Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 1 May 1992:
Vol. 256. no. 5057, pp. 628 - 632
DOI: 10.1126/science.1533953

Articles

Science, Vol 256, Issue 5057, 628-632
Copyright © 1992 by American Association for the Advancement of Science


articles

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

DC Wallace

Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322.

Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?.
A. Maagaard and D. Kvale (2009)
J. Antimicrob. Chemother. 64, 901-909
   Abstract »    Full Text »    PDF »
The pathophysiology of mitochondrial disease as modeled in the mouse.
D. C. Wallace and W. Fan (2009)
Genes & Dev. 23, 1714-1736
   Abstract »    Full Text »    PDF »
Mitochondria as Chi.
D. C. Wallace (2008)
Genetics 179, 727-735
   Full Text »    PDF »
Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration.
L. Ai, M. Rouhanizadeh, J. C. Wu, W. Takabe, H. Yu, M. Alavi, R. Li, Y. Chu, J. Miller, D. D. Heistad, et al. (2008)
Am J Physiol Cell Physiol 294, C1576-C1585
   Abstract »    Full Text »    PDF »
Age-Related Correlation Between Antioxidant Enzymes and DNA Damage With Smoking and Body Mass Index.
P. K. Reddy Thavanati, K. R. Kanala, A. E. de Dios, and J. M. Cantu Garza (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 360-364
   Abstract »    Full Text »    PDF »
MnSOD Deficiency Increases Endothelial Dysfunction in ApoE-Deficient Mice.
M. Ohashi, M. S. Runge, F. M. Faraci, and D. D. Heistad (2006)
Arterioscler Thromb Vasc Biol 26, 2331-2336
   Abstract »    Full Text »    PDF »
A Quantitative Trait Locus Analysis of Natural Genetic Variation for Drosophila melanogaster Oxidative Stress Survival.
Y. Wang, D. Pot, S. D. Kachman, S. V. Nuzhdin, and L. G. Harshman (2006)
J. Hered. 97, 355-366
   Abstract »    Full Text »    PDF »
The role of mitochondrial haplogroups in primary open angle glaucoma..
R Andrews, T Ressiniotis, D M Turnbull, M Birch, S Keers, P F Chinnery, and P G Griffiths (2006)
Br J Ophthalmol 90, 488-490
   Abstract »    Full Text »    PDF »
Mitochondrial abnormalities in inclusion-body myositis.
A. Oldfors, A. R. Moslemi, L. Jonasson, M. Ohlsson, G. Kollberg, and C. Lindberg (2006)
Neurology 66, S49-S55
   Abstract »    Full Text »    PDF »
Developing a Research Agenda in Biogerontology: Basic Mechanisms.
H. R. Warner (2005)
Sci. Aging Knowl. Environ. 2005, pe33
   Abstract »    Full Text »
SOD2 Protects against Oxidation-Induced Apoptosis in Mouse Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration.
E. Kasahara, L.-R. Lin, Y.-S. Ho, and V. N. Reddy (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3426-3434
   Abstract »    Full Text »    PDF »
Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance.
J. F. Harrison, S. B. Hollensworth, D. R. Spitz, W. C. Copeland, G. L. Wilson, and S. P. LeDoux (2005)
Nucleic Acids Res. 33, 4660-4671
   Abstract »    Full Text »    PDF »
Progressive Accumulation of Mitochondrial DNA Mutations and Decline in Mitochondrial Function Lead to {beta}-Cell Failure.
R. A. Simmons, I. Suponitsky-Kroyter, and M. A. Selak (2005)
J. Biol. Chem. 280, 28785-28791
   Abstract »    Full Text »    PDF »
Effect of aerobic exercise training on mtDNA deletion in soleus muscle of trained and untrained Wistar rats.
A Jafari, M A Hosseinpourfaizi, M Houshmand, and A A Ravasi (2005)
Br. J. Sports Med. 39, 517-520
   Abstract »    Full Text »    PDF »
Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON.
