban, T. Yamagishi, and G. F Tomaselli (1998)
J. Physiol. 508, 647-657
   Abstract »    Full Text »    PDF »
Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells.
R. Chandra, C. F. Starmer, and A. O. Grant (1998)
Am J Physiol Heart Circ Physiol 274, H1643-H1654
   Abstract »    Full Text »    PDF »
Ion Channels and Early Development of Neural Cells.
K. TAKAHASHI and Y. OKAMURA (1998)
Physiol Rev 78, 307-337
   Abstract »    Full Text »    PDF »
mRNAs coding for neurotransmitter receptors and voltage-gated sodium channels in the adult rabbit visual cortex after monocular deafferentiation.
Q.-T. Nguyen, C. Matute, and R. Miledi (1998)
PNAS 95, 3257-3262
   Abstract »    Full Text »    PDF »
Molecular Determinants of Na+ Channel Function in the Extracellular Domain of the beta 1 Subunit.
K. A. McCormick, L. L. Isom, D. Ragsdale, D. Smith, T. Scheuer, and W. A. Catterall (1998)
J. Biol. Chem. 273, 3954-3962
   Abstract »    Full Text »    PDF »
Functional Analysis of the Rat I Sodium Channel in Xenopus Oocytes.
R. D. Smith and A. L. Goldin (1998)
J. Neurosci. 18, 811-820
   Abstract »    Full Text »    PDF »
A Critical Role for the S4-S5 Intracellular Loop in Domain IV of the Sodium Channel alpha -Subunit in Fast Inactivation.
J. C. McPhee, D. S. Ragsdale, T. Scheuer, and W. A. Catterall (1998)
J. Biol. Chem. 273, 1121-1129
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)