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Science 13 March 1992:
Vol. 255. no. 5050, pp. 1430 - 1432
DOI: 10.1126/science.1542792
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Articles

Science, Vol 255, Issue 5050, 1430-1432
Copyright © 1992 by American Association for the Advancement of Science

articles

Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M

BC Nair, AL DeVico, S Nakamura, TD Copeland, Y Chen, A Patel, T O'Neil, S Oroszlan, RC Gallo, and MG Sarngadharan

Department of Cell Biology, Advanced BioScience Laboratories, Inc., Kensington, MD.

Conditioned medium from human T cell leukemia virus type 2 (HTLV-II)-infected T cells supports the growth and long-term culture of cells derived from acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma lesions (AIDS-KS cells). A protein of 30 kilodaltons was purified from conditioned medium that supports the growth of AIDS-KS cells. The amino-terminal sequence of this protein was identical to the amino-terminal sequence of Oncostatin M, a glycoprotein that inhibits the growth of a variety of cancer cells. Oncostatin M from conditioned medium stimulated a twofold increase in the growth of AIDS-KS cells at a concentration of less than 1 nanogram of the protein per milliliter of medium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Box 2 Region of the Oncostatin M Receptor Determines Specificity for Recruitment of Janus Kinases and STAT5 Activation.
C. Hintzen, C. Evers, B. E. Lippok, R. Volkmer, P. C. Heinrich, S. Radtke, and H. M. Hermanns (2008)
J. Biol. Chem. 283, 19465-19477
   Abstract »    Full Text »    PDF »
Persistent Activation of STAT3 by Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells.
A. S. Punjabi, P. A. Carroll, L. Chen, and M. Lagunoff (2007)
J. Virol. 81, 2449-2458
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Molecular and Functional Characterization of a Soluble Form of Oncostatin M/Interleukin-31 Shared Receptor.
C. Diveu, E. Venereau, J. Froger, E. Ravon, L. Grimaud, F. Rousseau, S. Chevalier, and H. Gascan (2006)
J. Biol. Chem. 281, 36673-36682
   Abstract »    Full Text »    PDF »
Oncostatin M Enhances CCL21 Expression by Microvascular Endothelial Cells and Increases the Efficiency of Dendritic Cell Trafficking to Lymph Nodes.
M. Sugaya, L. Fang, A. R. Cardones, T. Kakinuma, S. H. Jaber, A. Blauvelt, and S. T. Hwang (2006)
J. Immunol. 177, 7665-7672
   Abstract »    Full Text »    PDF »
Associations of Classic Kaposi Sarcoma with Common Variants in Genes that Modulate Host Immunity..
E. E. Brown, D. Fallin, I. Ruczinski, A. Hutchinson, B. Staats, F. Vitale, C. Lauria, D. Serraino, G. Rezza, G. Mbisa, et al. (2006)
Cancer Epidemiol. Biomarkers Prev. 15, 926-934
   Abstract »    Full Text »    PDF »
Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression.
S. Radtke, H. M. Hermanns, C. Haan, H. Schmitz-Van de Leur, H. Gascan, P. C. Heinrich, and I. Behrmann (2002)
J. Biol. Chem. 277, 11297-11305
   Abstract »    Full Text »    PDF »
Interstitial Collagens I, III, and VI Sequester and Modulate the Multifunctional Cytokine Oncostatin M.
R. Somasundaram, M. Ruehl, B. Schaefer, M. Schmid, R. Ackermann, E. O. Riecken, M. Zeitz, and D. Schuppan (2002)
J. Biol. Chem. 277, 3242-3246
   Abstract »    Full Text »    PDF »
Human Herpesvirus-8-Transformed Endothelial Cells Have Functionally Activated Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor.
R. Masood, E. Cesarman, D. L. Smith, P. S. Gill, and O. Flore (2002)
Am. J. Pathol. 160, 23-29
   Abstract »    Full Text »    PDF »
Interleukin 8 Is an Autocrine Growth Factor and a Surrogate Marker for Kaposi's Sarcoma.
R. Masood, J. Cai, A. Tulpule, T. Zheng, A. Hamilton, S. Sharma, B. M. Espina, D. L. Smith, and P. S. Gill (2001)
Clin. Cancer Res. 7, 2693-2702
   Abstract »    Full Text »    PDF »
Menstrual cycle-specific inhibition of endometrial stromal cell proliferation by oncostatin M.
Y. Ohata, T. Harada, A. Fujii, S. Yoshida, T. Iwabe, and N. Terakawa (2001)
Mol. Hum. Reprod. 7, 665-670
