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Science 27 March 1992:
Vol. 255. no. 5052, pp. 1693 - 1695
DOI: 10.1126/science.1553556
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Articles

Science, Vol 255, Issue 5052, 1693-1695
Copyright © 1992 by American Association for the Advancement of Science

articles

Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene

C Walker, TL Goldsworthy, DC Wolf, and J Everitt

Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.

A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.


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