Science 1 May 1992: Vol. 256. no. 5057, pp. 668 - 670 DOI: 10.1126/science.1350108

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Articles

Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi.

K. J. Ritchie, S. Walsh, O. J. Sansom, C. J. Henderson, and C. R. Wolf (2009)
PNAS 106, 20859-20864
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Fat-Influenced Development of Colon Neoplasia in ApcMin Mice Exposed to Benzo(a)pyrene.

D. L. Harris, M. K. Washington, D. B. Hood, L. J. Roberts II, and A. Ramesh (2009)
Toxicol Pathol 37, 938-946
 |  Abstract »  |  Full Text »  |  PDF »

Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution.

E. L. Huttlin, X. Chen, G. A. Barrett-Wilt, A. D. Hegeman, R. B. Halberg, A. C. Harms, M. A. Newton, W. F. Dove, and M. R. Sussman (2009)
PNAS 106, 17235-17240
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice.

C. V. Rao, H. Y. Yamada, Y. Yao, and W. Dai (2009)
Carcinogenesis 30, 1469-1474
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C{varepsilon} promotes intestinal tumorigenesis of ApcMin/+ mice through augmentation of inflammation and angiogenesis.

M. Li, H. Edamatsu, R. Kitazawa, S. Kitazawa, and T. Kataoka (2009)
Carcinogenesis 30, 1424-1432
 |  Abstract »  |  Full Text »  |  PDF »

Flavones as Colorectal Cancer Chemopreventive Agents--Phenol-O-Methylation Enhances Efficacy.

H. Cai, S. Sale, R. Schmid, R. G. Britton, K. Brown, W. P. Steward, and A. J. Gescher (2009)
Cancer Prevention Research 2, 743-750
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation.

W.-C. Lee, K. Beebe, L. Sudmeier, and C. A. Micchelli (2009)
Development 136, 2255-2264
 |  Abstract »  |  Full Text »  |  PDF »

The putative tumour modifier gene ATP5A1 is not mutated in human colorectal cancer cell lines but expression levels correlate with TP53 mutations and chromosomal instability.

R Seth, J Keeley, G Abu-Ali, S Crook, D Jackson, and M Ilyas (2009)
J. Clin. Pathol. 62, 598-603
 |  Abstract »  |  Full Text »  |  PDF »

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.

S. P.J. Fancy, S. E. Baranzini, C. Zhao, D.-I. Yuk, K.-A. Irvine, S. Kaing, N. Sanai, R. J.M. Franklin, and D. H. Rowitch (2009)
Genes & Dev. 23, 1571-1585
 |  Abstract »  |  Full Text »  |  PDF »

PUMA Suppresses Intestinal Tumorigenesis in Mice.

W. Qiu, E. B. Carson-Walter, S. F. Kuan, L. Zhang, and J. Yu (2009)
Cancer Res. 69, 4999-5006
 |  Abstract »  |  Full Text »  |  PDF »

Haploinsufficiency of Kruppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the ApcMin Mutation in the Intestine.

B. B. McConnell, A. B. Bialkowska, M. O. Nandan, A. M. Ghaleb, F. J. Gordon, and V. W. Yang (2009)
Cancer Res. 69, 4125-4133
 |  Abstract »  |  Full Text »  |  PDF »

Inflammation Recapitulates the Ontogeny of Lymphoid Stromal Cells.

L. Peduto, S. Dulauroy, M. Lochner, G. F. Spath, M. A. Morales, A. Cumano, and G. Eberl (2009)
J. Immunol. 182, 5789-5799
 |  Abstract »  |  Full Text »  |  PDF »

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer.

V. Rodilla, A. Villanueva, A. Obrador-Hevia, A. Robert-Moreno, V. Fernandez-Majada, A. Grilli, N. Lopez-Bigas, N. Bellora, M. M. Alba, F. Torres, et al. (2009)
PNAS 106, 6315-6320
 |  Abstract »  |  Full Text »  |  PDF »

SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.

H. Sadakata, H. Okazawa, T. Sato, Y. Supriatna, H. Ohnishi, S. Kusakari, Y. Murata, T. Ito, U. Nishiyama, T. Minegishi, et al. (2009)
Genes Cells 14, 295-308
 |  Abstract »  |  Full Text »  |  PDF »

Intestinal Neoplasia Induced by Low Dietary Folate Is Associated with Altered Tumor Expression Profiles and Decreased Apoptosis in Mouse Normal Intestine.

