Related Content
Search Google Scholar for:
|
|
Science 27 March 1992:
Vol. 255. no. 5052, pp. 1700 - 1702
DOI: 10.1126/science.1372755
|
|
Articles
Science, Vol 255, Issue 5052, 1700-1702
Copyright © 1992 by American Association for the Advancement of Science
Inhibition of myeloid differentiation by the helix-loop-helix protein Id
BL Kreider,
R Benezra,
G Rovera,
and
T Kadesch
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Id is a helix-loop-helix (HLH) protein that represses activity of several basic helix-loop-helix (bHLH) proteins involved in cell type--specific transcription and cell lineage commitment. The myeloid precursor cell line 32DC13(G) expressed Id messenger RNA, which was transiently decreased when cells were induced to terminally differentiate with granulocyte--colony-stimulating factor. Concomitant with the decrease of Id messenger RNA was the appearance in nuclear extracts of DNA binding proteins that recognized a canonical E-box motif, a DNA binding site for some bHLH proteins. Constitutive expression of an Id complementary DNA in 32DC13(G) cells blocked their ability to differentiate and to induce E-box-binding activity. These results suggest that Id and, hence, bHLH proteins function in the process of myeloid differentiation.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- BMP2 and BMP7 play antagonistic roles in feather induction.
- F. Michon, L. Forest, E. Collomb, J. Demongeot, and D. Dhouailly (2008)
Development
135, 2797-2805
| Abstract »
| Full Text »
| PDF »
- Cross Talk between Id1 and Its Interactive Protein Dril1 Mediate Fibroblast Responses to Transforming Growth Factor-{beta} in Pulmonary Fibrosis.
- L. Lin, Z. Zhou, L. Zheng, S. Alber, S. Watkins, P. Ray, N. Kaminski, Y. Zhang, and D. Morse (2008)
Am. J. Pathol.
173, 337-346
| Abstract »
| Full Text »
| PDF »
- Regulation of Angiogenesis by Id-1 through Hypoxia-Inducible Factor-1{alpha}-Mediated Vascular Endothelial Growth Factor Up-regulation in Hepatocellular Carcinoma.
- T. K. Lee, R. T.P. Poon, A. P. Yuen, M. T. Ling, X. H. Wang, Y. C. Wong, X. Y. Guan, K. Man, Z. Y. Tang, and S. T. Fan (2006)
Clin. Cancer Res.
12, 6910-6919
| Abstract »
| Full Text »
| PDF »
- Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes.
- G. Pache, C. Schafer, S. Wiesemann, E. Springer, M. Liebau, H. C. Reinhardt, C. August, H. Pavenstadt, and M. J. Bek (2006)
Am J Physiol Renal Physiol
291, F654-F662
| Abstract »
| Full Text »
| PDF »
- Extracellular Phosphate Alters Cementoblast Gene Expression.
- R.B. Rutherford, B.L. Foster, T. Bammler, R.P. Beyer, S. Sato, and M.J. Somerman (2006)
Journal of Dental Research
85, 505-509
| Abstract »
| Full Text »
| PDF »
- Hypoxia Inhibits Differentiation of Lineage-Specific Rcho-1 Trophoblast Giant Cells.
- A. D. Gultice, K. L. Selesniemi, and T. L. Brown (2006)
Biol Reprod
74, 1041-1050
| Abstract »
| Full Text »
| PDF »
- Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation.
- J. Lee, K. Kim, J. H. Kim, H. M. Jin, H. K. Choi, S.-H. Lee, H. Kook, K. K. Kim, Y. Yokota, S. Y. Lee, et al. (2006)
Blood
107, 2686-2693
| Abstract »
| Full Text »
| PDF »
- Inhibitors of Differentiation and DNA Binding (Ids) Regulate Math1 and Hair Cell Formation during the Development of the Organ of Corti.
- J. M. Jones, M. Montcouquiol, A. Dabdoub, C. Woods, and M. W. Kelley (2006)
J. Neurosci.
26, 550-558
| Abstract »
| Full Text »
| PDF »
- Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF).
- M.-T. Ling, T. C.M. Lau, C. Zhou, C. W. Chua, W. K. Kwok, Q. Wang, X. Wang, and Y.-C. Wong (2005)
Carcinogenesis
26, 1668-1676
| Abstract »
| Full Text »
| PDF »
- SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.
- D. Reynaud, E. Ravet, M. Titeux, F. Mazurier, L. Renia, A. Dubart-Kupperschmitt, P.-H. Romeo, and F. Pflumio (2005)
Blood
106, 2318-2328
| Abstract »
| Full Text »
| PDF »
- IL-3 Induces Inhibitor of DNA-Binding Protein-1 in Hemopoietic Progenitor Cells and Promotes Myeloid Cell Development.
