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Science 27 March 1992:
Vol. 255. no. 5052, pp. 1671 - 1677
DOI: 10.1126/science.1313187
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Articles

Science, Vol 255, Issue 5052, 1671-1677
Copyright © 1992 by American Association for the Advancement of Science

articles

Intercellular communication and cell-cell adhesion

SJ Singer

Department of Biology, University of California, San Diego, La Jolla 92093.

In developmental biology, binary cell-cell interactions often determine the fate of one or both cell partners. The two cells must adhere to one another to allow chemical signals to be transmitted in one or both directions across the regions of cell-cell contact. The molecular mechanisms of cell-cell adhesion and intercellular communication, even if they are mediated by different cell surface components, may be functionally integrated in several different ways. Studies of helper T cells with antigen-presenting B cells in culture have illuminated such binary interactions. The possible application of similar mechanisms to other binary developmental systems is briefly explored.


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