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Science 1 May 1992:
Vol. 256. no. 5057, pp. 670 - 673
DOI: 10.1126/science.1316633
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Articles

Science, Vol 256, Issue 5057, 670-673
Copyright © 1992 by American Association for the Advancement of Science

articles

Enhanced degradation of the ferritin repressor protein during induction of ferritin messenger RNA translation

LS Goessling, S Daniels-McQueen, M Bhattacharyya-Pakrasi, JJ Lin, and RE Thach

Department of Biology, Washington University, St. Louis, MO 63130.

Induction of ferritin synthesis in cultured cells by heme or iron is accompanied by degradation of the ferritin repressor protein (FRP). Intermediates in the degradative pathway apparently include FRP covalently linked in larger aggregates. The effect of iron on FRP degradation is enhanced by porphyrin precursors but is decreased by inhibitors of porphyrin synthesis, which implies that heme is an active agent. These results suggest that translational induction in this system may be caused by enhanced repressor degradation. While unique among translational regulatory systems, this process is common to a variety of other biosynthetic control mechanisms.


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