D. Garcia-Crespo, E. Knock, N. Jabado, and R. Rozen (2009)
J. Nutr. 139, 488-494
 |  Abstract »  |  Full Text »  |  PDF »

Tgfbr1 Haploinsufficiency Is a Potent Modifier of Colorectal Cancer Development.

Q. Zeng, S. Phukan, Y. Xu, M. Sadim, D. S. Rosman, M. Pennison, J. Liao, G.-Y. Yang, C.-C. Huang, L. Valle, et al. (2009)
Cancer Res. 69, 678-686
 |  Abstract »  |  Full Text »  |  PDF »

Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice.

I. Eude-Le Parco, G. Gendronneau, T. Dang, D. Delacour, V. L Thijssen, W. Edelmann, M. Peuchmaur, and F. Poirier (2009)
Glycobiology 19, 68-75
 |  Abstract »  |  Full Text »  |  PDF »

rNAPc2 Inhibits Colorectal Cancer in Mice through Tissue Factor.

J. Zhao, G. Aguilar, S. Palencia, E. Newton, and A. Abo (2009)
Clin. Cancer Res. 15, 208-216
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Bile Acid Receptor FXR Protects against Intestinal Tumorigenesis.

S. Modica, S. Murzilli, L. Salvatore, D. R. Schmidt, and A. Moschetta (2008)
Cancer Res. 68, 9589-9594
 |  Abstract »  |  Full Text »  |  PDF »

Ku80 Deletion Suppresses Spontaneous Tumors and Induces a p53-Mediated DNA Damage Response.

V. B. Holcomb, F. Rodier, Y. Choi, R. A. Busuttil, H. Vogel, J. Vijg, J. Campisi, and P. Hasty (2008)
Cancer Res. 68, 9497-9502
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency of Mbd2 Attenuates Wnt Signaling.

T. J. Phesse, L. Parry, K. R. Reed, K. B. Ewan, T. C. Dale, O. J. Sansom, and A. R. Clarke (2008)
Mol. Cell. Biol. 28, 6094-6103
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Muc2 and Apc on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation.

K. Yang, N. V. Popova, W. C. Yang, I. Lozonschi, S. Tadesse, S. Kent, L. Bancroft, I. Matise, R. T. Cormier, S. J. Scherer, et al. (2008)
Cancer Res. 68, 7313-7322
 |  Abstract »  |  Full Text »  |  PDF »

Lactaturia and Loss of Sodium-dependent Lactate Uptake in the Colon of SLC5A8-deficient Mice.

H. Frank, N. Groger, M. Diener, C. Becker, T. Braun, and T. Boettger (2008)
J. Biol. Chem. 283, 24729-24737
 |  Abstract »  |  Full Text »  |  PDF »

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of {beta}-catenin in mice.

T. Grigoryan, P. Wend, A. Klaus, and W. Birchmeier (2008)
Genes & Dev. 22, 2308-2341
 |  Abstract »  |  Full Text »  |  PDF »

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis.

A. Bilger, R. Sullivan, A. J. Prunuske, L. Clipson, N. R. Drinkwater, and W. F. Dove (2008)
Carcinogenesis 29, 1825-1830
 |  Abstract »  |  Full Text »  |  PDF »

Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice.

C. B. Yoo, J. C. Chuang, H.-M. Byun, G. Egger, A. S. Yang, L. Dubeau, T. Long, P. W. Laird, V. E. Marquez, and P. A. Jones (2008)
Cancer Prevention Research 1, 233-240
 |  Abstract »  |  Full Text »  |  PDF »

The Pleiotropic Phenotype of Apc Mutations in the Mouse: Allele Specificity and Effects of the Genetic Background.

R. B. Halberg, X. Chen, J. M. Amos-Landgraf, A. White, K. Rasmussen, L. Clipson, C. Pasch, R. Sullivan, H. C. Pitot, and W. F. Dove (2008)
Genetics 180, 601-609
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Cancer Stem Cells with Phytochemicals.

B. T. Kawasaki, E. M. Hurt, T. Mistree, and W. L. Farrar (2008)
Mol. Interv. 8, 174-184
 |  Abstract »  |  Full Text »  |  PDF »

Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice.