N. Li, Q. Wang, J. Li, X. Wang, M. R. Hellmich, S. Rajaraman, G. H. Greeley Jr., C. M. Townsend Jr., and B. M. Evers (2005)
Am J Physiol Gastrointest Liver Physiol 288, G213-G220
   Abstract »    Full Text »    PDF »
Mitochondria and Cancer: Warburg Addressed.
D.C. WALLACE (2005)
Cold Spring Harb Symp Quant Biol 70, 363-374
   Abstract »    PDF »
Skeletal Muscle Aging in F344BN F1-Hybrid Rats: I. Mitochondrial Dysfunction Contributes to the Age-Associated Reduction in VO2max.
J. L. Hagen, D. J. Krause, D. J. Baker, M. H. Fu, M. A. Tarnopolsky, and R. T. Hepple (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, 1099-1110
   Abstract »    Full Text »    PDF »
In Vivo Interaction Between Mitochondria Carrying mtDNAs From Different Mouse Species.
A. Sato, K. Nakada, H. Shitara, H. Yonekawa, and J.-I. Hayashi (2004)
Genetics 167, 1855-1861
   Abstract »    Full Text »    PDF »
Three-Dimensional Microarray Compared with PCR-Single-Strand Conformation Polymorphism Analysis/DNA Sequencing for Mutation Analysis of K-ras Codons 12 and 13.
M. Maekawa, T. Nagaoka, T. Taniguchi, H. Higashi, H. Sugimura, K. Sugano, H. Yonekawa, T. Satoh, T. Horii, N. Shirai, et al. (2004)
Clin. Chem. 50, 1322-1327
   Abstract »    Full Text »    PDF »
Anatomic capillarization is maintained in relative excess of fiber oxidative capacity in some skeletal muscles of late middle-aged rats.
R. T. Hepple and J. E. Vogell (2004)
J Appl Physiol 96, 2257-2264
   Abstract »    Full Text »    PDF »
A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts.
A. Hansson, N. Hance, E. Dufour, A. Rantanen, K. Hultenby, D. A. Clayton, R. Wibom, and N.-G. Larsson (2004)
PNAS 101, 3136-3141
   Abstract »    Full Text »    PDF »
Determination of Normal Ranges of Mitochondrial Respiratory Activities by mtDNA Transfer from 54 Human Subjects to mtDNA-less HeLa Cells for Identification of the Pathogenicities of Mutated mtDNAs.
C.-S. Chen, R. Matsuoka, S. Arai, Y. Momiyama, H. Murakami, S.-y. Kuno, K. Ishikawa, K. Nakada, M. Tawata, and J.-I. Hayashi (2004)
J. Biochem. 135, 237-243
   Abstract »    Full Text »    PDF »
Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation.
J. A. Maassen, Leen. M. 't Hart, E. van Essen, R. J. Heine, G. Nijpels, R. S. Jahangir Tafrechi, A. K. Raap, G. M.C. Janssen, and H. H.P.J. Lemkes (2004)
Diabetes 53, S103-109
   Abstract »    Full Text »
Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction.
B. Drew and C. Leeuwenburgh (2003)
Am J Physiol Regulatory Integrative Comp Physiol 285, R1259-R1267
   Abstract »    Full Text »    PDF »
Fetal and Early Postnatal Protein Malnutrition Cause Long-Term Changes in Rat Liver and Muscle Mitochondria.
K. S. Park, S. K. Kim, M. S. Kim, E. Y. Cho, J. H. Lee, K.-U. Lee, Y. K. Pak, and H. K. Lee (2003)
J. Nutr. 133, 3085-3090
   Abstract »    Full Text »    PDF »
Optic Neuropathy Induced by Reductions in Mitochondrial Superoxide Dismutase.
X. Qi, A. S. Lewin, W. W. Hauswirth, and J. Guy (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1088-1096
   Abstract »    Full Text »    PDF »
Imbalancing the DNA Base Excision Repair Pathway in the Mitochondria; Targeting and Overexpressing N-Methylpurine DNA Glycosylase in Mitochondria Leads to Enhanced Cell Killing.
