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Science 27 March 1992:
Vol. 255. no. 5052, pp. 1707 - 1710
DOI: 10.1126/science.1553558

Articles

Science, Vol 255, Issue 5052, 1707-1710
Copyright © 1992 by American Association for the Advancement of Science


articles

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

BA Reynolds and S Weiss

Department of Pathology, University of Calgary Faculty of Medicine, Alberta, Canada.

Neurogenesis in the mammalian central nervous system is believed to end in the period just after birth; in the mouse striatum no new neurons are produced after the first few days after birth. In this study, cells isolated from the striatum of the adult mouse brain were induced to proliferate in vitro by epidermal growth factor. The proliferating cells initially expressed nestin, an intermediate filament found in neuroepithelial stem cells, and subsequently developed the morphology and antigenic properties of neurons and astrocytes. Newly generated cells with neuronal morphology were immunoreactive for gamma-aminobutyric acid and substance P, two neurotransmitters of the adult striatum in vivo. Thus, cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.


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J. Neurosci. 27, 3416-3428
   Abstract »    Full Text »    PDF »
Oligodendrocytes and Radial Glia Derived From Adult Rat Spinal Cord Progenitors: Morphological and Immunocytochemical Characterization.
I. Kulbatski, A. J. Mothe, A. Keating, Y. Hakamata, E. Kobayashi, and C. H. Tator (2007)
J. Histochem. Cytochem. 55, 209-222
   Abstract »    Full Text »    PDF »
Differentiation of Adult Mouse Olfactory Precursor Cells into Hair Cells In Vitro.
K. L. Doyle, A. Kazda, Y. Hort, S. M. McKay, and S. Oleskevich (2007)
Stem Cells 25, 621-627
   Abstract »    Full Text »    PDF »
Regenerative Potential of Cardiosphere-Derived Cells Expanded From Percutaneous Endomyocardial Biopsy Specimens.
R. R. Smith, L. Barile, H. C. Cho, M. K. Leppo, J. M. Hare, E. Messina, A. Giacomello, M. R. Abraham, and E. Marban (2007)
Circulation 115, 896-908
   Abstract »    Full Text »    PDF »
Introduction to Neural Stem Cells.
H. I. Kornblum (2007)
Stroke 38, 810-816
   Abstract »    Full Text »    PDF »
NG2 and Olig2 Expression Provides Evidence for Phenotypic Deregulation of Cultured Central Nervous System and Peripheral Nervous System Neural Precursor Cells.
C. Dromard, S. Bartolami, L. Deleyrolle, H. Takebayashi, C. Ripoll, L. Simonneau, S. Prome, S. Puech, C. Tran Van Ba, C. Duperray, et al. (2007)
Stem Cells 25, 340-353
   Abstract »    Full Text »    PDF »
Concise Review: Therapeutic Strategies for Parkinson Disease Based on the Modulation of Adult Neurogenesis.
M. Geraerts, O. Krylyshkina, Z. Debyser, and V. Baekelandt (2007)
Stem Cells 25, 263-270
   Abstract »    Full Text »    PDF »
Attenuation of Herpes Simplex Virus Neurovirulence with Picornavirus cis-Acting Genetic Elements.
S. A. Campbell, M. Mulvey, I. Mohr, and M. Gromeier (2007)
J. Virol. 81, 791-799
   Abstract »    Full Text »    PDF »
Nitric Oxide Decreases Subventricular Zone Stem Cell Proliferation by Inhibition of Epidermal Growth Factor Receptor and Phosphoinositide-3-Kinase/Akt Pathway.
A. Torroglosa, M. Murillo-Carretero, C. Romero-Grimaldi, E. R. Matarredona, A. Campos-Caro, and C. Estrada (2007)
Stem Cells 25, 88-97
   Abstract »    Full Text »    PDF »
Developmental ability of cloned embryos from neural stem cells..
E. Mizutani, H. Ohta, S. Kishigami, N. Van Thuan, T. Hikichi, S. Wakayama, M. Kosaka, E. Sato, and T. Wakayama (2006)
Reproduction 132, 849-857
   Abstract »    Full Text »    PDF »
Expression of the Receptor Tyrosine Kinase Tie2 in Neoplastic Glial Cells Is Associated with Integrin {beta}1-Dependent Adhesion to the Extracellular Matrix.
O.-H. Lee, J. Xu, J. Fueyo, G. N. Fuller, K. D. Aldape, M. M. Alonso, Y. Piao, T.-J. Liu, F. F. Lang, B. N. Bekele, et al. (2006)
Mol. Cancer Res. 4, 915-926
   Abstract »    Full Text »    PDF »
Isolation of Multipotent Neural Crest-Derived Stem Cells from the Adult Mouse Cornea.
S. Yoshida, S. Shimmura, N. Nagoshi, K. Fukuda, Y. Matsuzaki, H. Okano, and K. Tsubota (2006)
Stem Cells 24, 2714-2722
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Isolation and Characterization of a Stem Cell Population from Adult Human Liver.
M. B. Herrera, S. Bruno, S. Buttiglieri, C. Tetta, S. Gatti, M. C. Deregibus, B. Bussolati, and G. Camussi (2006)
Stem Cells 24, 2840-2850
   Abstract »    Full Text »    PDF »



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