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Science 24 April 1992:
Vol. 256. no. 5056, pp. 538 - 542
DOI: 10.1126/science.1315077
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Articles

Science, Vol 256, Issue 5056, 538-542
Copyright © 1992 by American Association for the Advancement of Science

articles

Regulatory elements that control the lineage-specific expression of myoD

DJ Goldhamer, A Faerman, M Shani, and CP Emerson Jr

Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111.

The molecular basis of skeletal muscle lineage determination was investigated by analyzing DNA control elements that regulate the myogenic determination gene myoD. A distal enhancer was identified that positively regulates expression of the human myoD gene. The myoD enhancer and promoter were active in myogenic and several nonmyogenic cell lines. In transgenic mouse embryos, however, the myoD enhancer and promoter together directed expression of a lacZ transgene specifically to the skeletal muscle lineage. These data suggest that during development myoD is regulated by mechanisms that restrict accessibility of myoD control elements to positive trans-acting factors.


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