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Science 27 March 1992: Vol. 255. no. 5052, pp. 1707 - 1710 DOI: 10.1126/science.1553558
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Articles
Science, Vol 255, Issue 5052, 1707-1710
Copyright © 1992 by American Association for the Advancement of Science
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
BA Reynolds
and
S Weiss
Department of Pathology, University of Calgary Faculty of Medicine, Alberta, Canada.
Neurogenesis in the mammalian central nervous system is believed to end in the period just after birth; in the mouse striatum no new neurons are produced after the first few days after birth. In this study, cells isolated from the striatum of the adult mouse brain were induced to proliferate in vitro by epidermal growth factor. The proliferating cells initially expressed nestin, an intermediate filament found in neuroepithelial stem cells, and subsequently developed the morphology and antigenic properties of neurons and astrocytes. Newly generated cells with neuronal morphology were immunoreactive for gamma-aminobutyric acid and substance P, two neurotransmitters of the adult striatum in vivo. Thus, cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.
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- Resilience to Transformation and Inherent Genetic and Functional Stability of Adult Neural Stem Cells Ex vivo.
- C. Foroni, R. Galli, B. Cipelletti, A. Caumo, S. Alberti, R. Fiocco, and A. Vescovi (2007)
Cancer Res.
67, 3725-3733
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- Human Cortical Neurons Originate from Radial Glia and Neuron-Restricted Progenitors.
- Z. Mo, A. R. Moore, R. Filipovic, Y. Ogawa, I. Kazuhiro, S. D. Antic, and N. Zecevic (2007)
J. Neurosci.
27, 4132-4145
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- Characteristics of Progenitor Cells Derived from Adult Ciliary Body in Mouse, Rat, and Human Eyes.
- H. Xu, D. D. Sta. Iglesia, J. L. Kielczewski, D. F. Valenta, M. E. Pease, D. J. Zack, and H. A. Quigley (2007)
Invest. Ophthalmol. Vis. Sci.
48, 1674-1682
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- Spontaneous Fusion and Nonclonal Growth of Adult Neural Stem Cells.
- S. Jessberger, G. D. Clemenson Jr, and F. H. Gage (2007)
Stem Cells
25, 871-874
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- Myelination of Congenitally Dysmyelinated Spinal Cord Axons by Adult Neural Precursor Cells Results in Formation of Nodes of Ranvier and Improved Axonal Conduction.
- E. Eftekharpour, S. Karimi-Abdolrezaee, J. Wang, H. El Beheiry, C. Morshead, and M. G. Fehlings (2007)
J. Neurosci.
27, 3416-3428
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- Oligodendrocytes and Radial Glia Derived From Adult Rat Spinal Cord Progenitors: Morphological and Immunocytochemical Characterization.
- I. Kulbatski, A. J. Mothe, A. Keating, Y. Hakamata, E. Kobayashi, and C. H. Tator (2007)
J. Histochem. Cytochem.
55, 209-222
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- Differentiation of Adult Mouse Olfactory Precursor Cells into Hair Cells In Vitro.
- K. L. Doyle, A. Kazda, Y. Hort, S. M. McKay, and S. Oleskevich (2007)
Stem Cells
25, 621-627
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- Regenerative Potential of Cardiosphere-Derived Cells Expanded From Percutaneous Endomyocardial Biopsy Specimens.
- R. R. Smith, L. Barile, H. C. Cho, M. K. Leppo, J. M. Hare, E. Messina, A. Giacomello, M. R. Abraham, and E. Marban (2007)
Circulation
115, 896-908
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- Introduction to Neural Stem Cells.
- H. I. Kornblum (2007)
Stroke
38, 810-816
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- NG2 and Olig2 Expression Provides Evidence for Phenotypic Deregulation of Cultured Central Nervous System and Peripheral Nervous System Neural Precursor Cells.
- C. Dromard, S. Bartolami, L. Deleyrolle, H. Takebayashi, C. Ripoll, L. Simonneau, S. Prome, S. Puech, C. Tran Van Ba, C. Duperray, et al. (2007)
Stem Cells
25, 340-353
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- Concise Review: Therapeutic Strategies for Parkinson Disease Based on the Modulation of Adult Neurogenesis.
- M. Geraerts, O. Krylyshkina, Z. Debyser, and V. Baekelandt (2007)
Stem Cells
25, 263-270
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- Attenuation of Herpes Simplex Virus Neurovirulence with Picornavirus cis-Acting Genetic Elements.
- S. A. Campbell, M. Mulvey, I. Mohr, and M. Gromeier (2007)
J. Virol.
81, 791-799
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- Nitric Oxide Decreases Subventricular Zone Stem Cell Proliferation by Inhibition of Epidermal Growth Factor Receptor and Phosphoinositide-3-Kinase/Akt Pathway.
- A. Torroglosa, M. Murillo-Carretero, C. Romero-Grimaldi, E. R. Matarredona, A. Campos-Caro, and C. Estrada (2007)
Stem Cells
25, 88-97
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- Developmental ability of cloned embryos from neural stem cells..
- E. Mizutani, H. Ohta, S. Kishigami, N. Van Thuan, T. Hikichi, S. Wakayama, M. Kosaka, E. Sato, and T. Wakayama (2006)
Reproduction
132, 849-857
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- Expression of the Receptor Tyrosine Kinase Tie2 in Neoplastic Glial Cells Is Associated with Integrin {beta}1-Dependent Adhesion to the Extracellular Matrix.
- O.-H. Lee, J. Xu, J. Fueyo, G. N. Fuller, K. D. Aldape, M. M. Alonso, Y. Piao, T.-J. Liu, F. F. Lang, B. N. Bekele, et al. (2006)
Mol. Cancer Res.
4, 915-926
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- Isolation of Multipotent Neural Crest-Derived Stem Cells from the Adult Mouse Cornea.
- S. Yoshida, S. Shimmura, N. Nagoshi, K. Fukuda, Y. Matsuzaki, H. Okano, and K. Tsubota (2006)
Stem Cells
24, 2714-2722
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- Isolation and Characterization of a Stem Cell Population from Adult Human Liver.
- M. B. Herrera, S. Bruno, S. Buttiglieri, C. Tetta, S. Gatti, M. C. Deregibus, B. Bussolati, and G. Camussi (2006)
Stem Cells
24, 2840-2850
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