   Abstract »    Full Text »    PDF »
Oncostatin M promotes biphasic tissue factor expression in smooth muscle cells: evidence for Erk-1/2 activation.
T. Nishibe, G. Parry, A. Ishida, S. Aziz, J. Murray, Y. Patel, S. Rahman, K. Strand, K. Saito, Y. Saito, et al. (2001)
Blood 97, 692-699
   Abstract »    Full Text »    PDF »
Kaposi sarcoma is a therapeutic target for vitamin D3 receptor agonist.
R. Masood, S. Nagpal, T. Zheng, J. Cai, A. Tulpule, D. L. Smith, and P. S. Gill (2000)
Blood 96, 3188-3194
   Abstract »    Full Text »    PDF »
Murine Oncostatin M Stimulates Mouse Synovial Fibroblasts in Vitro and Induces Inflammation and Destruction in Mouse Joints in Vivo.
C. Langdon, C. Kerr, M. Hassen, T. Hara, A. L. Arsenault, and C. D. Richards (2000)
Am. J. Pathol. 157, 1187-1196
   Abstract »    Full Text »    PDF »
An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.
C. B. Foster, T. Lehrnbecher, S. Samuels, S. Stein, F. Mol, J. A. Metcalf, K. Wyvill, S. M. Steinberg, J. Kovacs, A. Blauvelt, et al. (2000)
Blood 96, 2562-2567
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Variant genotypes of Fcgamma RIIIA influence the development of Kaposi's sarcoma in HIV-infected men.
T. L. nbecher, C. B. Foster, S. Zhu, D. Venzon, S. M. Steinberg, K. Wyvill, J. A. Metcalf, S. S. Cohen, J. Kovacs, R. Yarchoan, et al. (2000)
Blood 95, 2386-2390
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Results of a Randomized Study of IM862 Nasal Solution in the Treatment of AIDS-Related Kaposi’s Sarcoma.
A. Tulpule, D. T. Scadden, B. M. Espina, S. Cabriales, W. Howard, K. Shea, and P. S. Gill (2000)
J. Clin. Oncol. 18, 716
   Abstract »    Full Text »    PDF »
c-Src Mediates Mitogenic Signals and Associates with Cytoskeletal Proteins upon Vascular Endothelial Growth Factor Stimulation in Kaposi's Sarcoma Cells.
N. Munshi, J. E. Groopman, P. S. Gill, and R. K. Ganju (2000)
J. Immunol. 164, 1169-1174
   Abstract »    Full Text »    PDF »
Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130.
H. M. Hermanns, S. Radtke, C. Haan, H. Schmitz-Van de Leur, J. Tavernier, P. C. Heinrich, and I. Behrmann (1999)
J. Immunol. 163, 6651-6658
   Abstract »    Full Text »    PDF »
The Expression of p53 Tumor Suppressor Gene in Breast Cancer Cells Is Down-Regulated by Cytokine Oncostatin M.
J. Liu, C. Li, T. E. Ahlborn, M. J. Spence, L. Meng, and L. M. Boxer (1999)
Cell Growth Differ. 10, 677-683
   Abstract »    Full Text »
Perspective on Kaposi's Sarcoma: Facts, Concepts, and Conjectures.
M. S. Reitz Jr., L. S. Nerurkar, and R. C. Gallo (1999)
J Natl Cancer Inst 91, 1453-1458
   Full Text »    PDF »
Oncostatin M Induces Angiogenesis In Vitro and In Vivo.
M. Vasse, J. Pourtau, V. Trochon, M. Muraine, J.-P. Vannier, H. Lu, J. Soria, and C. Soria (1999)
Arterioscler. Thromb. Vasc. Biol. 19, 1835-1842
   Abstract »    Full Text »    PDF »
Kinetics of Kaposi's Sarcoma-Associated Herpesvirus Gene Expression.
R. Sun, S.-F. Lin, K. Staskus, L. Gradoville, E. Grogan, A. Haase, and G. Miller (1999)
J. Virol. 73, 2232-2242
   Abstract »    Full Text »
Endogenous Basic Fibroblast Growth Factor Is Essential for Cyclin E-CDK2 Activity in Multiple External Cytokine-Induced Proliferation of AIDS-Associated Kaposi's Sarcoma Cells: Dual Control of AIDS-Associated Kaposi's Sarcoma Cell Growth and Cyclin E-CDK2 Activity by Endogenous and External Signals.
K. Murakami-Mori, S. Mori, and S. Nakamura (1998)
J. Immunol. 161, 1694-1704
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Tat Modulates the Flk-1/KDR Receptor, Mitogen-Activated Protein Kinases, and Components of Focal Adhesion in Kaposi's Sarcoma Cells.
R. K. Ganju, N. Munshi, B. C. Nair, Z.-Y. Liu, P. Gill, and J. E. Groopman (1998)
J. Virol. 72, 6131-6137
   Abstract »    Full Text »    PDF »
Mechanisms of Growth Control of Kaposi's Sarcoma-Associated Herpes Virus-Associated Primary Effusion Lymphoma Cells.
H. Asou, J. W. Said, R. Yang, R. Munker, D. J. Park, N. Kamada, and H. P. Koeffler (1998)
Blood 91, 2475-2481