M. L. Fishel, Y. R. Seo, M. L. Smith, and M. R. Kelley (2003)
Cancer Res. 63, 608-615
   Abstract »    Full Text »    PDF »
Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart.
B. Drew, S. Phaneuf, A. Dirks, C. Selman, R. Gredilla, A. Lezza, G. Barja, and C. Leeuwenburgh (2003)
Am J Physiol Regulatory Integrative Comp Physiol 284, R474-R480
   Abstract »    Full Text »    PDF »
Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy.
W. Lewis (2003)
Am J Physiol Heart Circ Physiol 284, H1-H9
   Full Text »    PDF »
Large Deletions in Mitochondrial DNA in Radiation-associated Human Thyroid Tumors.
T. I. Rogounovitch, V. A. Saenko, Y. Shimizu-Yoshida, A. Yu. Abrosimov, E. F. Lushnikov, P. O. Roumiantsev, A. Ohtsuru, H. Namba, A. F. Tsyb, and S. Yamashita (2002)
Cancer Res. 62, 7031-7041
   Abstract »    Full Text »    PDF »
Risk Factors for Alzheimer's Disease: Role of Multiple Antioxidants, Non-Steroidal Anti-inflammatory and Cholinergic Agents Alone or in Combination in Prevention and Treatment.
K. N. Prasad, W. C. Cole, and K. C. Prasad (2002)
J. Am. Coll. Nutr. 21, 506-522
   Abstract »    Full Text »    PDF »
Design and Use of a Peptide Nucleic Acid for Detection of the Heteroplasmic Low-Frequency Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) Mutation in Human Mitochondrial DNA.
D. K. Hancock, F. P. Schwarz, F. Song, L.-J. C. Wong, and B. C. Levin (2002)
Clin. Chem. 48, 2155-2163
   Abstract »    Full Text »    PDF »
Increased mitochondrial mass in mitochondrial myopathy mice.
A. Wredenberg, R. Wibom, H. Wilhelmsson, C. Graff, H. H. Wiener, S. J. Burden, A. Oldfors, H. Westerblad, and N.-G. Larsson (2002)
PNAS 99, 15066-15071
   Abstract »    Full Text »    PDF »
Mitochondrial Integrity and Function in Atherogenesis.
S. W. Ballinger, C. Patterson, C. A. Knight-Lozano, D. L. Burow, C. A. Conklin, Z. Hu, J. Reuf, C. Horaist, R. Lebovitz, G. C. Hunter, et al. (2002)
Circulation 106, 544-549
   Abstract »    Full Text »    PDF »
Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle.
R. Sreekumar, J. Unnikrishnan, A. Fu, J. Nygren, K. R. Short, J. Schimke, R. Barazzoni, and K. S. Nair (2002)
Am J Physiol Endocrinol Metab 282, E1055-E1061
   Abstract »    Full Text »    PDF »
Mitochondrial DNA Somatic Mutations (Point Mutations and Large Deletions) and Mitochondrial DNA Variants in Human Thyroid Pathology : A Study with Emphasis on Hurthle Cell Tumors.
V. Maximo, P. Soares, J. Lima, J. Cameselle-Teijeiro, and M. Sobrinho-Simoes (2002)
Am. J. Pathol. 160, 1857-1865
   Abstract »    Full Text »    PDF »
Chronic Treatment with Azide in Situ Leads to an Irreversible Loss of Cytochrome c Oxidase Activity via Holoenzyme Dissociation.
S. C. Leary, B. C. Hill, C. N. Lyons, C. G. Carlson, D. Michaud, C. S. Kraft, K. Ko, D. M. Glerum, and C. D. Moyes (2002)
J. Biol. Chem. 277, 11321-11328
   Abstract »    Full Text »    PDF »
8-Oxo-dGTPase, Which Prevents Oxidative Stress-Induced DNA Damage, Increases in the Mitochondria From Failing Hearts.
