Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
AAAS Promotion

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 May 1992:
Vol. 256. no. 5058, pp. 808 - 813
DOI: 10.1126/science.1589762

Articles

Science, Vol 256, Issue 5058, 808-813
Copyright © 1992 by American Association for the Advancement of Science


articles

Human gene therapy

WF Anderson

Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Human gene therapy is a procedure that is being used in an attempt to treat genetic and other diseases. Eleven clinical protocols are under way at the present time, each with scientific and clinical objectives. Human genetic engineering raises unique safety, social, and ethical concerns.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gene therapy in clinical medicine.
S M Selkirk (2004)
Postgrad. Med. J. 80, 560-570
   Abstract »    Full Text »    PDF »
Gene Transfer of Human Hepatocyte Growth Factor into Rat Skin Wounds Mediated by Liposomes Coated with the Sendai Virus (Hemagglutinating Virus of Japan).
K. Nakanishi, M. Uenoyama, N. Tomita, R. Morishita, Y. Kaneda, T. Ogihara, K. Matsumoto, T. Nakamura, A. Maruta, S. Matsuyama, et al. (2002)
Am. J. Pathol. 161, 1761-1772
   Abstract »    Full Text »    PDF »
Gene Therapy in Orthopaedic Surgery.
D. Hannallah, B. Peterson, J. R. Lieberman, F. H. Fu, and J. Huard (2002)
J. Bone Joint Surg. Am. 84, 1046-1061
   Full Text »
Molecular Imaging and Gene Therapy.
C. Nichol and E. E. Kim (2001)
J. Nucl. Med. 42, 1368-1374
   Abstract »    Full Text »    PDF »
Gene Transfer of Heat-Shock Protein 70 Reduces Infarct Size In Vivo After Ischemia/Reperfusion in the Rabbit Heart.
S. Okubo, O. Wildner, M. R. Shah, J. C. Chelliah, M. L. Hess, and R. C. Kukreja (2001)
Circulation 103, 877-881
   Abstract »    Full Text »    PDF »
Percutaneous in vivo gene transfer to the peripheral lungs using plasmid-liposome complexes.
H. Saito, H. Nakamura, S. Kato, S. Inoue, M. Inage, M. Ito, and H. Tomoike (2000)
Am J Physiol Lung Cell Mol Physiol 279, L651-L657
   Abstract »    Full Text »    PDF »
Expression of Herpes Simplex Virus ICP47 and Human Cytomegalovirus US11 Prevents Recognition of Transgene Products by CD8+ Cytotoxic T Lymphocytes.
C. Berger, S. Xuereb, D. C. Johnson, K. S. Watanabe, H.-P. Kiem, P. D. Greenberg, and S. R. Riddell (2000)
J. Virol. 74, 4465-4473
   Abstract »    Full Text »
Gene Therapy for Lung Disease: Hype or Hope?.
S. M. Albelda, R. Wiewrodt, and J. B. Zuckerman (2000)
Ann Intern Med 132, 649-660
   Abstract »    Full Text »    PDF »
Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121.
L. Y. Lee, S. R. Patel, N. R. Hackett, C. A. Mack, D. R. Polce, T. El-Sawy, R. Hachamovitch, P. Zanzonico, T. A. Sanborn, M. Parikh, et al. (2000)
Ann. Thorac. Surg. 69, 14-23
   Abstract »    Full Text »    PDF »
Mutations in the Retinoblastoma-related Gene RB2/p130 in Lung Tumors and Suppression of Tumor Growth in Vivo by Retrovirus-mediated Gene Transfer.
P. P. Claudio, C. M. Howard, C. Pacilio, C. Cinti, G. Romano, C. Minimo, N. M. Maraldi, J. D. Minna, L. Gelbert, L. Leoncini, et al. (2000)
Cancer Res. 60, 372-382
   Abstract »    Full Text »
Prospects for in Utero Human Gene Therapy.
E. D. Zanjani and W. F. Anderson (1999)
Science 285, 2084-2088
   Abstract »    Full Text »
Highly efficient liposome-mediated gene transfer of inducible nitric oxide synthase in vivo and in vitro in vascular smooth muscle cells.
K. Veit, J.-P. Boissel, M. Buerke, T. Grosser, J. Meyer, and H. Darius (1999)
Cardiovasc Res 43, 808-822
   Abstract »    Full Text »    PDF »
EXOGENOUS CONTROL OF CARDIAC GENE THERAPY: EVIDENCE OF REGULATED MYOCARDIAL TRANSGENE EXPRESSION AFTER ADENOVIRUS AND ADENO-ASSOCIATED VIRUS TRANSFER OF EXPRESSION CASSETTES CONTAINING CORTICOSTEROID RESPONSE ELEMENT PROMOTERS.
