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Science 13 March 1992:
Vol. 255. no. 5050, pp. 1441 - 1443
DOI: 10.1126/science.1542795
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Articles

Science, Vol 255, Issue 5050, 1441-1443
Copyright © 1992 by American Association for the Advancement of Science

articles

Involvement of subplate neurons in the formation of ocular dominance columns

A Ghosh and CJ Shatz

Department of Neurobiology, Stanford University School of Medicine, CA 94305.

During development of the mammalian visual system, axon terminals of lateral geniculate nucleus (LGN) neurons, initially intermixed within layer 4 of the visual cortex, gradually segregate according to eye preference to form ocular dominance columns. In addition to LGN axons and layer 4 neurons, subplate neurons may also participate in interactions leading to column formation. Deletion of subplate neurons before the formation of ocular dominance columns prevents the segregation of LGN axons within layer 4. Thus, interactions between LGN axons and layer 4 neurons are not sufficient; subplate neurons are also required for formation of ocular dominance columns in the visual cortex.


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