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Science 17 April 1992:
Vol. 256. no. 5055, pp. 370 - 373
DOI: 10.1126/science.256.5055.370
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Articles

Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPbeta

Michael Wegner 1, Zhaodan Cao 2, and Michael G. Rosenfeld 1

1 Eukaryotic Regulatory Biology Program and Howard Hughes Medical Institute, Cellular and Molecular Medicine Building, University of California, San Diego, La Jolla, CA 92093-0648
2 Department of Embryology, Howard Hughes Research Laboratories, Carnegie Institution of Washington, Baltimore, MD 21210

Alterations in intracellular calcium levels activate several signal transduction pathways resulting in distinct patterns of gene expression. Here, a pathway for calcium-mediated signals is demonstrated that involves C/EBPbeta, a member of the bZip family of transcription factors. In pituitary cells C/EBPbeta was phosphorylated in response to increased intracellular calcium concentrations as a consequence of the activation of a calcium-calmodulin— dependent protein kinase. Phosphorylation of serine at position 276 within the leucine zipper of C/EBPbeta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBPbeta.


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The alternatively initiated c-Myc proteins differentially regulate transcription through a noncanonical DNA-binding site..
S R Hann, M Dixit, R C Sears, and L Sealy (1994)
Genes & Dev. 8, 2441-2452
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Insulin Suppresses Transactivation by CAAT/Enhancer-binding Proteins beta (C/EBPbeta ). SIGNALING TO p300/CREB-BINDING PROTEIN BY PROTEIN KINASE B DISRUPTS INTERACTION WITH THE MAJOR ACTIVATION DOMAIN OF C/EBPbeta.
S. Guo, S. B. Cichy, X. He, Q. Yang, M. Ragland, A. K. Ghosh, P. F. Johnson, and T. G. Unterman (2001)
J. Biol. Chem. 276, 8516-8523
   Abstract »    Full Text »    PDF »
Interleukin-6-induced Tethering of STAT3 to the LAP/C/EBPbeta Promoter Suggests a New Mechanism of Transcriptional Regulation by STAT3.
M. Niehof, K. Streetz, T. Rakemann, S. C. Bischoff, M. P. Manns, F. Horn, and C. Trautwein (2001)
J. Biol. Chem. 276, 9016-9027
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Regulated Nuclear-Cytoplasmic Localization of CCAAT/ Enhancer-binding Protein delta in Osteoblasts.
J. Billiard, Y. Umayahara, K. Wiren, M. Centrella, T. L. McCarthy, and P. Rotwein (2001)
J. Biol. Chem. 276, 15354-15361
   Abstract »    Full Text »    PDF »
Growth Hormone Regulates Phosphorylation and Function of CCAAT/Enhancer-binding Protein beta by Modulating Akt and Glycogen Synthase Kinase-3.
G. Piwien-Pilipuk, D. Van Mater, S. E. Ross, O. A. MacDougald, and J. Schwartz (2001)
J. Biol. Chem. 276, 19664-19671
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Selective Suppression of CCAAT/Enhancer-binding Protein beta Binding and Cyclooxygenase-2 Promoter Activity by Sodium Salicylate in Quiescent Human Fibroblasts.
M. A. Saunders, L. Sansores-Garcia, D. W. Gilroy, and K. K. Wu (2001)
J. Biol. Chem. 276, 18897-18904
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Localization of the Cyclic ADP-ribose-dependent Calcium Signaling Pathway in Hepatocyte Nucleus.
K. M. Khoo, M.-K. Han, J. B. Park, S. W. Chae, U.-H. Kim, H. C. Lee, B. H. Bay, and C. F. Chang (2000)
J. Biol. Chem. 275, 24807-24817
   Abstract »    Full Text »    PDF »
The C/EBP bZIP Domain Can Mediate Lipopolysaccharide Induction of the Proinflammatory Cytokines Interleukin-6 and Monocyte Chemoattractant Protein-1.
H.-M. Hu, Q. Tian, M. Baer, C. J. Spooner, S. C. Williams, P. F. Johnson, and R. C. Schwartz (2000)
J. Biol. Chem. 275, 16373-16381
   Abstract »    Full Text »    PDF »
Cellular Signaling through Multifunctional Ca2+/Calmodulin-dependent Protein Kinase II.
T. R. Soderling, B. Chang, and D. Brickey (2001)
J. Biol. Chem. 276, 3719-3722
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