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Science 1 May 1992: Vol. 256. no. 5057, pp. 628 - 632 DOI: 10.1126/science.1533953
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Articles
Science, Vol 256, Issue 5057, 628-632
Copyright © 1992 by American Association for the Advancement of Science
Mitochondrial genetics: a paradigm for aging and degenerative diseases?
DC Wallace
Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging.
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