- W. Leeanansaksiri, H. Wang, J. M. Gooya, K. Renn, M. Abshari, S. Tsai, and J. R. Keller (2005)
J. Immunol.
174, 7014-7021
| Abstract »
| Full Text »
| PDF »
- Id Family of Transcription Factors and Vascular Lesion Formation.
- S. Forrest and C. McNamara (2004)
Arterioscler. Thromb. Vasc. Biol.
24, 2014-2020
| Abstract »
| Full Text »
| PDF »
- Genomic Mechanisms of p210BCR-ABL Signaling: INDUCTION OF HEAT SHOCK PROTEIN 70 THROUGH THE GATA RESPONSE ELEMENT CONFERS RESISTANCE TO PACLITAXEL-INDUCED APOPTOSIS.
- S. Ray, Y. Lu, S. H. Kaufmann, W. C. Gustafson, J. E. Karp, I. Boldogh, A. P. Fields, and A. R. Brasier (2004)
J. Biol. Chem.
279, 35604-35615
| Abstract »
| Full Text »
| PDF »
- Inhibitor of DNA Binding/Differentiation Helix-Loop-Helix Proteins Mediate Bone Morphogenetic Protein-induced Osteoblast Differentiation of Mesenchymal Stem Cells.
- Y. Peng, Q. Kang, Q. Luo, W. Jiang, W. Si, B. A. Liu, H. H. Luu, J. K. Park, X. Li, J. Luo, et al. (2004)
J. Biol. Chem.
279, 32941-32949
| Abstract »
| Full Text »
| PDF »
- Regulation of Cellular Senescence and p16INK4a Expression by Id1 and E47 Proteins in Human Diploid Fibroblast.
- W. Zheng, H. Wang, L. Xue, Z. Zhang, and T. Tong (2004)
J. Biol. Chem.
279, 31524-31532
| Abstract »
| Full Text »
| PDF »
- Role of Pescadillo and Upstream Binding Factor in the Proliferation and Differentiation of Murine Myeloid Cells.
- M. Prisco, A. Maiorana, C. Guerzoni, G. Calin, B. Calabretta, R. Voit, I. Grummt, and R. Baserga (2004)
Mol. Cell. Biol.
24, 5421-5433
| Abstract »
| Full Text »
| PDF »
- E2A/HEB and Id3 Proteins Control the Sensitivity to Glucocorticoid-induced Apoptosis in Thymocytes by Regulating the SRG3 Expression.
- M. Ko, J. Ahn, C. Lee, H. Chung, S. H. Jeon, H.-Y. Chung, and R. H. Seong (2004)
J. Biol. Chem.
279, 21916-21923
| Abstract »
| Full Text »
| PDF »
- Signaling Differences from the A and B Isoforms of the Insulin Receptor (IR) in 32D Cells in the Presence or Absence of IR Substrate-1.
- L. Sciacca, M. Prisco, A. Wu, A. Belfiore, R. Vigneri, and R. Baserga (2003)
Endocrinology
144, 2650-2658
| Abstract »
| Full Text »
| PDF »
- Regulation of Id2 Gene Expression by the Type 1 IGF Receptor and the Insulin Receptor Substrate-1.
- M. Navarro, B. Valentinis, B. Belletti, G. Romano, K. Reiss, and R. Baserga (2001)
Endocrinology
142, 5149-5157
| Abstract »
| Full Text »
| PDF »
- Id-1, ITF-2, and Id-2 Comprise a Network of Helix-Loop-Helix Proteins That Regulate Mammary Epithelial Cell Proliferation, Differentiation, and Apoptosis.
- S. Parrinello, C. Q. Lin, K. Murata, Y. Itahana, J. Singh, A. Krtolica, J. Campisi, and P.-Y. Desprez (2001)
J. Biol. Chem.
276, 39213-39219
| Abstract »
| Full Text »
| PDF »
- Regulation of Id Gene Expression by Type I Insulin-Like Growth Factor: Roles of STAT3 and the Tyrosine 950 Residue of the Receptor.
- M. Prisco, F. Peruzzi, B. Belletti, and R. Baserga (2001)
Mol. Cell. Biol.
21, 5447-5458
| Abstract »
| Full Text »
| PDF »
- Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat.
- X.S. Ouyang, X. Wang, D.T.W. Lee, S.W. Tsao, and Y.C. Wong (2001)
Carcinogenesis
22, 965-973
| Abstract »
| Full Text »
| PDF »
- A Role for Id-1 in the Aggressive Phenotype and Steroid Hormone Response of Human Breast Cancer Cells.