H. Guillen-Ahlers, S. A. Buechler, M. A. Suckow, F. J. Castellino, and V. A. Ploplis (2008)
Carcinogenesis 29, 1421-1427
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter hepaticus Infection Promotes Colon Tumorigenesis in the BALB/c-Rag2-/- ApcMin/+ Mouse.

C. M. Nagamine, J. J. Sohn, B. H. Rickman, A. B. Rogers, J. G. Fox, and D. B. Schauer (2008)
Infect. Immun. 76, 2758-2766
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis.

J. Zeilstra, S. P.J. Joosten, M. Dokter, E. Verwiel, M. Spaargaren, and S. T. Pals (2008)
Cancer Res. 68, 3655-3661
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Expression Patterns of Genes Upregulated in Murine and Human Colonic Neoplasms.

X. Chen, W. M. Ehrhardt, R. B. Halberg, B. J. Aronow, and W. F. Dove (2008)
J. Histochem. Cytochem. 56, 433-441
 |  Abstract »  |  Full Text »  |  PDF »

A protective role of mast cells in intestinal tumorigenesis.

M. J. Sinnamon, K. J. Carter, L. P. Sims, B. LaFleur, B. Fingleton, and L. M. Matrisian (2008)
Carcinogenesis 29, 880-886
 |  Abstract »  |  Full Text »  |  PDF »

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in ApcMin/+ mice.

D. Alferez, R. W. Wilkinson, J. Watkins, R. Poulsom, N. Mandir, S. R. Wedge, I. T. Pyrah, N. R. Smith, L. Jackson, A. J. Ryan, et al. (2008)
Mol. Cancer Ther. 7, 590-598
 |  Abstract »  |  Full Text »  |  PDF »

Further upregulation of {beta}-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.

T. Oyama, Y. Yamada, K. Hata, H. Tomita, A. Hirata, H. Sheng, A. Hara, H. Aoki, T. Kunisada, S. Yamashita, et al. (2008)
Carcinogenesis 29, 666-672
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk.

A. Kaneda, C. J. Wang, R. Cheong, W. Timp, P. Onyango, B. Wen, C. A. Iacobuzio-Donahue, R. Ohlsson, R. Andraos, M. A. Pearson, et al. (2007)
PNAS 104, 20926-20931
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Novel Modifier Loci of ApcMin Affecting Mammary Tumor Development.

H. Wang, D. Teske, A. Tess, R. Kohlhepp, Y. Choi, C. Kendziorski, and A. R. Moser (2007)
Cancer Res. 67, 11226-11233
 |  Abstract »  |  Full Text »  |  PDF »

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.

H. G. Linhart, H. Lin, Y. Yamada, E. Moran, E. J. Steine, S. Gokhale, G. Lo, E. Cantu, M. Ehrich, T. He, et al. (2007)
Genes & Dev. 21, 3110-3122
 |  Abstract »  |  Full Text »  |  PDF »

Mouse Model of Colonic Adenoma-Carcinoma Progression Based on Somatic Apc Inactivation.

T. Hinoi, A. Akyol, B. K. Theisen, D. O. Ferguson, J. K. Greenson, B. O. Williams, K. R. Cho, and E. R. Fearon (2007)
Cancer Res. 67, 9721-9730
 |  Abstract »  |  Full Text »  |  PDF »

Chemoprevention of Familial Adenomatous Polyposis by Natural Dietary Compounds Sulforaphane and Dibenzoylmethane Alone and in Combination in ApcMin/+ Mouse.

G. Shen, T. O. Khor, R. Hu, S. Yu, S. Nair, C.-T. Ho, B. S. Reddy, M.-T. Huang, H. L. Newmark, and A.-N. T. Kong (2007)
Cancer Res. 67, 9937-9944
 |  Abstract »  |  Full Text »  |  PDF »

The genetics of hereditary colon cancer.

A. K. Rustgi (2007)
Genes & Dev. 21, 2525-2538
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.

K. Aoki and M. M. Taketo (2007)
J. Cell Sci. 120, 3327-3335
 |  Abstract »  |  Full Text »  |  PDF »

Giving APCmin tumours a SPARC.

A. Gregorieff and H. Clevers (2007)
Gut 56, 1341-1343
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Haploinsufficiency of Kruppel-Like Factor 4 Promotes Adenomatous Polyposis Coli Dependent Intestinal Tumorigenesis.