H. Tsutsui, T. Ide, T. Shiomi, D. Kang, S. Hayashidani, N. Suematsu, J. Wen, H. Utsumi, N. Hamasaki, and A. Takeshita (2001)
Circulation 104, 2883-2885
   Abstract »    Full Text »    PDF »
Mitochondrial Abnormalities in Ageing Macular Photoreceptors.
M. J. Barron, M. A. Johnson, R. M. Andrews, M. P. Clarke, P. G. Griffiths, E. Bristow, L.-P. He, S. Durham, and D. M. Turnbull (2001)
Invest. Ophthalmol. Vis. Sci. 42, 3016-3022
   Abstract »    Full Text »    PDF »
Late-Onset Corticohippocampal Neurodepletion Attributable to Catastrophic Failure of Oxidative Phosphorylation in MILON Mice.
L. Sorensen, M. Ekstrand, J. P. Silva, E. Lindqvist, B. Xu, P. Rustin, L. Olson, and N.-G. Larsson (2001)
J. Neurosci. 21, 8082-8090
   Abstract »    Full Text »    PDF »
Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice.
M. Osterod, S. Hollenbach, J. G. Hengstler, D. E. Barnes, T. Lindahl, and B. Epe (2001)
Carcinogenesis 22, 1459-1463
   Abstract »    Full Text »    PDF »
Milestone or Genomania? The Relevance of the Human Genome Project to Biological Aging and the Age-Related Diseases.
H. T. Blumenthal (2001)
J. Gerontol. A Biol. Sci. Med. Sci. 56, M529-537
   Full Text »    PDF »
Rapid Analysis of Mitochondrial DNA Heteroplasmy in Diabetes by Gel-Microchip Electrophoresis.
A. Guttman, H.-G. Gao, and R. Haas (2001)
Clin. Chem. 47, 1469-1472
   Full Text »    PDF »
Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points.
S. De Flora, A. Izzotti, F. D'Agostini, and R. M. Balansky (2001)
Carcinogenesis 22, 999-1013
   Abstract »    Full Text »    PDF »
Depletion of mitochondrial DNA alters glucose metabolism in SK-Hep1 cells.
K.-S. Park, K.-J. Nam, J.-W. Kim, Y.-B. Lee, C.-Y. Han, J.-K. Jeong, H.-K. Lee, and Y. K. Pak (2001)
Am J Physiol Endocrinol Metab 280, E1007-E1014
   Abstract »    Full Text »    PDF »
Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos.
M. Wilding, B. Dale, M. Marino, L. di Matteo, C. Alviggi, M. L. Pisaturo, L. Lombardi, and G. De Placido (2001)
Hum. Reprod. 16, 909-917
   Abstract »    Full Text »    PDF »
Biomarkers of DNA damage in patients with end-stage renal disease: mitochondrial DNA mutation in hair follicles.
C.-S. Liu, L.-Y. Ko, P.-S. Lim, S.-H. Kao, and Y.-H. Wei (2001)
Nephrol. Dial. Transplant. 16, 561-565
   Abstract »    Full Text »    PDF »
Changes in uncoupling protein-2 and -3 expression in aging rat skeletal muscle, liver, and heart.
R. Barazzoni and K. S. Nair (2001)
Am J Physiol Endocrinol Metab 280, E413-E419
   Abstract »    Full Text »    PDF »
Cerebral blood flow and glucose metabolism in mitochondrial disorders.
M. J. Molnar, A. Valikovics, S. Molnar, L. Tron, P. Dioszeghy, F. Mechler, and B. Gulyas (2000)
Neurology 55, 544-548
   Abstract »    Full Text »    PDF »
Replicative ageing and senescence in Saccharomyces cerevisiae and the impact on brewing fermentations.
C. D. Powell, S. M. Van Zandycke, D. E. Quain, and K. A. Smart (2000)
Microbiology 146, 1023-1034
   Full Text »
Effects of Aging on Mitochondrial DNA Copy Number and Cytochrome c Oxidase Gene Expression in Rat Skeletal Muscle, Liver, and Heart.