- C. Q. Lin, J. Singh, K. Murata, Y. Itahana, S. Parrinello, S. H. Liang, C. E. Gillett, J. Campisi, and P.-Y. Desprez (2000)
Cancer Res.
60, 1332-1340
| Abstract »
| Full Text »
- .
- A. Pagliuca (2000)
Cancer Res.
60, 1376-1382
- Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis.
- H. Maruyama, J. Kleeff, S. Wildi, H. Friess, M. W. Buchler, M. A. Israel, and M. Korc (1999)
Am. J. Pathol.
155, 815-822
| Abstract »
| Full Text »
| PDF »
- Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1.
- R. M. Alani, J. Hasskarl, M. Grace, M.-C. Hernandez, M. A. Israel, and K. Munger (1999)
PNAS
96, 9637-9641
| Abstract »
| Full Text »
| PDF »
- Identification of Id2 as a Globin Regulatory Protein by Representational Difference Analysis of K562 Cells Induced To Express gamma -Globin with a Fungal Compound.
- M. L. Holmes, J. D. Haley, L. Cerruti, W.-l. Zhou, H. Zogos, D. E. Smith, J. M. Cunningham, and S. M. Jane (1999)
Mol. Cell. Biol.
19, 4182-4190
| Abstract »
| Full Text »
| PDF »
- PU.1 and USF Are Required for Macrophage-specific Mannose Receptor Promoter Activity.
- B. S. Egan, K. B. Lane, and V. L. Shepherd (1999)
J. Biol. Chem.
274, 9098-9107
| Abstract »
| Full Text »
| PDF »
- Two Isoforms of Protein Disulfide Isomerase Alter the Dimerization Status of E2A Proteins by a Redox Mechanism.
- M. Markus and R. Benezra (1999)
J. Biol. Chem.
274, 1040-1049
| Abstract »
| Full Text »
| PDF »
- Expression of Id1 Results in Apoptosis of Cardiac Myocytes through a Redox-dependent Mechanism.
- K. Tanaka, J. B. Pracyk, K. Takeda, Z.-X. Yu, V. J. Ferrans, S. S. Deshpande, M. Ozaki, P. M. Hwang, C. J. Lowenstein, K. Irani, et al. (1998)
J. Biol. Chem.
273, 25922-25928
| Abstract »
| Full Text »
| PDF »
- Forced Expression of Id-1 in the Adult Mouse Small Intestinal Epithelium Is Associated with Development of Adenomas.
- B. M. Wice and J. I. Gordon (1998)
J. Biol. Chem.
273, 25310-25319
| Abstract »
| Full Text »
| PDF »
- Id2 Promotes Apoptosis by a Novel Mechanism Independent of Dimerization to Basic Helix-Loop-Helix Factors.
- M. Florio, M.-C. Hernandez, H. Yang, H.-K. Shu, J. L. Cleveland, and M. A. Israel (1998)
Mol. Cell. Biol.
18, 5435-5444
| Abstract »
| Full Text »
- Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12.
- B. L. Kee and C. Murre (1998)
J. Exp. Med.
188, 699-713
| Abstract »
| Full Text »
| PDF »
- A Novel Pathway for Mammary Epithelial Cell Invasion Induced by the Helix-Loop-Helix Protein Id-1.
- P.-Y. Desprez, C. Q. Lin, N. Thomasset, C. J. Sympson, M. J. Bissell, and J. Campisi (1998)
Mol. Cell. Biol.
18, 4577-4588
| Abstract »
| Full Text »
- Lymphoid-specific Expression of the Id3 Gene in Hematopoietic Cells. SELECTIVE ANTAGONISM OF E2A BASIC HELIX-LOOP-HELIX PROTEIN ASSOCIATED WITH Id3-INDUCED DIFFERENTIATION OF ERYTHROLEUKEMIA CELLS.
- R. W. Deed, M. Jasiok, and J. D. Norton (1998)
J. Biol. Chem.
273, 8278-8286
| Abstract »
| Full Text »
| PDF »
- A Role for Sp and Helix-Loop-Helix Transcription Factors in the Regulation of the Human Id4 Gene Promoter Activity.
- A. Pagliuca, P. Cannada-Bartoli, and L. Lania (1998)
J. Biol. Chem.
273, 7668-7674
| Abstract »
| Full Text »
| PDF »
- A Novel, Myeloid Transcription Factor, C/EBPepsilon , Is Upregulated During Granulocytic, But Not Monocytic, Differentiation.
- R. Morosetti, D. J. Park, A. M. Chumakov, I. Grillier, M. Shiohara, A. F. Gombart, T. Nakamaki, K. Weinberg, and H. P. Koeffler (1997)
Blood
90, 2591-2600
| Abstract »
| Full Text »
| PDF »
- Lineage-Specific Regulation of Hematopoiesis by HOX-B8 (HOX-2.4): Inhibition of Granulocytic Differentiation and Potentiation of Monocytic Differentiation.