L. Y. Lee, X. Zhou, D. R. Polce, T. El-Sawy, S. R. Patel, G. D. Thakker, K. Narumi, R. G. Crystal, and T. K. Rosengart (1999)
J. Thorac. Cardiovasc. Surg. 118, 26-25
   Abstract »    Full Text »    PDF »
Molecular advances in cardiac and cardiovascular disease.
A. Basile-Borgia, J. H Abel, and H. Mahloogi (1999)
Perfusion 14, 89-99
   Abstract »    PDF »
Site-Specific Integration in Mammalian Cells Mediated by a New Hybrid Baculovirus-Adeno-Associated Virus Vector.
F. Palombo, A. Monciotti, A. Recchia, R. Cortese, G. Ciliberto, and N. La Monica (1998)
J. Virol. 72, 5025-5034
   Abstract »    Full Text »    PDF »
Delayed Targeting of Cytokine-Nonresponsive Human Bone Marrow CD34+ Cells With Retrovirus-Mediated Gene Transfer Enhances Transduction Efficiency and Long-Term Expression of Transduced Genes.
P. Veena, C. M. Traycoff, D. A. Williams, J. McMahel, S. Rice, K. Cornetta, and E. F. Srour (1998)
Blood 91, 3693-3701
   Abstract »    Full Text »    PDF »
Gene Therapy for Infectious Diseases.
B. A. Bunnell and R. A. Morgan (1998)
Clin. Microbiol. Rev. 11, 42-56
   Abstract »    Full Text »    PDF »
Severe Combined Immunodeficiency Mice Engrafted With Human T Cells, B Cells, and Myeloid Cells After Transplantation With Human Fetal Bone Marrow or Liver Cells and Implanted With Human Fetal Thymus: A Model for Studying Human Gene Therapy.
S. Yurasov, T. R. Kollmann, A. Kim, C. A. Raker, M. Hachamovitch, F. Wong-Staal, and H. Goldstein (1997)
Blood 89, 1800-1810
   Abstract »    Full Text »    PDF »
Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery.
I. van der Woude, A. Wagenaar, A. A. P. Meekel, M. B. A. ter Beest, M. H. J. Ruiters, J. B. F. N. Engberts, and D. Hoekstra (1997)
PNAS 94, 1160-1165
   Abstract »    Full Text »    PDF »
A Novel Herpes Vector for the High-Efficiency Transduction of Normal and Malignant Human Hematopoietic Cells.
D. Dilloo, D. Rill, C. Entwistle, M. Boursnell, W. Zhong, W. Holden, M. Holladay, S. Inglis, and M. Brenner (1997)
Blood 89, 119-127
   Abstract »    Full Text »    PDF »
Avoidance of Immune Response Prolongs Expression of Genes Delivered to the Adult Rat Myocardium by Replication-Defective Adenovirus.
M. J. Quinones, J. Leor, R. A. Kloner, M. Ito, M. Patterson, W. F. Witke, and L. Kedes (1996)
Circulation 94, 1394-1401
   Abstract »    Full Text »
Heterogeneity of Adenovirus-Mediated Gene Transfer in Cultured Thoracic Aorta and Renal Artery of Rats.
A. Yao and D. H. Wang (1995)
Hypertension 26, 1046-1050
   Abstract »    Full Text »
Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA- Immunodeficient Patients.
C. Bordignon, L. D. Notarangelo, N. Nobili, G. Ferrari, G. Casorati, P. Panina, E. Mazzolari, D. Maggioni, C. Rossi, P. Servida, et al. (1995)
Science 270, 470-475
   Abstract »    PDF »
Innovation in the pharmaceutical industry.
R Sykes (1994)
BMJ 309, 422-3
   Full Text »
Regulation of Somatic-Cell Therapy and Gene Therapy by the Food and Drug Administration.
D. A. Kessler, J. P. Siegel, P. D. Noguchi, K. C. Zoon, K. L. Feiden, and J. Woodcock (1993)
N. Engl. J. Med. 329, 1169-1173
   Full Text »
New startups move in as gene therapy goes commercial.
E Culotta (1993)
Science 260, 914-915
   PDF »
The basic science of gene therapy.
R. Mulligan (1993)
Science 260, 926-932
   Abstract »    PDF »
Structure-Based Strategies for Drug Design and Discovery.
I. D. Kuntz (1992)
Science 257, 1078-1082
   Abstract »    PDF »
Genetically engineered macrophages expressing IFN-gamma restore alveolar immune function in scid mice.
M. Wu, S. Hussain, Y.-H. He, R. Pasula, P. A. Smith, and W. J. Martin II (2001)
PNAS 98, 14589-14594
   Abstract »    Full Text »    PDF »



ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)