A. M. Ghaleb, B. B. McConnell, M. O. Nandan, J. P. Katz, K. H. Kaestner, and V. W. Yang (2007)
Cancer Res. 67, 7147-7154
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88.

S. Rakoff-Nahoum and R. Medzhitov (2007)
Science 317, 124-127
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice.

N. Korsisaari, I. M. Kasman, W. F. Forrest, N. Pal, W. Bai, G. Fuh, F. V. Peale, R. Smits, and N. Ferrara (2007)
PNAS 104, 10625-10630
 |  Abstract »  |  Full Text »  |  PDF »

New Waves of Discovery: Modeling Cancer in Zebrafish.

W. Goessling, T. E. North, and L. I. Zon (2007)
J. Clin. Oncol. 25, 2473-2479
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Loss of Functional Fas Ligand Enhances Intestinal Tumorigenesis in the Min Mouse Model.

B. Fingleton, K. J. Carter, and L. M. Matrisian (2007)
Cancer Res. 67, 4800-4806
 |  Abstract »  |  Full Text »  |  PDF »

Development of Gastric Tumors in ApcMin/+ Mice by the Activation of the {beta}-Catenin/Tcf Signaling Pathway.

H. Tomita, Y. Yamada, T. Oyama, K. Hata, Y. Hirose, A. Hara, T. Kunisada, Y. Sugiyama, Y. Adachi, H. Linhart, et al. (2007)
Cancer Res. 67, 4079-4087
 |  Abstract »  |  Full Text »  |  PDF »

Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma.

R. Zhang, A. Ma, S. J. Urbanski, and D.-M. McCafferty (2007)
Carcinogenesis 28, 1122-1130
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen Receptors {alpha} and {beta} Are Inhibitory Modifiers of Apc-Dependent Tumorigenesis in the Proximal Colon of Min/+ Mice.

N. L. Cho, S. H. Javid, A. M. Carothers, M. Redston, and M. M. Bertagnolli (2007)
Cancer Res. 67, 2366-2372
 |  Abstract »  |  Full Text »  |  PDF »

Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells.

G. S. Yochum, S. McWeeney, V. Rajaraman, R. Cleland, S. Peters, and R. H. Goodman (2007)
PNAS 104, 3324-3329
 |  Abstract »  |  Full Text »  |  PDF »

Hematopoietic Prostaglandin D Synthase Suppresses Intestinal Adenomas in ApcMin/+ Mice.

J. M. Park, Y. Kanaoka, N. Eguchi, K. Aritake, S. Grujic, A. M. Materi, V. S. Buslon, B. L. Tippin, A. M. Kwong, E. Salido, et al. (2007)
Cancer Res. 67, 881-889
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer.

V. Fernandez-Majada, C. Aguilera, A. Villanueva, F. Vilardell, A. Robert-Moreno, A. Aytes, F. X. Real, G. Capella, M. W. Mayo, L. Espinosa, et al. (2007)
PNAS 104, 276-281
 |  Abstract »  |  Full Text »  |  PDF »

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.

R. Hu, T. O. Khor, G. Shen, W.-S. Jeong, V. Hebbar, C. Chen, C. Xu, B. Reddy, K. Chada, and A.-N. T. Kong (2006)
Carcinogenesis 27, 2038-2046
 |  Abstract »  |  Full Text »  |  PDF »

Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ Mice..

N. M. Sodir, X. Chen, R. Park, A. E. Nickel, P. S. Conti, R. Moats, J. R. Bading, D. Shibata, and P. W. Laird (2006)
Cancer Res. 66, 8430-8438
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of early proximodistal patterning and AVE formation in Apc mutants.

C. Chazaud and J. Rossant (2006)
Development 133, 3379-3387
 |  Abstract »  |  Full Text »  |  PDF »

15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.

S.-J. Myung, R. M. Rerko, M. Yan, P. Platzer, K. Guda, A. Dotson, E. Lawrence, A. J. Dannenberg, A. K. Lovgren, G. Luo, et al. (2006)
PNAS 103, 12098-12102
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C {alpha} but not PKC{zeta} Suppresses Intestinal Tumor Formation in ApcMin/+ Mice..