R. Barazzoni, K. R. Short, and K. S. Nair (2000)
J. Biol. Chem. 275, 3343-3347
   Abstract »    Full Text »    PDF »
The spectrum of hearing loss due to mitochondrial DNA defects.
P. F. Chinnery, C. Elliott, G. R. Green, A. Rees, A. Coulthard, D. M. Turnbull, and T. D. Griffiths (2000)
Brain 123, 82-92
   Abstract »    Full Text »    PDF »
Aging: Is Oxidative Stress a Marker or Is It Causal?.
N. K. Fukagawa (1999)
Experimental Biology and Medicine 222, 293-298
   Abstract »    Full Text »
Mapping of autosomal dominant progressive external ophthalmoplegia to a 7-cM critical region on 10q24.
F. Y. Li, M. Tariq, R. Croxen, K. Morten, W. Squier, J. Newsom-Davis, D. Beeson, and C. Larsson (1999)
Neurology 53, 1265
   Abstract »    Full Text »
Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans.
G. DE BENEDICTIS, G. ROSE, G. CARRIERI, M. DE LUCA, E. FALCONE, G. PASSARINO, M. BONAFÉ, D. MONTI, G. BAGGIO, S. BERTOLINI, et al. (1999)
FASEB J 13, 1532-1536
   Abstract »    Full Text »
The Other Genome.
W. D. Parker Jr (1999)
Clin. Chem. 45, 1129-1130
   Full Text »    PDF »
Autosomal dominant progressive external ophthalmoplegia: Distribution of multiple mitochondrial DNA deletions.
A.-R. Moslemi, A. Melberg, E. Holme, and A. Oldfors (1999)
Neurology 53, 79
   Abstract »    Full Text »
Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons.
J. Zhang, G. Perry, M. A. Smith, D. Robertson, S. J. Olson, D. G. Graham, and T. J. Montine (1999)
Am. J. Pathol. 154, 1423-1429
   Abstract »    Full Text »    PDF »
Transcomplementation between Different Types of Respiration-deficient Mitochondria with Different Pathogenic Mutant Mitochondrial DNAs.
D. Takai, K. Isobe, and J.-I. Hayashi (1999)
J. Biol. Chem. 274, 11199-11202
   Abstract »    Full Text »    PDF »
Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease.
S. Ito, S. Ohta, K. Nishimaki, Y. Kagawa, R. Soma, S.-y. Kuno, Y. Komatsuzaki, H. Mizusawa, and J.-I. Hayashi (1999)
PNAS 96, 2099-2103
   Abstract »    Full Text »    PDF »
An Electron Spin Resonance Spin-trapping Investigation of the Free Radicals Formed by the Reaction of Mitochondrial Cytochrome c Oxidase with H2O2.
Y.-R. Chen, M. R. Gunther, and R. P. Mason (1999)
J. Biol. Chem. 274, 3308-3314
   Abstract »    Full Text »    PDF »
Mitochondrial disease in superoxide dismutase 2 mutant mice.
S. Melov, P. Coskun, M. Patel, R. Tuinstra, B. Cottrell, A. S. Jun, T. H. Zastawny, M. Dizdaroglu, S. I. Goodman, T.-T. Huang, et al. (1999)
PNAS 96, 846-851
   Abstract »    Full Text »    PDF »
Influence of glutathione levels and heat-shock on the steady-state levels of oxidative DNA base modifications in mammalian cells.
O. Will, H.-C. Mahler, A.-P. Arrigo, and B. Epe (1999)
Carcinogenesis 20, 333-337
   Abstract »    Full Text »    PDF »
Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice.
M. D. Williams, H. Van Remmen, C. C. Conrad, T. T. Huang, C. J. Epstein, and A. Richardson (1998)
J. Biol. Chem. 273, 28510-28515
   Abstract »    Full Text »    PDF »
Ethidium Bromide-induced Inhibition of Mitochondrial Gene Transcription Suppresses Glucose-stimulated Insulin Release in the Mouse Pancreatic beta -Cell Line beta HC9.
