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Science 10 April 1992:
Vol. 256. no. 5054, pp. 228 - 232
DOI: 10.1126/science.1566070
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Articles

Science, Vol 256, Issue 5054, 228-232
Copyright © 1992 by American Association for the Advancement of Science

articles

Chromosome size-dependent control of meiotic recombination

DB Kaback, V Guacci, D Barber, and JW Mahon

Department of Microbiology and Molecular Genetics, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103.

Smaller chromosomes have higher rates of meiotic reciprocal recombination (centimorgans per kilobase pair) than larger chromosomes. This report demonstrates that decreasing the size of Saccharomyces cerevisiae chromosomal DNA molecules increases rates of meiotic recombination and increasing chromosome size decreases recombination rates. These results indicate that chromosome size directly affects meiotic reciprocal recombination.


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