H. Oster and M. Leitges (2006)
Cancer Res. 66, 6955-6963
 |  Abstract »  |  Full Text »  |  PDF »

Chemoprevention of Familial Adenomatous Polyposis by Low Doses of Atorvastatin and Celecoxib Given Individually and in Combination to APCMin Mice..

M. V. Swamy, J. M.R. Patlolla, V. E. Steele, L. Kopelovich, B. S. Reddy, and C. V. Rao (2006)
Cancer Res. 66, 7370-7377
 |  Abstract »  |  Full Text »  |  PDF »

The {beta}-Catenin/T-Cell Factor/Lymphocyte Enhancer Factor Signaling Pathway Is Required for Normal and Stress-Induced Cardiac Hypertrophy.

X. Chen, S. P. Shevtsov, E. Hsich, L. Cui, S. Haq, M. Aronovitz, R. Kerkela, J. D. Molkentin, R. Liao, R. N. Salomon, et al. (2006)
Mol. Cell. Biol. 26, 4462-4473
 |  Abstract »  |  Full Text »  |  PDF »

CANCER STEM CELLS: Redefining the Paradigm of Cancer Treatment Strategies.

M. Dean (2006)
Mol. Interv. 6, 140-148
 |  Abstract »  |  Full Text »  |  PDF »

Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research.

J. I. Fenton and N. G. Hord (2006)
Carcinogenesis 27, 893-902
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Manipulation of Polyamine Catabolism in Rodents.

J. Janne, L. Alhonen, M. Pietila, T. A. Keinanen, A. Uimari, M. T. Hyvonen, E. Pirinen, and A. Jarvinen (2006)
J. Biochem. 139, 155-160
 |  Abstract »  |  Full Text »  |  PDF »

The Rac Activator Tiam1 Is a Wnt-responsive Gene That Modifies Intestinal Tumor Development.

A. Malliri, T. P. Rygiel, R. A. van der Kammen, J.-Y. Song, R. Engers, A. F. L. Hurlstone, H. Clevers, and J. G. Collard (2006)
J. Biol. Chem. 281, 543-548
 |  Abstract »  |  Full Text »  |  PDF »

Kaiso-Deficient Mice Show Resistance to Intestinal Cancer.

A. Prokhortchouk, O. Sansom, J. Selfridge, I. M. Caballero, S. Salozhin, D. Aithozhina, L. Cerchietti, F. G. Meng, L. H. Augenlicht, J. M. Mariadason, et al. (2006)
Mol. Cell. Biol. 26, 199-208
 |  Abstract »  |  Full Text »  |  PDF »

EphB/EphrinB Receptors and Wnt Signaling in Colorectal Cancer.

H. Clevers and E. Batlle (2006)
Cancer Res. 66, 2-5
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Imprinting of IGF2: A Common Epigenetic Modifier of Intestinal Tumor Risk.

A. Kaneda and A. P. Feinberg (2005)
Cancer Res. 65, 11236-11240
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Intestinal Tumorigenesis in Apcmin/+ Mice by (-)-Epigallocatechin-3-Gallate, the Major Catechin in Green Tea.

J. Ju, J. Hong, J.-n. Zhou, Z. Pan, M. Bose, J. Liao, G.-y. Yang, Y. Y. Liu, Z. Hou, Y. Lin, et al. (2005)
Cancer Res. 65, 10623-10631
 |  Abstract »  |  Full Text »  |  PDF »

Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.

Y. Yamada, L. Jackson-Grusby, H. Linhart, A. Meissner, A. Eden, H. Lin, and R. Jaenisch (2005)
PNAS 102, 13580-13585
 |  Abstract »  |  Full Text »  |  PDF »

Kinase-Inactive Glycogen Synthase Kinase 3{beta} Promotes Wnt Signaling and Mammary Tumorigenesis.

M. Farago, I. Dominguez, E. Landesman-Bollag, X. Xu, A. Rosner, R. D. Cardiff, and D. C. Seldin (2005)
Cancer Res. 65, 5792-5801
 |  Abstract »  |  Full Text »  |  PDF »

Uniform Overexpression and Rapid Accessibility of {alpha}5{beta}1 Integrin on Blood Vessels in Tumors.