T. Hayakawa, M. Noda, K. Yasuda, H. Yorifuji, S. Taniguchi, I. Miwa, H. Sakura, Y. Terauchi, J.-i. Hayashi, G. W. G. Sharp, et al. (1998)
J. Biol. Chem. 273, 20300-20307
   Abstract »    Full Text »    PDF »
Aging, mating, and the evolution of mtDNA heteroplasmy in Drosophila melanogaster.
L. M. Kann, E. B. Rosenblum, and D. M. Rand (1998)
PNAS 95, 2372-2377
   Abstract »    Full Text »    PDF »
Efficient Repair of Abasic Sites in DNA by Mitochondrial Enzymes.
K. G. Pinz and D. F. Bogenhagen (1998)
Mol. Cell. Biol. 18, 1257-1265
   Abstract »    Full Text »
Nuclear-recessive Mutations of Factors Involved in Mitochondrial Translation Are Responsible for Age-related Respiration Deficiency of Human Skin Fibroblasts.
K. Isobe, S. Ito, H. Hosaka, Y. Iwamura, H. Kondo, Y. Kagawa, and J.-I. Hayashi (1998)
J. Biol. Chem. 273, 4601-4606
   Abstract »    Full Text »    PDF »
Treatment of congenital lactic acidosis with dichloroacetate.
P. W Stacpoole, C. L Barnes, M. D Hurbanis, S. L Cannon, and D. S Kerr (1997)
Arch. Dis. Child. 77, 535-541
   Full Text »
Vitamins C and E Inhibit O2- Production in the Pig Coronary Artery.
G. L. Nunes, K. Robinson, A. Kalynych, S. B. King III, D. S. Sgoutas, and B. C. Berk (1997)
Circulation 96, 3593-3601
   Abstract »    Full Text »
Mitochondrial DNA Deletions Associated With Aging and Presbyacusis.
M. D. Seidman, U. Bai, M. J. Khan, and W. S. Quirk (1997)
Arch Otolaryngol Head Neck Surg 123, 1039-1045
   Abstract »    PDF »
Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea.
C. Borghouts, E. Kimpel, and H. D. Osiewacz (1997)
PNAS 94, 10768-10773
   Abstract »    Full Text »    PDF »
Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases.
Y. Luo, J. D. Bond, and V. M. Ingram (1997)
PNAS 94, 9705-9710
   Abstract »    Full Text »    PDF »
Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease.
R. E. Davis, S. Miller, C. Herrnstadt, S. S. Ghosh, E. Fahy, L. A. Shinobu, D. Galasko, L. J. Thal, M. F. Beal, N. Howell, et al. (1997)
PNAS 94, 4526-4531
   Abstract »    Full Text »    PDF »
Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase.
T. M. Hagen, D. L. Yowe, J. C. Bartholomew, C. M. Wehr, K. L. Do, J.-Y. Park, and B. N. Ames (1997)
PNAS 94, 3064-3069
   Abstract »    Full Text »    PDF »
The Interorganellar Interaction between Distinct Human Mitochondria with Deletion Mutant mtDNA from a Patient with Mitochondrial Disease and with HeLa mtDNA.
D. Takai, K. Inoue, Y.-i. Goto, I. Nonaka, and J.-I. Hayashi (1997)
J. Biol. Chem. 272, 6028-6033
   Abstract »    Full Text »    PDF »
Implants of Encapsulated Human CNTF-Producing Fibroblasts Prevent Behavioral Deficits and Striatal Degeneration in a Rodent Model of Huntington''s Disease.
D. F. Emerich, M. D. Lindner, S. R. Winn, E.-Y. Chen, B. R. Frydel, and J. H. Kordower (1996)
J. Neurosci. 16, 5168-5181
   Abstract »    Full Text »    PDF »
Aging-dependent Functional Alterations of Mitochondrial DNA (mtDNA) from Human Fibroblasts Transferred into mtDNA-less Cells.
