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Science 3 April 1992:
Vol. 256. no. 5053, pp. 107 - 110
DOI: 10.1126/science.1314418
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Articles

Science, Vol 256, Issue 5053, 107-110
Copyright © 1992 by American Association for the Advancement of Science

articles

Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors

TE Wilson, RE Paulsen, KA Padgett, and J Milbrandt

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.

Steroid-thyroid hormone receptors typically bind as dimers to DNA sequences that contain repeated elements termed half-sites. NGFI-B, an early response protein and orphan member of this receptor superfamily, binds to a DNA sequence that contains only one half-site (5'-AAAGGTCA-3'). A domain separate from the NGFI-B zinc fingers, termed the A box, was identified and is required for recognition of the two adenine-thymidine (A-T) base pairs at the 5' end of the NGFI-B DNA binding element. In addition, a domain downstream of the zinc fingers of the orphan receptor H-2 region II binding protein, termed the T box, determined binding to tandem repeats of the estrogen receptor half-site (5'-AGGTCA-3').


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Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors..
V Giguere, M Tini, G Flock, E Ong, R M Evans, and G Otulakowski (1994)
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Cooperative dimerization of paired class homeo domains on DNA..
D Wilson, G Sheng, T Lecuit, N Dostatni, and C Desplan (1993)
Genes & Dev. 7, 2120-2134
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Determinants for selective RAR and TR recognition of direct repeat HREs..
T Perlmann, P N Rangarajan, K Umesono, and R M Evans (1993)
Genes & Dev. 7, 1411-1422
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Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers..
R Kurokawa, V C Yu, A Naar, S Kyakumoto, Z Han, S Silverman, M G Rosenfeld, and C K Glass (1993)
Genes & Dev. 7, 1423-1435
   Abstract »    PDF »
Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding.
M. Lee, S. Kliewer, J Provencal, P. Wright, and R. Evans (1993)
Science 260, 1117-1121
   Abstract »    PDF »
A Naturally Occurring Steroidogenic Factor-1 Mutation Exhibits Differential Binding and Activation of Target Genes.
M. Ito, J. C. Achermann, and J. L. Jameson (2000)
J. Biol. Chem. 275, 31708-31714
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Retinoic Acid-mediated Activation of the Mouse Renin Enhancer.
Q. Shi, K. W. Gross, and C. D. Sigmund (2001)
J. Biol. Chem. 276, 3597-3603
   Abstract »    Full Text »    PDF »


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