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gamma -Interferon Production in Peripheral Blood Mononuclear Cells and Tumor Infiltrating Lymphocytes From Kaposi's Sarcoma Patients: Correlation With the Presence of Human Herpesvirus-8 in Peripheral Blood Mononuclear Cells and Lesional Macrophages.
M. C. Sirianni, L. Vincenzi, V. Fiorelli, S. Topino, E. Scala, S. Uccini, A. Angeloni, A. Faggioni, D. Cerimele, F. Cottoni, et al. (1998)
Blood 91, 968-976
   Abstract »    Full Text »    PDF »
Signaling of Type II Oncostatin M Receptor.
P. Auguste, C. Guillet, M. Fourcin, C. Olivier, J. Veziers, A. Pouplard-Barthelaix, and H. Gascan (1997)
J. Biol. Chem. 272, 15760-15764
   Abstract »    Full Text »    PDF »
Glucocorticoids Induce Kaposi's Sarcoma Cell Proliferation Through the Regulation of Transforming Growth Factor-beta.
J. Cai, T. Zheng, M. Lotz, Y. Zhang, R. Masood, and P. Gill (1997)
Blood 89, 1491-1500
   Abstract »    Full Text »    PDF »
Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma.
R. Masood, J. Cai, T. Zheng, D. L. Smith, Y. Naidu, and P. S. Gill (1997)
PNAS 94, 979-984
   Abstract »    Full Text »    PDF »
The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1Gene Expression.
E. Korzus, H. Nagase, R. Rydell, and J. Travis (1997)
J. Biol. Chem. 272, 1188-1196
   Abstract »    Full Text »    PDF »
Oncostatin M induces basic fibroblast growth factor expression in endothelial cells and promotes endothelial cell proliferation, migration and spindle morphology.
E. Wijelath, B Carlsen, T Cole, J Chen, S Kothari, and W. Hammond (1997)
J. Cell Sci. 110, 871-879
   Abstract »    PDF »
Dual Oncostatin M (OSM) Receptors. CLONING AND CHARACTERIZATION OF AN ALTERNATIVE SIGNALING SUBUNIT CONFERRING OSM-SPECIFIC RECEPTOR ACTIVATION.
B. Mosley, C. De Imus, D. Friend, N. Boiani, B. Thoma, L. S. Park, and D. Cosman (1996)
J. Biol. Chem. 271, 32635-32643
   Abstract »    Full Text »    PDF »
The Effects of Preparations of Human Chorionic Gonadotropin on AIDS-Related Kaposi's Sarcoma.
P. S. Gill, Y. Lunardi-Iskandar, S. Louie, A. Tulpule, T. Zheng, B. M. Espina, J. M. Besnier, P. Hermans, A. M. Levine, J. L. Bryant, et al. (1996)
N. Engl. J. Med. 335, 1261-1267
   Abstract »    Full Text »    PDF »
Inhibition of Endothelial Cell Growth by Macrophage-like U-937 Cell-derived Oncostatin M, Leukemia Inhibitory Factor, and Transforming Growth Factor beta 1.
S. Takashima and M. Klagsbrun (1996)
J. Biol. Chem. 271, 24901-24906
   Abstract »    Full Text »    PDF »
Interleukin-6 Family of Cytokines Induced Activation of Different Functional Sites Expressed by gp130 Transducing Protein.
S. Chevalier, M. Fourcin, O. Robledo, J. Wijdenes, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 14764-14772
   Abstract »    Full Text »    PDF »
HIV-Related Tumors of the Oral Cavity.
G. Ficarra and L.E. Eversole (1994)
Critical Reviews in Oral Biology & Medicine 5, 159-185
   Abstract »    Full Text »    PDF »
Detection of Human Immunodeficiency Virus Type 1 and Human Papillomavirus Type 16 in Acquired Immunodeficiency Syndrome-Related and Classic Kaposi's Sarcoma.
H. Fujiwara, K. Hashimoto, K. Fujiwara, and A. H. Mehregan (1993)
Arch Dermatol 129, 1620-1622
   Abstract »    PDF »
Kaposi's Sarcoma: Where Do We Go From Here?.
P. L. Myskowski (1993)
Arch Dermatol 129, 1320-1323
   Abstract »    PDF »
The Immunopathogenesis of Human Immunodeficiency Virus Infection.
G. Pantaleo, C. Graziosi, and A. S. Fauci (1993)
N. Engl. J. Med. 328, 327-335
   Full Text »
Interleukin-6 and its receptor: a paradigm for cytokines.
T Kishimoto, S Akira, and T Taga (1992)
Science 258, 593-597
   Abstract »    PDF »
Kaposi's sarcoma gives on key fronts.
J Palca (1992)
Science 255, 1352-1354
   PDF »
Non-redundant Signal Transduction of Interleukin-6-type Cytokines. THE ADAPTER PROTEIN Shc IS SPECIFICALLY RECRUITED TO THE ONCOSTATIN M RECEPTOR.
H. M. Hermanns, S. Radtke, F. Schaper, P. C. Heinrich, and I. Behrmann (2000)
J. Biol. Chem. 275, 40742-40748
   Abstract »    Full Text »    PDF »


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