K. A. Laderman, J. R. Penny, F. Mazzucchelli, N. Bresolin, G. Scarlato, and G. Attardi (1996)
J. Biol. Chem. 271, 15891-15897
   Abstract »    Full Text »    PDF »
A Delayed-early Response Nuclear Gene Encoding MRPL12, the Mitochondrial Homologue to the Bacterial Translational Regulator L7/L12 Protein.
L. Marty and P. Fort (1996)
J. Biol. Chem. 271, 11468-11476
   Abstract »    Full Text »    PDF »
Multiple Deletions Are Detectable in Mitochondrial DNA of Aging Mice.
S. M. Tanhauser and P. J. Laipis (1995)
J. Biol. Chem. 270, 24769-24775
   Abstract »    Full Text »    PDF »
Identification by in Organello Footprinting of Protein Contact Sites and of Single-stranded DNA Sequences in the Regulatory Region of Rat Mitochondrial DNA.
P. Cantatore, L. Daddabbo, F. Fracasso, and M. N. Gadaleta (1995)
J. Biol. Chem. 270, 25020-25027
   Abstract »    Full Text »    PDF »
Heteroplasmy in the control region of human mitochondrial DNA..
D Comas, S Paabo, and J Bertranpetit (1995)
Genome Res. 5, 89-90
   Abstract »    PDF »
Ischemic Delayed Neuronal Death : A Mitochondrial Hypothesis.
K. Abe, M. Aoki, J. Kawagoe, T. Yoshida, A. Hattori, K. Kogure, and Y. Itoyama (1995)
Stroke 26, 1478-1489
   Abstract »    Full Text »
Intracellular Localization of 8-Oxo-dGTPase in Human Cells, with Special Reference to the Role of the Enzyme in Mitochondria.
D. Kang, J.-i. Nishida, A. Iyama, Y. Nakabeppu, M. Furuichi, T. Fujiwara, M. Sekiguchi, and K. Takeshige (1995)
J. Biol. Chem. 270, 14659-14665
   Abstract »    Full Text »    PDF »
Action of Mitochondrial DNA Polymerase [IMAGE] at Sites of Base Loss or Oxidative Damage.
K. G. Pinz, S. Shibutani, and D. F. Bogenhagen (1995)
J. Biol. Chem. 270, 9202-9206
   Abstract »    Full Text »    PDF »
Cardiac Involvement in Mitochondrial Diseases : A Study on 17 Patients With Documented Mitochondrial DNA Defects.
R. Anan, M. Nakagawa, M. Miyata, I. Higuchi, S. Nakao, M. Suehara, M. Osame, and H. Tanaka (1995)
Circulation 91, 955-961
   Abstract »    Full Text »
A Subtype of Diabetes Mellitus Associated with a Mutation of Mitochondrial DNA.
T. Kadowaki, H. Kadowaki, Y. Mori, K. Tobe, R. Sakuta, Y. Suzuki, Y. Tanabe, H. Sakura, T. Awata, Y.-i. Goto, et al. (1994)
N. Engl. J. Med. 330, 962-968
   Abstract »    Full Text »
Mitochondria in Evolution and Disease.
R. N. Rosenberg (1994)
J Child Neurol 9, 1-3
   PDF »
Clinical, Neuroimaging, and Environmental Risk Differences in Monozygotic Female Twins Appearing Discordant for Dementia of the Alzheimer Type.
G. W. Small, A. F. Leuchter, M. A. Mandelkern, A. L. Rue, A. Okonek, R. B. Lufkin, L. F. Jarvik, S. S. Matsuyama, and W. Bondareff (1993)
Arch Neurol 50, 209-219
   Abstract »    PDF »
Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene.
I Garcia, I Martinou, Y Tsujimoto, and J. Martinou (1992)
Science 258, 302-304
   Abstract »    PDF »
Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis.
J. E. Kokoszka, P. Coskun, L. A. Esposito, and D. C. Wallace (2001)
PNAS 98, 2278-2283
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)