P. Parsons-Wingerter, I. M. Kasman, S. Norberg, A. Magnussen, S. Zanivan, A. Rissone, P. Baluk, C. J. Favre, U. Jeffry, R. Murray, et al. (2005)
Am. J. Pathol. 167, 193-211
 |  Abstract »  |  Full Text »  |  PDF »

Potent Modulation of Intestinal Tumorigenesis in Apcmin/+ Mice by the Polyamine Catabolic Enzyme Spermidine/Spermine N1-acetyltransferase.

J. M. Tucker, J. T. Murphy, N. Kisiel, P. Diegelman, K. W. Barbour, C. Davis, M. Medda, L. Alhonen, J. Janne, D. L. Kramer, et al. (2005)
Cancer Res. 65, 5390-5398
 |  Abstract »  |  Full Text »  |  PDF »

Divergent phenotypes in Gaucher disease implicate the role of modifiers.

O Goker-Alpan, K S Hruska, E Orvisky, P S Kishnani, B K Stubblefield, R Schiffmann, and E Sidransky (2005)
J. Med. Genet. 42, e37
 |  Abstract »  |  Full Text »  |  PDF »

Non-steroidal anti-inflammatory drugs and colorectal cancer prevention.

S Sangha, M Yao, and M M Wolfe (2005)
Postgrad. Med. J. 81, 223-227
 |  Abstract »  |  Full Text »  |  PDF »

Self-Renewal and Cancer of the Gut: Two Sides of a Coin.

F. Radtke and H. Clevers (2005)
Science 307, 1904-1909
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice.

T. Sakatani, A. Kaneda, C. A. Iacobuzio-Donahue, M. G. Carter, S. de Boom Witzel, H. Okano, M. S. H. Ko, R. Ohlsson, D. L. Longo, and A. P. Feinberg (2005)
Science 307, 1976-1978
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of tumor formation and intestinal cell migration by estrogens in the ApcMin/+ mouse model of colorectal cancer.

S. H. Javid, A. E. Moran, A. M. Carothers, M. Redston, and M. M. Bertagnolli (2005)
Carcinogenesis 26, 587-595
 |  Abstract »  |  Full Text »  |  PDF »

Alteration of Gene Expression in Macroscopically Normal Colonic Mucosa from Individuals with a Family History of Sporadic Colon Cancer.

C.-Y. Hao, D. H. Moore, P. Wong, J. L. Bennington, N. M. Lee, and L.-C. Chen (2005)
Clin. Cancer Res. 11, 1400-1407
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Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.

K. Schoonjans, L. Dubuquoy, J. Mebis, E. Fayard, O. Wendling, C. Haby, K. Geboes, and J. Auwerx (2005)
PNAS 102, 2058-2062
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Carnosol Inhibits {beta}-Catenin Tyrosine Phosphorylation and Prevents Adenoma Formation in the C57BL/6J/Min/+ (Min/+) Mouse.

A. E. Moran, A. M. Carothers, M. J. Weyant, M. Redston, and M. M. Bertagnolli (2005)
Cancer Res. 65, 1097-1104
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The Wnt/{beta}-catenin signaling pathway targets PPAR{gamma} activity in colon cancer cells.

E. A. Jansson, A. Are, G. Greicius, I-C. Kuo, D. Kelly, V. Arulampalam, and S. Pettersson (2005)
PNAS 102, 1460-1465
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Global Analysis of Altered Gene Expressions during the Process of Esophageal Squamous Cell Carcinogenesis in the Rat: A Study Combined with a Laser Microdissection and a cDNA Microarray.

K. Nishida, S. Mine, T. Utsunomiya, H. Inoue, M. Okamoto, H. Udagawa, T. Hanai, and M. Mori (2005)
Cancer Res. 65, 401-409
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Epiregulin Is Not Essential for Development of Intestinal Tumors but Is Required for Protection from Intestinal Damage.

D. Lee, R. S. Pearsall, S. Das, S. K. Dey, V. L. Godfrey, and D. W. Threadgill (2004)
Mol. Cell. Biol. 24, 8907-8916
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Apc Deficiency Is Associated with Increased Egfr Activity in the Intestinal Enterocytes and Adenomas of C57BL/6J-Min/+ Mice.

A. E. Moran, D. H. Hunt, S. H. Javid, M. Redston, A. M. Carothers, and M. M. Bertagnolli (2004)
J. Biol. Chem. 279, 43261-43272
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Strain-Specific Effects of Alachlor on Murine Olfactory Mucosal Responses.