- K. Krishnaraju, B. Hoffman, and D. A. Liebermann (1997)
Blood
90, 1840-1849
| Abstract »
| Full Text »
| PDF »
- Differential Interactions of Id Proteins with Basic-Helix-Loop-Helix Transcription Factors.
- K. Langlands, X. Yin, G. Anand, and E. V. Prochownik (1997)
J. Biol. Chem.
272, 19785-19793
| Abstract »
| Full Text »
| PDF »
- Novel Regulation of the Helix-Loop-Helix Protein Id1 by S5a, a Subunit of the 26 S Proteasome.
- G. Anand, X. Yin, A. K. Shahidi, L. Grove, and E. V. Prochownik (1997)
J. Biol. Chem.
272, 19140-19151
| Abstract »
| Full Text »
| PDF »
- Transcription Factors, Normal Myeloid Development, and Leukemia.
- D. G. Tenen, R. Hromas, J. D. Licht, and D.-E. Zhang (1997)
Blood
90, 489-519
| Full Text »
| PDF »
- Expression of the Id Family Helix-Loop-Helix Regulators During Growth and Development in the Hematopoietic System.
- C. L. Cooper, G. Brady, F. Bilia, N. N. Iscove, and P. J. Quesenberry (1997)
Blood
89, 3155-3165
| Abstract »
| Full Text »
| PDF »
- E-box Sequence and Context-dependent TAL1/SCL Modulation of Basic Helix-Loop-Helix Protein-mediated Transcriptional Activation.
- A. L. Nielsen, P. L. Norby, F. S. Pedersen, and P. Jorgensen (1996)
J. Biol. Chem.
271, 31463-31469
| Abstract »
| Full Text »
| PDF »
- Inhibition of granulocytic differentiation by mNotch1.
- L. A. Milner, A. Bigas, R. Kopan, C. Brashem-Stein, I. D. Bernstein, and D. I. K. Martin (1996)
PNAS
93, 13014-13019
| Abstract »
| Full Text »
| PDF »
- An E-Box Motif Conveys Inhibitory Activity on the Atrial Natriuretic Peptide Gene.
- M. Garami and D. G. Gardner (1996)
Hypertension
28, 315-319
| Abstract »
| Full Text »
- MIDA1, a Protein Associated with Id, Regulates Cell Growth.
- W. Shoji, T. Inoue, T. Yamamoto, and M. Obinata (1995)
J. Biol. Chem.
270, 24818-24825
| Abstract »
| Full Text »
| PDF »
- Inhibition of an Erythroid Differentiation Switch by the Helix-Loop-Helix Protein Id1.
- J. Lister, W. C. Forrester, and M. H. Baron (1995)
J. Biol. Chem.
270, 17939-17946
| Abstract »
| Full Text »
| PDF »
- The Upstream Promoter Element of the Glucagon Gene, G1, Confers Pancreatic Alpha Cell-specific Expression.
- C. Morel, M. Cordier-Bussat, and J. Philippe (1995)
J. Biol. Chem.
270, 3046-3055
| Abstract »
| Full Text »
| PDF »
- The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein..
- A Iavarone, P Garg, A Lasorella, J Hsu, and M A Israel (1994)
Genes & Dev.
8, 1270-1284
| Abstract »
| PDF »
- Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins.
- B Nelsen, G Tian, B Erman, J Gregoire, R Maki, B Graves, and R Sen (1993)
Science
261, 82-86
| Abstract »
| PDF »
- Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins..
- Y Jen, H Weintraub, and R Benezra (1992)
Genes & Dev.
6, 1466-1479
| Abstract »
| PDF »
- Molecular Cloning and Characterization of a Zinc Finger Protein Involved in Id-1-stimulated Mammary Epithelial Cell Growth.
- J. Singh, Y. Itahana, S. Parrinello, K. Murata, and P.-Y. Desprez (2001)
J. Biol. Chem.
276, 11852-11858
| Abstract »
| Full Text »
| PDF »
- Regulation of Id2 Gene Expression by the Insulin-like Growth Factor I Receptor Requires Signaling by Phosphatidylinositol 3-Kinase.
- B. Belletti, M. Prisco, A. Morrione, B. Valentinis, M. Navarro, and R. Baserga (2001)
J. Biol. Chem.
276, 13867-13874
| Abstract »
| Full Text »
| PDF »
- Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2.
- T. Ikawa, S. Fujimoto, H. Kawamoto, Y. Katsura, and Y. Yokota (2001)
PNAS
98, 5164-5169
| Abstract »
| Full Text »
| PDF »
|
|
