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Science 27 March 1992:
Vol. 255. no. 5052, pp. 1718 - 1720
DOI: 10.1126/science.1553561
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Articles

Science, Vol 255, Issue 5052, 1718-1720
Copyright © 1992 by American Association for the Advancement of Science

articles

Identification of the integrin VLA-2 as a receptor for echovirus 1

JM Bergelson, MP Shepley, BM Chan, ME Hemler, and RW Finberg

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.

Cell surface receptors for echovirus, a common human pathogen, were identified with monoclonal antibodies that protected susceptible cells from infection with echovirus 1. These monoclonal antibodies, which prevented virus attachment to specific receptor sites, recognized the alpha and beta subunits of the integrin VLA-2 (alpha 2 beta 1), a receptor for collagen and laminin. RD rhabdomyosarcoma cells expressed little VLA-2, did not bind to 35S-labeled virus, and resisted infection until transfected with complementary DNA encoding the alpha 2 subunit of VLA-2. Thus, integrins, adhesion receptors important in interactions between cells and with the extracellular matrix, can mediate virus attachment and infection.


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Finding out how a viral hitchhiker snags a ride.
R Eisner (1992)
Science 255, 1647
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