M. B. Genter, K. H. Goss, and J. Groden (2004)
Toxicol Pathol 32, 719-725
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The Von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer.

W. G. Kaelin Jr. (2004)
Clin. Cancer Res. 10, 6290S-6295S
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Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice.

J. Hulit, C. Wang, Z. Li, C. Albanese, M. Rao, D. Di Vizio, S. Shah, S. W. Byers, R. Mahmood, L. H. Augenlicht, et al. (2004)
Mol. Cell. Biol. 24, 7598-7611
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Both suboptimal and elevated vitamin intake increase intestinal neoplasia and alter crypt fission in the ApcMin/+ mouse.

O. Bashir, A.J. FitzGerald, and R.A. Goodlad (2004)
Carcinogenesis 25, 1507-1515
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Colon Carcinoma Cell Growth Is Associated with Prostaglandin E2/EP4 Receptor-evoked ERK Activation.

A. Pozzi, X. Yan, I. Macias-Perez, S. Wei, A. N. Hata, R. M. Breyer, J. D. Morrow, and J. H. Capdevila (2004)
J. Biol. Chem. 279, 29797-29804
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Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.

K. M. Haigis, P. D. Hoff, A. White, A. R. Shoemaker, R. B. Halberg, and W. F. Dove (2004)
PNAS 101, 9769-9773
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Modulation of Patched-Associated Susceptibility to Radiation Induced Tumorigenesis by Genetic Background.

S. Pazzaglia, M. Mancuso, M. Tanori, M. J. Atkinson, P. Merola, S. Rebessi, V. Di Majo, V. Covelli, H. Hahn, and A. Saran (2004)
Cancer Res. 64, 3798-3806
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Combination of a Poxvirus-Based Vaccine with a Cyclooxygenase-2 Inhibitor (Celecoxib) Elicits Antitumor Immunity and Long-Term Survival in CEA.Tg/MIN Mice.

H. E. Zeytin, A. C. Patel, C. J. Rogers, D. Canter, S. D. Hursting, J. Schlom, and J. W. Greiner (2004)
Cancer Res. 64, 3668-3678
 |  Abstract »  |  Full Text »  |  PDF »

Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis.

P. L. Coletta, A. M. Muller, E. A. Jones, B. Muhl, S. Holwell, D. Clarke, J. L. Meade, G. P. Cook, G. Hawcroft, F. Ponchel, et al. (2004)
Blood 103, 1050-1058
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Promotion of Colon Tumors in C57BL/6J-APCmin/+ Mice by Thiazolidinedione PPAR{gamma} Agonists and a Structurally Unrelated PPAR{gamma} Agonist.

M. V. Pino, M. F. Kelley, and Z. Jayyosi (2004)
Toxicol Pathol 32, 58-63
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Dietary retinoic acid supplementation stimulates intestinal tumour formation and growth in multiple intestinal neoplasia (Min)/+ mice.

L. Mollersen, J. E. Paulsen, H. B. Olstorn, H. K. Knutsen, and J. Alexander (2004)
Carcinogenesis 25, 149-153
 |  Abstract »  |  Full Text »  |  PDF »

Mouse Models of Human Familial Cancer Syndromes.

J. M. Ward and D. E. Devor-Henneman (2004)
Toxicol Pathol 32, 90-98
 |  Abstract »  |  PDF »

Up-Regulation of Fibroblast Growth Factor-Binding Protein, by {beta}-Catenin during Colon Carcinogenesis.

R. Ray, R. Cabal-Manzano, A. R. Moser, T. Waldman, L. M. Zipper, A. Aigner, S. W. Byers, A. T. Riegel, and A. Wellstein (2003)
Cancer Res. 63, 8085-8089
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Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse.

N. F. Paoni, M. W. Feldman, L. S. Gutierrez, V. A. Ploplis, and F. J. Castellino (2003)
Physiol Genomics 15, 228-235
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Spontaneous Aberrant Crypt Foci in Apc1638N Mice with a Mutant Apc Allele.

T. P. Pretlow, W. Edelmann, R. Kucherlapati, T. G. Pretlow, and L. H. Augenlicht (2003)
Am. J. Pathol. 163, 1757-1763
 |  Abstract »  |  Full Text »  |  PDF »

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